Research at Oslo University Hospital

The Norwegian-Danish BETAMI-DANBLOCK study shows that beta-blockers still provide clear health benefits after a heart attack – even in patients with normal or slightly reduced heart function. The study included over 5,600 patients who had recently had a heart attack within the past fourteen days.

Professor Dan Atar presented the results as "Hot Line" findings at the European Cardiology Congress (ESC) in Madrid (33.000 participants) on August 30 2025. At the same time, they were simultaneously published in the prestigious journals New England Journal of Medicine and The Lancet.

The National Research Conference in Musculoskeletal Health is an interdisciplinary conference that covers research in musculoskeletal injuries, diseases and ailments. The conference will be a meeting point for researchers, healthcare professionals, users, clinicians and others interested in musculoskeletal health.

Time and place: November 13-14 2025 at Clarion Hotel Oslo Airport, Gardermoen 
Deadline for abstract submission: Sept 12 (possible to apply for extended deadline)

Complete information from the conference homepage (muss.no) (in Norwegian)

The article "Targeting the roots of myeloid malignancies with T cell receptors" has been published online in the prestigious journal Nature Reviews Cancer.
Senior author is Johanna Olweus, head of the Experimental Immunotherapy Group at the Department of Cancer Immunology at the Insitute for Cancer Research.

The work is a collaboration with Sten Eirik Jacobsens group at Karolinska Institutet.

Link to the article (view only version)

Researchers from the Department of Ophthalmology at OUH participated in three events at "Arendalsuka 2025" on Tuesday August 11th. Scientists Thea Melsen Sudmann, Øystein Kalsnes Jørstad, Agate Noer, Henrik Jespersen and Olav Kristianslund will give presentations on various subjects relating to eye research.

The presentations were streamed. Also available after the meeting.

Oslo University Hospital was otherwise broadly represented.

Overview day by day: events with participation from OUH researchers (August 11-15 2025).

Project leader Maja Radulovic and group leader Harald Stenmark at Department of Molecular Cell Biology, Institute for Cancer Research, have recently published a review in Nature Reviews Molecular Cell Biology entitled “Lysosomal membrane homeostasis and its importance in physiology and disease”. The motivation for this review is that lysosomes play a central role in disease progression, including neurodegenerative diseases and cancer, but also offer opportunities for novel therapies. 

Cristin is closing – NVA is launching
As of August 19, 2025, Cristin will be closed for new registrations. All data will be migrated to the new system: the National Research Archive (NVA).

What’s new with NVA?
NVA will:

• Replace Cristin as the national system for registering research publications and projects
• Offer functionality for archiving full-text publications
• Support open access to research outputs

Research Director Andreas Kleppe, at the Institute for Cancer Genetics and Informatics (ICGI), has been awarded funding from the Norwegian Research Council's FRIPRO scheme for the ENDPATH – End-to-End Pathology project. This initiative sets out to develop a new imaging system for digital pathology, using it to train artificial intelligence (AI) models that could improve predictions of cancer progression. The project, initially focusing on prostate cancer, aims to enhance both the accuracy and reliability of diagnostic tools.

In the 25 June issue of Nature, Harald Stenmark at Institute for Cancer Research and colleagues in Berkeley, Baltimore and Warsaw publish a review article on “The expanding repertoire of ESCRT functions in cell biology and disease”.

The review discusses the functions of ESCRT proteins in diverse cellular functions and highlights the associations between ESCRT dysfunctions in neurodegenerative diseases and cancer. 

Eirik Malinen at the Department of Radiation Biology received this year’s Michael Goitein Biology Award at the Annual Conference of the Particle Therapy Cooperative Group (PTCOG) for the work “Enhancing immunotherapy with proton- vs x-irradiation in mouse tumor models”.  
The work is a collaborative effort between Malinen and the group of Nina Jeppesen Edin at the Physics Department, UiO, and Brita Sørensen at the Danish Centre for Particle Therapy in Aarhus. The proton experiments were performed in Aarhus, paving the way for follow-up activities at our new preclinical proton facility in Oslo.