Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2016 from OUS - Dept. of Gastroenterology RH (Div SIMT)

34 publications found

Adami HO, Csermely P, Veres DV, Emilsson L, Løberg M, Bretthauer M, Kalager M (2016)
Are rapidly growing cancers more lethal?
Eur J Cancer, 72, 210-214
DOI 10.1016/j.ejca.2016.11.011, PubMed 28042992

Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D (2016)
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Nat Rev Gastroenterol Hepatol, 13 (5), 261-80
DOI 10.1038/nrgastro.2016.51, PubMed 27095655

Bernuzzi F, Marabita F, Lleo A, Carbone M, Mirolo M, Marzioni M, Alpini G, Alvaro D, Boberg KM, Locati M, Torzilli G, Rimassa L, Piscaglia F, He XS, Bowlus CL, Yang GX, Gershwin ME, Invernizzi P (2016)
Serum microRNAs as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma
Clin Exp Immunol, 185 (1), 61-71
DOI 10.1111/cei.12776, PubMed 26864161

Berstad P, Botteri E, Larsen IK, Løberg M, Kalager M, Holme Ø, Bretthauer M, Hoff G (2016)
Lifestyle changes at middle age and mortality: a population-based prospective cohort study
J Epidemiol Community Health, 71 (1), 59-66
DOI 10.1136/jech-2015-206760, PubMed 27312250

Birk M, Bauerfeind P, Deprez PH, Häfner M, Hartmann D, Hassan C, Hucl T, Lesur G, Aabakken L, Meining A (2016)
Removal of foreign bodies in the upper gastrointestinal tract in adults: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline
Endoscopy, 48 (5), 489-96
DOI 10.1055/s-0042-100456, PubMed 26862844

Bisschops R, Areia M, Coron E, Dobru D, Kaskas B, Kuvaev R, Pech O, Ragunath K, Weusten B, Familiari P, Domagk D, Valori R, Kaminski MF, Spada C, Bretthauer M, Bennett C, Senore C, Dinis-Ribeiro M, Rutter MD (2016)
Performance measures for upper gastrointestinal endoscopy: A European Society of Gastrointestinal Endoscopy quality improvement initiative
United European Gastroenterol J, 4 (5), 629-656
DOI 10.1177/2050640616664843, PubMed 27733906

Bretthauer M, Kaminski MF, Løberg M, Zauber AG, Regula J, Kuipers EJ, Hernán MA, McFadden E, Sunde A, Kalager M, Dekker E, Lansdorp-Vogelaar I, Garborg K, Rupinski M, Spaander MC, Bugajski M, Høie O, Stefansson T, Hoff G, Adami HO, Nordic-European Initiative on Colorectal Cancer (NordICC) Study Group (2016)
Population-Based Colonoscopy Screening for Colorectal Cancer: A Randomized Clinical Trial
JAMA Intern Med, 176 (7), 894-902
DOI 10.1001/jamainternmed.2016.0960, PubMed 27214731

Bretthauer M, Aabakken L, Dekker E, Kaminski MF, Rösch T, Hultcrantz R, Suchanek S, Jover R, Kuipers EJ, Bisschops R, Spada C, Valori R, Domagk D, Rees C, Rutter MD, ESGE Quality Improvement Committee (2016)
Requirements and standards facilitating quality improvement for reporting systems in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement
Endoscopy, 48 (3), 291-4
DOI 10.1055/s-0042-100186, PubMed 26841269

Bretthauer M, Aabakken L, Dekker E, Kaminski MF, Rösch T, Hultcrantz R, Suchanek S, Jover R, Kuipers EJ, Bisschops R, Spada C, Valori R, Domagk D, Rees C, Rutter MD, ESGE Quality Improvement Committee (2016)
Reporting systems in gastrointestinal endoscopy: Requirements and standards facilitating quality improvement: European Society of Gastrointestinal Endoscopy position statement
United European Gastroenterol J, 4 (2), 172-6
DOI 10.1177/2050640616629079, PubMed 27087943

Christophersen A, Risnes LF, Bergseng E, Lundin KE, Sollid LM, Qiao SW (2016)
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease
J Immunol, 196 (6), 2819-26
DOI 10.4049/jimmunol.1501152, PubMed 26895834

Dahal-Koirala S, Risnes LF, Christophersen A, Sarna VK, Lundin KE, Sollid LM, Qiao SW (2016)
TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage
Mucosal Immunol, 9 (3), 587-96
DOI 10.1038/mi.2015.147, PubMed 26838051

Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, Han B, Park YR, Raychaudhuri S, Pouget JG, Hübenthal M, Folseraas T, Wang Y, Esko T, Metspalu A, Westra HJ, Franke L, Pers TH, Weersma RK, Collij V, D'Amato M, Halfvarson J, Jensen AB, Lieb W, Degenhardt F, Forstner AJ et al. (2016)
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
Nat Genet, 48 (5), 510-8
DOI 10.1038/ng.3528, PubMed 26974007

Emilsson L, Holme Ø, Bretthauer M, Cook NR, Buring JE, Løberg M, Adami HO, Sesso HD, Gaziano MJ, Kalager M (2016)
Systematic review with meta-analysis: the comparative effectiveness of aspirin vs. screening for colorectal cancer prevention
Aliment Pharmacol Ther, 45 (2), 193-204
DOI 10.1111/apt.13857, PubMed 27859394

Eskeland SL, Brunborg C, Seip B, Wiencke K, Hovde Ø, Owen T, Skogestad E, Huppertz-Hauss G, Halvorsen FA, Garborg K, Aabakken L, de Lange T (2016)
First quality score for referral letters in gastroenterology-a validation study
BMJ Open, 6 (10), e012835
DOI 10.1136/bmjopen-2016-012835, PubMed 27855107

Fløisand Y, Lundin KEA, Lazarevic V, Kristiansen JD, Osnes LTN, Tjønnfjord GE, Reims HM, Gedde-Dahl T (2016)
Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease
Biol Blood Marrow Transplant, 23 (1), 172-175
DOI 10.1016/j.bbmt.2016.10.009, PubMed 27777142

Garborg K, Wiig H, Hasund A, Matre J, Holme Ø, Noraberg G, Løberg M, Kalager M, Adami HO, Bretthauer M (2016)
Gradual stiffness versus magnetic imaging-guided variable stiffness colonoscopes: A randomized noninferiority trial
United European Gastroenterol J, 5 (1), 128-133
DOI 10.1177/2050640616639162, PubMed 28405331

Grimstad T, Norheim KB, Kvaløy JT, Isaksen K, Leitao K, Carlsen A, Karlsen LN, Aabakken L, Omdal R (2016)
Conventional treatment regimens for ulcerative colitis alleviate fatigue - an observational cohort study
Scand J Gastroenterol, 51 (10), 1213-9
DOI 10.1080/00365521.2016.1195869, PubMed 27310658

Holme Ø, Løberg M (2016)
Methodological considerations for surveillance in GI practice
Best Pract Res Clin Gastroenterol, 30 (6), 867-878
DOI 10.1016/j.bpg.2016.10.011, PubMed 27938782

Jendrek ST, Gotthardt D, Nitzsche T, Widmann L, Korf T, Michaels MA, Weiss KH, Liaskou E, Vesterhus M, Karlsen TH, Mindorf S, Schemmer P, Bär F, Teegen B, Schröder T, Ehlers M, Hammers CM, Komorowski L, Lehnert H, Fellermann K, Derer S, Hov JR, Sina C (2016)
Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis
Gut, 66 (1), 137-144
DOI 10.1136/gutjnl-2016-311739, PubMed 27406039

Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L, Melum E, Kumasaka N, Atkinson EJ, Schlicht EM, Liu JZ, Shah T, Gutierrez-Achury J, Boberg KM, Bergquist A, Vermeire S, Eksteen B, Durie PR, Farkkila M, Müller T, Schramm C, Sterneck M, Weismüller TJ, Gotthardt DN, Ellinghaus D, Braun F et al. (2016)
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Nat Genet, 49 (2), 269-273
DOI 10.1038/ng.3745, PubMed 27992413

Jørgensen SF, Reims HM, Frydenlund D, Holm K, Paulsen V, Michelsen AE, Jørgensen KK, Osnes LT, Bratlie J, Eide TJ, Dahl CP, Holter E, Tronstad RR, Hanevik K, Brattbakk HR, Kaveh F, Fiskerstrand T, Kran AB, Ueland T, Karlsen TH, Aukrust P, Lundin KE, Fevang B (2016)
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency
Am J Gastroenterol, 111 (10), 1467-1475
DOI 10.1038/ajg.2016.329, PubMed 27527747

Jørgensen SF, Trøseid M, Kummen M, Anmarkrud JA, Michelsen AE, Osnes LT, Holm K, Høivik ML, Rashidi A, Dahl CP, Vesterhus M, Halvorsen B, Mollnes TE, Berge RK, Moum B, Lundin KE, Fevang B, Ueland T, Karlsen TH, Aukrust P, Hov JR (2016)
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol, 9 (6), 1455-1465
DOI 10.1038/mi.2016.18, PubMed 26982597

Kummen M, Holm K, Anmarkrud JA, Nygård S, Vesterhus M, Høivik ML, Trøseid M, Marschall HU, Schrumpf E, Moum B, Røsjø H, Aukrust P, Karlsen TH, Hov JR (2016)
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
Gut, 66 (4), 611-619
DOI 10.1136/gutjnl-2015-310500, PubMed 26887816

