Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2016 from OUS - Centre for Immune Regulation (CIR)

29 publications found

Bartee E, Bartee MY, Bogen B, Yu XZ (2016)
Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice
Mol Ther Oncolytics, 3, 16032
DOI 10.1038/mto.2016.32, PubMed 27933316

Bottermann M, Lode HE, Watkinson RE, Foss S, Sandlie I, Andersen JT, James LC (2016)
Antibody-antigen kinetics constrain intracellular humoral immunity
Sci Rep, 6, 37457
DOI 10.1038/srep37457, PubMed 27881870

Cardoso I, Østerlund EC, Stamnaes J, Iversen R, Andersen JT, Jørgensen TJ, Sollid LM (2016)
Dissecting the interaction between transglutaminase 2 and fibronectin
Amino Acids, 49 (3), 489-500
DOI 10.1007/s00726-016-2296-y, PubMed 27394141

Chen JQ, Papp G, Szodoray P, Zeher M (2016)
The role of microRNAs in the pathogenesis of autoimmune diseases
Autoimmun Rev, 15 (12), 1171-1180
DOI 10.1016/j.autrev.2016.09.003, PubMed 27639156

Chen JQ, Szodoray P, Zeher M (2016)
Toll-Like Receptor Pathways in Autoimmune Diseases
Clin Rev Allergy Immunol, 50 (1), 1-17
DOI 10.1007/s12016-015-8473-z, PubMed 25687121

Christophersen A, Risnes LF, Bergseng E, Lundin KE, Sollid LM, Qiao SW (2016)
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease
J Immunol, 196 (6), 2819-26
DOI 10.4049/jimmunol.1501152, PubMed 26895834

Dahal-Koirala S, Risnes LF, Christophersen A, Sarna VK, Lundin KE, Sollid LM, Qiao SW (2016)
TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage
Mucosal Immunol, 9 (3), 587-96
DOI 10.1038/mi.2015.147, PubMed 26838051

Deloizy C, Bouguyon E, Fossum E, Sebo P, Osicka R, Bole A, Pierres M, Biacchesi S, Dalod M, Bogen B, Bertho N, Schwartz-Cornil I (2016)
Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1
Dev Comp Immunol, 65, 31-40
DOI 10.1016/j.dci.2016.06.015, PubMed 27345169

Dørum S, Steinsbø Ø, Bergseng E, Arntzen MØ, de Souza GA, Sollid LM (2016)
Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
Sci Rep, 6, 25565
DOI 10.1038/srep25565, PubMed 27146306

Eguíluz-Gracia I, Bosco A, Dollner R, Melum GR, Lexberg MH, Jones AC, Dheyauldeen SA, Holt PG, Bækkevold ES, Jahnsen FL (2016)
Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects
J Allergy Clin Immunol, 137 (6), 1872-1881.e12
DOI 10.1016/j.jaci.2015.11.025, PubMed 26851967

Foss S, Watkinson RE, Grevys A, McAdam MB, Bern M, Høydahl LS, Dalhus B, Michaelsen TE, Sandlie I, James LC, Andersen JT (2016)
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
DOI 10.4049/jimmunol.1502601, PubMed 26962230

Grodeland G, Fredriksen AB, Løset GÅ, Vikse E, Fugger L, Bogen B (2016)
Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination
J Immunol, 197 (9), 3575-3585
DOI 10.4049/jimmunol.1600893, PubMed 27671110

Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GHL, Chung TJK, Chan DKH, Tan KK, Hon TLK, Fossum E, Bogen B, Choolani M, Chan JKY, Larbi A et al. (2016)
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species
Immunity, 45 (3), 669-684
DOI 10.1016/j.immuni.2016.08.015, PubMed 27637149

Hnida K, Stamnaes J, du Pré MF, Mysling S, Jørgensen TJ, Sollid LM, Iversen R (2016)
Epitope-dependent Functional Effects of Celiac Disease Autoantibodies on Transglutaminase 2
J Biol Chem, 291 (49), 25542-25552
DOI 10.1074/jbc.M116.738161, PubMed 27784785

Hære P, Høie O, Schulz T, Schönhardt I, Raki M, Lundin KE (2016)
Long-term mucosal recovery and healing in celiac disease is the rule - not the exception
Scand J Gastroenterol, 51 (12), 1439-1446
DOI 10.1080/00365521.2016.1218540, PubMed 27534885

Høydahl LS, Nilssen NR, Gunnarsen KS, Pré MF, Iversen R, Roos N, Chen X, Michaelsen TE, Sollid LM, Sandlie I, Løset GÅ (2016)
Multivalent pIX phage display selects for distinct and improved antibody properties
Sci Rep, 6, 39066
DOI 10.1038/srep39066, PubMed 27966617

