Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

Click here to see hierarchical division and subunit overview

Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Department of Gastrointestinal and Paediatric Surgery

52 publications found

Abrahamsson H, Porojnicu AC, Lindstrøm JC, Dueland S, Flatmark K, Hole KH, Seierstad T, Moan J, Redalen KR, Meltzer S, Ree AH (2019)
High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer
BMC Cancer, 19 (1), 488
DOI 10.1186/s12885-019-5724-z, PubMed 31122213

Aghayan DL, Fretland ÅA, Kazaryan AM, Sahakyan MA, Dagenborg VJ, Bjørnbeth BA, Flatmark K, Kristiansen R, Edwin B (2019)
Laparoscopic versus open liver resection in the posterosuperior segments: a sub-group analysis from the OSLO-COMET randomized controlled trial
HPB (Oxford) (in press)
DOI 10.1016/j.hpb.2019.03.358, PubMed 30962136

Amrutkar M, Aasrum M, Verbeke CS, Gladhaug IP (2019)
Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells
BMC Cancer, 19 (1), 596
DOI 10.1186/s12885-019-5803-1, PubMed 31208372

Bartolomé-Casado R, Landsverk OJB, Chauhan SK, Richter L, Phung D, Greiff V, Risnes LF, Yao Y, Neumann RS, Yaqub S, Øyen O, Horneland R, Aandahl EM, Paulsen V, Sollid LM, Qiao SW, Baekkevold ES, Jahnsen FL (2019)
Resident memory CD8 T cells persist for years in human small intestine
J Exp Med (in press)
DOI 10.1084/jem.20190414, PubMed 31337737

Berg KCG, Sveen A, Høland M, Alagaratnam S, Berg M, Danielsen SA, Nesbakken A, Søreide K, Lothe RA (2019)
Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains
Oncogene, 38 (33), 6109-6122
DOI 10.1038/s41388-019-0868-5, PubMed 31308487

Blom-Høgestøl IK, Mala T, Kristinsson JA, Hauge EM, Brunborg C, Gulseth HL, Eriksen EF (2019)
Changes in Bone Marrow Adipose Tissue One Year After Roux-en-Y Gastric Bypass: A Prospective Cohort Study
J Bone Miner Res (in press)
DOI 10.1002/jbmr.3814, PubMed 31216081

Bowitz Lothe IM, Kleive D, Pomianowska E, Cvancarova M, Kure E, Dueland S, Gladhaug IP, Labori KJ (2019)
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy
Pancreatology, 19 (2), 316-324
DOI 10.1016/j.pan.2019.01.019, PubMed 30713128

Brudvik KW, Jones RP, Giuliante F, Shindoh J, Passot G, Chung MH, Song J, Li L, Dagenborg VJ, Fretland ÅA, Røsok B, De Rose AM, Ardito F, Edwin B, Panettieri E, Larocca LM, Yamashita S, Conrad C, Aloia TA, Poston GJ, Bjørnbeth BA, Vauthey JN (2019)
RAS Mutation Clinical Risk Score to Predict Survival After Resection of Colorectal Liver Metastases
Ann Surg, 269 (1), 120-126
DOI 10.1097/SLA.0000000000002319, PubMed 28549012

Brunsell TH, Cengija V, Sveen A, Bjørnbeth BA, Røsok BI, Brudvik KW, Guren MG, Lothe RA, Abildgaard A, Nesbakken A (2019)
Heterogeneous radiological response to neoadjuvant therapy is associated with poor prognosis after resection of colorectal liver metastases
Eur J Surg Oncol (in press)
DOI 10.1016/j.ejso.2019.07.017, PubMed 31350075

Carling U, Barkhatov L, Reims HM, Storås T, Courivaud F, Kazaryan AM, Halvorsen PS, Dorenberg E, Edwin B, Hol PK (2019)
Can we ablate liver lesions close to large portal and hepatic veins with MR-guided HIFU? An experimental study in a porcine model
Eur Radiol, 29 (9), 5013-5021
DOI 10.1007/s00330-018-5996-8, PubMed 30737565

