Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Department of Gastrointestinal and Paediatric Surgery

29 publications found

Aghayan DL, Fretland ÅA, Kazaryan AM, Sahakyan MA, Dagenborg VJ, Bjørnbeth BA, Flatmark K, Kristiansen R, Edwin B (2019)
Laparoscopic versus open liver resection in the posterosuperior segments: a sub-group analysis from the OSLO-COMET randomized controlled trial
HPB (Oxford) (in press)
DOI 10.1016/j.hpb.2019.03.358, PubMed 30962136

Bowitz Lothe IM, Kleive D, Pomianowska E, Cvancarova M, Kure E, Dueland S, Gladhaug IP, Labori KJ (2019)
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy
Pancreatology, 19 (2), 316-324
DOI 10.1016/j.pan.2019.01.019, PubMed 30713128

Brudvik KW, Jones RP, Giuliante F, Shindoh J, Passot G, Chung MH, Song J, Li L, Dagenborg VJ, Fretland ÅA, Røsok B, De Rose AM, Ardito F, Edwin B, Panettieri E, Larocca LM, Yamashita S, Conrad C, Aloia TA, Poston GJ, Bjørnbeth BA, Vauthey JN (2019)
RAS Mutation Clinical Risk Score to Predict Survival After Resection of Colorectal Liver Metastases
Ann Surg, 269 (1), 120-126
DOI 10.1097/SLA.0000000000002319, PubMed 28549012

Carling U, Barkhatov L, Reims HM, Storås T, Courivaud F, Kazaryan AM, Halvorsen PS, Dorenberg E, Edwin B, Hol PK (2019)
Can we ablate liver lesions close to large portal and hepatic veins with MR-guided HIFU? An experimental study in a porcine model
Eur Radiol (in press)
DOI 10.1007/s00330-018-5996-8, PubMed 30737565

Ciria R, Ocaña S, Gomez-Luque I, Cipriani F, Halls M, Fretland ÅA, Okuda Y, Aroori S, Briceño J, Aldrighetti L, Edwin B, Hilal MA (2019)
A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer
Surg Endosc (in press)
DOI 10.1007/s00464-019-06774-2, PubMed 30989374

Flørenes VA, Flem-Karlsen K, McFadden E, Bergheim IR, Nygaard V, Nygård V, Farstad IN, Øy GF, Emilsen E, Giller-Fleten K, Ree AH, Flatmark K, Gullestad HP, Hermann R, Ryder T, Wernhoff P, Mælandsmo GM (2019)
A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
Transl Oncol, 12 (7), 951-958 (in press)
DOI 10.1016/j.tranon.2019.04.001, PubMed 31096111

Frøysnes IS, Andersson Y, Larsen SG, Davidson B, Øien JT, Julsrud L, Fodstad Ø, Dueland S, Flatmark K (2019)
ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis
Eur J Surg Oncol (in press)
DOI 10.1016/j.ejso.2019.04.014, PubMed 31036394

Hauge T, Kleven OC, Johnson E, Hofstad B, Johannessen HO (2019)
Outcome after iatrogenic esophageal perforation
Scand J Gastroenterol, 54 (2), 140-144
DOI 10.1080/00365521.2019.1575464, PubMed 30857441

Hausken J, Fretland ÅA, Edwin B, Andersen MH, Dagenborg VJ, Bjørnelv GMW, Kristiansen R, Røysland K, Kvarstein G, Tønnessen TI (2019)
Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority Trial
Ann Surg (in press)
DOI 10.1097/SLA.0000000000003209, PubMed 30676382

Klompmaker S, Peters NA, van Hilst J, Bassi C, Boggi U, Busch OR, Niesen W, Van Gulik TM, Javed AA, Kleeff J, Kawai M, Lesurtel M, Lombardo C, Moser AJ, Okada KI, Popescu I, Prasad R, Salvia R, Sauvanet A, Sturesson C, Weiss MJ, Zeh HJ, Zureikat AH, Yamaue H, Wolfgang CL et al. (2019)
Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): An International Multicenter Analysis
Ann Surg Oncol, 26 (3), 772-781
DOI 10.1245/s10434-018-07101-0, PubMed 30610560

