Research projects at Oslo University Hospital related to COVID-19

On this web page you will find an overview over planned and ongoing clinical trials and other research projects at Oslo University Hospital related to COVID-19 and SARS CoV-2 infection. The information has been retrieved from applications to the regional ethics committee, the Norwegian Research Council, other funding sources, or directly from the researchers behind the projects.

The aim for this web page is to encourage collaboration between researchers and, if possible, to coordinate projects and facilitate data sharing. Oslo University Hospital also encourages researchers to base their protocols on the WHO recommendations, if applicable. For more information see: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/early-investigations

An updated list of publications related to COVID-19 research at Oslo University Hospital can be found here.

If you have any questions regarding this website, please respond here 

National overview of covid-19 studies (external link)

Project summary

Projects at Oslo University Hospital

 

Project leader

Project name

Type of study

Ethics approval

Biobank

1

Anne Hege Aamodt

Division of Clinical Neuroscience

The Norwegian NeuroCOVID study

Multicenter prospective observational study

Conditional approval

Own collection

2

Anne Hege Aamodt

Division of Clinical Neuroscience

Compicated headache after COVID-19 vaccination

Multicenter observational study

Conditional approval

No

3

Hanne Birgit Alfheim

Division of Emergencies and Critical Care

Corona virus-related visitation restrictions enforced in ICUs in the Scandinavian countries – what can we learn to meet future challenges?

Survey

N/A

No

4

Erik Koldberg Amundsen

Division of Laboratory Medicine

Laboratory diagnostics for risk stratification in COVID-19

Observational study.

Laboratory based study

Approved

Own collection

5

Anders Åsberg

Division of Surgery, Inflammatory Diseases and Transplantation

COVID-19 outcome in patients with chronic kidney disease

Epidemiological study, registry study, Diagnostic/Prognostic study

Approved

Other biobank

6

Anders Åsberg

Division of Surgery, Inflammatory Diseases and Transplantation

Pharmacokinetic population analysis of antiviral drugs in the  NOR SOLIDARITY study

Pharmacokinetic population modelling

Conditional approval

Own collection

7

Andreas Barratt-Due

 

Pål Aukrust

 

 

Anne Ma Dyrhol Riise

Division of Emergencies and Critical Care

Division of Surgery, Inflammatory Diseases and Transplantation

Division of Medicine

WHO: The NOR Solidarity multicenter trial on the efficacy of different anti-viral drugs in SARS CoV-2 infected patients

 

Clinical Trials.gov 

Multicenter prospective clinical trial

Approved

Own collection

8

Andreas Barratt-Due

 

Division of Emergencies and Critical Care

Veno-venous ECMO-treatment of patients with COVID-ARDS

Quality study

N/A

No

9

Andreas Barratt-Due

 

Division of Emergencies and Critical Care

Handling and treatment of pregnant COVID-19 ICU patients

Quality study

N/A

No

10

Kristin Bjordal

 

Cecilie Delphin Amdal

Oslo Hospital Service

 

Division of Cancer Medicine

Development of an international questionnaire to assess patient-reported symptoms and concerns related to COVID-19 disease, the COVID-19 QLQ-##

Questionnaire development

Approved

No

11

Atle Bjørnerud

Division of Radiology and Nuclear Medicine

Artificial intelligence to quantify important segments from CT in COVID-19

Innovation

Under revision

No

12

Elisabeth Bø

Division of Medicine

Physiotherapy treatment of hospitalised patients with COVID-19 at Oslo University Hospital

Health service research

N/A

No

13

Marion Ingeborg Boldingh

Division of Clinical Neuroscience

Sars-CoV2 vaccine response in myasthenia patients

Observational study

Approved

COVID-19 general biobank

14

Arne Broch Brantsæter

Division of Medicine

Development of an antibody reference standards for COVID-19

Collection of plasma samples for vaccine development

Conditional approval

Own collection

15

Michael Bretthauer

 

Mette Kalager

Division of Surgery, Inflammatory Diseases and Transplantation

Rapid-Cycle Re-Implementation of TRAining Facilities in Norway (TRAiN study)

Observational study

Approved

No

16

John Arne Dahl

Division of Laboratory Medicine

PREDCOV

Observational study

Approved

Yes

17

Veselka Petrova Dimova-Svetoslavova

Division of Laboratory Medicine

Establishment of Interferon-gamma-analysis for accurate detection of SARS-CoV-2 T-cell response

