Monika HĂ„kerud from Kristian BergÂs group at the Department of Radiation Biolgy is first author on an important pre-clinical work on the use of the photochemical internalization (PCI) technology to improve vaccination for stimulation of cytotoxic T cells. The article - entitled "Intradermal photosensitisation facilitates stimulation of MHC class-I restricted CD8 T-cell responses of co-administered antigen" - was recently published in the Journal of Controlled Release (journal IF 7.6). HĂ„kerud is currently a visiting scientist in PĂ„l JohansenÂs lab at the University Hospital Zurich, Switzerland.
The study demonstrates that PCI can facilitate targeting of protein antigen to cytosol and thereby enable MHC class-I antigen presentation and stimulation of CD8 T cells as measured by proliferation and pro-inflammatory cytokine secretion. Most importantly, PCI-based vaccination hampered growth of CD8 T-cell-sensitive malignant tumours in mice. This fruitful academic-industry collaboration was initiated when PĂ„l K. Selbo (co-author in paper and member of Kristian Berg group) introduced the PCI technology for the Zurich group in 2010.
Intradermal photosensitisation facilitates stimulation of MHC class-I restricted CD8 T-cell responses of co-administered antigen.
HĂ„kerud M, Waeckerle-Men Y, Selbo PK, KĂŒndig TM, HĂžgset A, Johansen P.
J Control Release. 2013 Nov 23.