The institute seminar on Wednesday June 16th is given by Rolf Inge Skotheim from the Department of Cancer Prevention.
Title of his talk: Qualitative transcriptomics: identification of cancer specific transcripts and potential clinical implications
The seminar takes place in Auditorium (New Research Building Montebello) and starts at 10:30.
Qualitative transcriptomics: identification of cancer specific transcripts and potential clinical implications
Rolf Skotheim, Dept of Cancer Prevention
The Genome biology group investigate cancer genomes by integrated computational and laboratory based approaches. Our aim is to identify and characterise critical genes involved in the cancer development. Such genes may serve as diagnostic or prognostic biomarkers and also as targets for future molecularly tailored therapy. Our studies are mainly focused on colorectal, testicular, and prostate cancers.
In the institute seminar, I will describe a qualitative transcriptomics approach where we aim to identify and characterize cancer-specific transcript variants, such as those originating from alternative splicing, alternative promoter usage, and fusion genes. In particular we use methods such as exon level microarrays and high-throughput sequencing. We are also using a novel oligonucleotide microarray-based system for fusion gene detection. This new tool enables screening of a sample for the presence of all oncogenic fusion transcripts known to date in a single experiment.