Basic research

N/A

No

18

Lars Eide

Division of Laboratory Medicine

COVID-19 general biobank

General research biobank

Approved

COVID-19 general biobank

19

Ane Gerda Z Eriksson

Division of Cancer Medicine

Influence of the COVID-19 pandemic on women with gynecological cancer

Quality study

N/A

No

20

Stig Evensen

Division of Mental Health and Addiction

COPSYC-19: Consequences for patients with psychosis from the SARS-CoV-2 shut-down

Observational study and patient survey

Approved

No

21

Ann Færden

Division of Mental Health and Addiction

The COVID-19 pandemic: Reactions of acutely ill psychiatric patients

 

Quality study

N/A

 

 

No

22

Ann Færden

Division of Mental Health and Addiction

The COVID-19 pandemic: reactions from mental health workers in the acute psychiatric department

Quality study

N/A

No

23

Yngvar Fløisand

 

Hanne Scholz

Division of Cancer Medicine

 

Division of Surgery, Inflammatory Diseases and Transplantation

Decidual stromal cells (DSC) in treatment of COVID-19 induced respiratory failure

Clinical trial

Conditional approval

Own collection

24

Tine Kristin Grimholt

Division of Medicine

COVID-19 and reactions in the Norwegian population

Survey

Approved

No

25

Tine Kristin Grimholt

Division of Medicine

Mental reactions to COVID-19 among adults with heart failure

Survey

Approved

No

26

Gunnveig Grødeland

Division of Laboratory Medicine

Novel vaccine development against COVID-19

Innovation project

N/A

No

27

Jostein Skjalg Hagemo

Divison of Prehospital Services

Prehospital treatment of "silent hypoxia" in young patients COVID-19 

Case series

Conditional approval

No

28

Nina Eide Hasselberg

Division of Cardio-vascular and Pulmonary Diseases

Myocarditis and pericarditis after COVID-19 mRNA vaccination

Observational study

Conditional approval

No

29

Ansgar Heck

Division of Medicine

COVID-19 in patients with pituitary disease

Multicenter observational study

Conditional approval

Own collection

30

Åslaug Helland

Division of Cancer

SARS-CoV-2 and Cancer

Epidemiological observational study

Approved

No

31

Fridtjof Heyerdahl

Division of Prehospital Services

Inhaled NO as a bridge to rapid sequence intubation in COVID-19 related hypoxemia (INOCOV-19)

Randomized Controlled Trial

Conditional approval

No

32

Kristin Hofsø

Division of Emergencies and Critical Care

Survival rates and long-term outcomes for patients with COVID-19 admitted to Norwegian ICUs 

Multicenter observational study

Approved

No

33

Aleksander Rygh Holten

Division of Medicine

VHP + 1836: EU-SolidAct - Baricitinib. A randomized, controlled multicenter study of hospitalized COVID-19 patients

Randomized Controlled Trial

Approved

No

34

Jan Cato Holter,

Susanne Dudman

Anne Ma Dyrhol-Riise

Aleksander Rygh Holten

Division of Laboratory Medicine

 

 

 

Division of Medicine

Norwegian SARS-CoV-2 study

 

Clinicaltrials.gov

Multicenter observational study

Approved

Own collection

35

Eivind Hovig

Division of Cancer Medicine

Production of "in house" versions of reverse transcriptase and Taq DNA polymerase for use in SARS-CoV-2 assays

Innovation project

N/A

No

36

Håvard Kalvøy

Oslo Hospital Service

Splitting one ventilator for multiple patients

Technical assessment

N/A

No

37

Tom Hemming Karlsen

Division of Surgery, Inflammatory Diseases and Transplantation

Genetic risk for severe lung affection during COVID-19

Case-control association study

Conditional approval

COVID-19 general biobank

38

Per Kristian Knudsen

Division of Paediatric and Adolescent Medicine

Best treatment of multisystem inflammatory syndrome with COVID-19 (MIS-C)

Multicenter observational study

Conditional approval

No

39

Arne Kolstad

Division of Cancer Medicine

Monitoring of immunological response to COVID-19 vaccine in lymphoma/leukemia patients treated with anti-CD20 monoclonal antibodies and in patients who have completed allogenic stem cell transplantation

Observational study

Conditional approval

Own collection

40

Maria Stylianou Korsnes

Division of Mental Health and Addiction

COVID-19 impact on patient care

Quality study

N/A

No

41

Elfrida Hartveit Kvarstein 

 

Geir Pedersen  

Division of Mental Health and Addiction

Vulnerable patients with personality disorder - consequences of the corona crisis

