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Science Signalling paper from Taskén group: Systems analysis of prostaglandin E2 signaling networks through four GPCRs on T cells

Anna Mari Lone (1st author) & Kjetil Taskén (senior author), both Dept. of Cancer Immunology, Institute for Cancer Research, OUH
Anna Mari Lone (1st author) & Kjetil Taskén (senior author), both Dept. of Cancer Immunology, Institute for Cancer Research, OUH

Immune suppressive mechanisms serve several important biological functions in the human body, which includes controlling autoimmunity and minimizing harmful side effects, inflammation and tissue damage in the course of healthy and successful immune responses to pathogens. These mechanisms, which prevent immunological overshoot, can be hijacked by growing tumor cells, resulting in tumor immune escape, which is a crucial process in tumorigenesis. The lipid mediator prostaglandin E2 suppresses antitumor immunity by activating its four related GPCRs (EP1 to EP4) on T cells.

 

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