In a collaborative effort headed by the Syljuåsen group at the Department of Radiation Biology and Thomas Küntziger from Philippe Collas' group at the University of Oslo, Helga Bjarnason Landsverk (photo) has found that PNUTS (Protein phosphatase 1 NUclear Targeting Subunit) plays an unexpected and important role in control of the radiation-induced G2 checkpoint and DNA damage repair. These results were recently published in EMBO Reports.
Understanding basic molecular mechanisms of the DNA damage response is important to increase our knowledge about carcinogenesis and to develop improved cancer treatment strategies.
The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.
Landsverk HB, Mora-Bermúdez F, Landsverk OJ, Hasvold G, Naderi S, Bakke O, Ellenberg J, Collas P, Syljuåsen RG, Küntziger T.
EMBO Rep. 2010 Oct 1. [Epub ahead of print]
Link to PubMed - Direct link to the article at EMBO Reports
About the journal "EMBO Reports" (journal impact factor 6.9)
Helga B Landsverk
Randi Syljuåsen's group - Radiation Biology and DNA Damage Signaling
P. Collas lab