Kvello M, Åvitsland TL, Knatten CK, Fyhn TJ, Malt U, Emblem R, Bjørnland K (2019)
Psychologic distress and anxiety in mothers of children with gastroesophageal reflux undergoing antireflux surgery
J Pediatr Gastroenterol Nutr (in press)
DOI 10.1097/MPG.0000000000002286, PubMed 30985443

Lenggenhager D, Amrutkar M, Sántha P, Aasrum M, Löhr JM, Gladhaug IP, Verbeke CS (2019)
Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells
Cells, 8 (1)
DOI 10.3390/cells8010023, PubMed 30621293

Lillemoe HA, Brudvik KW, Vauthey JN (2019)
Treatment Options for Metastatic Gastrointestinal Stromal Tumors to the Liver: A Review
Semin Liver Dis (in press)
DOI 10.1055/s-0039-1685517, PubMed 31100757

Lund-Andersen C, Nakken S, Nygård S, Fromm B, Aasheim LB, Davidson B, Julsrud L, Abrahamsen TW, Kristensen AT, Dybdahl B, Larsen SG, Hovig E, Flatmark K (2019)
Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response
Cold Spring Harb Mol Case Stud, 5 (2)
DOI 10.1101/mcs.a003566, PubMed 30862609

Lundar L, Aksnes G, Mørkrid L, Emblem R (2019)
Prenatal extravasation of urine seems to preserve renal function in boys with posterior urethral valves
J Pediatr Urol (in press)
DOI 10.1016/j.jpurol.2019.02.010, PubMed 30982696

Olesen SS, Nøjgaard C, Poulsen JL, Haas SL, Vujasinovic M, Löhr M, Lindkvist B, Bexander L, Gulbinas A, Kalaitzakis E, Ebrahim M, Erchinger F, Engjom T, Roug S, Novovic S, Hauge T, Waage A, Laukkarinen J, Parhiala M, Pukitis A, Ozola-Zālīte I, Drewes AM, Scandinavian Baltic Pancreatic Club (2019)
Chronic Pancreatitis Is Characterized by Distinct Complication Clusters That Associate With Etiological Risk Factors
Am J Gastroenterol, 114 (4), 656-664
DOI 10.14309/ajg.0000000000000147, PubMed 30741740

Poelemeijer YQM, Liem RSL, Våge V, Mala T, Sundbom M, Ottosson J, Nienhuijs SW (2019)
Gastric Bypass Versus Sleeve Gastrectomy: Patient Selection and Short-term Outcome of 47,101 Primary Operations from the Swedish, Norwegian, and Dutch National Quality Registries
Ann Surg (in press)
DOI 10.1097/SLA.0000000000003279, PubMed 30921054

Ree AH, Nygaard V, Russnes HG, Heinrich D, Nygaard V, Johansen C, Bergheim IR, Hovig E, Beiske K, Negård A, Børresen-Dale AL, Flatmark K, Mælandsmo GM (2019)
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006

Røsok BI, Høst-Brunsell T, Brudvik KW, Carling U, Dorenberg E, Björnsson B, Lothe RA, Bjørnbeth BA, Sandström P (2019)
Characterization of early recurrences following liver resection by ALPPS and two stage hepatectomy in patients with colorectal liver-metastases and small future liver remnants; a translational substudy of the LIGRO-RCT
HPB (Oxford) (in press)
DOI 10.1016/j.hpb.2018.12.003, PubMed 30765198

