In a recent article in Journal of Nanobiotechnology, Tore-Geir Iversen and coworkers show that quantum dots covered with ricin B is taken up by a macropinocytosis-like mechanism. The results demonstrate that the internalization of a ligand-nanoparticle conjugate can be dependent on other endocytic mechanisms than those used by the free ligand. The results are thus highlighting the challenges of using ligand-mediated targeting of nanoparticle-based drug delivery vehicles to cells of diseased tissues.”
Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism.
Iversen TG, Frerker N, Sandvig K.
J Nanobiotechnology. 2012 Jul 31;10(1):33.
Tore-Geir Iversen's project group: Entry of nanoparticles into cells
Tore-Geir Iversen's publications
Kirsten Sandvig'r group: Intracellular transport
Department of Biochemistry