In a recent paper in Nature Cell Biology, an international team led by scientists at Institute for Cancer Research and Institute of Basic Medical Sciences shows that uncontrolled repair of micronuclear membranes causes chromosome shattering associated with cancer.
The incidence of Ductal Carcinoma in Situ (DCIS) has increased dramatically in parallel with widespread implementation of screening mammography and comprises today about 20% of newly diagnosed breast cancers. These non-invasive breast tumors are heterogeneous and many will never progress to invasive cancer.
In an article published in npj Breast Cancer 17. June 2020, Helga Bergholtz, Tonje Lien and colleagues in Therese Sørlie’s group present a comprehensive analysis of gene expression, DNA methylation and copy number data in DCIS and invasive breast cancer and found distinct molecular subtype-specific differences.