Sandhu V, Labori KJ, Borgida A, Lungu I, Bartlett J, Hafezi-Bakhtiari S, Denroche RE, Jang GH, Pasternack D, Mbaabali F, Watson M, Wilson J, Kure EH, Gallinger S, Haibe-Kains B (2019)
Meta-Analysis of 1,200 Transcriptomic Profiles Identifies a Prognostic Model for Pancreatic Ductal Adenocarcinoma
JCO Clin Cancer Inform, 3, 1-16
DOI 10.1200/CCI.18.00102, PubMed 31070984

Sandström P, Røsok BI, Sparrelid E, Larsen PN, Larsson AL, Lindell G, Schultz NA, Bjørnbeth BA, Isaksson B, Rizell M, Björnsson B (2019)
Response to "ALPPS Versus Conventional Two-stage Hepatectomy in Patients With Advanced Colorectal Liver Metastases"
Ann Surg, 269 (1), e16-e17
DOI 10.1097/SLA.0000000000003046, PubMed 30247325

Sandström P, Røsok BI, Sparrelid E, Lindell G, Nørgaard Larsen P, Lindhoff Larsson A, Schultz NA, Bjørnbeth BA, Isaksson B, Rizell M, Björnsson B (2019)
Response to the Comment on "Should We Have a Little More Patience With the Conventional 2-Stage Hepatectomy?"
Ann Surg, 269 (3), e33-e34
DOI 10.1097/SLA.0000000000002739, PubMed 29557882

Smeby J, Sveen A, Eilertsen IA, Danielsen SA, Hoff AM, Eide PW, Johannessen B, Hektoen M, Skotheim RI, Guren MG, Nesbakken A, Lothe RA (2019)
Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
Oncogenesis, 8 (6), 35
DOI 10.1038/s41389-019-0141-3, PubMed 31092812

Svanevik M, Risstad H, Hofsø D, Blom-Høgestøl IK, Kristinsson JA, Sandbu R, Småstuen MC, Thorsby PM, Mala T, Hjelmesæth J (2019)
Bone Turnover Markers After Standard and Distal Roux-en-Y Gastric Bypass: Results from a Randomized Controlled Trial
Obes Surg (in press)
DOI 10.1007/s11695-019-03909-1, PubMed 31065919

Thorgersen EB, Barratt-Due A, Haugaa H, Harboe M, Pischke SE, Nilsson PH, Mollnes TE (2019)
The role of complement in liver injury, regeneration and transplantation
Hepatology (in press)
DOI 10.1002/hep.30508, PubMed 30653682

Thorsen T, Solheim JM, Labori KJ, Line PD, Aandahl EM (2019)
Liver transplantation as a lifesaving procedure for posthepatectomy liver failure and iatrogenic liver injuries
Langenbecks Arch Surg, 404 (3), 301-308
DOI 10.1007/s00423-019-01780-3, PubMed 30929063

Udjus C, Cero FT, Halvorsen B, Behmen D, Carlson CR, Bendiksen BA, Espe EK, Sjaastad I, Løberg EM, Yndestad A, Aukrust P, Christensen G, Skjønsberg OH, Larsen KO (2019)
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol (in press)
DOI 10.1152/ajplung.00322.2018, PubMed 30908936

van der Poel MJ, Barkhatov L, Fuks D, Berardi G, Cipriani F, Aljaiuossi A, Lainas P, Dagher I, D'Hondt M, Rotellar F, Besselink MG, Aldrighetti L, Troisi RI, Gayet B, Edwin B, Abu Hilal M (2019)
Multicentre propensity score-matched study of laparoscopic versus open repeat liver resection for colorectal liver metastases
Br J Surg, 106 (6), 783-789
DOI 10.1002/bjs.11096, PubMed 30706451

von Döbeln GA, Klevebro F, Jacobsen AB, Johannessen HO, Nielsen NH, Johnsen G, Hatlevoll I, Glenjen NI, Friesland S, Lundell L, Yu J, Nilsson M (2019)
Neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for cancer of the esophagus or gastroesophageal junction: long-term results of a randomized clinical trial
Dis Esophagus, 32 (2)
DOI 10.1093/dote/doy078, PubMed 30137281

 
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