Magnus Løberg and Michael Bretthauer from the Department of Transplantation Medicine at Oslo University Hospital are first and last author respectively on an article recently published in New Eng J Med (journal impact factor 54.42), entitled "Long-Term Colorectal-Cancer Mortality after Adenoma Removal".
Taking advantage of nationwide data in the Cancer Registry of Norway on patients who have had colorectal adenomas removed, they have evaluated colorectal-cancer mortality in a large, population-based cohort with virtually complete follow-up for death from colorectal cancer.
The findings are commented in an editorial in NEJM.
Their finding that the removal of low-risk adenomas reduces the risk of death from colorectal cancer over a period of 8 years to a level below the risk in the general population is consistent with the hypothesis that surveillance every 5 years after removal of low-risk adenomas may confer little benefit over less intensive surveillance strategies. Furthermore, complications associated with colonoscopy are not trivial and might offset the benefit of surveillance.
Long-term colorectal-cancer mortality after adenoma removal.
Løberg M, Kalager M, Holme Ø, Hoff G, Adami HO, Bretthauer M.
N Engl J Med. 2014 Aug 28;371(9):799-807.
Editorial in NEJM about the findings: Colon-Polyp Surveillance - Do Patients Benefit?
Coverage in Norwegian media:
University of Oslo home page: Unødvendige kontroller for tarmkreft
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