Chahal-Kummen M, Blom-Høgestøl IK, Eribe I, Klungsøyr O, Kristinsson J, Mala T (2019)
Abdominal pain and symptoms before and after Roux-en-Y gastric bypass
BJS Open, 3 (3), 317-326
DOI 10.1002/bjs5.50148, PubMed 31183448

Cipriani F, Alzoubi M, Fuks D, Ratti F, Kawai T, Berardi G, Barkhatov L, Lainas P, Van der Poel M, Faoury M, Besselink M, D'Hondt M, Dagher I, Edwin B, Troisi RI, Scatton O, Gayet B, Aldrighetti L, Abu Hilal M (2019)
Pure laparoscopic versus open hemihepatectomy: a critical assessment and realistic expectations. A propensity score-based analysis of right and left hemihepatectomies from 9 European tertiary referral centers
J Hepatobiliary Pancreat Sci (in press)
DOI 10.1002/jhbp.662, PubMed 31419040

Ciria R, Ocaña S, Gomez-Luque I, Cipriani F, Halls M, Fretland ÅA, Okuda Y, Aroori S, Briceño J, Aldrighetti L, Edwin B, Hilal MA (2019)
A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer
Surg Endosc (in press)
DOI 10.1007/s00464-019-06774-2, PubMed 30989374

Dingemann C, Eaton S, Aksnes G, Bagolan P, Cross KM, Decoppi P, Fruithof J, Gamba P, Husby S, Koivusalo A, Rasmussen L, Sfeir R, Slater G, Svensson JF, Van der Zee DC, Wessel LM, Widenmann-Grolig A, Wijnen R, Ure BM (2019)
ERNICA Consensus Conference on the Management of Patients with Esophageal Atresia and Tracheoesophageal Fistula: Diagnostics, Preoperative, Operative, and Postoperative Management
Eur J Pediatr Surg (in press)
DOI 10.1055/s-0039-1693116, PubMed 31266084

Dueland S, Syversveen T, Solheim JM, Solberg S, Grut H, Bjørnbeth BA, Hagness M, Line PD (2019)
Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases
Ann Surg (in press)
DOI 10.1097/SLA.0000000000003404, PubMed 31188200

Flørenes VA, Flem-Karlsen K, McFadden E, Bergheim IR, Nygaard V, Nygård V, Farstad IN, Øy GF, Emilsen E, Giller-Fleten K, Ree AH, Flatmark K, Gullestad HP, Hermann R, Ryder T, Wernhoff P, Mælandsmo GM (2019)
A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
Transl Oncol, 12 (7), 951-958
DOI 10.1016/j.tranon.2019.04.001, PubMed 31096111

Frøysnes IS, Andersson Y, Larsen SG, Davidson B, Øien JT, Julsrud L, Fodstad Ø, Dueland S, Flatmark K (2019)
ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis
Eur J Surg Oncol (in press)
DOI 10.1016/j.ejso.2019.04.014, PubMed 31036394

Glaire MA, Domingo E, Sveen A, Bruun J, Nesbakken A, Nicholson G, Novelli M, Lawson K, Oukrif D, Kildal W, Danielsen HE, Kerr R, Kerr D, Tomlinson I, Lothe RA, Church DN (2019)
Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
Br J Cancer (in press)
DOI 10.1038/s41416-019-0540-4, PubMed 31388185

Hauge T, Kleven OC, Johnson E, Hofstad B, Johannessen HO (2019)
Outcome after iatrogenic esophageal perforation
Scand J Gastroenterol, 54 (2), 140-144
DOI 10.1080/00365521.2019.1575464, PubMed 30857441

Hausken J, Fretland ÅA, Edwin B, Andersen MH, Dagenborg VJ, Bjørnelv GMW, Kristiansen R, Røysland K, Kvarstein G, Tønnessen TI (2019)
Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority Trial
Ann Surg, 270 (2), 193-199
DOI 10.1097/SLA.0000000000003209, PubMed 30676382

