Light Meets Precision: EIC Pathfinder Project SCALPEL Pioneering a Revolutionary Photoimmunotherapy for Cancer

Theo Theodossiou, Project coordinator

In a groundbreaking effort to revolutionise modern oncology, the SCALPEL project launches a Europe wide initiative aimed at redefining cancer treatment by using light to precisely ‘click’ tags to cancer cells, enabling the immune system to recognise and destroy them with unparalleled accuracy. Project coordinator is Theo Theodossiou, head of the Protonics project group at the Department of Radiation Biology at OUH.

The multidisciplinary initiative funded by the European Innovation Council Pathfinder programme under Horizon Europe with a total budget of more than EUR 4 million aims to revolutionise modern oncology offering new hope for millions worldwide.

Links:

SCALPEL press release (PDF) (March 19 2025)

Theodossis Athanassios Theodossiou's publications

Protonics project group, headed by Theo Theodossiou

Department of Radiation Biology

Institute for Cancer Research

Recent publications

From major journals, first or last author from the Institute for Cancer Research

Brodal HP, Pharo H, Vedeld HM, Lind GE (2025)
PoDCall: a robust tool for automated droplet classification in DNA-methylation droplet digital PCR
Mol Oncol (in press)
DOI 10.1002/1878-0261.70105, PubMed 40761129

Radulovic M, Yang C, Stenmark H (2025)
Lysosomal membrane homeostasis and its importance in physiology and disease
Nat Rev Mol Cell Biol (in press)
DOI 10.1038/s41580-025-00873-w, PubMed 40759742

Hermansen JU, Athanasiadis P, Yin Y, Rise AF, Arribas AJ, Cascione L, Russnes HG, Helland Å, Mato AR, Bertoni F, Tjønnfjord GE, Aittokallio T, Skånland SS (2025)
Proteasome inhibition overcomes resistance to targeted therapies in B-cell malignancy models and in an index patient
Cell Death Dis, 16 (1), 555
DOI 10.1038/s41419-025-07884-7, PubMed 40701968

More selected publications

Most recent publications

Brodal HP, Pharo H, Vedeld HM, Lind GE (2025)
PoDCall: a robust tool for automated droplet classification in DNA-methylation droplet digital PCR
Mol Oncol (in press)
DOI 10.1002/1878-0261.70105, PubMed 40761129

Radulovic M, Yang C, Stenmark H (2025)
Lysosomal membrane homeostasis and its importance in physiology and disease
Nat Rev Mol Cell Biol (in press)
DOI 10.1038/s41580-025-00873-w, PubMed 40759742

Schmidt N, Kornrumpf K, Ries L, Markus K, Ksionsko N, Mazzeo P, Lohrberg M, Sitte M, Salinas-Riester G, Braun T, Dechow A, Herling M, Ianevski A, Aittokallio T, Chapuy B, Bastians H, Wulf GG, Beißbarth T, Dönitz J, Koch R (2025)
Discovery of molecularly-informed therapeutic strategies for mature T-cell leukemias and lymphomas
Blood Adv (in press)
DOI 10.1182/bloodadvances.2024015167, PubMed 40758950

More publications

Annual summary of publications