Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Dept. of Microbiology (MIK), Section for Research (former CMBN)

30 publications found

Ahmadi A, Till K, Hafting Y, Schüttpelz M, Bjørås M, Glette K, Tørresen J, Rowe AD, Dalhus B (2019)
Additive manufacturing of laminar flow cells for single-molecule experiments
Sci Rep, 9 (1), 16784
DOI 10.1038/s41598-019-53151-z, PubMed 31727950

Alexeeva M, Moen MN, Grøsvik K, Tesfahun AN, Xu XM, Muruzábal-Lecumberri I, Olsen KM, Rasmussen A, Ruoff P, Kirpekar F, Klungland A, Bjelland S (2019)
Excision of uracil from DNA by hSMUG1 includes strand incision and processing
Nucleic Acids Res, 47 (2), 779-793
DOI 10.1093/nar/gky1184, PubMed 30496516

Andersen TCB, Kristiansen PE, Huszenicza Z, Johansson MU, Gopalakrishnan RP, Kjelstrup H, Boyken S, Sundvold-Gjerstad V, Granum S, Sørli M, Backe PH, Fulton DB, Karlsson BG, Andreotti AH, Spurkland A (2019)
The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein
J Biol Chem, 294 (42), 15480-15494
DOI 10.1074/jbc.RA119.008318, PubMed 31484725

Berges N, Nawaz MS, Børresdatter Dahl T, Hagen L, Bjørås M, Laerdahl JK, Alseth I (2019)
Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
PLoS One, 14 (11), e0225081
DOI 10.1371/journal.pone.0225081, PubMed 31703097

Blomberg B, Muller KE, Helgeland L, Fladeby C, Morch K (2019)
A man in his 80s with arthritis and persistent fever
Tidsskr. Nor. Laegeforen., 139 (13), 1286-1289

Blomberg B, Müller KE, Helgeland L, Fladeby C, Mørch K (2019)
Rettelse: En mann i 80-årene med leddgikt og vedvarende feber
Tidsskr Nor Laegeforen, 139 (15)
DOI 10.4045/tidsskr.19.0632, PubMed 31642621

Fosslie M, Manaf A, Lerdrup M, Hansen K, Gilfillan GD, Dahl JA (2019)
Going low to reach high: Small-scale ChIP-seq maps new terrain
Wiley Interdiscip Rev Syst Biol Med, 12 (1), e1465
DOI 10.1002/wsbm.1465, PubMed 31478357

Høydahl LS, Frick R, Sandlie I, Løset GÅ (2019)
Targeting the MHC Ligandome by Use of TCR-Like Antibodies
Antibodies (Basel), 8 (2)
DOI 10.3390/antib8020032, PubMed 31544838

Ianevski A, Andersen PI, Merits A, Bjørås M, Kainov D (2019)
Expanding the activity spectrum of antiviral agents
Drug Discov Today, 24 (5), 1224-1228
DOI 10.1016/j.drudis.2019.04.006, PubMed 30980905

Iversen R, Roy B, Stamnaes J, Høydahl LS, Hnida K, Neumann RS, Korponay-Szabó IR, Lundin KEA, Sollid LM (2019)
Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease
Proc Natl Acad Sci U S A, 116 (30), 15134-15139
DOI 10.1073/pnas.1901561116, PubMed 31285344

Jaroy EG, Acosta-Jimenez L, Hotta R, Goldstein AM, Emblem R, Klungland A, Ougland R (2019)
"Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review
Clin Epigenetics, 11 (1), 135
DOI 10.1186/s13148-019-0718-x, PubMed 31519213

Lie-Jensen A, Ivanauskiene K, Malerød L, Jain A, Tan KW, Laerdahl JK, Liestøl K, Stenmark H, Haglund K (2019)
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533

Lien VT, Kristiansen MK, Pettersen S, Haugen MH, Olberg DE, Waaler J, Klaveness J (2019)
Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation
RSC Adv., 9 (63), 37092-37100

Lin A, Sved Skottvoll F, Rayner S, Pedersen-Bjergaard S, Sullivan G, Krauss S, Ray Wilson S, Harrison S (2019)
3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry
Electrophoresis
DOI 10.1002/elps.201900170, PubMed 31544246

Lång A, Lång E, Bøe SO (2019)
PML Bodies in Mitosis
Cells, 8 (8)
DOI 10.3390/cells8080893, PubMed 31416160

