Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Department of Haematology

56 publications found

Andersen E, Chollet ME, Baroni M, Pinotti M, Bernardi F, Skarpen E, Sandset PM, Skretting G (2019)
The effect of the chemical chaperone 4-phenylbutyrate on secretion and activity of the p.Q160R missense variant of coagulation factor FVII
Cell Biosci, 9, 69
DOI 10.1186/s13578-019-0333-8, PubMed 31467667

Andersen MF, Holme PA, Tjønnfjord GE (2019)
Surgical procedures in patients with severe haemophilia 1997–2014
Tidsskr Nor Laegeforen, 139 (8)
DOI 10.4045/tidsskr.18.0592, PubMed 31062561

Andersen MLF, Holme PA, Tjonnfjord GE (2019)
Surgical intervention in patients with severe bleeding disorder 1997-2014
Tidsskr. Nor. Laegeforen., 139 (8), 709-712

Attal M, Richardson PG, Rajkumar SV, San-Miguel J, Beksac M, Spicka I, Leleu X, Schjesvold F, Moreau P, Dimopoulos MA, Huang JS, Minarik J, Cavo M, Prince HM, Macé S, Corzo KP, Campana F, Le-Guennec S, Dubin F, Anderson KC, ICARIA-MM study group (2019)
Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study
Lancet, 394 (10214), 2096-2107
DOI 10.1016/S0140-6736(19)32556-5, PubMed 31735560

Atukunda P, Muhoozi GKM, van den Broek TJ, Kort R, Diep LM, Kaaya AN, Iversen PO, Westerberg AC (2019)
Child development, growth and microbiota: follow-up of a randomized education trial in Uganda
J Glob Health, 9 (1), 010431
DOI 10.7189/jogh-09-010431, PubMed 31131103

Atukunda P, Muhoozi GKM, Westerberg AC, Iversen PO (2019)
Nutrition, Hygiene and Stimulation Education for Impoverished Mothers in Rural Uganda: Effect on Maternal Depression Symptoms and Their Associations to Child Development Outcomes
Nutrients, 11 (7)
DOI 10.3390/nu11071561, PubMed 31373314

Beitland S, Wimmer H, Lorentsen T, Jacobsen D, Draegni T, Brunborg C, Kløw NE, Sandset PM, Sunde K (2019)
Venous thromboembolism in the critically ill: A prospective observational study of occurrence, risk factors and outcome
Acta Anaesthesiol Scand, 63 (5), 630-638
DOI 10.1111/aas.13316, PubMed 30623406

Berentsen S, Röth A, Randen U, Jilma B, Tjønnfjord GE (2019)
Cold agglutinin disease: current challenges and future prospects
J Blood Med, 10, 93-103
DOI 10.2147/JBM.S177621, PubMed 31114413

Birgegard G, Samuelsson J, Ahlstrand E, Ejerblad E, Enevold C, Ghanima W, Hasselbalch H, Nielsen CH, Knutsen H, Pedersen OB, Sørensen A, Andreasson B (2019)
Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group
Eur J Haematol, 102 (3), 235-240
DOI 10.1111/ejh.13198, PubMed 30472746

Blakstad EW, Korpela K, Lee S, Nakstad B, Moltu SJ, Strømmen K, Rønnestad AE, Brække K, Iversen PO, de Vos WM, Drevon CA (2019)
Enhanced nutrient supply and intestinal microbiota development in very low birth weight infants
Pediatr Res, 86 (3), 323-332
DOI 10.1038/s41390-019-0412-x, PubMed 31086354

Blomkvist AW, Zadig P, Christoffersen S, Kaushal S, Nordengen E, Shanmugarajah I, Ghanima W (2019)
Home treatment for pulmonary embolism
Tidsskr Nor Laegeforen, 139 (18)
DOI 10.4045/tidsskr.19.0115, PubMed 31823570

Chellappa S, Kushekhar K, Munthe LA, Tjønnfjord GE, Aandahl EM, Okkenhaug K, Taskén K (2019)
The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
J Immunol, 202 (5), 1397-1405
DOI 10.4049/jimmunol.1701703, PubMed 30692213

Chowdary P, Carcao M, Holme PA, Jiménez-Yuste V, Lentz SR, Møss J, Poulsen LH, Shen C, Tosetto A, Wheeler A, Santagostino E (2019)
Fixed doses of N8-GP prophylaxis maintain moderate-to-mild factor VIII levels in the majority of patients with severe hemophilia A
Res Pract Thromb Haemost, 3 (3), 542-554
DOI 10.1002/rth2.12220, PubMed 31294338

Cooper N, Ghanima W (2019)
Immune Thrombocytopenia
N Engl J Med, 381 (10), 945-955
DOI 10.1056/NEJMcp1810479, PubMed 31483965

Cremers EMP, de Witte T, de Wreede L, Eikema DJ, Koster L, van Biezen A, Finke J, Socié G, Beelen D, Maertens J, Nagler A, Kobbe G, Ziagkos D, Itälä-Remes M, Gedde-Dahl T, Sierra J, Niederwieser D, Ljungman P, Beguin Y, Ozkurt ZN, Anagnostopoulos A, Jindra P, Robin M, Kröger N (2019)
A prospective non-interventional study on the impact of transfusion burden and related iron toxicity on outcome in myelodysplastic syndromes undergoing allogeneic hematopoietic cell transplantation
Leuk Lymphoma, 60 (10), 2404-2414
DOI 10.1080/10428194.2019.1594215, PubMed 30997844

Curry N, Albayrak C, Escobar M, Andre Holme P, Kearney S, Klamroth R, Misgav M, Négrier C, Wheeler A, Santagostino E, Shima M, Landorph A, Tønder SM, Lentz SR (2019)
Once-weekly prophylaxis with glycoPEGylated recombinant factor VIII (N8-GP) in severe haemophilia A: Safety and efficacy results from pathfinder 2 (randomized phase III trial)
Haemophilia, 25 (3), 373-381
DOI 10.1111/hae.13712, PubMed 30817066

Dahm AEA, Jacobsen EM, Wik HS, Jacobsen AF, Mollnes TE, Kanse SM, Sandset PM (2019)
Elevated Complement C3 and C4 Levels are Associated with Postnatal Pregnancy-Related Venous Thrombosis
Thromb Haemost, 119 (9), 1481-1488
DOI 10.1055/s-0039-1692426, PubMed 31254974

Eilertsen AL, Dahm AEA, Høibraaten E, Lofthus CM, Mowinckel MC, Sandset PM (2019)
Relationship between sex hormone binding globulin and blood coagulation in women on postmenopausal hormone treatment
Blood Coagul Fibrinolysis, 30 (1), 17-23
DOI 10.1097/MBC.0000000000000784, PubMed 30507711

El-Serafi I, Loy O, Zhao Y, Oerther S, Mattsson J (2019)
Pre-formulation investigations for establishing a protocol for treosulfan handling and activation
Pharm Dev Technol, 24 (5), 639-648
DOI 10.1080/10837450.2018.1551903, PubMed 30474459

Engeseth M, Enden T, Andersen MH, Sandset PM, Wik HS (2019)
Does the Villalta scale capture the essence of postthrombotic syndrome? A qualitative study of patient experience and expert opinion
J Thromb Haemost, 17 (10), 1707-1714
DOI 10.1111/jth.14557, PubMed 31265193

Engeseth M, Enden T, Sandset PM, Wik HS (2019)
Limitations of the Villalta scale in diagnosing post-thrombotic syndrome
Thromb Res, 184, 62-66
DOI 10.1016/j.thromres.2019.10.018, PubMed 31707153

Gamage TH, Lengle E, Gunnes G, Pullisaar H, Holmgren A, Reseland JE, Merckoll E, Corti S, Mizobuchi M, Morales RJ, Tsiokas L, Tjønnfjord GE, Lacruz RS, Lyngstadaas SP, Misceo D, Frengen E (2019)
STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone
Cell Calcium, 85, 102110
DOI 10.1016/j.ceca.2019.102110, PubMed 31785581

Garabet L, Ghanima W, Hellum M, Sandset PM, Bussel JB, Tran H, Henriksson CE (2019)
Increased microvesicle-associated thrombin generation in patients with immune thrombocytopenia after initiation of thrombopoietin receptor agonists
Platelets
DOI 10.1080/09537104.2019.1639655, PubMed 31280643

Garabet L, Ghanima W, Rangberg A, Teruel-Montoya R, Martinez C, Lozano ML, Nystrand CF, Bussel JB, Sandset PM, Jonassen CM (2019)
Circulating microRNAs in patients with immune thrombocytopenia before and after treatment with thrombopoietin-receptor agonists
Platelets, 1-8
DOI 10.1080/09537104.2019.1585527, PubMed 30885035

Garabet L, Henriksson CE, Lozano ML, Ghanima W, Bussel J, Brodin E, Fernández-Pérez MP, Martínez C, González-Conejero R, Mowinckel MC, Sandset PM (2019)
Markers of endothelial cell activation and neutrophil extracellular traps are elevated in immune thrombocytopenia but are not enhanced by thrombopoietin receptor agonists
Thromb Res, 185, 119-124
DOI 10.1016/j.thromres.2019.11.031, PubMed 31805421

Gilleece MH, Labopin M, Savani BN, Yakoub-Agha I, Socié G, Gedde-Dahl T, Blaise D, Byrne JL, Craddock C, Cornelissen JJ, Arcese W, Forcade E, Crawley C, Polge E, Mohty M, Nagler A (2019)
Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT
Leukemia, 34 (1), 87-99
DOI 10.1038/s41375-019-0527-4, PubMed 31363160

Godolphin PJ, Bath PM, Algra A, Berge E, Brown MM, Chalmers J, Duley L, Eliasziw M, Gregson J, Greving JP, Hankey GJ, Hosomi N, Johnston SC, Patsko E, Ranta A, Sandset PM, Serena J, Weimar C, Montgomery AA, Knipp SC, Giugliano RP, Bonati LH, Nagai Y, Matsumoto M, Barnett HJM et al. (2019)
Outcome Assessment by Central Adjudicators Versus Site Investigators in Stroke Trials: A Systematic Review and Meta-Analysis
Stroke, 50 (8), 2187-2196

Gregersen I, Høibraaten E, Holven KB, Løvdahl L, Ueland T, Mowinckel MC, Dahl TB, Aukrust P, Halvorsen B, Sandset PM (2019)
Effect of hormone replacement therapy on atherogenic lipid profile in postmenopausal women
Thromb Res, 184, 1-7
DOI 10.1016/j.thromres.2019.10.005, PubMed 31677448

Halaburda K, Labopin M, Mailhol A, Socié G, Craddock C, Aljurf M, Beelen D, Cornelissen JJ, Bourhis JH, Labussière-Wallet H, Blaise D, Gedde-Dahl T, Gilleece M, Yakoub-Agha I, Mufti G, Esteve J, Mohty M, Nagler A (2019)
Allogeneic stem cell transplantation in second complete remission for core binding factor acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Haematologica (in press)
DOI 10.3324/haematol.2019.222810, PubMed 31439677

Hillengass J, Usmani S, Rajkumar SV, Durie BGM, Mateos MV, Lonial S, Joao C, Anderson KC, García-Sanz R, Riva E, Du J, van de Donk N, Berdeja JG, Terpos E, Zamagni E, Kyle RA, San Miguel J, Goldschmidt H, Giralt S, Kumar S, Raje N, Ludwig H, Ocio E, Schots R, Einsele H et al. (2019)
International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders
Lancet Oncol, 20 (6), e302-e312
DOI 10.1016/S1470-2045(19)30309-2, PubMed 31162104

Johansen S, Helgeland L, Vetti N, Dybedal I, Reikvam H (2019)
A man in his 70s with back pain, abdominal pain and rash
Tidsskr. Nor. Laegeforen., 139 (15), 1477-1481

Jønsson V, Awan H, Jones ND, Johannesen TB, Steig BÁ, Andosdottir G, Tjønnfjord GE (2019)
Inheritance of Susceptibility to Malignant Blood Disorders
Sci Rep, 9 (1), 2444
DOI 10.1038/s41598-019-38879-y, PubMed 30792429

Kristoffersen AH, Jacobsen EM, Varsi K, Henriksson CE (2019)
Analysis of lupus anticoagulant during ongoing anticoagulation therapy
Tidsskr Nor Laegeforen, 139 (15)
DOI 10.4045/tidsskr.19.0096, PubMed 31642626

Lalezari S, Reding MT, Pabinger I, Holme PA, Negrier C, Chalasani P, Shin HJ, Wang M, Tseneklidou-Stoeter D, Maas Enriquez M (2019)
BAY 94-9027 prophylaxis is efficacious and well tolerated for up to >5 years with extended dosing intervals: PROTECT VIII extension interim results
Haemophilia, 25 (6), 1011-1019
DOI 10.1111/hae.13853, PubMed 31621991

Lenartova A, Randen U, Johannesen TB, Tjønnfjord GE (2019)
Richter syndrome epidemiology in a large population based chronic lymphocytic leukemia cohort from Norway
Cancer Epidemiol, 60, 128-133
DOI 10.1016/j.canep.2019.04.002, PubMed 30986631

Lien K, Johansen B, Veierød MB, Haslestad AS, Bøhn SK, Melsom MN, Kardel KR, Iversen PO (2019)
Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome
Physiol Rep, 7 (11), e14138
DOI 10.14814/phy2.14138, PubMed 31161646

Ljungkvist M, Strandberg K, Berntorp E, Chaireti R, Holme PA, Larsen OH, Lassila R, Jouppila A, Szanto T, Zetterberg E (2019)
Evaluation of a standardized protocol for thrombin generation using the calibrated automated thrombogram: A Nordic study
Haemophilia, 25 (2), 334-342
DOI 10.1111/hae.13640, PubMed 30715788

Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N (2019)
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
J Biol Chem, 294 (20), 8197-8217
DOI 10.1074/jbc.RA118.002829, PubMed 30926605

Mateos MV, Blacklock H, Schjesvold F, Oriol A, Simpson D, George A, Goldschmidt H, Larocca A, Chanan-Khan A, Sherbenou D, Avivi I, Benyamini N, Iida S, Matsumoto M, Suzuki K, Ribrag V, Usmani SZ, Jagannath S, Ocio EM, Rodriguez-Otero P, San Miguel J, Kher U, Farooqui M, Liao J, Marinello P et al. (2019)
Pembrolizumab plus pomalidomide and dexamethasone for patients with relapsed or refractory multiple myeloma (KEYNOTE-183): a randomised, open-label, phase 3 trial
Lancet Haematol, 6 (9), e459-e469
DOI 10.1016/S2352-3026(19)30110-3, PubMed 31327687

Nielsen NV, Roedel E, Manna D, Etscheid M, Morth JP, Kanse SM (2019)
Characterization of the enzymatic activity of the serine protease domain of Factor VII activating protease (FSAP)
Sci Rep, 9 (1), 18990
DOI 10.1038/s41598-019-55531-x, PubMed 31831842

Passweg JR, Labopin M, Christopeit M, Cornelissen J, Pabst T, Socié G, Russel N, Yakoub-Agha I, Blaise D, Gedde-Dahl T, Labussière-Wallet H, Malladi R, Forcade E, Maury S, Polge E, Lanza F, Gorin NC, Mohty M, Nagler A (2019)
Postremission Consolidation by Autologous Hematopoietic Cell Transplantation (HCT) for Acute Myeloid Leukemia in First Complete Remission (CR) and Negative Implications for Subsequent Allogeneic HCT in Second CR: A Study by the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)
Biol Blood Marrow Transplant (in press)
DOI 10.1016/j.bbmt.2019.11.021, PubMed 31759159

Richardson PG, Oriol A, Beksac M, Liberati AM, Galli M, Schjesvold F, Lindsay J, Weisel K, White D, Facon T, San Miguel J, Sunami K, O'Gorman P, Sonneveld P, Robak P, Semochkin S, Schey S, Yu X, Doerr T, Bensmaine A, Biyukov T, Peluso T, Zaki M, Anderson K, Dimopoulos M et al. (2019)
Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial
Lancet Oncol, 20 (6), 781-794
DOI 10.1016/S1470-2045(19)30152-4, PubMed 31097405

Rukundo PM, Rukooko B, Andreassen BA, Iversen PO (2019)
Housing, water and sanitation implications on food insecurity and diet diversity in landslide affected communities: A cross-sectional survey of two districts in Uganda
Clin Nutr ESPEN, 33, 47-56
DOI 10.1016/j.clnesp.2019.07.010, PubMed 31451275

Rut W, Nielsen NV, Czarna J, Poreba M, Kanse SM, Drag M (2019)
Fluorescent activity-based probe for the selective detection of Factor VII activating protease (FSAP) in human plasma
Thromb Res, 182, 124-132
DOI 10.1016/j.thromres.2019.08.016, PubMed 31479940

Savikj M, Kostovski E, Lundell LS, Iversen PO, Massart J, Widegren U (2019)
Altered oxidative stress and antioxidant defence in skeletal muscle during the first year following spinal cord injury
Physiol Rep, 7 (16), e14218
DOI 10.14814/phy2.14218, PubMed 31456346

Schjesvold F, Goldschmidt H, Maisnar V, Spicka I, Abildgaard N, Rowlings P, Cain L, Romanus D, Suryanarayan K, Rajkumar V, Odom D, Gnanasakthy A, Dimopoulos M (2019)
Quality of life is maintained with ixazomib maintenance in post-transplant newly diagnosed multiple myeloma: the TOURMALINE-MM3 trial
Eur J Haematol (in press)
DOI 10.1111/ejh.13379, PubMed 31880006

Sioud M, Pettersen S, Ailte I, Fløisand Y (2019)
Targeted Killing of Monocytes/Macrophages and Myeloid Leukemia Cells with Pro-Apoptotic Peptides
Cancers (Basel), 11 (8)
DOI 10.3390/cancers11081088, PubMed 31370273

Skretting G, Andersen E, Myklebust CF, Sandset PM, Tinholt M, Iversen N, Stavik B (2019)
Transcription factor FOXP3: A repressor of the TFPI gene?
J Cell Biochem, 120 (8), 12924-12936
DOI 10.1002/jcb.28563, PubMed 30861202

Skånland SS, Cremaschi A, Bendiksen H, Hermansen JU, Thimiri Govinda Raj DB, Munthe LA, Tjønnfjord GE, Taskén K (2019)
An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL
Leukemia (in press)
DOI 10.1038/s41375-019-0569-7, PubMed 31471562

Skaarud KJ, Veierød MB, Lergenmuller S, Bye A, Iversen PO, Tjønnfjord GE (2019)
Body weight, body composition and survival after 1 year: follow-up of a nutritional intervention trial in allo-HSCT recipients
Bone Marrow Transplant, 54 (12), 2102-2109
DOI 10.1038/s41409-019-0638-6, PubMed 31455897

Søraas A, Matsuyama M, de Lima M, Wald D, Buechner J, Gedde-Dahl T, Søraas CL, Chen B, Ferrucci L, Dahl JA, Horvath S, Matsuyama S (2019)
Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
Aging Cell, 18 (2), e12897
DOI 10.1111/acel.12897, PubMed 30712319

Saad A, Lamb L, Wang T, Hemmer MT, Spellman S, Couriel D, Alousi A, Pidala J, Abdel-Azim H, Agrawal V, Aljurf M, Beitinjaneh AM, Bhatt VR, Buchbinder D, Byrne M, Cahn JY, Cairo M, Castillo P, Chhabra S, Diaz MA, Farhan S, Floisand Y, Frangoul HA, Gadalla SM, Gajewski J et al. (2019)
Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
Biol Blood Marrow Transplant, 25 (9), 1875-1883
DOI 10.1016/j.bbmt.2019.05.007, PubMed 31085303

Thomas AM, Gerogianni A, McAdam MB, Fløisand Y, Lau C, Espevik T, Nilsson PH, Mollnes TE, Barratt-Due A (2019)
Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood
J Immunol, 203 (6), 1571-1578
DOI 10.4049/jimmunol.1900047, PubMed 31413105

Torkildsen S, Gorunova L, Heim S, Tjønnfjord GE, Spetalen S, Risberg B, Tran HTT, Panagopoulos I (2019)
Molecular Genetic Characterization of Acute Myeloid Leukemia With Trisomy 4 as the Sole Chromosome Abnormality
Cancer Genomics Proteomics, 16 (3), 175-178
DOI 10.21873/cgp.20123, PubMed 31018948

Usmani SZ, Schjesvold F, Oriol A, Karlin L, Cavo M, Rifkin RM, Yimer HA, LeBlanc R, Takezako N, McCroskey RD, Lim ABM, Suzuki K, Kosugi H, Grigoriadis G, Avivi I, Facon T, Jagannath S, Lonial S, Ghori RU, Farooqui MZH, Marinello P, San-Miguel J, KEYNOTE-185 Investigators (2019)
Pembrolizumab plus lenalidomide and dexamethasone for patients with treatment-naive multiple myeloma (KEYNOTE-185): a randomised, open-label, phase 3 trial
Lancet Haematol, 6 (9), e448-e458
DOI 10.1016/S2352-3026(19)30109-7, PubMed 31327689

Wiktor-Jedrzejczak W, Drozd-Sokolowska J, Eikema DJ, Hoek J, Potter M, Wulf G, Sellner L, Ljungman P, Chevallier P, Volin L, Koc Y, Martin S, Bunjes D, Rovira M, Itälä-Remes M, Foá R, Deconinck E, Gedde-Dahl T, Cornelissen J, Collin M, Brecht A, Patel A, de Groot M, Reményi P, Nagler A et al. (2019)
EBMT prospective observational study on allogeneic hematopoietic stem cell transplantation in T-prolymphocytic leukemia (T-PLL)
Bone Marrow Transplant, 54 (9), 1391-1398
DOI 10.1038/s41409-019-0448-x, PubMed 30664723

 
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