Hukkinen M, Björnland K, Gatzinsky V, Iber T, Johansen LS, Qvist N, Stenström P, Svensson JF, Pakarinen MP (2019)
Management strategies and treatment results of pediatric choledochal malformations in the Nordic countries
HPB (Oxford) (in press)
DOI 10.1016/j.hpb.2019.07.001, PubMed 31371244

Kazaryan AM, Aghayan DL, Barkhatov LI, Fretland ÅA, Edwin B (2019)
Laparoscopic Multiple Parenchyma-sparing Concomitant Liver Resections for Colorectal Liver Metastases
Surg Laparosc Endosc Percutan Tech, 29 (3), 187-193
DOI 10.1097/SLE.0000000000000606, PubMed 30520815

Kleive D, Labori KJ, Line PD, Gladhaug IP, Verbeke CS (2019)
Pancreatoduodenectomy with venous resection for ductal adenocarcinoma rarely achieves complete (R0) resection
HPB (Oxford) (in press)
DOI 10.1016/j.hpb.2019.05.005, PubMed 31186199

Kleive D, Sahakyan MA, Labori KJ, Lassen K (2019)
Nasogastric Tube on Demand is Rarely Necessary After Pancreatoduodenectomy Within an Enhanced Recovery Pathway
World J Surg (in press)
DOI 10.1007/s00268-019-05045-4, PubMed 31161355

Klompmaker S, Peters NA, van Hilst J, Bassi C, Boggi U, Busch OR, Niesen W, Van Gulik TM, Javed AA, Kleeff J, Kawai M, Lesurtel M, Lombardo C, Moser AJ, Okada KI, Popescu I, Prasad R, Salvia R, Sauvanet A, Sturesson C, Weiss MJ, Zeh HJ, Zureikat AH, Yamaue H, Wolfgang CL et al. (2019)
Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): An International Multicenter Analysis
Ann Surg Oncol, 26 (3), 772-781
DOI 10.1245/s10434-018-07101-0, PubMed 30610560

Larsen SG, Pfeffer F, Kørner H, Norwegian Colorectal Cancer Group (2019)
Norwegian moratorium on transanal total mesorectal excision
Br J Surg, 106 (9), 1120-1121
DOI 10.1002/bjs.11287, PubMed 31304578

Lenggenhager D, Amrutkar M, Sántha P, Aasrum M, Löhr JM, Gladhaug IP, Verbeke CS (2019)
Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells
Cells, 8 (1)
DOI 10.3390/cells8010023, PubMed 30621293

Lillemoe HA, Brudvik KW, Vauthey JN (2019)
Treatment Options for Metastatic Gastrointestinal Stromal Tumors to the Liver: A Review
Semin Liver Dis, 39 (3), 395-402
DOI 10.1055/s-0039-1685517, PubMed 31100757

Lund-Andersen C, Nakken S, Nygård S, Fromm B, Aasheim LB, Davidson B, Julsrud L, Abrahamsen TW, Kristensen AT, Dybdahl B, Larsen SG, Hovig E, Flatmark K (2019)
Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response
Cold Spring Harb Mol Case Stud, 5 (2)
DOI 10.1101/mcs.a003566, PubMed 30862609

Lundar L, Aksnes G, Mørkrid L, Emblem R (2019)
Prenatal extravasation of urine seems to preserve renal function in boys with posterior urethral valves
J Pediatr Urol, 15 (3), 241.e1-241.e7
DOI 10.1016/j.jpurol.2019.02.010, PubMed 30982696

Meltzer S, Bjørnetrø T, Lyckander LG, Flatmark K, Dueland S, Samiappan R, Johansen C, Kalanxhi E, Ree AH, Redalen KR (2019)
Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer
Transl Oncol, 12 (8), 1038-1044
DOI 10.1016/j.tranon.2019.04.014, PubMed 31146167

