Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2017 from OUS - Dept. of Gastroenterology RH (Div SIMT)

33 publications found

Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J et al. (2017)
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598, PubMed 28779025

Berntsen NL, Fosby B, Valestrand L, Tan C, Reims HM, Schrumpf E, Karlsen TH, Line PD, Melum E (2017)
Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree
Am J Physiol Gastrointest Liver Physiol, 314 (3), G349-G359
DOI 10.1152/ajpgi.00124.2017, PubMed 29212771

Boyar Cetinkaya R, Aagnes B, Myklebust TÅ, Thiis-Evensen E (2017)
Survival in neuroendocrine neoplasms; A report from a large Norwegian population-based study
Int J Cancer, 142 (6), 1139-1147
DOI 10.1002/ijc.31137, PubMed 29082524

Brandrud AS, Bretthauer M, Brattebø G, Pedersen MJ, Håpnes K, Møller K, Bjorge T, Nyen B, Strauman L, Schreiner A, Haldorsen GS, Bergli M, Nelson E, Morgan TS, Hjortdahl P (2017)
Local emergency medical response after a terrorist attack in Norway: a qualitative study
BMJ Qual Saf, 26 (10), 806-816
DOI 10.1136/bmjqs-2017-006517, PubMed 28676492

Chung BK, Karlsen TH (2017)
Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease
Dig Dis, 35 (4), 323-333
DOI 10.1159/000456583, PubMed 28468012

de Vries EMG, Färkkilä M, Milkiewicz P, Hov JR, Eksteen B, Thorburn D, Chazouillères O, Pares A, Nygård S, Gilja OH, Wunsch E, Invernizzi P, Carbone M, Bernuzzi F, Boberg KM, Røsjø H, Rosenberg W, Beuers UH, Ponsioen CY, Karlsen TH, Vesterhus M (2017)
Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
Liver Int, 37 (10), 1554-1561
DOI 10.1111/liv.13402, PubMed 28267887

Emilsson L, Løberg M, Bretthauer M, Holme Ø, Fall K, Jodal HC, Adami HO, Kalager M (2017)
Colorectal cancer death after adenoma removal in Scandinavia
Scand J Gastroenterol, 52 (12), 1377-1384
DOI 10.1080/00365521.2017.1377763, PubMed 28906163

Eskeland SL, Brunborg C, Rueegg CS, Aabakken L, de Lange T (2017)
Assessment of the effect of an Interactive Dynamic Referral Interface (IDRI) on the quality of referral letters from general practitioners to gastroenterologists: a randomised cross-over vignette trial
BMJ Open, 7 (6), e014636
DOI 10.1136/bmjopen-2016-014636, PubMed 28667208

Fickert P, Hirschfield GM, Denk G, Marschall HU, Altorjay I, Färkkilä M, Schramm C, Spengler U, Chapman R, Bergquist A, Schrumpf E, Nevens F, Trivedi P, Reiter FP, Tornai I, Halilbasic E, Greinwald R, Pröls M, Manns MP, Trauner M, European PSC norUDCA Study Group (2017)
norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis
J Hepatol, 67 (3), 549-558
DOI 10.1016/j.jhep.2017.05.009, PubMed 28529147

Garborg K, de Lange T, Bretthauer M (2017)
Quality Indicators in Colonoscopy
Curr Treat Options Gastroenterol, 15 (3), 416-428
DOI 10.1007/s11938-017-0140-4, PubMed 28702775

Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ (2017)
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17), e95193
DOI 10.1172/jci.insight.95193, PubMed 28878121

Henriksen EKK, Viken MK, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov JR, Lazaridis KN, Juran BD, Chazouillères O, Färkkilä M, Gotthardt DN, Invernizzi P, Carbone M, Hirschfield GM, Rushbrook SM, Goode E, UK-PSC Consortium, Ponsioen CY, Weersma RK, Eksteen B, Yimam KK, Gordon SC, Goldberg D et al. (2017)
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076, PubMed 28695657

Hoff G, de Lange T, Bretthauer M, Buset M, Dahler S, Halvorsen FA, Halwe JM, Heibert M, Høie O, Kjellevold Ø, Moritz V, Sandvei P, Seip B, Aabakken L, Holme Ø (2017)
Patient-reported adverse events after colonoscopy in Norway
Endoscopy, 49 (8), 745-753
DOI 10.1055/s-0043-105265, PubMed 28445903

