Department of Genetics has been involved in an article presented in Nature (journal impact factor 36.10). By integrating the copy number and gene expression of 2000 breast tumors, novel subgroups of breast cancer with distinct clinical outcome were revealed. Copy number was associated with expression in ~40% of genes. Co-authors from the Department of Genetics are Anita Langerød and Anne-Lise Børresen-Dale.
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis et al., Nature, (2012).
Brief summary, by co-author Anita Langerød:
The study is a follow-up and continuance of what Børresen-Dale and her group showed 12 years ago, where new breast cancer subtypes were defined by gene expression. The resulting classification of breast tumors has been used worldwide since. Børresen-Dale has been advisor of study design, and her lab has contributed to the mutation analysis and identification of different mutation patterns in the 10 subgroups that were identified.
The ”METABRIC” study is a collaboration between Canada and UK (Samuel Aparicio and Carlos Caldas) and consists of more than 2000 patients with 15 years follow-up. The dataset is remarkably massive and will become a reference material for breast cancer research in years to come. The data also builds a solid foundation for development of “personalized medicine”.
|Anne-Lise Børresen-Dale (left) and Anita Langerød (click to enlarge image)|
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Curtis C et al. (OUS co-authors: Anita Langerød and Anne-Lise Børresen-Dale)
Nature. 2012 Apr 18. doi: 10.1038/nature10983. [Epub ahead of print]
News article in Norwegian from web site abcnyheter.no:
- Brystkreft er ikke én, men ti sykdommer