Nesgaard JM, Stimec BV, Bakka AO, Edwin B, Bergamaschi R, Ignjatovic D (2019)
Right Colectomy with Extended D3 Mesenterectomy: Anterior and Posterior to the Mesenteric Vessels
Surg Technol Int, 35 (in press)
PubMed 31237343

Olesen SS, Nøjgaard C, Poulsen JL, Haas SL, Vujasinovic M, Löhr M, Lindkvist B, Bexander L, Gulbinas A, Kalaitzakis E, Ebrahim M, Erchinger F, Engjom T, Roug S, Novovic S, Hauge T, Waage A, Laukkarinen J, Parhiala M, Pukitis A, Ozola-Zālīte I, Drewes AM, Scandinavian Baltic Pancreatic Club (2019)
Chronic Pancreatitis Is Characterized by Distinct Complication Clusters That Associate With Etiological Risk Factors
Am J Gastroenterol, 114 (4), 656-664
DOI 10.14309/ajg.0000000000000147, PubMed 30741740

Poelemeijer YQM, Liem RSL, Våge V, Mala T, Sundbom M, Ottosson J, Nienhuijs SW (2019)
Gastric Bypass Versus Sleeve Gastrectomy: Patient Selection and Short-term Outcome of 47,101 Primary Operations from the Swedish, Norwegian, and Dutch National Quality Registries
Ann Surg (in press)
DOI 10.1097/SLA.0000000000003279, PubMed 30921054

Ree AH, Nygaard V, Russnes HG, Heinrich D, Nygaard V, Johansen C, Bergheim IR, Hovig E, Beiske K, Negård A, Børresen-Dale AL, Flatmark K, Mælandsmo GM (2019)
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006

Røsok BI, Høst-Brunsell T, Brudvik KW, Carling U, Dorenberg E, Björnsson B, Lothe RA, Bjørnbeth BA, Sandström P (2019)
Characterization of early recurrences following liver resection by ALPPS and two stage hepatectomy in patients with colorectal liver-metastases and small future liver remnants; a translational substudy of the LIGRO-RCT
HPB (Oxford), 21 (8), 1017-1023
DOI 10.1016/j.hpb.2018.12.003, PubMed 30765198

Sahakyan MA, Labori KJ, Primavesi F, Soreide K, Stattner S, Edwin B (2019)
Minimally invasive pancreatic surgerywhere are we going?
Eur. Surg., 51 (3), 98-104

Salte OB, Sovik TT, Risstad H, Skattum J, Blom-Hogestol IK, Eribe IEL, Kristinsson JA, Mala T (2019)
Bariatric surgery at Oslo University Hospital 2004-14
Tidsskr. Nor. Laegeforen., 139 (10), 921-926

Salte OB, Søvik TT, Risstad H, Skattum J, Blom-Høgestøl IK, Eribe IEL, Kristinsson JA, Mala T (2019)
Fedmekirurgi ved Oslo universitetssykehus 2004–14
Tidsskr Nor Laegeforen, 139 (10)
DOI 10.4045/tidsskr.18.0495, PubMed 31238674

Sandhu V, Labori KJ, Borgida A, Lungu I, Bartlett J, Hafezi-Bakhtiari S, Denroche RE, Jang GH, Pasternack D, Mbaabali F, Watson M, Wilson J, Kure EH, Gallinger S, Haibe-Kains B (2019)
Meta-Analysis of 1,200 Transcriptomic Profiles Identifies a Prognostic Model for Pancreatic Ductal Adenocarcinoma
JCO Clin Cancer Inform, 3, 1-16
DOI 10.1200/CCI.18.00102, PubMed 31070984

Sandström P, Larsson AL, Björnsson B, Røsok BI, Sparrelid E, Larsen PN, Schultz NA, Björnbeth BA, Lindell G, Isaksson B, Rizell M (2019)
Response to Comment on "When Innovation Is Not Enough"
Ann Surg, 270 (2), e36-e37
DOI 10.1097/SLA.0000000000003028, PubMed 30169399

