Breaking advances in prognostic testing of colorectal cancer
Results from colorectal cancer research at Department of Cancer Prevention, Institute for Cancer Research and Department of Gastrointestinal Surgery have been highlighted from recent cancer literature as Breaking Advances in the AACR journal Cancer Research, October 15th, 2012.
Dr. Anita Sveen and co- workers have shown in a paper published online September 18th in Clinical Cancer Research, that the expression levels of 7 genes can predict the outcome in particular among stage III colorectal cancer patients. About 400 patients from 3 independent clinical series were included in the study. The genetic signature remained significant across technology platforms, in multivariate analyses, and was independent of treatment. The latter opens for guidance on who may benefit from surgery alone and can avoid chemotherapy and the side effects thereof.
This study is part of a translational research programme on colorectal cancer led by Professor Ragnhild A. Lothe.
Sveen A, Ågesen TH, Nesbakken A, Meling GI, Rognum TO, Liestøl K, Skotheim RI, and Lothe RA (2012).
ColoGuidePro: A prognostic 7-gene expression signature for stage III colorectal cancer patients.
Clin. Cancer Res. 2012 Oct 12 [Epub ahead of print]
Highlights from Recent Cancer Literature, from the AACR publication "Cancer Research" (journal impact factor 7.856), Oct 15 2012
Department of Cancer Prevention (Institute for Cancer Research, Oslo University Hospital)
CCB - Centre for Cancer Biomedicine - University of Oslo
Anita Sveen and Trude H. Ågesen first and second authors in the recent publication.