Flotillin-2: A new potential predictor for prognosis of breast cancer
Sascha Pust, first author
Overexpression of ErbB2 occurs in up to 30% of human breast cancers. ErbB2 is not down-regulated by ligand-induced mechanisms as many other receptors. In a new study now published in Oncogene (journal impact factor 6.4), Sascha Pust (photo) from Kirsten Sandvig's group at the Institute for Cancer Research and coworkers show that flotillins stabilize ErbB2 at the plasma membrane. Moreover, microarray analysis of biopsies of 194 breast cancer patients indicated that flotillin-2 is a good prognostic marker for breast cancer. Depletion of flotillins leads to internalization and degradation of ErbB2, thereby inhibiting the ErbB2-triggered signaling.
This study was a collaboration between several groups, including three groups (Sandvig, Danielsen, Liestøl) from the Center for Cancer Biomedicine (CCB).
From major journals, first or last author from the Institute for Cancer Research
Brodal HP, Pharo H, Vedeld HM, Lind GE(2025) PoDCall: a robust tool for automated droplet classification in DNA-methylation droplet digital PCR Mol Oncol(in press) DOI 10.1002/1878-0261.70105, PubMed 40761129
Radulovic M, Yang C, Stenmark H(2025) Lysosomal membrane homeostasis and its importance in physiology and disease Nat Rev Mol Cell Biol(in press) DOI 10.1038/s41580-025-00873-w, PubMed 40759742
Hermansen JU, Athanasiadis P, Yin Y, Rise AF, Arribas AJ, Cascione L, Russnes HG, Helland Å, Mato AR, Bertoni F, Tjønnfjord GE, Aittokallio T, Skånland SS(2025) Proteasome inhibition overcomes resistance to targeted therapies in B-cell malignancy models and in an index patient Cell Death Dis, 16(1), 555 DOI 10.1038/s41419-025-07884-7, PubMed 40701968
Brodal HP, Pharo H, Vedeld HM, Lind GE(2025) PoDCall: a robust tool for automated droplet classification in DNA-methylation droplet digital PCR Mol Oncol(in press) DOI 10.1002/1878-0261.70105, PubMed 40761129
Radulovic M, Yang C, Stenmark H(2025) Lysosomal membrane homeostasis and its importance in physiology and disease Nat Rev Mol Cell Biol(in press) DOI 10.1038/s41580-025-00873-w, PubMed 40759742
Schmidt N, Kornrumpf K, Ries L, Markus K, Ksionsko N, Mazzeo P, Lohrberg M, Sitte M, Salinas-Riester G, Braun T, Dechow A, Herling M, Ianevski A, Aittokallio T, Chapuy B, Bastians H, Wulf GG, Beißbarth T, Dönitz J, Koch R(2025) Discovery of molecularly-informed therapeutic strategies for mature T-cell leukemias and lymphomas Blood Adv(in press) DOI 10.1182/bloodadvances.2024015167, PubMed 40758950