Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2020 from OUS - Research Institute of Internal Medicine
64 publications found
Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T
Eur J Heart Fail, 22 (11), 2078-2088
DOI 10.1002/ejhf.1701, PubMed 31919929
Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells
Brain Behav Immun, 87, 634-644
DOI 10.1016/j.bbi.2020.02.008, PubMed 32109548
Utility of coagulation analyses to assess thromboprophylaxis with dalteparin in intensive care unit patients
Acta Anaesthesiol Scand
DOI 10.1111/aas.13748, PubMed 33205407
Indirect regulation of TFPI-2 expression by miR-494 in breast cancer cells
Sci Rep, 10 (1), 4036
DOI 10.1038/s41598-020-61018-x, PubMed 32132611
Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection
Infection, 48 (3), 367-373
DOI 10.1007/s15010-020-01399-3, PubMed 32077073
A man in his 90s with fever and dry cough
Tidsskr. Nor. Laegeforen., 140 (6), 569-573
Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas
Cancers (Basel), 12 (10)
DOI 10.3390/cancers12102980, PubMed 33066652
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739, PubMed 32437393
Impact of Human Immunodeficiency Virus-Related Gut Microbiota Alterations on Metabolic Comorbid Conditions
Clin Infect Dis, 71 (8), e359-e367
DOI 10.1093/cid/ciz1235, PubMed 31894240
Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform
J Am Heart Assoc, 9 (12), e015628
DOI 10.1161/JAHA.119.015628, PubMed 32515246
Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities
Hepatology, 72 (4), 1253-1266
DOI 10.1002/hep.31110, PubMed 31925805
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial
J Am Heart Assoc, 9 (17), e016360
DOI 10.1161/JAHA.120.016360, PubMed 32809893
Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism
Blood, 136 (16), 1863-1870
DOI 10.1182/blood.2019004572, PubMed 32645137
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
J Intern Med
DOI 10.1111/joim.13178, PubMed 32976665
Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection
Open Forum Infect Dis, 7 (2), ofaa033
DOI 10.1093/ofid/ofaa033, PubMed 32055642
Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals
J Infect Dis, 221 (4), 506-509
DOI 10.1093/infdis/jiz253, PubMed 31077280
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538
No evidence of a synergistic effect of HIV infection and diabetes mellitus type 2 on fat distribution, plasma adiponectin or inflammatory markers
BMC Infect Dis, 20 (1), 882
DOI 10.1186/s12879-020-05594-3, PubMed 33238950
Subjects with familial hypercholesterolemia have lower aortic valve area and higher levels of inflammatory biomarkers
J Clin Lipidol (in press)
DOI 10.1016/j.jacl.2020.12.006, PubMed 33358307
Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
Scand Cardiovasc J, 54 (5), 274-279
DOI 10.1080/14017431.2020.1775878, PubMed 32500743
A population-based study of inflammatory mechanisms and pain sensitivity
Pain, 161 (2), 338-350
DOI 10.1097/j.pain.0000000000001731, PubMed 31651577
Pregnancy and postpartum levels of circulating maternal sHLA-G in preeclampsia
J Reprod Immunol, 143, 103249 (in press)
DOI 10.1016/j.jri.2020.103249, PubMed 33254097
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843
Editor's Choice - European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis
Eur J Vasc Endovasc Surg, 61 (1), 9-82
DOI 10.1016/j.ejvs.2020.09.023, PubMed 33334670
Coaggregation properties of trimeric autotransporter adhesins
Microbiologyopen, 9 (10), e1109
DOI 10.1002/mbo3.1109, PubMed 32864901
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res, 48 (8), 4463-4479
DOI 10.1093/nar/gkaa115, PubMed 32083667
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y, PubMed 32214138
Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis
Gastroenterology (in press)
DOI 10.1053/j.gastro.2020.12.058, PubMed 33387530
Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension
Sci Rep, 10 (1), 18540
DOI 10.1038/s41598-020-75654-w, PubMed 33122779
Multiplex Analysis of Circulating Maternal Cardiovascular Biomarkers Comparing Preeclampsia Subtypes
Hypertension, 75 (6), 1513-1522
DOI 10.1161/HYPERTENSIONAHA.119.14580, PubMed 32336238
Liver Transplantation for Acute Intermittent Porphyria
Liver Transpl (in press)
DOI 10.1002/lt.25959, PubMed 33259654
