Kushtrim Kryeziu is 37 years and defended his PhD at the Medical University of Vienna in 2016. Kryeziu was recruited to the Lothe lab in 2016 via an EU financed fellowship and was included in the Scientia Fellows postdoc program at the University of Oslo. His recruitment has proven highly beneficial for the development of the current project on functional oncology in advanced solid tumors. His competence in molecular cell biology and hands-on experience with anti-cancer drug development was instrumental to the development of our pre-clinical pharmacogenomics platform. Kryeziu has recently accepted a permanent position at the Institute for Cancer Research.
Ina A. Eilertsen and Christian Holst Bergsland defended their respective work in transcriptomics and molecular pathology of colorectal cancer, Maren Høland recently defended her work on genomics of Malignant peripheral nerve sheath tumors, and Jonas Meier Strømme defended his computational analyses in solid tumors last week, 9th Dec. Their PhD theses comprise a total of thirteen papers from our groups, including eleven first-authorships among the PhD candidates.
Molecular biologist Anita Sveen and surgeon Pål-Dag Line join forces in a new project to improve the patient benefit from liver transplantation of metastatic colorectal cancer. This is a collaborative effort between Dept Molecular Oncology (KRE) and Dept Transplantation Medicine (KIT)
The project is a translational substudy of ongoing clinical studies and will generate the first large-scale molecular and pharmacological data of transplantable metastatic colorectal cancers. This project was recently supported by a research grant from the Norwegian Cancer Society.
Anita Sveen, project group leader and member of the Lothe lab at the Department of Molecular Oncology at the Institute for Cancer research, was invited speaker at the AACR special conference colorectal cancer, held October 1-4th in Portland, Oregon, USA.
In her well received speech Dr. Sveen presented the multidisciplinary work from the TEAM-ACT (Tumor Evolution in Advanced Models to Accelerate precision Cancer Therapy) - a strategic research area of OUS.
Our prostate cancer projects received attention and interest at the recent Norwegian Cancer Symposium held in Oslo and at the 34th European Congress of Pathology held in Basel, Switzerland.
On the 21st of April, the 4x-great-grandchild of Frederik Holst - the first who defended a doctoral thesis in Norway, University of Christiania - Christian Holst Bergsland defended his thesis “Fluorescence-based multiplex immunohistochemistry in precision medicine of colorectal cancer” for the PhD degree at the Faculty of Medicine, University of Oslo.
He received excellent assessment from the committee, both in the written report and during the defense. The first and second opponents were Professors Manuel Salto-Tellez, Institute for Cancer Research, London and Lars Akslen, University of Bergen. Professor Anne Hansen Ree was the chair of the evaluation committee.
Biomarkers in prostate cancer: Multi-sample transcriptomics overcomes heterogeneity and reveals genes with prognostic biomarker potential
Gene expression profiling of multiple intra-patient tumor foci reveals new insights about the heterogeneity in prostate cancer.
Multiplex immunohistochemistry of metastatic colorectal cancer and ex vivo tumor avatars
Editorial and selected cover image for the calender year 2022 of BBA Rev on Cancer.
Anita Sveen from the Department of Molecular Oncolocy is this year's winner of the prestigious Dr. Ragnar Mørk's Prize for cancer research. Anita received the prize of NOK 200.000 for her excellent work on colorectal cancer during an award ceremony in the Auditorium of the Research building on Friday 19th November. After receiving the prize, Anita gave a 30-minutes presentation of her work, and this was be followed by cakes and drinks in the canteen area.
On October 15th 2021, Kristina Totland Carm successfully defended her thesis “Genomic aberrations and molecular subtypes in multifocal prostate cancer” for the PhD degree at the Medical Faculty, University of Oslo. She also gave a trial lecture on the given topic: “Multiparametric MRI-guided biopsies in prostate cancer diagnostics – challenges on the road towards radiogenomics”.
The adjudication committee included first opponent, Professor Ian Mills, University of Oxford, UK; second opponent, Professor Karl-Henning Kalland, University of Bergen, and chair of the evaluation committee was Associate Professor Stig Müller, University of Oslo. Chair of the defence was Associate Professor June Helen Myklebust, University of Oslo.
Principal Supervisor was Rolf I. Skotheim, and co-supervisors were Marthe Løvf, Andreas Hoff and Ragnhild A. Lothe.