Schulz A, Joelsen-Hatlehol ES, Brudvik KW, Aasand KK, Hanekamp B, Viktil E, Johansen CK, Dormagen JB (2019)
Preoperative detection of colorectal liver metastases: DWI alone or combined with MDCT is no substitute for Gd-EOB-DTPA-enhanced MRI
Acta Radiol, 284185119864000 (in press)
DOI 10.1177/0284185119864000, PubMed 31335157

Skeie E, Tangvik RJ, Nymo LS, Harthug S, Lassen K, Viste A (2019)
Weight loss and BMI criteria in GLIM's definition of malnutrition is associated with postoperative complications following abdominal resections - Results from a National Quality Registry
Clin Nutr (in press)
DOI 10.1016/j.clnu.2019.07.003, PubMed 31375303

Smeby J, Sveen A, Bergsland CH, Eilertsen IA, Danielsen SA, Eide PW, Hektoen M, Guren MG, Nesbakken A, Bruun J, Lothe RA (2019)
Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
ESMO Open, 4 (3), e000523
DOI 10.1136/esmoopen-2019-000523, PubMed 31321083

Smeby J, Sveen A, Eilertsen IA, Danielsen SA, Hoff AM, Eide PW, Johannessen B, Hektoen M, Skotheim RI, Guren MG, Nesbakken A, Lothe RA (2019)
Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
Oncogenesis, 8 (6), 35
DOI 10.1038/s41389-019-0141-3, PubMed 31092812

Soreide K, Primavesi F, Labori KJ, Watson MM, Stattner S (2019)
Molecular biology in pancreatic ductal adenocarcinoma: implications for future diagnostics and therapy
Eur. Surg., 51 (3), 126-134

Svanevik M, Risstad H, Hofsø D, Blom-Høgestøl IK, Kristinsson JA, Sandbu R, Småstuen MC, Thorsby PM, Mala T, Hjelmesæth J (2019)
Bone Turnover Markers After Standard and Distal Roux-en-Y Gastric Bypass: Results from a Randomized Controlled Trial
Obes Surg (in press)
DOI 10.1007/s11695-019-03909-1, PubMed 31065919

Søreide K, Nymo LS, Kleive D, Olsen F, Lassen K (2019)
Variation in use of open and laparoscopic distal pancreatectomy and associated outcome metrics in a universal health care system
Pancreatology (in press)
DOI 10.1016/j.pan.2019.07.047, PubMed 31395453

Thorgersen EB, Barratt-Due A, Haugaa H, Harboe M, Pischke SE, Nilsson PH, Mollnes TE (2019)
The Role of Complement in Liver Injury, Regeneration, and Transplantation
Hepatology, 70 (2), 725-736
DOI 10.1002/hep.30508, PubMed 30653682

Thorsen T, Solheim JM, Labori KJ, Line PD, Aandahl EM (2019)
Liver transplantation as a lifesaving procedure for posthepatectomy liver failure and iatrogenic liver injuries
Langenbecks Arch Surg, 404 (3), 301-308
DOI 10.1007/s00423-019-01780-3, PubMed 30929063

van der Poel MJ, Barkhatov L, Fuks D, Berardi G, Cipriani F, Aljaiuossi A, Lainas P, Dagher I, D'Hondt M, Rotellar F, Besselink MG, Aldrighetti L, Troisi RI, Gayet B, Edwin B, Abu Hilal M (2019)
Multicentre propensity score-matched study of laparoscopic versus open repeat liver resection for colorectal liver metastases
Br J Surg, 106 (6), 783-789
DOI 10.1002/bjs.11096, PubMed 30706451

von Döbeln GA, Klevebro F, Jacobsen AB, Johannessen HO, Nielsen NH, Johnsen G, Hatlevoll I, Glenjen NI, Friesland S, Lundell L, Yu J, Nilsson M (2019)
Neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for cancer of the esophagus or gastroesophageal junction: long-term results of a randomized clinical trial
Dis Esophagus, 32 (2)
DOI 10.1093/dote/doy078, PubMed 30137281

 
Page visits: 222156