Alicia Llorente and coworkers from the Department of Molecular Cell Biology at the Institute for Cancer Research recently published in Oncotarget detailed mass spectrometry analyses of exosomes purified from urine of 16 prostate cancer patients and 15 healthy volunteers that revealed upregulation of 221 proteins in the patient samples. At 100% specificity, 17 of these proteins displayed individual sensitivities between 60 and 94%. Combination of two of the upregulated proteins (TM256 and LAMTOR1) resulted in 100% specificity and 100% sensitivity for these samples.
Alicia Llorente is heading the project group "Exosomes and prostate cancer", organised under the "Intracellular transport" research group, which is led by Kirsten Sandvig.
Identification of prostate cancer biomarkers in urinary exosomes.
Øverbye A, Skotland T, Koehler CJ, Thiede B, Seierstad T, Berge V, Sandvig K, Llorente A.
Oncotarget. 2015 Jul 13. [Epub ahead of print]
Alicia Llorente's project group "Exosomes and prostate cancer"
Kirsten Sandvig's "Intracellular transport" group
Department of Molecular Cell Biology