Scientists from the Department of Genetics, Institute for Cancer Research and the KG Jebsen Center for Breast Cancer Research, Department of Biostatistics , Faculty of Medicine and Institute for Informatics, University in Oslo have published an article in the prestigious journal Nature Review Cancer (impact factor 35), entitled "Principles and methods of integrative genomic analyses in cancer".
The authors discuss how combined analyses of molecular data, such as DNA copy-number alteration, mRNA and protein expression, may point to biological functions and molecular pathways being deregulated in multiple cancers and can be used to identify novel patient subgroups for tailored therapy and monitoring.
Principles and methods of integrative genomic analyses in cancer.
Kristensen VN, LingjĂ¦rde OC, Russnes HG, Vollan HK, Frigessi A, BĂ¸rresen-Dale AL.
Nat Rev Cancer. 2014 Apr 24;14(5):299-313. doi: 10.1038/nrc3721.
Download article in PDF format