Hoff G, Holme Ø, Bretthauer M, Sandvei P, Darre-Næss O, Stallemo A, Wiig H, Høie O, Noraberg G, Moritz V, de Lange T (2017)
Cecum intubation rate as quality indicator in clinical versus screening colonoscopy
Endosc Int Open, 5 (6), E489-E495
DOI 10.1055/s-0043-106180, PubMed 28573182

Holme Ø, Schoen RE, Senore C, Segnan N, Hoff G, Løberg M, Bretthauer M, Adami HO, Kalager M (2017)
Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials
BMJ, 356, i6673
DOI 10.1136/bmj.i6673, PubMed 28087510

Iversen R, Snir O, Stensland M, Kroll JE, Steinsbø Ø, Korponay-Szabó IR, Lundin KEA, de Souza GA, Sollid LM (2017)
Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins
Cell Rep, 20 (10), 2357-2367
DOI 10.1016/j.celrep.2017.08.036, PubMed 28877470

Kaminski MF, Thomas-Gibson S, Bugajski M, Bretthauer M, Rees CJ, Dekker E, Hoff G, Jover R, Suchanek S, Ferlitsch M, Anderson J, Roesch T, Hultcranz R, Racz I, Kuipers EJ, Garborg K, East JE, Rupinski M, Seip B, Bennett C, Senore C, Minozzi S, Bisschops R, Domagk D, Valori R et al. (2017)
Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) quality improvement initiative
United European Gastroenterol J, 5 (3), 309-334
DOI 10.1177/2050640617700014, PubMed 28507745

Kaminski MF, Thomas-Gibson S, Bugajski M, Bretthauer M, Rees CJ, Dekker E, Hoff G, Jover R, Suchanek S, Ferlitsch M, Anderson J, Roesch T, Hultcranz R, Racz I, Kuipers EJ, Garborg K, East JE, Rupinski M, Seip B, Bennett C, Senore C, Minozzi S, Bisschops R, Domagk D, Valori R et al. (2017)
Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative
Endoscopy, 49 (4), 378-397
DOI 10.1055/s-0043-103411, PubMed 28268235

Koch M, Freitag-Wolf S, Schlesinger S, Borggrefe J, Hov JR, Jensen MK, Pick J, Markus MRP, Höpfner T, Jacobs G, Siegert S, Artati A, Kastenmüller G, Römisch-Margl W, Adamski J, Illig T, Nothnagel M, Karlsen TH, Schreiber S, Franke A, Krawczak M, Nöthlings U, Lieb W (2017)
Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
Eur J Clin Nutr, 71 (8), 995-1001
DOI 10.1038/ejcn.2017.43, PubMed 28378853

Landsverk OJ, Snir O, Casado RB, Richter L, Mold JE, Réu P, Horneland R, Paulsen V, Yaqub S, Aandahl EM, Øyen OM, Thorarensen HS, Salehpour M, Possnert G, Frisén J, Sollid LM, Baekkevold ES, Jahnsen FL (2017)
Antibody-secreting plasma cells persist for decades in human intestine
J Exp Med, 214 (2), 309-317
DOI 10.1084/jem.20161590, PubMed 28104812

Lange T, Randel KR, Schult AL, Knudsen MD, Kirkøen B, Botteri E, Berstad P, Jørgensen A, Ursin G, Bretthauer M, Hoff G (2017)
Sigmoidoscopy and faecal occult blood test - a comparative screening trial
Tidsskr Nor Laegeforen, 137 (10), 727-730
DOI 10.4045/tidsskr.16.1031, PubMed 28551972

Myklebust-Hansen T, Aamodt G, Haugen M, Brantsæter AL, Vatn MH, Bengtson MB (2017)
Dietary Patterns in women with Inflammatory Bowel Disease and Risk of Adverse Pregnancy Outcomes: Results from The Norwegian Mother and Child Cohort Study (MoBa)
Inflamm Bowel Dis, 24 (1), 12-24
DOI 10.1093/ibd/izx006, PubMed 29272477

