Research at Oslo University Hospital

Researchers from the Department of Ophthalmology at OUH are participating in three events at "Arendalsuka 2025" on Tuesday August 11th. Scientists Thea Melsen Sudmann, Øystein Kalsnes Jørstad, Agate Noer, Henrik Jespersen and Olav Kristianslund will give presentations on various subjects relating to eye research.

The presentations are streamed.

Oslo University Hospital is otherwise broadly represented.

Overview day by day: events with participation from OUH researchers (August 11-15 2025).

From the organiser:
Welcome to this meeting place where we want to inspire researchers and students, give them self-confidence and knowledge about the innovation process, help them build networks, and facilitate collaboration between academia and industry. This hangout is a collaboration with The Life Science Cluster and Nansen Neuroscience Network.

Time and place: Sep. 4, 2025 5:00 PM – 8:00 PM, Oslo Science Park, Forum auditorium
Free of charge, but you have to sign up.
Complete information:
Innovation hangout 4. september

Project leader Maja Radulovic and group leader Harald Stenmark at Department of Molecular Cell Biology, Institute for Cancer Research, have recently published a review in Nature Reviews Molecular Cell Biology entitled “Lysosomal membrane homeostasis and its importance in physiology and disease”. The motivation for this review is that lysosomes play a central role in disease progression, including neurodegenerative diseases and cancer, but also offer opportunities for novel therapies. 

Cristin is closing – NVA is launching
As of August 19, 2025, Cristin will be closed for new registrations. All data will be migrated to the new system: the National Research Archive (NVA).

What’s new with NVA?
NVA will:

• Replace Cristin as the national system for registering research publications and projects
• Offer functionality for archiving full-text publications
• Support open access to research outputs

Helse Sør-Øst RHF announces a call for applications with total funding of approx. 135 million NOKs for health research in the region. The call has both a thematic open structure, available to all research areas in the specialist healthcare services, and a targeted part where funding is decided after strategic assessment of applications within prioritised thematic areas. In addition, applications submitted from non-university hospitals will be considered for strategically earmarked research awards.
The application deadline is Thursday 4th September 2025 at 16:00

Research Director Andreas Kleppe, at the Institute for Cancer Genetics and Informatics (ICGI), has been awarded funding from the Norwegian Research Council's FRIPRO scheme for the ENDPATH – End-to-End Pathology project. This initiative sets out to develop a new imaging system for digital pathology, using it to train artificial intelligence (AI) models that could improve predictions of cancer progression. The project, initially focusing on prostate cancer, aims to enhance both the accuracy and reliability of diagnostic tools.

In the 25 June issue of Nature, Harald Stenmark at Institute for Cancer Research and colleagues in Berkeley, Baltimore and Warsaw publish a review article on “The expanding repertoire of ESCRT functions in cell biology and disease”.

The review discusses the functions of ESCRT proteins in diverse cellular functions and highlights the associations between ESCRT dysfunctions in neurodegenerative diseases and cancer. 

Eirik Malinen at the Department of Radiation Biology received this year’s Michael Goitein Biology Award at the Annual Conference of the Particle Therapy Cooperative Group (PTCOG) for the work “Enhancing immunotherapy with proton- vs x-irradiation in mouse tumor models”.  
The work is a collaborative effort between Malinen and the group of Nina Jeppesen Edin at the Physics Department, UiO, and Brita Sørensen at the Danish Centre for Particle Therapy in Aarhus. The proton experiments were performed in Aarhus, paving the way for follow-up activities at our new preclinical proton facility in Oslo.

RNA modifications are tiny chemical marks added to RNA molecules to control how they work. One of the most common is m6A modification, which acts like a “sticky note” on RNA—telling the cell when to use it, store it, or discard it. In this study, the Klungland group used their latest cutting-edge, ultra-sensitive technique called picoMeRIP-seq, which can detect m6A even from just 10 cells. This allowed them to draw the first complete map of m6A across human eggs and early embryos—from immature eggs (GV) to mature eggs (MII), zygotes, and all the way to blastocysts.
The findings were published in the EMBO journal on June 4th, with Yanjiao Li as first author.