Anita Sveen from the Department of Molecular Oncolocy is this year's winner of the prestigious Dr. Ragnar Mørk's Prize for cancer research. Anita received the prize of NOK 200.000 for her excellent work on colorectal cancer during an award ceremony in the Auditorium of the Research building on Friday 19th November. After receiving the prize, Anita gave a 30-minutes presentation of her work, and this was be followed by cakes and drinks in the canteen area.
On October 15th 2021, Kristina Totland Carm successfully defended her thesis “Genomic aberrations and molecular subtypes in multifocal prostate cancer” for the PhD degree at the Medical Faculty, University of Oslo. She also gave a trial lecture on the given topic: “Multiparametric MRI-guided biopsies in prostate cancer diagnostics – challenges on the road towards radiogenomics”.
The adjudication committee included first opponent, Professor Ian Mills, University of Oxford, UK; second opponent, Professor Karl-Henning Kalland, University of Bergen, and chair of the evaluation committee was Associate Professor Stig Müller, University of Oslo. Chair of the defence was Associate Professor June Helen Myklebust, University of Oslo.
Principal Supervisor was Rolf I. Skotheim, and co-supervisors were Marthe Løvf, Andreas Hoff and Ragnhild A. Lothe.
Improved detection of cholangiocarcinoma in high risk patients by biomarker analyses of small amounts of bile
Primary sclerosing cholangitis (PSC) is a progressive chronic liver disease associated with increased risk of cholangiocarcinoma; a highly deadly malignancy that arises in the bile ducts. Due to nonspecific presenting features and overlapping findings in malignant and benign disease progression in PSC, the diagnostic accuracy for cholangiocarcinoma in PSC is low. Consequently, cholangiocarcinoma is commonly detected at advanced stage where most patients have a poor chance of surviving, making cholangiocarcinoma the most common cause of death among patients with PSC.
Project group leaders Anita Sveen and Bjarne Johannessen at Department of Molecular Oncology at the Institute for Cancer Research are 1st and 2nd authors of a major work presenting the ”expressed mutation dose” as a determinant of the functional consequences of mutations in colorectal cancer.
The article - entitled "The expressed mutational landscape of microsatellite stable colorectal cancers" is published in the journal Genome Medicine.
Novel gene expression-based classification of metastatic colorectal cancer published in Genome Medicine
The multidisciplinary team of the K.G.Jebsen Colorectal Cancer Research Centre publishes a novel gene expression-based classification of metastatic colorectal cancer.
PhD student S. Hossein Moosavi in Anita Sveen’s project group at the Dept. of Molecular Oncology at the Institute for Cancer Research is 1st author of this paper published in Genome Medicine.
This is the first large study of multi-metastatic gene expression profiling of colorectal cancer liver metastases, and the new metastasis-oriented subtyping framework showed prognostic relevance in the context of tumor heterogeneity.
Three Oslo University Hospital scientists received prestigous awards for their outstanding research on August 27th. The major prize - the "Excellent Researcher Award" - went to Ragnhild A. Lothe. Lasse Pihlstrøm and Marina Vietri both received the "Early Career Award".
The prize money - 300.000 and 150.000 NOK respectively - is earmarked for research activities.
The ceremony was streamed and is available via YouTube.
Anita Sveen (39) – senior researcher and project group leader at Institute for Cancer Research – was on December 16th awarded the prize Researcher-of-the-Year from the leadership at ICR for her outstanding scientific contributions. The award of 100 000 NOK is financed by the Radium Hospital Foundation (Radiumhospitalets legater) and is a personal scholarship for stimulating further excellence in research.
Three new academic degrees defended at Faculty of Medicine and Faculty of Mathematics and Natural Sciences, University of Oslo, by members of the Dept of Molecular Oncology
In June, Tuva Høst Brunsell (MD) digitally defended her PhD “ Heterogeneity of prognostic biomarkers in colorectal liver metastases”, Institute for Clinical Medicine, University of Oslo. The thesis includes three papers (Brunsell et al., Clin Colorectal Cancer 2020; Brunsell et al., Eur J Surg Oncol 2019; Berg*, Brunsell* et al., submitted).
On September the 4th, Christer Anker Andreassen, digitally defended his MSc, Institute of Biosciences, University of Oslo. “The functional and clinical impact of the E3 Ubiquitin ligase NEDD4 in colorectal cancer and its role in regulating PTEN and P53”.
On September the 11th, Mikael Ravndal, defended his MSc, Department of Informatics, University of Oslo. "Algorithms for exploring heterogeneity in prostate cancer patients from RNA-seq data".
By examining vulnerabilities in colorectal cancer, Jørgen Smeby, Kushtrim Kryeziu, and colleagues demonstrated the efficacy of PARP inhibitors for a subgroup of colorectal cancer cell lines in a recent paper in EBioMedicine (The Lancet’s open access).
