Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2017 from OUS - Centre for Immune Regulation (CIR)

29 publications found

Bujko A, Atlasy N, Landsverk OJB, Richter L, Yaqub S, Horneland R, Øyen O, Aandahl EM, Aabakken L, Stunnenberg HG, Bækkevold ES, Jahnsen FL (2017)
Transcriptional and functional profiling defines human small intestinal macrophage subsets
J Exp Med, 215 (2), 441-458
DOI 10.1084/jem.20170057, PubMed 29273642

Chen JQ, Papp G, Póliska S, Szabó K, Tarr T, Bálint BL, Szodoray P, Zeher M (2017)
MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome
PLoS One, 12 (3), e0174585
DOI 10.1371/journal.pone.0174585, PubMed 28339495

Deloizy C, Fossum E, Barnier-Quer C, Urien C, Chrun T, Duval A, Codjovi M, Bouguyon E, Maisonnasse P, Hervé PL, Barc C, Boulesteix O, Pezant J, Chevalier C, Collin N, Dalod M, Bogen B, Bertho N, Schwartz-Cornil I (2017)
The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin
Sci Rep, 7 (1), 7639
DOI 10.1038/s41598-017-07372-9, PubMed 28794452

Engen SA, Schreurs O, Petersen F, Blix IJS, Baekkevold ES, Schenck K (2017)
The Regulatory Role of the Oral Commensal Streptococcus mitis on Human Monocytes
Scand J Immunol, 87 (2), 80-87
DOI 10.1111/sji.12636, PubMed 29194752

Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD (2017)
Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
Immunity, 46 (6), 1045-1058.e6
DOI 10.1016/j.immuni.2017.06.005, PubMed 28636954

Gudjonsson A, Lysén A, Balan S, Sundvold-Gjerstad V, Arnold-Schrauf C, Richter L, Bækkevold ES, Dalod M, Bogen B, Fossum E (2017)
Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses
J Immunol, 198 (7), 2785-2795
DOI 10.4049/jimmunol.1601881, PubMed 28228559

Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ (2017)
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17), e95193
DOI 10.1172/jci.insight.95193, PubMed 28878121

Hassel B, De Souza GA, Stensland ME, Ivanovic J, Voie Ø, Dahlberg D (2017)
The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus
J Neurosurg, 129 (3), 829-837
DOI 10.3171/2017.4.JNS17284, PubMed 29053067

Iversen R, Snir O, Stensland M, Kroll JE, Steinsbø Ø, Korponay-Szabó IR, Lundin KEA, de Souza GA, Sollid LM (2017)
Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins
Cell Rep, 20 (10), 2357-2367
DOI 10.1016/j.celrep.2017.08.036, PubMed 28877470

Jabri B, Sollid LM (2017)
T Cells in Celiac Disease
J Immunol, 198 (8), 3005-3014
DOI 10.4049/jimmunol.1601693, PubMed 28373482

Jahnsen FL, Bækkevold ES, Hov JR, Landsverk OJ (2017)
Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
Trends Immunol, 39 (3), 196-208
DOI 10.1016/j.it.2017.10.006, PubMed 29162322

Kroll JE, da Silva VL, de Souza SJ, de Souza GA (2017)
A tool for integrating genetic and mass spectrometry-based peptide data: Proteogenomics Viewer: PV: A genome browser-like tool, which includes MS data visualization and peptide identification parameters
Bioessays, 39 (7)
DOI 10.1002/bies.201700015, PubMed 28582591

Landsverk OJ, Snir O, Casado RB, Richter L, Mold JE, Réu P, Horneland R, Paulsen V, Yaqub S, Aandahl EM, Øyen OM, Thorarensen HS, Salehpour M, Possnert G, Frisén J, Sollid LM, Baekkevold ES, Jahnsen FL (2017)
Antibody-secreting plasma cells persist for decades in human intestine
J Exp Med, 214 (2), 309-317
DOI 10.1084/jem.20161590, PubMed 28104812

Lubelwana Hafver T, Wanichawan P, Manfra O, de Souza GA, Lunde M, Martinsen M, Louch WE, Sejersted OM, Carlson CR (2017)
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1)
Proteomics, 17 (17-18)
DOI 10.1002/pmic.201600417, PubMed 28755400

Malmström K, Lohi J, Sajantila A, Jahnsen FL, Kajosaari M, Sarna S, Mäkelä MJ (2017)
Immunohistology and remodeling in fatal pediatric and adolescent asthma
Respir Res, 18 (1), 94
DOI 10.1186/s12931-017-0575-0, PubMed 28511697