- Improved detection of cholangiocarcinoma in high risk patients by biomarker analyses of small amounts of bile
- Publication from The Norwegian Cancer Genomics Consortium in Genome Medicine
- Novel gene expression-based classification of metastatic colorectal cancer published in Genome Medicine
- Three new academic degrees defended at Faculty of Medicine and Faculty of Mathematics and Natural Sciences, University of Oslo, by members of the Dept of Molecular Oncology
- The cancer patient’s own drug sensitivity model
- Jørgen Smeby the first to defend his PhD digitally at the Institute for Cancer Research
- Comprehensive review article about the complexity of biomarkers in colorectal cancer published in Nature Reviews Clinical Oncology
- Guro E. Lind new leader of The Norwegian Association of Researchers (Forskerforbundet)
- Skotheim group publishes important prostate cancer study in prestigious journal:
High degree of genomic heterogeneity in multifocal primary prostate cancer
- Postdoctor Andreas M. Hoff is shared first-author
New publication in Cell on structural genome alterations driving castration-resistant prostate cancer
- Novel subtype-specific prognostic associations of KRAS and BRAF mutations revealed in colorectal cancer
- International Women's day, March 8th 2018:
The Challenges women face in pursuing a career in STEM (science/ technology/ engineering/ mathematics)
- Standardization of methodology leads to innovation
- Popular science dissemination of cancer genomics
- Preclinical drug screening identifies novel stratified treatment options according to the consensus molecular subtypes of colorectal cancer
- Dr. Jarle Bruun's research profiled in the 2016 National report from the Health Regional Authorities
- Epigenetic markers stratify colorectal cancer patients within a genetically defined poor prognostic patient group
- Identified potent drugs for MPNST
- Three master's students graduated from the Department of Molecular Oncology
- Clinically important genetic heterogeneity in colorectal cancers with microsatellite instability
- Innovation project from the Lind group featured by GenomeWeb
- New PhD, Marianne L. Smebye, found RNA changes involved in ovarian cancer
- A retrospective pooled biomarker study to predict overall survival beyond the TNM system
- POLE proofreading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis
- The Norwegian Cancer Society calls attention to collaborative study on relevance of genetic heterogeneity
- Clinical relevance of genetic heterogeneity among distinct liver metastatic deposits identified in patients with colorectal cancer
- Article on colorectal cancer research at forskning.no
- Post doc Jarle Bruun awarded excellent article from Oslo University Hospital for the second half of 2015
- Group leader Guro E. Lind appointed leader of the newly established Young Academy of Norway
- Review article in Oncogene on alternative splicing in cancer
- Personalized cancer medicine. Chronicle in the Norwegian newspaper, Aftenposten
- Interview in weekly magazine on big data in cancer biomedicine
- Novel DNA methylation biomarkers provide accurate detection of bile duct cancer
- Rolf Skotheim interview in Apollon:
Supercomputing reveals the genetic code of cancer
- Masterstudent Heidi Pharo graduated from the Department of Cancer Prevention
- New comprehensive review on PI3K signaling in colorectal cancer
- SMART Colorectal Cancer featured in Norwegian patient safety publication
- Oslo University Hospital awarding excellent research
- Official opening of the KG Jebsen Colorectal Cancer Research Centre
- Marthe Løvf defended her thesis for the PhD degree
- Successful cancer genomics conference at Losby followed up by national media
- PhD student Deeqa Ahmed profiled in Uniforum
- Research based innovation
- Comprehensive review on molecular biology of germ cell tumors of the ovary
- Group leader Guro E. Lind invited to Ekko, NRK P2
- Alagaratnam article published in Stem Cells and Development
- Ragnhild A. Lothe appointed "Innovator of the month" by Helse Sør-Øst for March 2013
- New group in Epigenetics established at the Institute for Cancer Research, Dept of Cancer Prevention
- Ragnhild A. Lothe selected Scientist of the Month
- ColoGuideEx receives attention
- British biotech company signs agreement with Inven2 to secure exclusive rights to biomarkers identified in the Lothe group
- The Norwegian Oncology Forums Young Researcher award 2011 to Guro E. Lind
- Stine Aske Danielsen successfully defends her PhD thesis
- Researchers from Department of Cancer Prevention reveal importance for transcriptome instability in colorectal cancer
- Master students Marianne Guriby and Deeqa Ali finished their master's degrees in February and March 2010, respectively.
- Translational research on colorectal cancer within Oslo University hospital featured in Dagbladet newspaper
- Disputation and trial lecture - Terje Cruickshank Ahlquist
- Stine Danielsen awarded poster prize at the 30th Scandinavian Sarcoma Group Meeting
- New microarray design for detection of fusion genes
- Mutations in the Neurofibromin gene, an inhibitor of KRAS
- Marthe Eken graduated
- Ahlquist and colleagues identify time of occurrence of specific methylation events in colorectal development.