Research at Oslo University Hospital

Researchers at the Oslo University Hospital and University of Oslo are developing a computer program that can assist oncologists to find the best personalized treatment for each patient. The main driving force behind the project is Arnoldo Frigessi, professor in medical statistics at UiO, who is head of the "Oslo Centre for Biostatistics Epidemiology" at OUS and leader of the "Centre for Research-based Innovation" (SFI) "Big Insight".

The award winning research magazine "Apollon" recently presented the work of Frigessi and collaborators in an extensive feature article by Yngve Vogt.

A joint effort by several groups at the Institute for Cancer Research and University of Oslo, led by Dr. Jodie Goodridge and Prof. Karl-Johan Malmberg provide new insights into the molecular basis behind NK cell education.

NK cells calibrate their functional potential against host MHC in a process termed education. Paradoxically, the more inhibitory input the cell receives during its education, the stronger its functional potential. Although this phenomena is well documented and conserved across species, the cellular and molecular mechanisms underlying NK cell education have remained elusive. 

FRIPRO is an open, national competitive arena that covers all fields of research. FRIPRO aims to promote scientific excellence, bold and innovative research, support the careers of young research talents, as well as increasing the mobility for scientists early in their careers.

Five promising researchers and projects originating from Oslo University Hospital have now been granted suppoert from FRIPRIO.

A new study from NORMENT - Norwegian Centre for Mental Disorders Research -  shows an overlap in genes involved in mental illness and intelligence. Postdoctoral fellow Olav B. Smeland and colleagues found that risk genes for bipolar disorder were associated with higher intelligence.

The study is published in Molecular Psychiatry, and was covered by the Norwegian newspaper VG+

One branch of the Marie-Curie program, called “EU – Glia PhD” is a Europe wide consortium represented by internationally respected neuroscientists, industry and partner organizations.  Within this several million Euros grand program financing PhD students, Oslo is represented via Kjell Heuser and Toni Berger, who have met together with the "EU Glia-PhD" consortium at the College de France to discuss recent progresses of their research.

Researchers at Department for Microbiology, Department for Medical Biochemistry and Department for Newborn Screening have used single-molecule fluorescence microscopy to track single protein molecules as they move along a linear piece of DNA held in place by the use of a laser/optical tweezers. By tracking single protein molecules as they moved along the DNA molecule, the interaction between protein and DNA could be investigated in detail in real-time. This study has been performed by PhD student Arash Ahmadi and co-workers in the group of Bjørn Dalhus at the Department for Microbiology, OUS, and Department for Medical Biochemistry, UiO. The study is part of a collaboration between OUS, UiO, NTNU and the University of Bielefeld, Germany.