Research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic rsearch, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
Three scientists received awards for their outstanding work at a ceremony taking place at Oslo University Hospital April 24th. The major prize - the "Excellent Researcher Award" - went to professor Anne-Lise Børresen-Dale. Jan Terje Andersen and Jon Arne Dahl both received the "Early Career Award". The prize money - 300.000 and 150.000 NOK respectively - is earmarked for research activities. This is the third year such prizes have been distributed in order to honour excellent scientific achievements.
In a recent OUS research blog article (in Norwegian) Anja Nilsen (PhD) from Heidi Lyng's Clinical Radiation Biology group at the Departement of Radiation Biology at the Institute for Cancer Research writes about cancer treatment and how the use of RNA as biomarkers may be useful in order to give more precise radiation doses as well as to improve the targeting of chemotherapy.
In a recent paper in Nature (journal impact factor 42), project leader Camilla Raiborg and her co-workers in Harald Stenmark´s group at Institute for Cancer Research and Centre for Cancer Biomedicine show an unexpected connection between endosomes (organelles involved in protein import into cells) and the endoplasmic reticulum (ER, organelle involved in protein export) in formation of cellular protrusions.
EMBO journal has already published a commentary article about the findings, entitled "A grab to move on: ER–endosome contacts in membrane protrusion formation and neurite outgrowth".
The well visited Norwegian popular science website forskning.no has also published an article about the findings, entitled "The secrets of neurone protrusion formation revealed".
Oslo University Hospital has rewarded six research groups for their excellent papers published during the second half-year of 2014. Each group receives NOK 50.000 for use in further research. The prizes were distributed during the Friday meeting at Ullevål April 17th.
The award winners gave short presentations of the main findings in their respective articles.
The six selected articles are of especially high quality, and they present important finding on both-short and long-term scales. The works reflect the good quality and the interdisciplinarity that characterises several research environments at Oslo University Hospital. The research is a fundamental condition for the institution to maintain and strenghten the quality in the patient treatment.
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Sumo is a small protein that is attached to other proteins to regulate their function. A major class of Sumo targets are transcription factors. However, it is not well known which transcription factors are sumoylated, how sumoylation of these proteins is regulated, and how Sumo controls their function.
To begin unraveling the function of Sumo in transcription, Chymkowitch et al first determined at which genes Sumo can be detected. The results are recently published in the prestigious journal Genome research (impact factor 13.9) with Pierre Chymkowitch and Jorrit Enserink from the Department of Microbiology at the Department of Diagnostics and Invention as first and last authors respectively.
The Fridtjof Nansen's award for excellent molecular cancer research goes to Anne-Lise Børresen-Dale from the Department of Genetics at the Institue for Cancer Research, OUH for the year of 2015.
The Fridtjof Nansen award for young researchers goes to Jan Terje Andersen from the Department of Immunology at the Division of Diagnostics and Intervention, OUH. He is also associated with the Centre for Immune Regulation (CIR).
The awards will be distributed during the annual meeting for The Norwegian Academy of Science and Letters at Grand hotel Monday May 4th.
More precise cancer treatment by use of RNA biomarkers
Apr 24, 2015
Andreas Brech from the Department of Core Facilities
Apr 21, 2015
Apr 17, 2015
Proteomics: breakthroughs and cutting edge applications in immunology, microbiology, and cancer
Apr 15, 2015
Selected latest publications
Journ. Impact factor > 8 First or last author from Oslo University Hospital
Improving paediatric care in the community
Lancet, 385 (9977), 1505
Genetics of liver disease: From pathophysiology to clinical practice
J Hepatol, 62 (1S), S6-S14
Emerging treatments for post-transplantation diabetes mellitus
Nat Rev Nephrol (in press)
More selected publications