Current news and events

Childhood trauma in patients with severe mental disorders linked to shorter telomeres

Monica Aas
First author

Research published March 21st in the open access Nature journal "Translational Psychiatry" found patients with severe mental disorders who had experienced childhood abuse to have shorter telomeres, a predictor of biological age. 

Here, Monica Aas, lead author of the study together with Torbjørn Elvsåshagen and Ole Andreassen tells us about the findings and what the next steps are for the field. 

Maria Torgersen and coworkers publish unexpected results about nanoparticle effects on cells

Maria Torgersen, senior author

The article entitled “Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death”, just published in Nanotoxicology, describes details about the toxic mechanisms obtained by testing three very similar nanoparticles on six cancer cell lines. The three different types of particles where all of the class poly(alkylcyanoacrylate), they differed only in their alkyl side chains being butyl (PBCA), ethylbutyl (PEBCA) or octyl (POCA). Such substances have for many years been used as medical glue. The authors describe different effects of these nanoparticles.

Computer simulated cancer treatment presented in research magazine Apollo

Arnoldo Frigessi (photo: Ola Sæther)

Researchers at the Oslo University Hospital and University of Oslo are developing a computer program that can assist oncologists to find the best personalized treatment for each patient. The main driving force behind the project is Arnoldo Frigessi, professor in medical statistics at UiO, who is head of the "Oslo Centre for Biostatistics Epidemiology" at OUS and leader of the "Centre for Research-based Innovation" (SFI) "Big Insight".

The award winning research magazine "Apollon" recently presented the work of Frigessi and collaborators in an extensive feature article by Yngve Vogt.

Nature Communications publication:How Natural Killer Cells Remember their Education

Karl-Johan Malmberg,
Senior author

A joint effort by several groups at the Institute for Cancer Research and University of Oslo, led by Dr. Jodie Goodridge and Prof. Karl-Johan Malmberg provide new insights into the molecular basis behind NK cell education.

NK cells calibrate their functional potential against host MHC in a process termed education. Paradoxically, the more inhibitory input the cell receives during its education, the stronger its functional potential. Although this phenomena is well documented and conserved across species, the cellular and molecular mechanisms underlying NK cell education have remained elusive. 

Funding from FRIPRO to five promising researchers from Oslo University Hospital

Anita Sveen (left) and Kaisa Haglund are among the supported researchers

FRIPRO is an open, national competitive arena that covers all fields of research. FRIPRO aims to promote scientific excellence, bold and innovative research, support the careers of young research talents, as well as increasing the mobility for scientists early in their careers.

Five promising researchers and projects originating from Oslo University Hospital have now been granted suppoert from FRIPRIO.

Research at Oslo University Hospital basis for international drug development initiative between Norway and India

Kjetil Taskén (left) and Ivar Sjaastad
SERCA Pharmaceuticals AS, a company established by Inven2 AS in October, recently entered a co-development agreement with Cadila Pharmaceuticals - an FDA-approved Indian Pharma company with some 6000 employees. SERCA  Pharmaceuticals AS is established based on a drug development and innovation project on ischemia reperfusion injury in myocardial infarction that has been going on in the groups of Professors Kjetil Tasken (formerly NCMM UiO/OUH, now ICR, OUH) and Ivar Sjaastad (IEMF, OUH). The researchers have taken this forward to a drug candidate and have documented effects biochemically, in heart cells, by electrophysiology, on normal rat hearts and in rats with ischemia reperfusion injury where there is a cardioprotective effect.

Genetic overlap between bipolar disorder and intelligence

Olav B. Smeland

A new study from NORMENT - Norwegian Centre for Mental Disorders Research -  shows an overlap in genes involved in mental illness and intelligence. Postdoctoral fellow Olav B. Smeland and colleagues found that risk genes for bipolar disorder were associated with higher intelligence.

The study is published in Molecular Psychiatry, and was covered by the Norwegian newspaper VG+

Oslo meets Paris:Researchers of an EU based Epilepsy Consortium discuss the latest research progress - EU Glia PhD

Kjetil Heuser (left) and Toni Berger

One branch of the Marie-Curie program, called “EU – Glia PhD” is a Europe wide consortium represented by internationally respected neuroscientists, industry and partner organizations.  Within this several million Euros grand program financing PhD students, Oslo is represented via Kjell Heuser and Toni Berger, who have met together with the "EU Glia-PhD" consortium at the College de France to discuss recent progresses of their research.

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