Nordin A, Åberg F, Pukkala E, Pedersen CR, Storm HH, Rasmussen A, Bennet W, Olausson M, Wilczek H, Ericzon BG, Tretli S, Line PD, Karlsen TH, Boberg KM, Isoniemi H (2017)
Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades
Am J Transplant, 18 (4), 952-963
DOI 10.1111/ajt.14507, PubMed 28925583

Nymo LS, Aabakken L, Lassen K (2017)
Priority and prejudice: does low socioeconomic status bias waiting time for endoscopy? A blinded, randomized survey
Scand J Gastroenterol, 53 (5), 621-625
DOI 10.1080/00365521.2017.1402207, PubMed 29141477

Rosati E, Dowds CM, Liaskou E, Henriksen EKK, Karlsen TH, Franke A (2017)
Overview of methodologies for T-cell receptor repertoire analysis
BMC Biotechnol, 17 (1), 61
DOI 10.1186/s12896-017-0379-9, PubMed 28693542

Rühlemann MC, Degenhardt F, Thingholm LB, Wang J, Skiecevičienė J, Rausch P, Hov JR, Lieb W, Karlsen TH, Laudes M, Baines JF, Heinsen FA, Franke A (2017)
Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci
Gut Microbes, 9 (1), 68-75
DOI 10.1080/19490976.2017.1356979, PubMed 28816579

Sarna VK, Skodje GI, Reims HM, Risnes LF, Dahal-Koirala S, Sollid LM, Lundin KEA (2017)
HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge
Gut, 67 (9), 1606-1613
DOI 10.1136/gutjnl-2017-314461, PubMed 28779027

Thomson M, Tringali A, Dumonceau JM, Tavares M, Tabbers MM, Furlano R, Spaander M, Hassan C, Tzvinikos C, Ijsselstijn H, Viala J, Dall'Oglio L, Benninga M, Orel R, Vandenplas Y, Keil R, Romano C, Brownstone E, Hlava Š, Gerner P, Dolak W, Landi R, Huber WD, Everett S, Vecsei A et al. (2017)
Paediatric Gastrointestinal Endoscopy: European Society for Paediatric Gastroenterology Hepatology and Nutrition and European Society of Gastrointestinal Endoscopy Guidelines
J Pediatr Gastroenterol Nutr, 64 (1), 133-153
DOI 10.1097/MPG.0000000000001408, PubMed 27622898

Tronstad RR, Kummen M, Holm K, von Volkmann HL, Anmarkrud JA, Høivik ML, Moum B, Gilja OH, Hausken T, Baines J, Karlsen TH, Fiskerstrand T, Hov JR (2017)
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
Inflamm Bowel Dis, 23 (10), 1752-1761
DOI 10.1097/MIB.0000000000001264, PubMed 28902124

Vesterhus M, Holm A, Hov JR, Nygård S, Schrumpf E, Melum E, Thorbjørnsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJLB, Vatn M, Schaap FG, Jansen PLM, Ueland T, Røsjø H, Moum B, Ponsioen CY, Boberg KM, Färkkilä M, Karlsen TH, Lund-Johansen F (2017)
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J Hepatol, 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472

Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, Thompson WK, Hernandez DG, Djurovic S, Schork AJ, Bettella F, Ellinghaus D, Franke A, Lie BA, McEvoy LK, Karlsen TH, Lesage S, Morris HR, Brice A, Wood NW, Heutink P, Hardy J, Singleton AB, Dale AM, Gasser T et al. (2017)
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases
JAMA Neurol, 74 (7), 780-792
DOI 10.1001/jamaneurol.2017.0469, PubMed 28586827

Øines M, Helsingen LM, Bretthauer M, Emilsson L (2017)
Epidemiology and risk factors of colorectal polyps
Best Pract Res Clin Gastroenterol, 31 (4), 419-424
DOI 10.1016/j.bpg.2017.06.004, PubMed 28842051

Aabakken L, Karlsen TH, Albert J, Arvanitakis M, Chazouilleres O, Dumonceau JM, Färkkilä M, Fickert P, Hirschfield GM, Laghi A, Marzioni M, Fernandez M, Pereira SP, Pohl J, Poley JW, Ponsioen CY, Schramm C, Swahn F, Tringali A, Hassan C (2017)
Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline
Endoscopy, 49 (6), 588-608
DOI 10.1055/s-0043-107029, PubMed 28420030

 
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