Centre for Cancer Biomedicine (CCB) welcomes you to a research seminar on Monday the 15th of April at 15.00 hrs in the Auditorium in the Research Building, the Norwegian Radium Hospital.
Professor Professor Robin Irvine from Cambridge Neuroscience, Department of Pharmacology, University of Cambridge, UK, will give a talk on the following subject: "Phosphatidylinositol 5-phosphate 4-kinases: an inositol lipid enigma?".
The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are currently the most enigmatic of the inositol lipid-metabolising enzymes. Although they catalyse an alternative route of synthesis of the important multi-tasking lipid, PI(4,5)P2, the low levels of their substrate, PI5P, compared with those of PI4P, the substrate for what is agreed to be the major route of PI(4,5)P2 synthesis, make it unlikely that they contribute much to cellular PI(4,5)P2 synthesis. So our current understanding is that they regulate PI5P levels, but what PI5P does, and how it is itself synthesised, is still not fully understood. The puzzle of PI5P4Ks is only deepened by our recent discoveries that the three mammalian isoforms PI5P4Ks a, b and g apparently (a) are in different cellular locations, (b) dimerise randomly with each other, and (c) differ in their PI5P 4-kinase activities by 3-4 orders of magnitude. How they talk to each other and what they actually do is therefore still very far from clear, and will be the major focus of this seminar.