Rusten and Stenmark with review in Nature Cell Biology
In the Dec 22 2011 issue of Nature Cell Biology (journal impact factor 19.407), Tor Erik Rusten and Harald Stenmark from the Institute for Cancer Research and the Centre for Cancer Biomedicine review recent findings that implicate the endosomal sorting complex required for transport (ESCRT) machinery in developmental processes. Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, ESCRT components have recently been shown to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA activity and mRNA transport.
Several of these functions are relevant to tumour suppression, and ESCRT components have indeed been identified as tumor suppressors in mice and fruit flies.
Rusten and Stenmark have co-authored the review with Thomas Vaccari from the FIRC Institute of Molecular Oncology in Milan, an expert on tumourigensis and developmental processes in fruit flies.
Developmental processes (indirectly) controlled by ESCRT proteins, and their underlying cell biological basis. (click to enlarge image)
Bai B, Vodák D, Nakken S, Wise JF, Blaker YN, Lingjærde OC, Brodtkorb M, Hilden V, Trøen G, Lorenz S, Lawrence MS, Myklebost O, Meza-Zepeda L, Beiske K, Hovig E, Smeland EB, Holte H, Myklebust JH(2019) Deep Profiling of Genetic Aberrations and Clonal Evolution in Follicular Lymphoma Blood, 134(Supplement_1), 20 DOI 10.1182/blood-2019-128403, PubMed 31723999
Fornes O, Castro-Mondragon JA, Khan A, van der Lee R, Zhang X, Richmond PA, Modi BP, Correard S, Gheorghe M, Baranašić D, Santana-Garcia W, Tan G, Chèneby J, Ballester B, Parcy F, Sandelin A, Lenhard B, Wasserman WW, Mathelier A(2019) JASPAR 2020: update of the open-access database of transcription factor binding profiles Nucleic Acids Res(in press) DOI 10.1093/nar/gkz1001, PubMed 31701148
Nygård S, Lingjærde OC, Caldas C, Hovig E, Børresen-Dale AL, Helland Å, Haakensen VD(2019) PathTracer: High-sensitivity detection of differential pathway activity in tumours Sci Rep, 9(1), 16332 DOI 10.1038/s41598-019-52529-3, PubMed 31704995