Cross sectional, multi-center survey

Approved

No

42

Nina M. Kynø

Division of Paediatric and Adolescent Medicine

Pandemic 2020 - Parental debut in isolation

Survey

N/A

No

43

Jon Henrik Laake

Division of Emergencies and Critical Care

Handling oxygenation targets in adults with COVID-19 associated acute hypoxaemic respiratory failure in the ICU

Multicenter clinical trial

Approved

No

44

Irene Lie

Division of Cardiovascular and Pulmonary Diseases

A Norwegian study on views and experiences of health care professions working in intensive care units during the COVID-19 pandemic

 

Clinicaltrials.gov

Multicenter cohort and focus group interview study

Conditional approval

No

45

Tom Mala

Division of Surgery, Inflammatory Diseases and Transplantation

Abdominal pain in COVID-19 patients

Case reports

Conditional approval

No

46

Karsten Midtvedt

Division of Surgery, Inflammatory Diseases and Transplantation

COVID IgG KTx

Multicenter observational study

Conditional approval

Own collection

47

Karsten Midtvedt

Division of Surgery, Inflammatory Diseases and Transplantation

SARS-CoV-2 Immune KTx-study

Multicenter observational study

Approved

Own collection

48

Peter Monrad-Hansen

Division of Emergencies and Critical Care

Acute appendicitis at Oslo University Hospital before and after Covid-19 restrictions: Business as usual or delay?

Quality study

N/A

No

49

Bjørn Moum

Division of Medicine

Secure IBD registry. Surveillance epidemiology of Coronavirus  (COVID-19) under research exclusion.

Quality study

N/A

No

50

Ludvig Munthe

Division of Laboratory Medicine

Defining the immune cells that correlate with fatal acute lung injury in COVID-19 

Epidemiological pathogenetic study

 

COVID-19 general biobank

51

Ludvig Munthe

Division of Laboratory Medicine

Establishing in tube-diagnostic tests for immunity or susceptibility for SARS-CoV-2 in elderly cancer patients and in high-risk children

Innovation project

N/A

No

52

Lise Sofie Nissen-Meyer 

Division of Laboratory Medicine

Convalescent plasma therapy for patients with severe COVID-19

Clinical trial

Conditional approval

COVID-19 general biobank

53

Lise Sofie Nissen-Meyer 

Division of Laboratory Medicine

NORPLASMA monitor

Observational study

Conditional approval

No

54

Lise Sofie Nissen-Meyer 

Division of Laboratory Medicine

Antibody screening in blood donors

Observational study

Approved

COVID-19 general biobank

55

Lise Sofie Nissen-Meyer 

Division of Laboratory Medicine

Novel antibodies against HLA1

Observational study

N/A

COVID-19 general biobank

56

Ingvild Nordøy

Division of Surgery, Inflammatory Diseases and Transplantation

Superinfections in Covid-19 patients in the ICU - before and after dexamethasone

National multicenter retrospective observational study

Approved

No

57

Gro Owren Nygaard

Division of Clinical Neuroscience

NevroVAX

Quality study

N/A

No

58

Randi Opheim

Division of Medicine

Views of patients with inflammatory bowel disease on the COVID-19 pandemic and the health care service 

Quality study

N/A

No

59

Karl Øyri

Division of Emergencies and Critical Care

Research and Development for a low-cost, quickly produced mechanical ventilator capacity scaling system for  COVID-19 affected communities

Technical assessment

N/A

No

60

Frank Olav Pettersen

Division of Medicine

SARS-CoV-2 antibody screening in health care professionals at OUS

Quality study

N/A

No

61

Frank Olav Pettersen

Division of Medicine

SARS-CoV-2 among hospital staff at Oslo University Hospital

Quality study

N/A

No

62

Frank Olav Pettersen

Division of Medicine

Incidence and characteristics of SARS-CoV-2 immune response among first line COVID-19 hospital staff 

Observational study

Approved

COVID-19 general biobank

63

Søren Pischke

Division of Emergencies and Critical Care

 

Division of Laboratory Medicine

Prevalence of complement activation in COVID-19 patients admitted to OUS

Quality study

N/A

No

64

Marius Rehn

Division of Prehospital Services

Pre-hospital management of COVID-19

Quality study

N/A

No

65

Anne Ma Dyrhol-Riise

 

Division of Medicine

A Phase 1/2 Study to Determine Safety and Immunogenicity of Two COVID 19 Vaccines VB10.2129 (RBD Candidate) and VB10.2210 (T Cell Candidate) Previously Vaccinated in Healthy Adult Volunteers

 

Clinicaltrials.gov

Clinical trial

Approved

No

66

Kristin Lie Romm

Division of Mental Health and Addiction

REACT-NOR - react now!

