Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2015 from OUS - Centre for Immune Regulation (CIR)

24 publications found

Almåsbak H, Walseng E, Kristian A, Myhre MR, Suso EM, Munthe LA, Andersen JT, Wang MY, Kvalheim G, Gaudernack G, Kyte JA (2015)
Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model
Gene Ther, 22 (5), 391-403
DOI 10.1038/gt.2015.4, PubMed 25652098

Chen X, Hnida K, Graewert MA, Andersen JT, Iversen R, Tuukkanen A, Svergun D, Sollid LM (2015)
Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease
J Biol Chem, 290 (35), 21365-75
DOI 10.1074/jbc.M115.669895, PubMed 26160175

Czajkowsky DM, Andersen JT, Fuchs A, Wilson TJ, Mekhaiel D, Colonna M, He J, Shao Z, Mitchell DA, Wu G, Dell A, Haslam S, Lloyd KA, Moore SC, Sandlie I, Blundell PA, Pleass RJ (2015)
Developing the IVIG biomimetic, hexa-Fc, for drug and vaccine applications
Sci Rep, 5, 9526
DOI 10.1038/srep09526, PubMed 25912958

De Giorgi U, Yuan J, Moroni M, Veronese S, Sartore-Bianchi A, Broggini M, Rosti G, Strebhardt K, Ruffini PA (2015)
Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function
Int J Biol Markers, 30 (3), e275-81
DOI 10.5301/jbm.5000149, PubMed 25982682

Di Niro R, Snir O, Kaukinen K, Yaari G, Lundin KE, Gupta NT, Kleinstein SH, Cols M, Cerutti A, Mäki M, Shlomchik MJ, Sollid LM (2015)
Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease
Mucosal Immunol, 9 (1), 254-64
DOI 10.1038/mi.2015.57, PubMed 26153762

du Pré MF, Sollid LM (2015)
T-cell and B-cell immunity in celiac disease
Best Pract Res Clin Gastroenterol, 29 (3), 413-23
DOI 10.1016/j.bpg.2015.04.001, PubMed 26060106

Grevys A, Bern M, Foss S, Bratlie DB, Moen A, Gunnarsen KS, Aase A, Michaelsen TE, Sandlie I, Andersen JT (2015)
Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions
J Immunol, 194 (11), 5497-508
DOI 10.4049/jimmunol.1401218, PubMed 25904551

Huszthy PC, Sakariassen PØ, Espedal H, Brokstad KA, Bjerkvig R, Miletic H (2015)
Engraftment of Human Glioblastoma Cells in Immunocompetent Rats through Acquired Immunosuppression
PLoS One, 10 (8), e0136089
DOI 10.1371/journal.pone.0136089, PubMed 26291724

Iversen R, Fleur du Pré M, Di Niro R, Sollid LM (2015)
Igs as Substrates for Transglutaminase 2: Implications for Autoantibody Production in Celiac Disease
J Immunol, 195 (11), 5159-68
DOI 10.4049/jimmunol.1501363, PubMed 26503953

Johansen JN, Vartdal F, Desmarais C, Tutturen AE, de Souza GA, Lossius A, Holmøy T (2015)
Intrathecal BCR transcriptome in multiple sclerosis versus other neuroinflammation: Equally diverse and compartmentalized, but more mutated, biased and overlapping with the proteome
Clin Immunol, 160 (2), 211-25
DOI 10.1016/j.clim.2015.06.001, PubMed 26055752

Kikuchi J, Koyama D, Wada T, Izumi T, Hofgaard PO, Bogen B, Furukawa Y (2015)
Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma
J Clin Invest, 125 (12), 4375-90
DOI 10.1172/JCI80325, PubMed 26517694

Kuczkowska K, Mathiesen G, Eijsink VG, Øynebråten I (2015)
Lactobacillus plantarum displaying CCL3 chemokine in fusion with HIV-1 Gag derived antigen causes increased recruitment of T cells
Microb Cell Fact, 14, 169
DOI 10.1186/s12934-015-0360-z, PubMed 26494531