The cancer patient’s own drug sensitivity model: researchers from the Lothe lab and collaborators recently published a paper in Clinical Cancer Research describing ex vivo patient-derived organoids from colorectal liver metastases in a heterogeneity context.
- The cancer patient’s own drug sensitivity model
- Jørgen Smeby the first to defend his PhD digitally at the Institute for Cancer Research
- Comprehensive review article about the complexity of biomarkers in colorectal cancer published in Nature Reviews Clinical Oncology
- Guro E. Lind new leader of The Norwegian Association of Researchers (Forskerforbundet)
- Skotheim group publishes important prostate cancer study in prestigious journal:
High degree of genomic heterogeneity in multifocal primary prostate cancer
- Postdoctor Andreas M. Hoff is shared first-author
New publication in Cell on structural genome alterations driving castration-resistant prostate cancer
- Novel subtype-specific prognostic associations of KRAS and BRAF mutations revealed in colorectal cancer
- International Women's day, March 8th 2018:
The Challenges women face in pursuing a career in STEM (science/ technology/ engineering/ mathematics)
- Standardization of methodology leads to innovation
- Popular science dissemination of cancer genomics
- Preclinical drug screening identifies novel stratified treatment options according to the consensus molecular subtypes of colorectal cancer
- Dr. Jarle Bruun's research profiled in the 2016 National report from the Health Regional Authorities
- Epigenetic markers stratify colorectal cancer patients within a genetically defined poor prognostic patient group
- Identified potent drugs for MPNST
- Three master's students graduated from the Department of Molecular Oncology
- Clinically important genetic heterogeneity in colorectal cancers with microsatellite instability
- Innovation project from the Lind group featured by GenomeWeb
- New PhD, Marianne L. Smebye, found RNA changes involved in ovarian cancer
- A retrospective pooled biomarker study to predict overall survival beyond the TNM system
- POLE proofreading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis
- The Norwegian Cancer Society calls attention to collaborative study on relevance of genetic heterogeneity
- Clinical relevance of genetic heterogeneity among distinct liver metastatic deposits identified in patients with colorectal cancer
- Article on colorectal cancer research at forskning.no
- Post doc Jarle Bruun awarded excellent article from Oslo University Hospital for the second half of 2015
- Group leader Guro E. Lind appointed leader of the newly established Young Academy of Norway
- Review article in Oncogene on alternative splicing in cancer
- Personalized cancer medicine. Chronicle in the Norwegian newspaper, Aftenposten
- Interview in weekly magazine on big data in cancer biomedicine
- Novel DNA methylation biomarkers provide accurate detection of bile duct cancer
- Rolf Skotheim interview in Apollon:
Supercomputing reveals the genetic code of cancer
- Masterstudent Heidi Pharo graduated from the Department of Cancer Prevention
- New comprehensive review on PI3K signaling in colorectal cancer
- SMART Colorectal Cancer featured in Norwegian patient safety publication
- Oslo University Hospital awarding excellent research
- Official opening of the KG Jebsen Colorectal Cancer Research Centre
- Marthe Løvf defended her thesis for the PhD degree
- Successful cancer genomics conference at Losby followed up by national media
- PhD student Deeqa Ahmed profiled in Uniforum
- Research based innovation
- Comprehensive review on molecular biology of germ cell tumors of the ovary
- Group leader Guro E. Lind invited to Ekko, NRK P2
- Alagaratnam article published in Stem Cells and Development
- Ragnhild A. Lothe appointed "Innovator of the month" by Helse Sør-Øst for March 2013
- New group in Epigenetics established at the Institute for Cancer Research, Dept of Cancer Prevention
- Ragnhild A. Lothe selected Scientist of the Month
- ColoGuideEx receives attention
- British biotech company signs agreement with Inven2 to secure exclusive rights to biomarkers identified in the Lothe group
- The Norwegian Oncology Forums Young Researcher award 2011 to Guro E. Lind
- Stine Aske Danielsen successfully defends her PhD thesis
- Researchers from Department of Cancer Prevention reveal importance for transcriptome instability in colorectal cancer
- Master students Marianne Guriby and Deeqa Ali finished their master's degrees in February and March 2010, respectively.
- Translational research on colorectal cancer within Oslo University hospital featured in Dagbladet newspaper
- Disputation and trial lecture - Terje Cruickshank Ahlquist
- Stine Danielsen awarded poster prize at the 30th Scandinavian Sarcoma Group Meeting
- New microarray design for detection of fusion genes
- Mutations in the Neurofibromin gene, an inhibitor of KRAS
- Marthe Eken graduated
- Ahlquist and colleagues identify time of occurrence of specific methylation events in colorectal development.
- Signaling in colorectal cancer. Two recent papers by PhD students Stine A. Danielsen and Terje Ahlquist and colleagues
- On the road again
- Dietary effects on genes - National Broadcasting Company
- Master student Hilde Honne graduated
- In thin air - The annual mountain trip