Remote follow-up of relatives of patients with psychosis during the COVID-19 crisis

Health service research

N/A

No

67

Kristin Lie Romm

Division of Mental Health and Addiction

COPE - Corona pandemic experiences by patients with psychotic - and bipolar disorders

Survey

Approved

No

68

Ellen Ruud

Division of Paediatric and Adolescent Medicine

Effect of the COVID19 pandemic on pediatric cancer incidence at Oslo University Hospital

Quality study

N/A

No

69

Nina Haagenrud Schultz

Division of Cancer Medicine

Venous thrombosis after COVID-19 vaccines 

Observational study

Conditional approval

Own collection

70

Nina Haagenrud Schultz

Division of Cancer Medicine

Do COVID-19 vaccines lead to increased coagulation ability? 

Observational study

Conditional approval

Own collection

71

Andreas Seierstad

Division of Mental Health and Addiction

COVID-19 and labor market participation for young adults with psychosis

Observational study

N/A

No

72

Vasilis Sitras

Division of Paediatric and Adolescent Medicine

COVID-19 in Pregnancy, Childbirth and Puerperium (COVID-Preg-ChiP Study)

Observational study with survey

Conditional approval

Own collection

73

Anne Lee Solevåg

Division of Paediatric and Adolescent Medicine

Visitor bans in hospitals: How are newborn infants affected during the COVID-19 pandemic?

Observational study with survey

Conditional approval

Own collection

74

Arne Vasli Søraas

Division of Laboratory Medicine

Risk factors for community- and workplace transmission of COVID-19

 

Clinical Trials.gov

Epidemiological observational study

Approved

No

75

Arne Vasli Søraas

Division of Laboratory Medicine

Cod Liver Oil for COVID-19 Prevention Study

Non-clinical interventional study

Approved

Other biobank

76

Ketil Størdal

Division of Paediatric and Adolescent Medicine

COVID-19 and children in BEREDT-C19

Epidemiological study

N/A

No

77

Eva Stylianou

Division of Medicine

Allergological evaluations of corona vaccination

Quality study

N/A

No

78

Kjetil Sunde

Division of Emergencies and Critical Care

Intensive medicine priority decisions during the COVID-19 pandemic (INTENSIVE TRIAGE)

Prospective multicentre observational study

Approved

No

79

Kjetil Taskén

Division of Cancer Medicine

Immunoregulatory and antiviral properties of compounds derived from anti-malaria drugs as hydroxychloroquine

Explorative preclinical drug development

N/A

No

80

Kjetil Taskén

Division of Cancer Medicine

Aminoacridines with dual SARS-CoV2 antiviral and immunostimulating activity

Explorative preclinical drug development

N/A

No

81

Suraj Bahadur Thapa

Division of Mental Health and Addiction

Psychological distress and Coping in Psychiatric Patients during COVID-19 pandemic (PsyCo-COVID-19): A cross-sectional study at Oslo University Hospital

Survey

Conditional approval

No

82

Kirsti Tøien

Division of Emergencies and Critical Care

Visiting restrain to hospitals; family caregivers of COVID-19 ICU-patients experiences. An exploratory study

Survey

N/A

No

83

Kristian Tonby 

 

Theresa Olasveengen 

 

Aleksander Rygh Holten

Division of Medicine


Division of Emergencies and Critical Care


Division of Medicine

 

COVID-19 OUS. Kvalitetsregister for alle pasienter innlagt ved Oslo Universitetssykehus med COVID-19 sykdom.

Quality study

N/A

No

84

Kristian Tonby 

Division of Medicine

 

Korona-screen

Quality study

N/A

No

85

Kristian Tonby 

Division of Medicine

 

Treatment of hospitalized COVID-19 – A randomized multicenter study (Discovery)

Clinical trial

Approved

No

86

Margrethe von Tangen

Division of Emergencies and Critical Care

Retrospektiv vurdering av triagering av Covid-19 pasienter ved bruk av nytt Kap 41: Mistanke om Corona-infeksjon

Quality study

N/A

No

87

Lars Wik

Division of Prehospital Services

Sensor based vital signs monitoring of patients with clinical manifestation of COVID-19 disease during home isolation

Randomized feasibility study

Conditional approval

No

 

Multicenter studies (external sponsor)

 

Project leader

Project name

Type of study

Ethics approval

Biobank

1

Lars Petter Bjørnsen

 

