Small proteins of less than 50 amino acids are important in cellular processes such as regulation, signalling, and antibacterial action. Ragnhild Weel-Sneve (photo) et al demonstrate that a small inner membrane protein of 27 amino acids, DinQ, modulates recombination and transformation of nucleoid morphology in response to UV damage. The results are published in the Feb 7th issue of the high-ranked journal "PLoS Genetics" (journal impact factor 8.694) and provide new insights into small hydrophobic peptides that regulate important DNA metabolic processes dependent on the inner membrane of the cell.
This work is a collaborative project between the research groups of Magnar Bjørås, Kirsten Skarstad and Torbjørn Rognes.
The PLoS article:
Single Transmembrane Peptide DinQ Modulates Membrane-Dependent Activities.
Weel-Sneve R, Kristiansen KI, Odsbu I, Dalhus B, Booth J, Rognes T, Skarstad K, Bjørås M.
PLoS Genet. 2013 Feb;9(2):e1003260. doi: 10.1371/journal.pgen.1003260. Epub 2013 Feb 7.
Magnar Bjørås's group - Laboratory for molecular biology
Kirsten Skarstad's group - Regulation of DNA replication
Torbjørn Rognes's group - Bioinformatics Group