Research projects at Oslo University Hospital related to COVID-19

On this web page you will find an overview over planned and ongoing clinical trials and other research projects at Oslo University Hospital related to COVID-19 and SARS CoV-2 infection. The information has been retrieved from applications to the regional ethics committee, the Norwegian Research Council, other funding sources, or directly from the researchers behind the projects.

The aim for this web page is to encourage collaboration between researchers and, if possible, to coordinate projects and facilitate data sharing. Oslo University Hospital also encourages researchers to base their protocols on the WHO recommendations, if applicable. For more information see: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/early-investigations

If you have any questions regarding this website, please respond here 

National overview of covid-19 studies (external link)

Project summary

Projects at Oslo University Hospital

 

Project status

Project leader

Project name

Type of study

Ethics approval

Biobank

1

Ongoing

Anne Hege Aamodt

Division of Clinical Neuroscience

The Norwegian NeuroCOVID study

Multicenter prospective observational study

Conditional approval

Own collection

2

Ongoing

Erik Koldberg Amundsen

Division of Laboratory Medicine

Laboratory diagnostics for risk stratification in COVID-19

Observational study.

Laboratory based study

Approved

Own collection

3

Ongoing

Anders Åsberg

Division of Surgery, Inflammatory Diseases and Transplantation

COVID-19 outcome in patients with chronic kidney disease

Epidemiological study, registry study, Diagnostic/Prognostic study

Approved

Other biobank

4

Ongoing

Anders Åsberg

Division of Surgery, Inflammatory Diseases and Transplantation

Pharmacokinetic population analysis of antiviral drugs in the  NOR SOLIDARITY study

Pharmacokinetic population modelling

Conditional approval

Own collection

5

Ongoing

Andreas Barratt-Due

 

Pål Aukrust

 

Anne Ma Dyrhol Riise

Division of Emergencies and Critical Care

 

Division of Surgery, Inflammatory Diseases and Transplantation

 

Division of Medicine

WHO: The NOR Solidarity multicenter trial on the efficacy of different anti-viral drugs in SARS CoV-2 infected patients

 

Clinical Trials.gov 

Multicenter prospective clinical trial

Approved

Own collection

6

Ongoing

Kristin Bjordal

Oslo Hospital Service

Development of an international questionnaire to assess patient-reported symptoms and concerns related to COVID-19 disease, the COVID-19 QLQ-##

Questionnaire development

N/A

No

7

Ongoing

Atle Bjørnerud

Division of Radiology and Nuclear Medicine

Artificial intelligence to quantify important segments from CT in COVID-19

Innovation

Under revision

No

8

Ongoing

Arne Broch Brantsæter

Division of Medicine

Development of an antibody reference standards for COVID-19

Collection of plasma samples for vaccine development

Conditional approval

Own collection

9

Ongoing

Michael Bretthauer

 

Mette Kalager

Division of Surgery, Inflammatory Diseases and Transplantation

Rapid-Cycle Re-Implementation of TRAining Facilities in Norway (TRAiN study)

Observational study

Approved

No

10

Ongoing

Lars Eide

Division of Laboratory Medicine

COVID-19 general biobank

General research biobank

Approved

COVID-19 general biobank

11

Ongoing

Stig Evensen

Division of Mental Health and Addiction

COPSYC-19: Consequences for patients with psychosis from the SARS-CoV-2 shut-down

Observational study and patient survey

Approved

No

12

Ongoing

Ann Færden

Division of Mental Health and Addiction

The COVID-19 pandemic: Reactions of acutely ill psychiatric patients

 

Quality study

N/A

 

 

No

13

Ongoing

Ann Færden

Division of Mental Health and Addiction

The COVID-19 pandemic: reactions from mental health workers in the acute psychiatric department

Quality study

N/A

No

14

Ongoing

Yngvar Fløisand

 

Hanne Scholz

Division of Cancer Medicine

 

Division of Surgery, Inflammatory Diseases and Transplantation

Decidual stromal cells (DSC) in treatment of COVID-19 induced respiratory failure

Clinical trial

Conditional approval

Own collection

15

Ongoing

Tine Kristin Grimholt

Division of Medicine

COVID-19 and reactions in the Norwegian population

Survey

Approved

No

16

Ongoing

Tine Kristin Grimholt

Division of Medicine

Mental reactions to COVID-19 among adults with heart failure

Survey

Approved

No

17

Ongoing

Gunnveig Grødeland

Division of Laboratory Medicine

Novel vaccine development against COVID-19

Innovation project

N/A

No

18

Ongoing

Jostein Skjalg Hagemo

Prehospital Services

Prehospital treatment of "silent hypoxia" in young patients COVID-19 

Case series

Conditional approval

No

19

Ongoing

Åslaug Helland

Division of Cancer

SARS-CoV-2 and Cancer

Epidemiological observational study

Approved

No

20

Ongoing

Fridtjof Heyerdahl

Prehospital Services

Inhaled NO as a bridge to rapid sequence intubation in COVID-19 related hypoxemia (INOCOV-19)

