Title of his talk: MicroRNAs in Osteosarcoma
Time and place: 12.00, Auditorium, new research building, Montebello.
MicroRNAs in Osteosarcoma
Subbaya Subramanian, Ph.D.
Research Program: Genetic Mechanisms of Cancer
Assistant Professor, Department of Surgery
MicroRNA mediated gene regulation in human sarcomas; gene expression profilesdeveloping novel diagnostic markers and identification of therapeutic targets in sarcomas and other cancers.
For more information, see Dr. Subramanian's Lab Web site: http://www.tc.umn.edu/~subree/
Speaker invited by Ola Myklebost, Tumor Biology
Beckman JD, Chen C, Nguyen J, Thayanithy V, Subramanian S, Steer CJ, and Vercellotti GM. Regulation of Heme-Oxygenase-1 protein expression by miR-377 in combination with miR-217. J Biol Chem 2010 [Epub ahead of print].
Sarver A, Li L, Subramanian S. miR-183 functions as a potential oncogene by targeting EGR1 and promoting tumor cell migration. Cancer Res 2010;70: 9570â"9580.
Park C, Zeng Y, Zhang X, Subramanian S and Steer CJ. MicroRNAs identified in highly purified nuclei from HCT116 colon cancer cells. RNA Biology 2010;7(5).
Sarver A, Phalak R, Thayanithy V, Subramanian S. S-MED: Sarcoma microRNA Expression Database. Lab Invest 2010 90 :753-761.
Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PCW, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CDM, van de Rijn M. Genome-wide transcriptome analyses reveals p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumors. J Pathol 2010;220:58-70.
Subramanian S, Steer CJ. MicroRNA as gatekeepers of apoptosis. J Cell Physiol 2010;223:289-298.
Kartha RV, Subramanian S. MicroRNAs in cardiovascular diseases: Biology and potential clinical applications. J Cardiovasc Tran Res 2010;3:256-270.
Wang L, Tang H, Thayanithy T, Subramanian S, Oberg AL, Cunningham JM, Cerhan JR, Steer CJ, Thibodeau SN. Gene networks and microRNAs implicated in aggressive prostate cancer. Cancer Res 2009;69:9490-9497.
Lee CH, Subramanian S, Beck AH, Espinosa I, Senz J, Zhu S, Huntsman D, van de Rijn M, Gilks C. MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation carrying high-grade serous carcinomas of ovary. PLoS One 2009 4(10):e7314.
Sarver AL, French A, Borralho PM , Thayanithy V, Silverstein K, Morlan B, Oberg A, Cunningham J, Subramanian S, Wang L, Rodrigues C, Thibodeau SN, Steer CJ. Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. BMC Cancer 2009;9:401.
Wang L, Oberg AL, Asmann YW, Sicotte H, McDonnell SK, Riska SM, Liu W, Steer CJ, Subramanian S, Cunningham JM, Cerhan JR and Thibodeau SN. Genome-wide transcriptional profiling reveals microRNA-correlated genes and pathways in human lymphoblastoid cell lines. PLoS One 2009 4 (6):e5878.
Hu Z, Fan C, Livasy C, He X, Oh DS, Ewend MG, Carey LA, Subramanian S, West R, Ikpatt F, Olopade OI, van de Rijn M, Perou CM. A compact VEGF signature associated with distant metastases and poor outcomes. BMC Med 2009;7:9.
Clarke B, Tinker AV, Lee C, Subramanian S, van de Rijn M, Turbin D, Cadungog MG, Huntsman D, Coukos G, Gilks CB. Intraepithelial T cells and prognosis in ovarian carcinoma: Novel associations with stage, tumor type and BRCA1 loss. Mod Pathol 2009 22:393-402.
Subramanian S, Lui WO, Lee CH, Espinosa E, Nielsen T, Heinrich M, Corless C, Fire A, and van de Rijn M. MicroRNA expression signature of human soft tissue tumors Oncogene 2008 27:2015-2016
Lubieniecka JM, de Bruijn D, Su L,van Dijk A, Subramanian S, van de Rijn M, Poulin N, van Kessel A,Nielsen TO.Histone deacetylase inhibitors reverse SS18-SSX mediated polycomb silencing of the tumor suppressor EGR1 in synovial sarcoma. Cancer Res 2008;68:4303-4310.
Lee C, Espinosa I, Jensen K, Subramanian S, Zhu S, Varma S, Montgomery K, Nielsen TO, van de Rijn M and West R. Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone. Mod Pathol. 2008;21:531-539.
Lee C, Espinosa I, Vrijaldenhoven S, Subramanian S, Montgomery K, Zhu S, Poulin N, Nielsen T, West R, Gilks B, van de Rijn M. Prognostic significance of macrophage marker in leiomyosarcomas. Clin Caner Res 2008 14; 1423-1430
Espinosa I, Lee C, Kim M, Rouse B, Subramanian S, Montgomery K, Corless CL, Heinrich MC, Smith KS, et al. A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Path 2007 32; 210-218
Terry J, Saito T, Subramanian S, Ruttan C, Antonescu CR, Goldblum JR, Downs-Kelly E, Corless CL, Rubin BP, van de Rijn M, Ladanyi M, and Nielsen TO. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies Am J Surg Path 2007 31: 240-246
West RB, Rubin BP, Miller M, Subramanian S, Kaygusuz G, Montgomery K, Luca AD, Gilks B, Nielsen TO, Huntsman D and van de Rijn M. CSF1-COL6A3 gene fusion is present in a minority of tumor cells in tenosynovial giant cell tumor and pigment villonodular synovitis Proc Natl Acad SciÂ USA 2006 103:690-695