Many cellular processes relevant to cancer, including cytokinesis, membrane sealing and formation intraluminal vesicles in endosomes, involve abscission of narrow membrane tubes filled with cytosol. Such processes are mediated by a protein machinery known as endosomal sorting complex required for transport, ESCRT. The review by Vietri, Radulovic and Stenmark highlights the functions of ESCRT proteins in diverse membrane scission/sealing reactions and discusses their relevance to cancer and other diseases.
The review article:
Home page of Harald Stenmark's group - Cellular Membrane Dynamics
Individual web pages: