Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2016 from OUS - Department of Gastrointestinal and Paediatric Surgery

57 publications found

Bains SJ, Mahic M, Myklebust TÅ, Småstuen MC, Yaqub S, Dørum LM, Bjørnbeth BA, Møller B, Brudvik KW, Taskén K (2016)
Aspirin As Secondary Prevention in Patients With Colorectal Cancer: An Unselected Population-Based Study
J Clin Oncol, 34 (21), 2501-8
DOI 10.1200/JCO.2015.65.3519, PubMed 27247217

Barkhatov L, Fretland ÅA, Kazaryan AM, Røsok BI, Brudvik KW, Waage A, Bjørnbeth BA, Sahakyan MA, Edwin B (2016)
Validation of clinical risk scores for laparoscopic liver resections of colorectal liver metastases: A 10-year observed follow-up study
J Surg Oncol, 114 (6), 757-763
DOI 10.1002/jso.24391, PubMed 27471127

Björnsson B, Sparrelid E, Røsok B, Pomianowska E, Hasselgren K, Gasslander T, Bjørnbeth BA, Isaksson B, Sandström P (2016)
Associating liver partition and portal vein ligation for staged hepatectomy in patients with colorectal liver metastases--Intermediate oncological results
Eur J Surg Oncol, 42 (4), 531-7
DOI 10.1016/j.ejso.2015.12.013, PubMed 26830731

Boye K, Jacob H, Frikstad KA, Nesland JM, Maelandsmo GM, Dahl O, Nesbakken A, Flatmark K (2016)
Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy
Cancer Med, 5 (8), 1840-9
DOI 10.1002/cam4.766, PubMed 27273130

Buanes TA (2016)
Updated therapeutic outcome for patients with periampullary and pancreatic cancer related to recent translational research
World J Gastroenterol, 22 (48), 10502-10511
DOI 10.3748/wjg.v22.i48.10502, PubMed 28082802

Domingo E, Freeman-Mills L, Rayner E, Glaire M, Briggs S, Vermeulen L, Fessler E, Medema JP, Boot A, Morreau H, van Wezel T, Liefers GJ, Lothe RA, Danielsen SA, Sveen A, Nesbakken A, Zlobec I, Lugli A, Koelzer VH, Berger MD, Castellví-Bel S, Muñoz J, Epicolon consortium, de Bruyn M, Nijman HW et al. (2016)
Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study
Lancet Gastroenterol Hepatol, 1 (3), 207-216
DOI 10.1016/S2468-1253(16)30014-0, PubMed 28404093

Dueland S, Ree AH, Grøholt KK, Saelen MG, Folkvord S, Hole KH, Seierstad T, Larsen SG, Giercksky KE, Wiig JN, Boye K, Flatmark K (2016)
Oxaliplatin-containing Preoperative Therapy in Locally Advanced Rectal Cancer: Local Response, Toxicity and Long-term Outcome
Clin Oncol (R Coll Radiol), 28 (8), 532-9
DOI 10.1016/j.clon.2016.01.014, PubMed 26888115

Egeland EV, Flatmark K, Nesland JM, Flørenes VA, Mælandsmo GM, Boye K (2016)
Expression and clinical significance of Wee1 in colorectal cancer
Tumour Biol, 37 (9), 12133-12140
DOI 10.1007/s13277-016-5081-3, PubMed 27220319

Flatmark K, Høye E, Fromm B (2016)
microRNAs as cancer biomarkers
Scand J Clin Lab Invest Suppl, 245, S80-3
DOI 10.1080/00365513.2016.1210330, PubMed 27542003

Flatmark K, Saelen MG, Hole KH, Abrahamsen TW, Fleten KG, Hektoen HH, Redalen KR, Seierstad T, Dueland S, Ree AH (2016)
Individual tumor volume responses to short-course oxaliplatin-containing induction chemotherapy in locally advanced rectal cancer - Targeting the tumor for radiation sensitivity?
Radiother Oncol, 119 (3), 505-11
DOI 10.1016/j.radonc.2016.02.020, PubMed 26968754

Fleten KG, Bakke KM, Mælandsmo GM, Abildgaard A, Redalen KR, Flatmark K (2016)
Use of non-invasive imaging to monitor response to aflibercept treatment in murine models of colorectal cancer liver metastases
Clin Exp Metastasis, 34 (1), 51-62
DOI 10.1007/s10585-016-9829-3, PubMed 27812769

Frøysnes IS, Larsen SG, Spasojevic M, Dueland S, Flatmark K (2016)
Complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastasis in Norway: Prognostic factors and oncologic outcome in a national patient cohort
J Surg Oncol, 114 (2), 222-7
DOI 10.1002/jso.24290, PubMed 27173150

Gaski IA, Barckman J, Naess PA, Skaga NO, Madsen JE, Kløw NE, Flugsrud G, Gaarder C (2016)
Reduced need for extraperitoneal pelvic packing for severe pelvic fractures is associated with improved resuscitation strategies
J Trauma Acute Care Surg, 81 (4), 644-51
DOI 10.1097/TA.0000000000001139, PubMed 27257711

Gleditsch D, Søreide OK, Nesbakken A (2016)
Managing Malignant Colorectal Obstruction with Self-Expanding Stents. A Closer Look at Bowel Perforations and Failed Procedures
J Gastrointest Surg, 20 (9), 1643-9
DOI 10.1007/s11605-016-3186-z, PubMed 27342437

Goscinski MA, Hole KH, Tønne E, Ryder T, Grøholt KK, Flatmark K (2016)
Fibromatosis in vertical rectus abdominis myocutaneous flap imitating tumor recurrence after surgery for locally advanced rectal cancer: case report
World J Surg Oncol, 14, 63
DOI 10.1186/s12957-016-0818-4, PubMed 26940557

Grøtting MS, Løberg EM, Johannessen HO, Johnson E (2016)
Resection for oesophageal cancer - complications and survival
Tidsskr Nor Laegeforen, 136 (9), 809-13
DOI 10.4045/tidsskr.15.1136, PubMed 27221180

Gudu T, Etcheto A, de Wit M, Heiberg T, Maccarone M, Balanescu A, Balint PV, Niedermayer DS, Cañete JD, Helliwell P, Kalyoncu U, Kiltz U, Otsa K, Veale DJ, de Vlam K, Scrivo R, Stamm T, Kvien TK, Gossec L (2016)
Fatigue in psoriatic arthritis - a cross-sectional study of 246 patients from 13 countries
Joint Bone Spine, 83 (4), 439-43
DOI 10.1016/j.jbspin.2015.07.017, PubMed 27055727

Haugvik SP, Kaemmerer D, Gaujoux S, Labori KJ, Verbeke CS, Gladhaug IP (2016)
Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape
Curr Oncol Rep, 18 (5), 28
DOI 10.1007/s11912-016-0518-9, PubMed 26984415

Haugvik SP, Vodák D, Haugom L, Hovig E, Gladhaug IP, Heim S, Micci F (2016)
Transcriptomic Profiling of Tumor Aggressiveness in Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms
Pancreas, 45 (8), 1196-203
DOI 10.1097/MPA.0000000000000610, PubMed 26918873

Johannessen LE, Panagopoulos I, Haugvik SP, Gladhaug IP, Heim S, Micci F (2016)
Upregulation of INS-IGF2 read-through expression and identification of a novel INS-IGF2 splice variant in insulinomas
Oncol Rep, 36 (5), 2653-2662
DOI 10.3892/or.2016.5132, PubMed 27667266

Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Frikstad KM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Flatmark K, Lyng H (2016)
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
Br J Cancer, 115 (8), 929-939
DOI 10.1038/bjc.2016.278, PubMed 27599042

Jorgensen JJ, Naess PA, Gaarder C (2016)
Injuries caused by fragmenting rifle ammunition
Injury, 47 (9), 1951-4
DOI 10.1016/j.injury.2016.03.023, PubMed 27037026

Kalanxhi E, Hektoen HH, Meltzer S, Dueland S, Flatmark K, Ree AH (2016)
Circulating proteins in response to combined-modality therapy in rectal cancer identified by antibody array screening
BMC Cancer, 16, 536
DOI 10.1186/s12885-016-2601-x, PubMed 27461255

Kalanxhi E, Risberg K, Barua IS, Dueland S, Waagene S, Andersen SN, Pettersen SJ, Lindvall JM, Redalen KR, Flatmark K, Ree AH (2016)
Induction of Apoptosis in Intestinal Toxicity to a Histone Deacetylase Inhibitor in a Phase I Study with Pelvic Radiotherapy
Cancer Res Treat, 49 (2), 374-386
DOI 10.4143/crt.2016.080, PubMed 27488871

Kleive D, Berstad AE, Verbeke CS, Haugvik SP, Gladhaug IP, Line PD, Labori KJ (2016)
Cold-stored cadaveric venous allograft for superior mesenteric/portal vein reconstruction during pancreatic surgery
HPB (Oxford), 18 (7), 615-22
DOI 10.1016/j.hpb.2016.05.010, PubMed 27346143

Knatten CK, Fjeld JG, Medhus AW, Pripp AH, Fyhn TJ, Aabakken L, Kjosbakken H, Edwin B, Emblem R, Bjørnland K (2016)
Preoperative liquid gastric emptying rate does not predict outcome after fundoplication
J Pediatr Surg, 52 (4), 540-543
DOI 10.1016/j.jpedsurg.2016.09.068, PubMed 28277299

Mala T (2016)
The Gastric Remnant in Roux-en-Y Gastric Bypass: Challenges and Possibilities
J Clin Gastroenterol, 50 (7), 527-31
DOI 10.1097/MCG.0000000000000550, PubMed 27203428

Meltzer S, Kalanxhi E, Hektoen HH, Dueland S, Flatmark K, Redalen KR, Ree AH (2016)
Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer
Oncotarget, 7 (23), 34907-17
DOI 10.18632/oncotarget.8995, PubMed 27145458

Mise Y, Aloia TA, Brudvik KW, Schwarz L, Vauthey JN, Conrad C (2016)
Parenchymal-sparing Hepatectomy in Colorectal Liver Metastasis Improves Salvageability and Survival
Ann Surg, 263 (1), 146-52
DOI 10.1097/SLA.0000000000001194, PubMed 25775068

Mise Y, Day RW, Vauthey JN, Brudvik KW, Schwarz L, Prakash L, Parker NH, Katz MH, Conrad C, Lee JE, Fleming JB, Aloia TA (2016)
After Pancreatectomy, the “90 Days from Surgery” Definition Is Superior to the “30 Days from Discharge” Definition for Capture of Clinically Relevant Readmissions
J Gastrointest Surg, 20 (1), 77-84; discussion 84
DOI 10.1007/s11605-015-2984-z, PubMed 26493976

Moltu K, Henjum K, Oberprieler NG, Bjørnbeth BA, Taskén K (2016)
Proximal signaling responses in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E2
Hum Immunol, 78 (2), 129-137
DOI 10.1016/j.humimm.2016.10.007, PubMed 27769746

Næss PA, Engeseth K, Grøtta O, Andersen GØ, Gaarder C (2016)
Minimal invasive treatment of life-threatening bleeding caused by cardiopulmonary resuscitation-associated liver injury: a case report
J Med Case Rep, 10 (1), 132
DOI 10.1186/s13256-016-0926-3, PubMed 27236329

Passot G, Vaudoyer D, Messager M, Brudvik KW, Kim BJ, Mariette C, Glehen O (2016)
Is Extended Lymphadenectomy Needed for Elderly Patients With Gastric Adenocarcinoma?
Ann Surg Oncol, 23 (8), 2391-7
DOI 10.1245/s10434-016-5260-x, PubMed 27169773

Pozzi-Mucelli RM, Rinta-Kiikka I, Wünsche K, Laukkarinen J, Labori KJ, Ånonsen K, Verbeke C, Del Chiaro M, Kartalis N (2016)
Pancreatic MRI for the surveillance of cystic neoplasms: comparison of a short with a comprehensive imaging protocol
Eur Radiol, 27 (1), 41-50
DOI 10.1007/s00330-016-4377-4, PubMed 27246720

Risstad H, Svanevik M, Kristinsson JA, Hjelmesæth J, Aasheim ET, Hofsø D, Søvik TT, Karlsen TI, Fagerland MW, Sandbu R, Mala T (2016)
Standard vs Distal Roux-en-Y Gastric Bypass in Patients With Body Mass Index 50 to 60: A Double-blind, Randomized Clinical Trial
JAMA Surg, 151 (12), 1146-1155
DOI 10.1001/jamasurg.2016.2798, PubMed 27626242

Rønning B, Wyller TB, Nesbakken A, Skovlund E, Jordhøy MS, Bakka A, Rostoft S (2016)
Quality of life in older and frail patients after surgery for colorectal cancer-A follow-up study
J Geriatr Oncol, 7 (3), 195-200
DOI 10.1016/j.jgo.2016.03.002, PubMed 27067579

Sahakyan MA, Kazaryan AM, Pomianowska E, Abildgaard A, Line PD, Bjørnbeth BA, Edwin B, Røsok BI (2016)
Laparoscopic Resection of Recurrence from Hepatocellular Carcinoma after Liver Transplantation: Case Reports and Review of the Literature
Case Rep Oncol Med, 2016, 8946471
DOI 10.1155/2016/8946471, PubMed 27034867

Sahakyan MA, Røsok BI, Kazaryan AM, Barkhatov L, Haugvik SP, Fretland ÅA, Ignjatovic D, Labori KJ, Edwin B (2016)
Role of laparoscopic enucleation in the treatment of pancreatic lesions: case series and case-matched analysis
Surg Endosc, 31 (5), 2310-2316
DOI 10.1007/s00464-016-5233-y, PubMed 27620912

Sahakyan MA, Røsok BI, Kazaryan AM, Barkhatov L, Lai X, Kleive D, Ignjatovic D, Labori KJ, Edwin B (2016)
Impact of obesity on surgical outcomes of laparoscopic distal pancreatectomy: A Norwegian single-center study
Surgery, 160 (5), 1271-1278
DOI 10.1016/j.surg.2016.05.046, PubMed 27498300

Sahakyan MA, Yaqub S, Kazaryan AM, Villanger O, Berstad AE, Labori KJ, Edwin B, Røsok BI (2016)
Laparoscopic Completion Pancreatectomy for Local Recurrence in the Pancreatic Remnant after Pancreaticoduodenectomy: Case Reports and Review of the Literature
J Gastrointest Cancer, 47 (4), 509-513
DOI 10.1007/s12029-015-9796-y, PubMed 26732389

Sandhu V, Wedge DC, Bowitz Lothe IM, Labori KJ, Dentro SC, Buanes T, Skrede ML, Dalsgaard AM, Munthe E, Myklebost O, Lingjærde OC, Børresen-Dale AL, Ikdahl T, Van Loo P, Nord S, Kure EH (2016)
The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma
Cancer Res, 76 (17), 5092-102
DOI 10.1158/0008-5472.CAN-16-0658, PubMed 27488532

Schrøder M, Melum GR, Landsverk OJ, Bujko A, Yaqub S, Gran E, Aamodt H, Bækkevold ES, Jahnsen FL, Richter L (2016)
CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits
PLoS One, 11 (6), e0157387
DOI 10.1371/journal.pone.0157387, PubMed 27311059

Schultz JK, Yaqub S, Øresland T (2016)
Management of Diverticular Disease in Scandinavia
J Clin Gastroenterol, 50 Suppl 1, S50-2
DOI 10.1097/MCG.0000000000000642, PubMed 27622365

Skyrud KD, Bray F, Eriksen MT, Nilssen Y, Møller B (2016)
Regional variations in cancer survival: Impact of tumour stage, socioeconomic status, comorbidity and type of treatment in Norway
Int J Cancer, 138 (9), 2190-200
DOI 10.1002/ijc.29967, PubMed 26679150

Stenström P, Sandelin H, Emblem R, Björnland K (2016)
Lower urinary tract symptoms in children with anorectal malformations with rectoperineal fistulas
J Pediatr Surg, 51 (8), 1234-40
DOI 10.1016/j.jpedsurg.2016.01.015, PubMed 26902512

Stormark K, Søreide K, Søreide JA, Kvaløy JT, Pfeffer F, Eriksen MT, Nedrebø BS, Kørner H (2016)
Nationwide implementation of laparoscopic surgery for colon cancer: short-term outcomes and long-term survival in a population-based cohort
Surg Endosc, 30 (11), 4853-4864
DOI 10.1007/s00464-016-4819-8, PubMed 26905577

Stornes T, Wibe A, Nesbakken A, Myklebust TÅ, Endreseth BH (2016)
National Early Rectal Cancer Treatment Revisited
Dis Colon Rectum, 59 (7), 623-9
DOI 10.1097/DCR.0000000000000591, PubMed 27270514

Søreide K, Labori KJ (2016)
Risk factors and preventive strategies for post-operative pancreatic fistula after pancreatic surgery: a comprehensive review
Scand J Gastroenterol, 51 (10), 1147-54
DOI 10.3109/00365521.2016.1169317, PubMed 27216233

Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E (2016)
Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study
PLoS One, 11 (3), e0150191
DOI 10.1371/journal.pone.0150191, PubMed 26933886

Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E (2016)
Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study
PLoS One, 11 (7), e0159288
DOI 10.1371/journal.pone.0159288, PubMed 27415795

Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E (2016)
Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan , in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study
Scand J Immunol, 84 (6), 323-331
DOI 10.1111/sji.12476, PubMed 27588816

Thorgersen EB, Goscinski MA, Spasojevic M, Solbakken AM, Mariathasan AB, Boye K, Larsen SG, Flatmark K (2016)
Deep Pelvic Surgical Site Infection After Radiotherapy and Surgery for Locally Advanced Rectal Cancer
Ann Surg Oncol, 24 (3), 721-728
DOI 10.1245/s10434-016-5621-5, PubMed 27766561

Tjomsland V, Pomianowska E, Aasrum M, Sandnes D, Verbeke CS, Gladhaug IP (2016)
Profile of MMP and TIMP Expression in Human Pancreatic Stellate Cells: Regulation by IL-1α and TGFβ and Implications for Migration of Pancreatic Cancer Cells
Neoplasia, 18 (7), 447-56
DOI 10.1016/j.neo.2016.06.003, PubMed 27435927

Tjomsland V, Sandnes D, Pomianowska E, Cizmovic ST, Aasrum M, Brusevold IJ, Christoffersen T, Gladhaug IP (2016)
The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration
J Exp Clin Cancer Res, 35 (1), 122
DOI 10.1186/s13046-016-0400-5, PubMed 27473228

Varghese M, Bruland O, Wiedswang AM, Lobmaier I, Røsok B, Benjamin RS, Hall KS (2016)
Metastatic mesenteric dedifferentiated leiomyosarcoma: a case report and a review of literature
Clin Sarcoma Res, 6, 2
DOI 10.1186/s13569-016-0042-6, PubMed 26913180

Verbeke CS, Gladhaug IP (2016)
Dissection of Pancreatic Resection Specimens
Surg Pathol Clin, 9 (4), 523-538
DOI 10.1016/j.path.2016.05.001, PubMed 27926357

Young VS, Eggesbø HB, Gaarder C, Næss PA, Enden T (2016)
Radiology response in the emergency department during a mass casualty incident: a retrospective study of the two terrorist attacks on 22 July 2011 in Norway
Eur Radiol, 27 (7), 2828-2834
DOI 10.1007/s00330-016-4677-8, PubMed 27957642

 
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