Randomized Controlled Trial

Conditional approval

No

21

Ongoing

Kristin Hofsø

Division of Emergencies and Critical Care

Survival rates and long-term outcomes for patients with COVID-19 admitted to Norwegian ICUs 

Multicenter observational study

Approved

No

22

Ongoing

Jan Cato Holter

 

Susanne Dudman

Division of Laboratory Medicine

Norwegian SARS-CoV-2 study

 

Clinicaltrials.gov

Multicenter observational study

Approved

Own collection

23

Ongoing

Eivind Hovig

Division of Cancer Medicine

Production of "in house" versions of reverse transcriptase and Taq DNA polymerase for use in SARS-CoV-2 assays

Innovation project

N/A

No

24

Ongoing

Henriette Cecilie Jodal

Division of Surgery, Inflammatory Diseases and Transplantation

Mortality from COVID-19

Quality study

N/A

No

25

Ongoing

Håvard Kalvøy

Oslo Hospital Service

Splitting one ventilator for multiple patients

Technical assessment

N/A

No

26

Ongoing

Tom Hemming Karlsen

Division of Surgery, Inflammatory Diseases and Transplantation

Genetic risk for severe lung affection during COVID-19

Case-control association study

Conditional approval

COVID-19 general biobank

27

Ongoing

Maria Stylianou Korsnes

Division of Mental Health and Addiction

COVID-19 impact on patient care

Quality study

N/A

No

28

Ongoing

Elfrida Hartveit Kvarstein 

 

Geir Pedersen  

Division of Mental Health and Addiction

Vulnerable patients with personality disorder - consequences of the corona crisis

Cross sectional, multi-center survey

Approved

No

29

Ongoing

Nina M. Kynø

Division of Paediatric and Adolescent Medicine

Pandemic 2020 - Parental debut in isolation

Survey

N/A

No

30

Ongoing

Jon Henrik Laake

Division of Emergencies and Critical Care

Handling oxygenation targets in adults with COVID-19 associated acute hypoxaemic respiratory failure in the ICU

Multicenter clinical trial

Approved

No

31

Ongoing

Irene Lie

Division of Cardiovascular and Pulmonary Diseases

A Norwegian study on views and experiences of health care professions working in intensive care units during the COVID-19 pandemic

Multicenter cohort and focus group interview study

Conditional approval

No

32

Ongoing

Tom Mala

Division of Surgery, Inflammatory Diseases and Transplantation

Abdominal pain in COVID-19 patients

Case reports

Conditional approval

No

33

Ongoing

Karsten Midtvedt

Division of Surgery, Inflammatory Diseases and Transplantation

COVID IgG KTx

Multicenter observational study

Conditional approval

Own collection

34

Ongoing

Peter Monrad-Hansen

Division of Emergencies and Critical Care

Acute appendicitis at Oslo University Hospital before and after Covid-19 restrictions: Business as usual or delay?

Quality study

N/A

No

35

Ongoing

Bjørn Moum

Division of Medicine

Secure IBD registry. Surveillance epidemiology of Coronavirus  (COVID-19) under research exclusion.

Quality study

N/A

No

36

Ongoing

Ludvig Munthe

Division of Laboratory Medicine

Defining the immune cells that correlate with fatal acute lung injury in COVID-19 

Epidemiological pathogenetic study

 

COVID-19 general biobank

37

Ongoing

Ludvig Munthe

Division of Laboratory Medicine

Establishing in tube-diagnostic tests for immunity or susceptibility for SARS-CoV-2 in elderly cancer patients and in high-risk children

Innovation project

N/A

No

38

Ongoing

Lise Sofie Nissen-Meyer 

Division of Laboratory Medicine

Convalescent plasma therapy for patients with severe COVID-19

Clinical trial

Conditional approval

Other biobank

39

Ongoing

Lise Sofie Nissen-Meyer 

Division of Laboratory Medicine

NORPLASMA monitor

Observational study

Conditional approval

No

40

Ongoing

Randi Opheim

Division of Medicine

Views of patients with inflammatory bowel disease on the COVID-19 pandemic and the health care service 

Quality study

N/A

No

41

Ongoing

Karl Øyri

Division of Emergencies and Critical Care

Research and Development for a low-cost, quickly produced mechanical ventilator capacity scaling system for  COVID-19 affected communities

Technical assessment

N/A

No

42

Ongoing

Frank Olav Pettersen

Division of Medicine

SARS-CoV-2 antibody screening in health care professionals at OUS

Quality study

N/A

No

43

Ongoing

Søren Pischke

Division of Emergencies and Critical Care

 

Division of Laboratory Medicine

Prevalence of complement activation in COVID-19 patients admitted to OUS

Quality study

N/A

No

44

Ongoing

Marius Rehn

Prehospital Services

Pre-hospital management of COVID-19

Quality study

N/A

No

45

Ongoing

Kristin Lie Romm

Division of Mental Health and Addiction

REACT-NOR - react now!

