The September issue of "Nature Reviews Cancer" review a recent article from Anne-Lise Børresen-Dale's group in the "Research highlight" section. The paper that has attracted special attention is entitled "Genomic architecture characterizes tumor progression paths and fate in breast cancer patients", and was published in the prestigious journal Science Translation Medicine in June 2010. The article is first-authored by Hege Russnes (photo) and has Anne-Lise Børresen-Dale as last author. In this work Borresen-Dale and colleagues identify chromosomal rearrangement patterns that might have prognostic value, independently of gene signature and histology.
Research Highlight: Genomics: A broad brush
Nature Reviews Cancer 10, 600-601 (September 2010)
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients.
Russnes HG, Vollan HK, Lingjaerde OC, Krasnitz A, Lundin P, Naume B, Sørlie T, Borgen E, Rye IH, Langerød A, Chin SF, Teschendorff AE, Stephens PJ, Månér S, Schlichting E, Baumbusch LO, Kåresen R, Stratton MP, Wigler M, Caldas C, Zetterberg A, Hicks J, Børresen-Dale AL.
Sci Transl Med. 2010 Jun 30;2(38):38ra47.