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155
Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B - The MoHem study
Haemophilia, 26 (5), 891-897
DOI 10.1111/hae.14114, PubMed 33021747
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail, 7 (2), 456-466
DOI 10.1002/ehf2.12596, PubMed 31978943
HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction
J Infect Dis (in press)
DOI 10.1093/infdis/jiaa714, PubMed 33216130
Interleukin 18 (IL-18) and its binding protein (IL-18BP) are increased in patients with epilepsy suggesting low-grade systemic inflammation
Seizure, 80, 221-225
DOI 10.1016/j.seizure.2020.05.018, PubMed 32659652
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
EBioMedicine, 60, 102985
DOI 10.1016/j.ebiom.2020.102985, PubMed 32927275
GABA, but Not Bestrophin-1, Is Localized in Astroglial Processes in the Mouse Hippocampus and the Cerebellum
Front Mol Neurosci, 13, 135
DOI 10.3389/fnmol.2020.00135, PubMed 32848599
Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria
BMC Infect Dis, 20 (1), 65
DOI 10.1186/s12879-020-4783-8, PubMed 31964363
Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients
PLoS One, 15 (12), e0243759
DOI 10.1371/journal.pone.0243759, PubMed 33326471
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
Biochem Biophys Res Commun, 533 (4), 631-637
DOI 10.1016/j.bbrc.2020.09.057, PubMed 33004177
Probiotics to manage inflammation in HIV infection
Curr Opin Infect Dis, 33 (1), 34-43
DOI 10.1097/QCO.0000000000000612, PubMed 31789692
Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders
Front Psychiatry, 11, 672
DOI 10.3389/fpsyt.2020.00672, PubMed 32754070
Changes in maternal blood glucose and lipid concentrations during pregnancy differ by maternal body mass index and are related to birthweight: A prospective, longitudinal study of healthy pregnancies
PLoS One, 15 (6), e0232749
DOI 10.1371/journal.pone.0232749, PubMed 32574162
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
N Engl J Med, 383 (16), 1522-1534
DOI 10.1056/NEJMoa2020283, PubMed 32558485
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
Biochem Biophys Res Commun, 523 (4), 867-873
DOI 10.1016/j.bbrc.2020.01.018, PubMed 31955888
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1, PubMed 33273482
Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder
Front Psychiatry, 11, 642
DOI 10.3389/fpsyt.2020.00642, PubMed 32714224
Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study
Cerebrovasc Dis Extra, 10 (1), 11-20
DOI 10.1159/000504529, PubMed 32028277
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Nature, 583 (7814), 90-95
DOI 10.1038/s41586-020-2265-1, PubMed 32499645
Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: a case report
J Med Case Rep, 14 (1), 187
DOI 10.1186/s13256-020-02503-9, PubMed 33054818
Independent Association of Interleukin 6 With Low Dynamic Lung Function and Airflow Limitation in Well-Treated People With Human Immunodeficiency Virus
J Infect Dis (in press)
DOI 10.1093/infdis/jiaa600, PubMed 33141877
Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer
OncoImmunology, 9 (1), 1824644
The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions
EBioMedicine, 52, 102649
DOI 10.1016/j.ebiom.2020.102649, PubMed 32062353
A man in his forties with increasing shortness of breath
Tidsskr. Nor. Laegeforen., 140 (6), 578-581
Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies
J Hypertens, 38 (7), 1347-1354
DOI 10.1097/HJH.0000000000002362, PubMed 31990902
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109
Elevated Cholesteryl Ester Transfer Protein Activity Early in Pregnancy Predicts Prediabetes 5 Years Later
J Clin Endocrinol Metab, 105 (3)
DOI 10.1210/clinem/dgz119, PubMed 31665383
Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells
Clin Exp Immunol, 203 (2), 304-314
DOI 10.1111/cei.13541, PubMed 33089489
Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease
JHEP Rep, 3 (1), 100178
DOI 10.1016/j.jhepr.2020.100178, PubMed 33225252
Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis
NPJ Schizophr, 6 (1), 20
DOI 10.1038/s41537-020-00112-5, PubMed 32811840
Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results
N Engl J Med (in press)
DOI 10.1056/NEJMoa2023184, PubMed 33264556
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476