Remote follow-up of relatives of patients with psychosis during the COVID-19 crisis

Health service research

N/A

No

46

Ongoing

Kristin Lie Romm

Division of Mental Health and Addiction

COPE - Corona pandemic experiences by patients with psychotic - and bipolar disorders

Survey

Approved

No

47

Ongoing

Ellen Ruud

Division of Paediatric and Adolescent Medicine

Effect of the COVID19 pandemic on pediatric cancer incidence at Oslo University Hospital

Quality study

N/A

No

48

Ongoing

Vasilis Sitras

Division of Paediatric and Adolescent Medicine

COVID-19 in Pregnancy, Childbirth and Puerperium (COVID-Preg-ChiP Study)

Observational study with survey

Conditional approval

Own collection

49

Ongoing

Anne Lee Solevåg

Division of Paediatric and Adolescent Medicine

Visitor bans in hospitals: How are newborn infants affected during the COVID-19 pandemic?

Observational study with survey

Conditional approval

Own collection

50

Ongoing

Arne Vasli Søraas

Division of Laboratory Medicine

Risk factors for community- and workplace transmission of COVID-19

 

Clinical Trials.gov

Epidemiological observational study

Approved

No

51

Ongoing

Kjetil Sunde

Division of Emergencies and Critical Care

Intensive medicine priority decisions during the COVID-19 pandemic (INTENSIVE TRIAGE)

Prospective multicentre observational study

Approved

No

52

Ongoing

Kjetil Taskén

Division of Cancer Medicine

Immunoregulatory and antiviral properties of compounds derived from anti-malaria drugs as hydroxychloroquine

Explorative preclinical drug development

N/A

No

53

Ongoing

Suraj Bahadur Thapa

Division of Mental Health and Addiction

Psychological distress and Coping in Psychiatric Patients during COVID-19 pandemic (PsyCo-COVID-19): A cross-sectional study at Oslo University Hospital

Survey

Conditional approval

No

54

Ongoing

Kristian Tonby 

 

Theresa Olasveengen 

 

Aleksander Rygh Holten

Division of Medicine


Division of Emergencies and Critical Care


Division of Medicine

 

COVID-19 OUS. Kvalitetsregister for alle pasienter innlagt ved Oslo Universitetssykehus med COVID-19 sykdom.

Quality study

N/A

No

55

Ongoing

Kristian Tonby 

Division of Medicine

 

Korona-screen

Quality study

N/A

No

56

Ongoing

Margrethe von Tangen

Division of Emergencies and Critical Care

Retrospektiv vurdering av triagering av Covid-19 pasienter ved bruk av nytt Kap 41: Mistanke om Corona-infeksjon

Quality study

N/A

No

57

Ongoing

Lars Wik

Prehospital Services

Sensor based vital signs monitoring of patients with clinical manifestation of COVID-19 disease during home isolation

Randomized feasibility study

Conditional approval

No

 

 

 

 

 

 

 

 

58

Planned

Trond H. Diseth

Division of Paediatric and Adolescent Medicine

How to prevent social isolation and psychosocial dysfunction in the general child population and in children with chronic/severe somatic diseases facing the COVID-19 pandemic

Survey

In preparation

No

59

Planned

Arnt Eltvedt Fiane 

Division of Cardiovascular and Pulmonary Diseases

EuroECMO-COVID

Multicenter prospective and retrospective observational study

In preparation

No

60

Planned

Arne Klungland

Division of Laboratory Medicine

Epitranscriptomic regulation of viral fitness upon SARS-CoV-2 infection; a host-virus study. 

 

 

 

61

 

Planned

Stefan Krauss

Division of Laboratory Medicine

Pharmacological WNT inhibition to attenuate the cytokine storm, the central severe complication in COVID-19 infections. 

