Immune suppressive mechanisms serve several important biological functions in the human body, which includes controlling autoimmunity and minimizing harmful side effects, inflammation and tissue damage in the course of healthy and successful immune responses to pathogens. These mechanisms, which prevent immunological overshoot, can be hijacked by growing tumor cells, resulting in tumor immune escape, which is a crucial process in tumorigenesis. The lipid mediator prostaglandin E2 suppresses antitumor immunity by activating its four related GPCRs (EP1 to EP4) on T cells.
From major journals, first or last author from the Institute for Cancer Research
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