The institute seminar on Wednesday November 10th is given by Randi G. Syluåasen from the Department of Radiation Biology.
Title of her talk: Molecular mechanisms and cancer relevance of DNA damage checkpoints
The seminar takes place in the Auditorium (New Research Building Montebello) and starts at 12:00.
Molecular mechanisms and cancer relevance of DNA damage checkpoints
Randi G. Syljuåsen from the Department of Radiation Biology, Institute for Cancer Research
In response to DNA damage, human cells activate signaling pathways to induce cell cycle checkpoints and DNA repair. Defects in DNA damage signaling may cause genomic instability and contribute to cancer development. The goals of our work are 1) to understand basic mechanisms of DNA damage checkpoints and 2) to explore potential clinical relevance. I will present our ongoing work regarding mechanisms of the ionizing radiation- induced G2 checkpoint, where we among other methods use siRNA large-scale screening. To explore potential clinical relevance we are currently investigating the hypothesis that abrogation of checkpoint signaling may be used to selectively target hypoxic cancer cells.
Organizers of Institute seminars:
Beata Grallert, Department of Cell Biology
Sebastian Patzke, Department of Radiation Biology