 

 

 

62

Planned

Fridtjof Lund-Johansen

Division of Laboratory Medicine

COVID-19 immunitet i befolkningen

 

 

 

63

Planned

Charles Ethan Paccione 

Division of Emergencies and Critical Care

The Mind-Body App for Mental Health Management 

 

 

 

64

Planned

Simon Rayner

Division of Laboratory Medicine

Integrated novel intervention strategies for COVID-19 : Using data mining to fight current and future pandemics 

 

 

 

65

Planned

Lene Bergendal Solberg

Division of Orthopaedic Surgery

OVID20: Longitudinal population-based environmental seroepidemiological investigation protocol for COVID-19 virus infection in healthcare workers in an orthopeadic emergency department 

 

Longitudinal prospective cohort study

In preparation

Own collection

66

Planned

Tone Tønjum

Division of Laboratory Medicine

 

University of Oslo

Reversing COVID-19 (RevCOVID-19) 

 

 

 

67

Planned

Hilde Wøien

Division of Emergencies and Critical Care

 

Delirium in critically ill patients with SARS-CoV-2 infection

Retrospective international multicenter observational cohort

In preparation

No

 

Multicenter studies (external sponsor)

 

Status

Project leader

Project name

Type of study

Ethics approval

Biobank

1

Ongoing

Lars Petter Bjørnsen

 

Local contact:
Anders B Martinsen

St Olav Hospital, Trondheim

Use of ultrasound in acute evaluation of patients with suspected COVID-19 infection

Multicenter observational study

Conditional approval

No

2

Ongoing

Oliver Distler

 

Local contact:
Anna Hoffmann-Vold

Zürich University Hospital, Switzerland

COVID-19 in the EUSTAR cohort of systemic sclerosis

Quality study

N/A

No

3

Ongoing

Grete Dyb

 

Local contact:

John Anker Zwart

Norwegian Center for Violence and Traumatic Stress Studies, Universitetet i Oslo

Stress responses and health complaints among hospital staff working in intensive care units and clinical wards during the COVID-19 pandemic

Survey

Approved

No

4

Ongoing

Gunnar Einvik

 

Local contact:

Michael Thomas Durheim

Akershus University Hospital, Lørenskog

Patient-reported outcomes and lung function after hospitalization for COVID-19 infection (PROLIFE)

Multicenter observational study

Approved

No

5

Ongoing

Hilde Marie Engjom

 

Local contact:

Katariina Laine

Haukeland University Hospital, Bergen

COVID-19 infection in pregnant women in Norway

Multicenter observational study

Approved

 

6

Ongoing

Hans Flaatten

 

Local contact:
Theresa Olasveengen

Haukeland University Hospital, Bergen

Outcome of patients >75 with COVID-19 severe acute respiratory insufficiency (SARI)

Multicenter observational study

Approved

No

7

Ongoing

Waleed Ghanima

 

Local contact:
Hilde Skuterud Wik

Østfold Hospital, Sarpsborg

The incidence of thromboembolic complications in patients admitted with COVID-19 infection

Multicenter observational study

Approved

No

8

Ongoing

Margrethe Greve-Isdahl

 

Local contact:
Per Kristian Knudsen

Norwegian Institute of Public Health, Oslo

MINI-Nor  Maternal and Infant Immunity against Vaccine Preventable Diseases in Norway

Prospective observational study

Approved

No

9

Ongoing

Eystein Sverre Husebye

Haukeland University Hospital, Bergen

COVID-19 infections in patients with adrenal cortex failure

Multicenter prospective observational study

Approved

No

10

Ongoing

Christopher Inchley

 

Local contacts:
Karin C. Lødrup Carlsen

Per Kristian Knudsen

Akershus University Hospital, Lørenskog

COVID-19 in Norwegian children in hospitals - risk factors, outcomes and immunology

Prospective cohort study

Approved

Own collection

11

Ongoing

Torbjørn Omland

 

Local contacts:
René Holst

Akershus University Hospital, Lørenskog

Bruk av blodtrykksmedisiner og risiko for COVID-19 infeksjon og komplikasjoner

Multicenter observational study

Approved

No

12

Ongoing

Kjetil Søreide

 

Local contact:

Sheraz Yacub

Stavanger University Hospital, Stavanger

COVID-19 surgery cohort

Multicenter observational study

Approved

No

13

Ongoing

Local contact:

Kjetil Juul Stensrud

Emma Children’s Hospital, Amsterdam, University of Amsterdam,
Vrije Universiteit Amsterdam,
The Netherlands

COVID-19 paNdemic on the maNagement of pEdiatric appendiCiTis; an international multicenter cohort study – CONNECT-study

Quality study

N/A

No

14

Ongoing

Local contact:

Geir E. Tjønnfjord

Memorial Sloan Kettering Cancer Center, New York

Examining COVID19 Course and Outcomes in Patients Previously Diagnosed  with Chronic Lymphocytic Leukemia

Quality study

N/A

No

15

Ongoing

Mette C. Tollånes

 

Local contact:
Veselka Petrova Dimova- Svetoslavova

University of Bergen

Protokoll for utprøving av immunologiske hurtigtester for COVID-19

Quality study

N/A

No

16

 Ongoing

Marit Tveito

 

Local contact:
Cecilie Hartberg 

Vestfold Hospital Trust, Tønsberg

COVID-19 and geriatric psychiatry health services 

Health Services Research

N/A

 No

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