Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2015 from OUS - Department of Molecular Oncology (2006-2014 Dept of Cancer Prev.)

26 publications found

Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM (2015)
Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms
PLoS One, 10 (4), e0123057
DOI 10.1371/journal.pone.0123057, PubMed 25853426

Andresen K, Boberg KM, Vedeld HM, Honne H, Jebsen P, Hektoen M, Wadsworth CA, Clausen OP, Lundin KE, Paulsen V, Foss A, Mathisen Ø, Aabakken L, Schrumpf E, Lothe RA, Lind GE (2015)
Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma
Hepatology, 61 (5), 1651-9
DOI 10.1002/hep.27707, PubMed 25644509

Asim M, Massie CE, Orafidiya F, Pértega-Gomes N, Warren AY, Esmaeili M, Selth LA, Zecchini HI, Luko K, Qureshi A, Baridi A, Menon S, Madhu B, Escriu C, Lyons S, Vowler SL, Zecchini VR, Shaw G, Hessenkemper W, Russell R, Mohammed H, Stefanos N, Lynch AG, Grigorenko E, D'Santos C et al. (2015)
Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target
J Natl Cancer Inst, 108 (5)
DOI 10.1093/jnci/djv371, PubMed 26657335

Barfeld SJ, Fazli L, Persson M, Marjavaara L, Urbanucci A, Kaukoniemi KM, Rennie PS, Ceder Y, Chabes A, Visakorpi T, Mills IG (2015)
Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer
Oncotarget, 6 (14), 12587-602
DOI 10.18632/oncotarget.3494, PubMed 25869206

Bjørnslett M, Dahl AA, Sørebø Ø, Dørum A (2015)
Psychological distress related to BRCA testing in ovarian cancer patients
Fam Cancer, 14 (4), 495-504
DOI 10.1007/s10689-015-9811-2, PubMed 25980896

Bollineni RC, Guldvik IJ, Grönberg H, Wiklund F, Mills IG, Thiede B (2015)
A differential protein solubility approach for the depletion of highly abundant proteins in plasma using ammonium sulfate
Analyst, 140 (24), 8109-17
DOI 10.1039/c5an01560j, PubMed 26541119

Brabrand S, Johannessen B, Axcrona U, Kraggerud SM, Berg KG, Bakken AC, Bruun J, Fosså SD, Lothe RA, Lehne G, Skotheim RI (2015)
Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages
Neoplasia, 17 (2), 167-74
DOI 10.1016/j.neo.2014.12.005, PubMed 25748235

Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
Clin Cancer Res, 21 (16), 3759-70
DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952

Du H, Liang Z, Zhao S, Nan MG, Tran LS, Lu K, Huang YB, Li JN (2015)
The Evolutionary History of R2R3-MYB Proteins Across 50 Eukaryotes: New Insights Into Subfamily Classification and Expansion
Sci Rep, 5, 11037
DOI 10.1038/srep11037, PubMed 26047035

Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI (2015)
Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
Cancer Res, 76 (1), 108-16
DOI 10.1158/0008-5472.CAN-15-1790, PubMed 26659575

Hoff AM, Johannessen B, Alagaratnam S, Zhao S, Nome T, Løvf M, Bakken AC, Hektoen M, Sveen A, Lothe RA, Skotheim RI (2015)
Novel RNA variants in colorectal cancers
Oncotarget, 6 (34), 36587-602
DOI 10.18632/oncotarget.5500, PubMed 26474385

Johannessen B, Sveen A, Skotheim RI (2015)
TIN: An R Package for Transcriptome Instability Analysis
Cancer Inform, 14, 109-12
DOI 10.4137/CIN.S31363, PubMed 26448683

Khanna A, Rane JK, Kivinummi KK, Urbanucci A, Helenius MA, Tolonen TT, Saramäki OR, Latonen L, Manni V, Pimanda JE, Maitland NJ, Westermarck J, Visakorpi T (2015)
CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations
Oncotarget, 6 (23), 19661-70
DOI 10.18632/oncotarget.3875, PubMed 25965834

Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA (2015)
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
Mol Oncol, 9 (6), 1129-39
DOI 10.1016/j.molonc.2015.02.005, PubMed 25769404

Kumar S, Krabberød AK, Neumann RS, Michalickova K, Zhao S, Zhang X, Shalchian-Tabrizi K (2015)
BIR Pipeline for Preparation of Phylogenomic Data
Evol Bioinform Online, 11, 79-83
DOI 10.4137/EBO.S10189, PubMed 25987827

Lund K, Dembinski JL, Solberg N, Urbanucci A, Mills IG, Krauss S (2015)
Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment
PLoS One, 10 (4), e0123684
DOI 10.1371/journal.pone.0123684, PubMed 25860483

Mesquita D, Barros-Silva JD, Santos J, Skotheim RI, Lothe RA, Paulo P, Teixeira MR (2015)
Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts
Oncotarget, 6 (7), 5217-36
DOI 10.18632/oncotarget.2847, PubMed 25595908

Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, McCullagh P, McGrath J, Crundwell M, Skotheim RI, Robson CN, Leung HY, Harries LW, Rajan P, Mills IG, Elliott DJ (2015)
The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer
Oncotarget, 6 (33), 34358-74
DOI 10.18632/oncotarget.6024, PubMed 26452038

Ross-Adams H, Lamb AD, Dunning MJ, Halim S, Lindberg J, Massie CM, Egevad LA, Russell R, Ramos-Montoya A, Vowler SL, Sharma NL, Kay J, Whitaker H, Clark J, Hurst R, Gnanapragasam VJ, Shah NC, Warren AY, Cooper CS, Lynch AG, Stark R, Mills IG, Grönberg H, Neal DE, CamCaP Study Group (2015)
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study
EBioMedicine, 2 (9), 1133-44
DOI 10.1016/j.ebiom.2015.07.017, PubMed 26501111

Rounge TB, Furu K, Skotheim RI, Haugen TB, Grotmol T, Enerly E (2015)
Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs
Mol Cancer, 14, 153
DOI 10.1186/s12943-015-0411-4, PubMed 26265322

Seglen PO, Luhr M, Mills IG, Sætre F, Szalai P, Engedal N (2015)
Macroautophagic cargo sequestration assays
Methods, 75, 25-36
DOI 10.1016/j.ymeth.2014.12.021, PubMed 25576638

Sevilla LM, Latorre V, Carceller E, Boix J, Vodák D, Mills IG, Pérez P (2015)
Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes
Mol Cell Endocrinol, 412, 281-9
DOI 10.1016/j.mce.2015.05.015, PubMed 26001834

Shaw GL, Whitaker H, Corcoran M, Dunning MJ, Luxton H, Kay J, Massie CE, Miller JL, Lamb AD, Ross-Adams H, Russell R, Nelson AW, Eldridge MD, Lynch AG, Ramos-Montoya A, Mills IG, Taylor AE, Arlt W, Shah N, Warren AY, Neal DE (2015)
The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer
Eur Urol, 70 (2), 214-8
DOI 10.1016/j.eururo.2015.10.042, PubMed 26572708

Sheng X, Arnoldussen YJ, Storm M, Tesikova M, Nenseth HZ, Zhao S, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen H, Mills IG, Jin Y, Hotamisligil G, Saatcioglu F (2015)
Divergent androgen regulation of unfolded protein response pathways drives prostate cancer
EMBO Mol Med, 7 (6), 788-801
DOI 10.15252/emmm.201404509, PubMed 25864123

Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI (2015)
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
Oncogene, 35 (19), 2413-27
DOI 10.1038/onc.2015.318, PubMed 26300000

Szalai P, Hagen LK, Sætre F, Luhr M, Sponheim M, Øverbye A, Mills IG, Seglen PO, Engedal N (2015)
Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs
Exp Cell Res, 333 (1), 21-38
DOI 10.1016/j.yexcr.2015.02.003, PubMed 25684710

 
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