Lambert L, Kinnear E, McDonald JU, Grodeland G, Bogen B, Stubsrud E, Lindeberg MM, Fredriksen AB, Tregoning JS (2016)
DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8(+) T Cell Responses, Enabling Faster Resolution of Influenza Disease
Front Immunol, 7, 321
DOI 10.3389/fimmu.2016.00321, PubMed 27602032

Lilly CL, Villa NY, Lemos de Matos A, Ali HM, Dhillon JS, Hofland T, Rahman MM, Chan W, Bogen B, Cogle C, McFadden G (2016)
Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor
Mol Ther Oncolytics, 4, 31-40
DOI 10.1016/j.omto.2016.12.002, PubMed 28345022

Lorvik KB, Hammarström C, Fauskanger M, Haabeth OA, Zangani M, Haraldsen G, Bogen B, Corthay A (2016)
Adoptive Transfer of Tumor-Specific Th2 Cells Eradicates Tumors by Triggering an In Situ Inflammatory Immune Response
Cancer Res, 76 (23), 6864-6876
DOI 10.1158/0008-5472.CAN-16-1219, PubMed 27634753

Luda KM, Joeris T, Persson EK, Rivollier A, Demiri M, Sitnik KM, Pool L, Holm JB, Melo-Gonzalez F, Richter L, Lambrecht BN, Kristiansen K, Travis MA, Svensson-Frej M, Kotarsky K, Agace WW (2016)
IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis
Immunity, 44 (4), 860-74
DOI 10.1016/j.immuni.2016.02.008, PubMed 27067057

Ludvigsson JF, Agreus L, Ciacci C, Crowe SE, Geller MG, Green PH, Hill I, Hungin AP, Koletzko S, Koltai T, Lundin KE, Mearin ML, Murray JA, Reilly N, Walker MM, Sanders DS, Shamir R, Troncone R, Husby S (2016)
Transition from childhood to adulthood in coeliac disease: the Prague consensus report
Gut, 65 (8), 1242-51
DOI 10.1136/gutjnl-2016-311574, PubMed 27196596

Marstad A, Landsverk OJ, Strømme O, Otterlei M, Collas P, Sundan A, Brede G (2016)
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis
FEBS J, 283 (4), 757-70
DOI 10.1111/febs.13630, PubMed 26683827

Spencer J, Sollid LM (2016)
The human intestinal B-cell response
Mucosal Immunol, 9 (5), 1113-24
DOI 10.1038/mi.2016.59, PubMed 27461177

Stamnaes J, Cardoso I, Iversen R, Sollid LM (2016)
Transglutaminase 2 strongly binds to an extracellular matrix component other than fibronectin via its second C-terminal beta-barrel domain
FEBS J, 283 (21), 3994-4010
DOI 10.1111/febs.13907, PubMed 27685605

Szodoray P, Stanford SM, Molberg Ø, Munthe LA, Bottini N, Nakken B (2016)
T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity
J Allergy Clin Immunol, 138 (3), 839-851.e8
DOI 10.1016/j.jaci.2016.01.035, PubMed 27056269

Ter Horst R, Jaeger M, Smeekens SP, Oosting M, Swertz MA, Li Y, Kumar V, Diavatopoulos DA, Jansen AFM, Lemmers H, Toenhake-Dijkstra H, van Herwaarden AE, Janssen M, van der Molen RG, Joosten I, Sweep FCGJ, Smit JW, Netea-Maier RT, Koenders MMJF, Xavier RJ, van der Meer JWM, Dinarello CA, Pavelka N, Wijmenga C, Notebaart RA et al. (2016)
Host and Environmental Factors Influencing Individual Human Cytokine Responses
Cell, 167 (4), 1111-1124.e13
DOI 10.1016/j.cell.2016.10.018, PubMed 27814508

Tveita A, Fauskanger M, Bogen B, Haabeth OA (2016)
Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display
Oncotarget, 7 (41), 67175-67182
DOI 10.18632/oncotarget.11946, PubMed 27626487

van Leeuwen MA, Costes LMM, van Berkel LA, Simons-Oosterhuis Y, du Pré MF, Kozijn AE, Raatgeep HC, Lindenbergh-Kortleve DJ, van Rooijen N, Koning F, Samsom JN (2016)
Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-γ-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance
Mucosal Immunol, 10 (3), 635-649
DOI 10.1038/mi.2016.76, PubMed 27579860

Zhou P, Chionh YT, Irac SE, Ahn M, Jia Ng JH, Fossum E, Bogen B, Ginhoux F, Irving AT, Dutertre CA, Wang LF (2016)
Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
Sci Rep, 6, 38597
DOI 10.1038/srep38597, PubMed 27934903

 
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