Erik S. Vik and Ingrun Alseth from Department of Microbiology are first and last authors of an article published in Nature Communications 05.08.2013 entitled "Endonuclease V cleaves at inosines in RNA".
In this paper novel enzymatic properties for humane Endonuclease V have been revealed. Whereas bacterial homologs of Endonuclease V are DNA repair proteins, the authors find that the humane enzyme rather is active on modified RNA.
RNA modifications are essential for normal function of the transcripts and defects in these processes are linked to various human disorders including cancer, infectious and neurological disease. Thus, these finding opens new avenues for research in various medical fields.
Endonuclease V cleaves at inosines in RNA.
Sebastian Vik E, Sameen Nawaz M, Strøm Andersen P, Fladeby C, Bjørås M, Dalhus B, and Alseth I.
Nat Commun. 2013 Aug 5;4:2271. doi: 10.1038/ncomms3271.