Local contact:
Anders B Martinsen

St Olav Hospital, Trondheim

Use of ultrasound in acute evaluation of patients with suspected COVID-19 infection

Multicenter observational study

Conditional approval

No

2

Oliver Distler

 

Local contact:
Anna Hoffmann-Vold

Zürich University Hospital, Switzerland

COVID-19 in the EUSTAR cohort of systemic sclerosis

Quality study

N/A

No

3

Grete Dyb

 

Local contact:

John Anker Zwart

Norwegian Center for Violence and Traumatic Stress Studies, Universitetet i Oslo

Stress responses and health complaints among hospital staff working in intensive care units and clinical wards during the COVID-19 pandemic

Survey

Approved

No

4

Gunnar Einvik

 

Local contact:

Michael Thomas Durheim

Akershus University Hospital, Lørenskog

Patient-reported outcomes and lung function after hospitalization for COVID-19 infection (PROLIFE)

Multicenter observational study

Approved

No

5

Louise Emilsson

 

Local contact:
Henriette Cecilie Jodal

University of Oslo

MORMOR-COVID: MORbidity and MORtality during the COVID-19 pandemic

Observational study

Approved

No

6

Hilde Marie Engjom

 

Local contact:

Katariina Laine

Haukeland University Hospital, Bergen

COVID-19 infection in pregnant women in Norway

Multicenter observational study

Approved

 

7

Hans Flaatten

 

Local contact:
Theresa Olasveengen

Haukeland University Hospital, Bergen

Outcome of patients >75 with COVID-19 severe acute respiratory insufficiency (SARI)

Multicenter observational study

Approved

No

8

Waleed Ghanima

 

Local contact:
Hilde Skuterud Wik

Østfold Hospital, Sarpsborg

The incidence of thromboembolic complications in patients admitted with COVID-19 infection

Multicenter observational study

Approved

No

9

Margrethe Greve-Isdahl

 

Local contact:
Per Kristian Knudsen

Norwegian Institute of Public Health, Oslo

MINI-Nor  Maternal and Infant Immunity against Vaccine Preventable Diseases in Norway

Prospective observational study

Approved

No

10

Eystein Sverre Husebye

 

Local contact:

Anders Jørgensen

Haukeland University Hospital, Bergen

COVID-19 infections in patients with adrenal cortex failure

Multicenter prospective observational study

Approved

No

11

Christopher Inchley

 

Local contacts:
Karin C. Lødrup Carlsen

Per Kristian Knudsen

Akershus University Hospital, Lørenskog

COVID-19 in Norwegian children in hospitals - risk factors, outcomes and immunology

Prospective cohort study

Approved

Own collection

12

Michael Levin

 

Local contact:

Per Kristian Knudsen

Imperial College London, UK

Best Available Treatment for Paediatric Inflammatory Syndromes Temporally Associated with SARS-CoV-2 (BATS)

Multicenter quality study

N/A

No

13

Torbjørn Omland

 

Local contacts:
René Holst

Akershus University Hospital, Lørenskog

Bruk av blodtrykksmedisiner og risiko for COVID-19 infeksjon og komplikasjoner

Multicenter observational study

Approved

No

14

Rainer Schaefert

 

Local contact:

Birgitte Boye

University of Basel, CH

COVID-19 online survey

Survey

N/A

No

15

Kjetil Søreide

 

Local contact:

Sheraz Yaqub

Stavanger University Hospital, Stavanger

COVID-19 surgery cohort

Multicenter observational study

Approved

No

16

Local contact:

Kjetil Juul Stensrud

Emma Children’s Hospital, Amsterdam, University of Amsterdam,
Vrije Universiteit Amsterdam,
The Netherlands

COVID-19 paNdemic on the maNagement of pEdiatric appendiCiTis; an international multicenter cohort study – CONNECT-study

Quality study

N/A

No

17

Local contact:

Geir E. Tjønnfjord

Memorial Sloan Kettering Cancer Center, New York

Examining COVID19 Course and Outcomes in Patients Previously Diagnosed  with Chronic Lymphocytic Leukemia

Quality study

N/A

No

18

Mette C. Tollånes

 

Local contact:
Veselka Petrova Dimova- Svetoslavova

University of Bergen

Protokoll for utprøving av immunologiske hurtigtester for COVID-19

Quality study

N/A

No

19

Marit Tveito

 

Local contact:
Cecilie Hartberg 

Vestfold Hospital Trust, Tønsberg

COVID-19 and geriatric psychiatry health services 

Health Services Research

N/A

 No