The Malmberg lab partner in major cancer immunotherapy project
Karl-Johan Malmberg
The Malmberg Lab is one of four partners in project that recently was awarded 31 MSEK to study and develop new technologies for cancer immunotherapy. The constellation is led by Professor Bjorn Onfelt at the Royal Institute of Technology in Sweden.
The team focus on T and NK cells and their interactions with tumor cells in both 2D and 3D models.
“One of the most exciting things with this collaboration is the interdisciplinary collaboration between biologists, clinical scientists and phycisists”, says Kalle Mamberg, who holds a Visiting Professor position at the Karolinska Institute.
The key challenge is to identify the right cells for the job of eliminating tumor cells. Onfelt Lab has developed a microchip screening platform with 30.000 wells measuring 22x22micrometer. The confined area and multiple wells allows visualization and quantification of multiple, serial interactions using advanced confocal microscopy. It holds potential to identify subpopulations of cells with increased killing capacity.
From major journals, first or last author from the Institute for Cancer Research
Brodal HP, Pharo H, Vedeld HM, Lind GE(2025) PoDCall: a robust tool for automated droplet classification in DNA-methylation droplet digital PCR Mol Oncol(in press) DOI 10.1002/1878-0261.70105, PubMed 40761129
Radulovic M, Yang C, Stenmark H(2025) Lysosomal membrane homeostasis and its importance in physiology and disease Nat Rev Mol Cell Biol(in press) DOI 10.1038/s41580-025-00873-w, PubMed 40759742
Hermansen JU, Athanasiadis P, Yin Y, Rise AF, Arribas AJ, Cascione L, Russnes HG, Helland Å, Mato AR, Bertoni F, Tjønnfjord GE, Aittokallio T, Skånland SS(2025) Proteasome inhibition overcomes resistance to targeted therapies in B-cell malignancy models and in an index patient Cell Death Dis, 16(1), 555 DOI 10.1038/s41419-025-07884-7, PubMed 40701968
Brodal HP, Pharo H, Vedeld HM, Lind GE(2025) PoDCall: a robust tool for automated droplet classification in DNA-methylation droplet digital PCR Mol Oncol(in press) DOI 10.1002/1878-0261.70105, PubMed 40761129
Radulovic M, Yang C, Stenmark H(2025) Lysosomal membrane homeostasis and its importance in physiology and disease Nat Rev Mol Cell Biol(in press) DOI 10.1038/s41580-025-00873-w, PubMed 40759742
Schmidt N, Kornrumpf K, Ries L, Markus K, Ksionsko N, Mazzeo P, Lohrberg M, Sitte M, Salinas-Riester G, Braun T, Dechow A, Herling M, Ianevski A, Aittokallio T, Chapuy B, Bastians H, Wulf GG, Beißbarth T, Dönitz J, Koch R(2025) Discovery of molecularly-informed therapeutic strategies for mature T-cell leukemias and lymphomas Blood Adv(in press) DOI 10.1182/bloodadvances.2024015167, PubMed 40758950