Kummen M, Vesterhus M, Trøseid M, Moum B, Svardal A, Boberg KM, Aukrust P, Karlsen TH, Berge RK, Hov JR (2016)
Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function
United European Gastroenterol J, 5 (4), 532-541
DOI 10.1177/2050640616663453, PubMed 28588885

Ludvigsson JF, Agreus L, Ciacci C, Crowe SE, Geller MG, Green PH, Hill I, Hungin AP, Koletzko S, Koltai T, Lundin KE, Mearin ML, Murray JA, Reilly N, Walker MM, Sanders DS, Shamir R, Troncone R, Husby S (2016)
Transition from childhood to adulthood in coeliac disease: the Prague consensus report
Gut, 65 (8), 1242-51
DOI 10.1136/gutjnl-2016-311574, PubMed 27196596

Olbjørn C, Cvancarova Småstuen M, Thiis-Evensen E, Nakstad B, Vatn MH, Perminow G (2016)
Serological markers in diagnosis of pediatric inflammatory bowel disease and as predictors for early tumor necrosis factor blocker therapy
Scand J Gastroenterol, 52 (4), 414-419
DOI 10.1080/00365521.2016.1259653, PubMed 27887202

Rees CJ, Ngu WS, Regula J, Bisschops R, Saftoiu A, Dekker E, Gralnek I, Ciocirlan M, Dinis-Ribeiro M, Jover R, Meisner S, Spada C, Hassan C, Valori R, Hucl T, Le Moine O, Domagk D, Kaminski MF, Bretthauer M, Rutter MD, Aabakken L, Ponchon T, Fockens P, Siersema PD (2016)
European Society of Gastrointestinal Endoscopy - Establishing the key unanswered research questions within gastrointestinal endoscopy
Endoscopy, 48 (10), 884-891
DOI 10.1055/s-0042-110398, PubMed 27485483

Ševo I, Avramović A, Balasingham I, Elle OJ, Bergsland J, Aabakken L (2016)
Edge density based automatic detection of inflammation in colonoscopy videos
Comput Biol Med, 72, 138-50
DOI 10.1016/j.compbiomed.2016.03.017, PubMed 27043856

Skagen K, Trøseid M, Ueland T, Holm S, Abbas A, Gregersen I, Kummen M, Bjerkeli V, Reier-Nilsen F, Russell D, Svardal A, Karlsen TH, Aukrust P, Berge RK, Hov JE, Halvorsen B, Skjelland M (2016)
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
Atherosclerosis, 247, 64-9
DOI 10.1016/j.atherosclerosis.2016.01.033, PubMed 26868510

Testoni PA, Mariani A, Aabakken L, Arvanitakis M, Bories E, Costamagna G, Devière J, Dinis-Ribeiro M, Dumonceau JM, Giovannini M, Gyokeres T, Hafner M, Halttunen J, Hassan C, Lopes L, Papanikolaou IS, Tham TC, Tringali A, van Hooft J, Williams EJ (2016)
Papillary cannulation and sphincterotomy techniques at ERCP: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline
Endoscopy, 48 (7), 657-83
DOI 10.1055/s-0042-108641, PubMed 27299638

Trøseid M, Hov JR, Nestvold TK, Thoresen H, Berge RK, Svardal A, Lappegård KT (2016)
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery
Metab Syndr Relat Disord, 14 (4), 197-201
DOI 10.1089/met.2015.0120, PubMed 27081744

Wang J, Thingholm LB, Skiecevičienė J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Rühlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P et al. (2016)
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Nat Genet, 48 (11), 1396-1406
DOI 10.1038/ng.3695, PubMed 27723756

Zenouzi R, Weismüller TJ, Jørgensen KK, Bubenheim M, Lenzen H, Hübener P, Schulze K, Weiler-Normann C, Sebode M, Ehlken H, Pannicke N, Hartl J, Peiseler M, Hübener S, Karlsen TH, Boberg KM, Manns MP, Lohse AW, Schramm C (2016)
No Evidence That Azathioprine Increases Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis
Clin Gastroenterol Hepatol, 14 (12), 1806-1812
DOI 10.1016/j.cgh.2016.07.032, PubMed 27521513

Zweers SJ, Shiryaev A, Komuta M, Vesterhus M, Hov JR, Perugorria MJ, de Waart DR, Chang JC, Tol S, Te Velde AA, de Jonge WJ, Banales JM, Roskams T, Beuers U, Karlsen TH, Jansen PL, Schaap FG (2016)
Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis
Liver Int, 36 (9), 1370-7
DOI 10.1111/liv.13092, PubMed 26866350

 
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