Report in Current Biology by Lie-Jensen and Haglund: Parallels between ALIX recruitment during cytokinetic abscission in flies and virus budding in human cells
Understanding how abscission between daughter cells during the final stage of cell division, cytokinesis, is accurately controlled is relevant for cancer, because failure in this process may give rise to binucleate cells and in the next cell division chromosomal missegregation, which might cause aneuploidy, a common feature of cancer cells. In a recent issue of Current Biology, Lie-Jensen and co-authors elucidate a mechanism by which the abscission machinery is recruited to the midbody in the fruit fly Drosophila melanogaster during abscission.
