Current news and events

Computer simulated cancer treatment presented in research magazine Apollo

Arnoldo Frigessi (photo: Ola Sæther)

Researchers at the Oslo University Hospital and University of Oslo are developing a computer program that can assist oncologists to find the best personalized treatment for each patient. The main driving force behind the project is Arnoldo Frigessi, professor in medical statistics at UiO, who is head of the "Oslo Centre for Biostatistics Epidemiology" at OUS and leader of the "Centre for Research-based Innovation" (SFI) "Big Insight".

The award winning research magazine "Apollon" recently presented the work of Frigessi and collaborators in an extensive feature article by Yngve Vogt.

Nature Communications publication:How Natural Killer Cells Remember their Education

Karl-Johan Malmberg,
Senior author

A joint effort by several groups at the Institute for Cancer Research and University of Oslo, led by Dr. Jodie Goodridge and Prof. Karl-Johan Malmberg provide new insights into the molecular basis behind NK cell education.

NK cells calibrate their functional potential against host MHC in a process termed education. Paradoxically, the more inhibitory input the cell receives during its education, the stronger its functional potential. Although this phenomena is well documented and conserved across species, the cellular and molecular mechanisms underlying NK cell education have remained elusive. 

Funding from FRIPRO to five promising researchers from Oslo University Hospital

Anita Sveen (left) and Kaisa Haglund are among the supported researchers

FRIPRO is an open, national competitive arena that covers all fields of research. FRIPRO aims to promote scientific excellence, bold and innovative research, support the careers of young research talents, as well as increasing the mobility for scientists early in their careers.

Five promising researchers and projects originating from Oslo University Hospital have now been granted suppoert from FRIPRIO.

Research at Oslo University Hospital basis for international drug development initiative between Norway and India

Kjetil Taskén (left) and Ivar Sjaastad
SERCA Pharmaceuticals AS, a company established by Inven2 AS in October, recently entered a co-development agreement with Cadila Pharmaceuticals - an FDA-approved Indian Pharma company with some 6000 employees. SERCA  Pharmaceuticals AS is established based on a drug development and innovation project on ischemia reperfusion injury in myocardial infarction that has been going on in the groups of Professors Kjetil Tasken (formerly NCMM UiO/OUH, now ICR, OUH) and Ivar Sjaastad (IEMF, OUH). The researchers have taken this forward to a drug candidate and have documented effects biochemically, in heart cells, by electrophysiology, on normal rat hearts and in rats with ischemia reperfusion injury where there is a cardioprotective effect.

Genetic overlap between bipolar disorder and intelligence

Olav B. Smeland

A new study from NORMENT - Norwegian Centre for Mental Disorders Research -  shows an overlap in genes involved in mental illness and intelligence. Postdoctoral fellow Olav B. Smeland and colleagues found that risk genes for bipolar disorder were associated with higher intelligence.

The study is published in Molecular Psychiatry, and was covered by the Norwegian newspaper VG+

Oslo meets Paris:Researchers of an EU based Epilepsy Consortium discuss the latest research progress - EU Glia PhD

Kjetil Heuser (left) and Toni Berger

One branch of the Marie-Curie program, called “EU – Glia PhD” is a Europe wide consortium represented by internationally respected neuroscientists, industry and partner organizations.  Within this several million Euros grand program financing PhD students, Oslo is represented via Kjell Heuser and Toni Berger, who have met together with the "EU Glia-PhD" consortium at the College de France to discuss recent progresses of their research.

Nature Biomedical Engineering publication:Study reveals how solid stress from brain tumors causes neuronal loss and neurologic dysfunction

Kyrre E, Emblem
Kyrre Eeg Emblem from the Department of Diagnostic Physics at OUS shares the first-authorship on a paper recently published in Nature Biomedical Engineering, entitled "Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium”. Using animal and human cancer data the authors show how solid stress – the physical forces exerted by the solid components of a tumor – impacts the tissue surrounding brain tumors and contributes to resulting neurological dysfunction and neuronal cell death. The authors also show how lithium treatment may protect against the effects of brain tissue compression.  
 

 

The Lancet article with statistical contribution from OUS:Avoiding unnecessary Caesarean sections

Inge C. Olsen
In a trial led by Stine Bernitz and Rebecka Dalbye at Østfold Hospital Trust, OUS statisticians Kathrine Frey Frøslie at the Norwegian National Advisory Unit on Women's Health and Inge Christoffer Olsen at Research Support Services CTU contributed with statistical analyses showing that a newly developed and widely applied guideline for labour progression is not better than a guideline developed almost 70 years ago in preventing unneccesary intrapartum Caesarean sections (ICS). An interesting observation was, however, that the overall frequency of ICS decreased in all the trial centres, indicating that close focus on assessing labour progression is more important than use of the guidelines. 

Nature Communications publication:Single-molecule experiments reveal how DNA repair enzymes look for damages using a combination of helical sliding and jumping

From left: Arash Ahmadi (first authors), Alex D Rowe and Bjørn Dalhus (senior authors)

Researchers at Department for Microbiology, Department for Medical Biochemistry and Department for Newborn Screening have used single-molecule fluorescence microscopy to track single protein molecules as they move along a linear piece of DNA held in place by the use of a laser/optical tweezers. By tracking single protein molecules as they moved along the DNA molecule, the interaction between protein and DNA could be investigated in detail in real-time. This study has been performed by PhD student Arash Ahmadi and co-workers in the group of Bjørn Dalhus at the Department for Microbiology, OUS, and Department for Medical Biochemistry, UiO. The study is part of a collaboration between OUS, UiO, NTNU and the University of Bielefeld, Germany.


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