Matziouridou C, Rocha SDC, Haabeth OA, Rudi K, Carlsen H, Kielland A (2017)
iNOS- and NOX1-dependent ROS production maintains bacterial homeostasis in the ileum of mice
Mucosal Immunol, 11 (3), 774-784
DOI 10.1038/mi.2017.106, PubMed 29210363

Nakken B, Papp G, Bosnes V, Zeher M, Nagy G, Szodoray P (2017)
Biomarkers for rheumatoid arthritis: From molecular processes to diagnostic applications-current concepts and future perspectives
Immunol Lett, 189, 13-18
DOI 10.1016/j.imlet.2017.05.010, PubMed 28526580

Nguyen TB, Jayaraman P, Bergseng E, Madhusudhan MS, Kim CY, Sollid LM (2017)
Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides
J Biol Chem, 292 (22), 9218-9228
DOI 10.1074/jbc.M117.785139, PubMed 28364043

Papp G, Boros P, Nakken B, Szodoray P, Zeher M (2017)
Regulatory immune cells and functions in autoimmunity and transplantation immunology
Autoimmun Rev, 16 (5), 435-444
DOI 10.1016/j.autrev.2017.03.011, PubMed 28286106

Park BM, Kim EJ, Nam HJ, Zhang D, Bae CH, Kang M, Kim H, Lee W, Bogen B, Lim SK (2017)
Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model
Yonsei Med J, 58 (3), 505-513
DOI 10.3349/ymj.2017.58.3.505, PubMed 28332354

Ráki M, Dahal-Koirala S, Yu H, Korponay-Szabó IR, Gyimesi J, Castillejo G, Jahnsen J, Qiao SW, Sollid LM (2017)
Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes
Gastroenterology, 153 (3), 787-798.e4
DOI 10.1053/j.gastro.2017.05.016, PubMed 28535873

Roy B, Neumann RS, Snir O, Iversen R, Sandve GK, Lundin KEA, Sollid LM (2017)
High-Throughput Single-Cell Analysis of B Cell Receptor Usage among Autoantigen-Specific Plasma Cells in Celiac Disease
J Immunol, 199 (2), 782-791
DOI 10.4049/jimmunol.1700169, PubMed 28600290

Sarna VK, Lundin KEA, Mørkrid L, Qiao SW, Sollid LM, Christophersen A (2017)
HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption
Gastroenterology, 154 (4), 886-896.e6
DOI 10.1053/j.gastro.2017.11.006, PubMed 29146521

Sarna VK, Skodje GI, Reims HM, Risnes LF, Dahal-Koirala S, Sollid LM, Lundin KEA (2017)
HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge
Gut, 67 (9), 1606-1613
DOI 10.1136/gutjnl-2017-314461, PubMed 28779027

Snir O, Chen X, Gidoni M, du Pré MF, Zhao Y, Steinsbø Ø, Lundin KE, Yaari G, Sollid LM (2017)
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease
JCI Insight, 2 (17), e93961
DOI 10.1172/jci.insight.93961, PubMed 28878138

Sollid LM (2017)
The roles of MHC class II genes and post-translational modification in celiac disease
Immunogenetics, 69 (8-9), 605-616
DOI 10.1007/s00251-017-0985-7, PubMed 28695286

Van Elssen CHMJ, Rashidian M, Vrbanac V, Wucherpfennig KW, Habre ZE, Sticht J, Freund C, Jacobsen JT, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh HL (2017)
Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease
J Nucl Med, 58 (6), 1003-1008
DOI 10.2967/jnumed.116.186007, PubMed 28209904

Weitzner BD, Jeliazkov JR, Lyskov S, Marze N, Kuroda D, Frick R, Adolf-Bryfogle J, Biswas N, Dunbrack RL, Gray JJ (2017)
Modeling and docking of antibody structures with Rosetta
Nat Protoc, 12 (2), 401-416
DOI 10.1038/nprot.2016.180, PubMed 28125104

Zeher M, Papp G, Nakken B, Szodoray P (2017)
Hematopoietic stem cell transplantation in autoimmune disorders: From immune-regulatory processes to clinical implications
Autoimmun Rev, 16 (8), 817-825
DOI 10.1016/j.autrev.2017.05.020, PubMed 28572052

 
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