Madhuprakash J, Dalhus B, Vaaje-Kolstad G, Sakuda S, Podile AR, Eijsink VGH, Sørlie M (2019)
Structural and Thermodynamic Signatures of Ligand Binding to the Enigmatic Chitinase D of Serratia proteamaculans
J Phys Chem B, 123 (10), 2270-2279
DOI 10.1021/acs.jpcb.8b11448, PubMed 30789732

Montaldo NP, Bordin DL, Brambilla A, Rösinger M, Fordyce Martin SL, Bjørås KØ, Bradamante S, Aas PA, Furrer A, Olsen LC, Kunath N, Otterlei M, Sætrom P, Bjørås M, Samson LD, van Loon B (2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
Nat Commun, 10 (1), 5460
DOI 10.1038/s41467-019-13394-w, PubMed 31784530

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE (2019)
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765

Pilžys T, Marcinkowski M, Kukwa W, Garbicz D, Dylewska M, Ferenc K, Mieczkowski A, Kukwa A, Migacz E, Wołosz D, Mielecki D, Klungland A, Piwowarski J, Poznański J, Grzesiuk E (2019)
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy
Sci Rep, 9 (1), 13249
DOI 10.1038/s41598-019-49550-x, PubMed 31519943

Prikrylova T, Robertson J, Ferrucci F, Konorska D, Aanes H, Manaf A, Zhang B, Vågbø CB, Kuśnierczyk A, Gilljam KM, Løvkvam-Køster C, Otterlei M, Dahl JA, Enserink J, Klungland A, Robertson AB (2019)
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication
Sci Rep, 9 (1), 11065
DOI 10.1038/s41598-019-47528-3, PubMed 31363131

Scheffler K, Bjørås KØ, Bjørås M (2019)
Diverse functions of DNA glycosylases processing oxidative base lesions in brain
DNA Repair (Amst), 81, 102665
DOI 10.1016/j.dnarep.2019.102665, PubMed 31327582

Schwartz T, Jensenius M, Blomberg B, Fladeby C, Mæland A, Pettersen FO (2019)
Imported visceral leishmaniasis and immunosuppression in seven Norwegian patients
Trop Dis Travel Med Vaccines, 5, 16
DOI 10.1186/s40794-019-0092-x, PubMed 31463070

Segala G, Bennesch MA, Ghahhari NM, Pandey DP, Echeverria PC, Karch F, Maeda RK, Picard D (2019)
Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
Nat Commun, 10 (1), 1833
DOI 10.1038/s41467-019-09800-y, PubMed 31015428

Shi W, Cui P, Niu H, Zhang S, Tønjum T, Zhu B, Zhang Y (2019)
Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of Mycobacterium tuberculosis Confirms Their Role in Causing Resistance to Pyrazinamide
Antimicrob Agents Chemother, 63 (6)
DOI 10.1128/AAC.02681-18, PubMed 30858213

Solberg NT, Melheim M, Strand MF, Olsen PA, Krauss S (2019)
MEK Inhibition Induces Canonical WNT Signaling through YAP in KRAS Mutated HCT-15 Cells, and a Cancer Preventive FOXO3/FOXM1 Ratio in Combination with TNKS Inhibition
Cancers (Basel), 11 (2)
DOI 10.3390/cancers11020164, PubMed 30717152

Strøm TB, Vinje T, Bjune K, da Costa LT, Laerdahl JK, Leren TP (2019)
Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein
Proteins
DOI 10.1002/prot.25821, PubMed 31587363

Søraas A, Matsuyama M, de Lima M, Wald D, Buechner J, Gedde-Dahl T, Søraas CL, Chen B, Ferrucci L, Dahl JA, Horvath S, Matsuyama S (2019)
Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
Aging Cell, 18 (2), e12897
DOI 10.1111/acel.12897, PubMed 30712319

Vinje T, Laerdahl JK, Bjune K, Leren TP, Strøm TB (2019)
Characterization of the mechanisms by which missense mutations in the lysosomal acid lipase gene disrupt enzymatic activity
Hum Mol Genet, 28 (18), 3043-3052
DOI 10.1093/hmg/ddz114, PubMed 31131398

Ystgaard MB, Scheffler K, Suganthan R, Bjørås M, Ranheim T, Sagen EL, Halvorsen B, Saugstad OD, Yndestad A (2019)
Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy
Neonatology, 115 (4), 355-362
DOI 10.1159/000497200, PubMed 30909283

Zhang Z, Manaf A, Li Y, Perez SP, Suganthan R, Dahl JA, Bjørås M, Klungland A (2019)
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone
Mol Neurobiol
DOI 10.1007/s12035-019-01777-5, PubMed 31654318

 
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