Kulkarni U, Karsten CM, Kohler T, Hammerschmidt S, Bommert K, Tiburzy B, Meng L, Thieme L, Recke A, Ludwig RJ, Pollok K, Kalies K, Bogen B, Boettcher M, Kamradt T, Hauser AE, Langer C, Huber-Lang M, Finkelman FD, Köhl J, Wong DM, Manz RA (2015)
IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration
J Allergy Clin Immunol, 137 (5), 1487-1497.e6
DOI 10.1016/j.jaci.2015.10.018, PubMed 26653800

Nagy G, Huszthy PC, Fossum E, Konttinen Y, Nakken B, Szodoray P (2015)
Selected Aspects in the Pathogenesis of Autoimmune Diseases
Mediators Inflamm, 2015, 351732
DOI 10.1155/2015/351732, PubMed 26300591

Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL (2015)
Noninvasive imaging of immune responses
Proc Natl Acad Sci U S A, 112 (19), 6146-51
DOI 10.1073/pnas.1502609112, PubMed 25902531

Riaz T, Sollid LM, Olsen I, de Souza GA (2015)
Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells
Mol Cell Proteomics, 15 (3), 1007-16
DOI 10.1074/mcp.M115.050138, PubMed 26637539

Skrindo I, Ballke C, Gran E, Johansen FE, Baekkevold ES, Jahnsen FL (2015)
IL-5 production by resident mucosal allergen-specific T cells in an explant model of allergic rhinitis
Clin Exp Allergy, 45 (8), 1296-304
DOI 10.1111/cea.12543, PubMed 25817862

Sollid LM, Iversen R, Steinsbø Ø, Qiao SW, Bergseng E, Dørum S, du Pré MF, Stamnaes J, Christophersen A, Cardoso I, Hnida K, Chen X, Snir O, Lundin KE (2015)
Small bowel, celiac disease and adaptive immunity
Dig Dis, 33 (2), 115-21
DOI 10.1159/000369512, PubMed 25925911

Stamnaes J, Iversen R, du Pré MF, Chen X, Sollid LM (2015)
Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization
PLoS One, 10 (8), e0134922
DOI 10.1371/journal.pone.0134922, PubMed 26244572

Stamnaes J, Sollid LM (2015)
Celiac disease: Autoimmunity in response to food antigen
Semin Immunol, 27 (5), 343-52
DOI 10.1016/j.smim.2015.11.001, PubMed 26603490

Steinsbø Ø, Dørum S, Lundin KE, Sollid LM (2015)
Serologic assay for diagnosis of celiac disease based on a patient-derived monoclonal antigliadin antibody
Gastroenterology, 149 (6), 1530-1540.e3
DOI 10.1053/j.gastro.2015.07.008, PubMed 26208894

Terhorst D, Fossum E, Baranska A, Tamoutounour S, Malosse C, Garbani M, Braun R, Lechat E, Crameri R, Bogen B, Henri S, Malissen B (2015)
Laser-assisted intradermal delivery of adjuvant-free vaccines targeting XCR1+ dendritic cells induces potent antitumoral responses
J Immunol, 194 (12), 5895-902
DOI 10.4049/jimmunol.1500564, PubMed 25941327

Tveita AA, Schjesvold F, Haabeth OA, Fauskanger M, Bogen B (2015)
Tumors Escape CD4+ T-cell-Mediated Immunosurveillance by Impairing the Ability of Infiltrating Macrophages to Indirectly Present Tumor Antigens
Cancer Res, 75 (16), 3268-78
DOI 10.1158/0008-5472.CAN-14-3640, PubMed 26038231

Øynebråten I, Barois N, Bergeland T, Küchler AM, Bakke O, Haraldsen G (2015)
Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells
Sci Rep, 5, 9261
DOI 10.1038/srep09261, PubMed 25791723

 
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