Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2018 from OUS - Department of Haematology

52 publications found

Andersen E, Chollet ME, Myklebust CF, Pinotti M, Bernardi F, Chuansumrit A, Skarpen E, Sandset PM, Skretting G (2018)
Activation of Endoplasmic Reticulum Stress and Unfolded Protein Response in Congenital Factor VII Deficiency
Thromb Haemost, 118 (4), 664-675
DOI 10.1055/s-0038-1637690, PubMed 29618153

Bhamra JS, Iversen PO, Titze TK, Tjønnfjord GE, Akkök ÇA (2018)
A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations
Case Rep Hematol, 2018, 8187659
DOI 10.1155/2018/8187659, PubMed 30510818

Birgegard G, Samuelsson J, Ahlstrand E, Ejerblad E, Enevold C, Ghanima W, Hasselbalch H, Nielsen CH, Knutsen H, Pedersen OB, Sørensen A, Andreasson B (2018)
Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group
Eur J Haematol (in press)
DOI 10.1111/ejh.13198, PubMed 30472746

Bruserud Ø, Melve GK, Gedde-Dahl T, Tvedt THA (2018)
Immunological heterogeneity of healthy peripheral blood stem cell donors - preharvesting donor characteristics, additional heterogeneity induced by granulocyte colony-stimulating factor and possible importance for outcome after allotransplantation
Expert Rev Hematol, 11 (10), 757-759
DOI 10.1080/17474086.2018.1511420, PubMed 30126308

Chortatos A, Iversen PO, Haugen M, Eberhard-Gran M, Bjelland EK, Veierød MB (2018)
Nausea and vomiting in pregnancy - association with pelvic girdle pain during pregnancy and 4-6 months post-partum
BMC Pregnancy Childbirth, 18 (1), 137
DOI 10.1186/s12884-018-1764-7, PubMed 29739355

Danylesko I, Bukauskas A, Paulson M, Peceliunas V, Gedde-Dahl D Y T, Shimoni A, Shouval R, Griskevicius L, Floisand Y, Nagler A (2018)
Anti-α4β7 integrin monoclonal antibody (vedolizumab) for the treatment of steroid-resistant severe intestinal acute graft-versus-host disease
Bone Marrow Transplant (in press)
DOI 10.1038/s41409-018-0364-5, PubMed 30356163

El-Serafi I, Loy O, Zhao Y, Oerther S, Mattsson J (2018)
Pre-formulation investigations for establishing a protocol for treosulfan handling and activation
Pharm Dev Technol, 1-27 (in press)
DOI 10.1080/10837450.2018.1551903, PubMed 30474459

Etscheid M, Subramaniam S, Lochnit G, Zabczyk M, Undas A, Lang IM, Hanschmann KM, Kanse SM (2018)
Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP)
Biochim Biophys Acta Mol Basis Dis, 1864 (10), 3397-3406
DOI 10.1016/j.bbadis.2018.07.030, PubMed 30076961

Fevang B, Fagerli UM, Sorte H, Aarset H, Hov H, Langmyr M, Keil TM, Bjørge E, Aukrust P, Stray-Pedersen A, Gedde-Dahl T (2018)
Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas
Case Reports Immunol, 2018, 2053716
DOI 10.1155/2018/2053716, PubMed 29888014

Fløisand Y, Lazarevic VL, Maertens J, Mattsson J, Shah NN, Zachée P, Taylor A, Akbari M, Quadri S, Parfionovas A, Chen Y (2018)
Safety and Effectiveness of Vedolizumab in Patients with Steroid-Refractory GI Acute GvHD: A Retrospective Record Review
Biol Blood Marrow Transplant (in press)
DOI 10.1016/j.bbmt.2018.11.013, PubMed 30468919

Fronas SG, Wik HS, Dahm AEA, Jørgensen CT, Gleditsch J, Raouf N, Klok FA, Ghanima W (2018)
Safety of D-dimer testing as a stand-alone test for the exclusion of deep vein thrombosis as compared with other strategies
J Thromb Haemost, 16 (12), 2471-2481
DOI 10.1111/jth.14314, PubMed 30303610

Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E (2018)
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
Cell Calcium, 76, 87-100
DOI 10.1016/j.ceca.2018.10.001, PubMed 30390422

Gravensteen IK, Jacobsen EM, Sandset PM, Helgadottir LB, Rådestad I, Sandvik L, Ekeberg Ø (2018)
Anxiety, depression and relationship satisfaction in the pregnancy following stillbirth and after the birth of a live-born baby: a prospective study
BMC Pregnancy Childbirth, 18 (1), 41
DOI 10.1186/s12884-018-1666-8, PubMed 29361916

Habberstad AH, Tran HTT, Randen U, Spetalen S, Dybedal I, Tjønnfjord GE, Dahm AEA (2018)
Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report
J Med Case Rep, 12 (1), 105
DOI 10.1186/s13256-018-1663-6, PubMed 29685167

Haffner J, Hager HB, Iversen PO, Nyquist E (2018)
Ikke nødvendig med injeksjoner ved vitamin B12-mangel
Tidsskr Nor Laegeforen, 138 (17)
DOI 10.4045/tidsskr.18.0668, PubMed 30378402

Hermansen JU, Tjønnfjord GE, Munthe LA, Taskén K, Skånland SS (2018)
Cryopreservation of primary B cells minimally influences their signaling responses
Sci Rep, 8 (1), 17651
DOI 10.1038/s41598-018-36121-9, PubMed 30518828

Holme PA, Tjønnfjord GE (2018)
Continuous infusion of simoctocog alfa in haemophilia A patients undergoing surgeries
Haemophilia (in press)
DOI 10.1111/hae.13625, PubMed 30394617

Korpela K, Blakstad EW, Moltu SJ, Strømmen K, Nakstad B, Rønnestad AE, Brække K, Iversen PO, Drevon CA, de Vos W (2018)
Intestinal microbiota development and gestational age in preterm neonates
Sci Rep, 8 (1), 2453
DOI 10.1038/s41598-018-20827-x, PubMed 29410448

Kostovski E, Frigato E, Savikj M, Dahm A, Sandset PM, Mowinckel MC, Skretting G, Østerud B, Bertolucci C, Iversen PO (2018)
Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation
Spinal Cord, 56 (11), 1076-1083
DOI 10.1038/s41393-018-0176-x, PubMed 29985456

Kverneland M, Molteberg E, Iversen PO, Veierød MB, Taubøll E, Selmer KK, Nakken KO (2018)
Effect of modified Atkins diet in adults with drug-resistant focal epilepsy: A randomized clinical trial
Epilepsia, 59 (8), 1567-1576
DOI 10.1111/epi.14457, PubMed 29901816

Lindgren M, Samuelsson J, Nilsson L, Knutsen H, Ghanima W, Westin J, Johansson PL, Andréasson B (2018)
Genetic variation in IL28B (IFNL3) and response to interferon-alpha treatment in myeloproliferative neoplasms
Eur J Haematol, 100 (5), 419-425
DOI 10.1111/ejh.13034, PubMed 29369421

Lorentino F, Labopin M, Bernardi M, Ciceri F, Socié G, Cornelissen JJ, Esteve J, Ruggeri A, Volin L, Yacoub-Agha I, Craddock C, Passweg J, Blaise D, Gedde-Dahl T, Poiani M, Fegueux N, Mohty M, Nagler A, Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (2018)
Comparable outcomes of haploidentical, 10/10 and 9/10 unrelated donor transplantation in adverse karyotype AML in first complete remission
Am J Hematol, 93 (10), 1236-1244
DOI 10.1002/ajh.25231, PubMed 30058714

Lundell LS, Savikj M, Kostovski E, Iversen PO, Zierath JR, Krook A, Chibalin AV, Widegren U (2018)
Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury
Acta Physiol (Oxf), 223 (3), e13051
DOI 10.1111/apha.13051, PubMed 29423932

McLornan DP, Szydlo R, Robin M, van Biezen A, Koster L, Blok HJP, Van Lint MT, Finke J, Vitek A, Carlson K, Griskevicius L, Holler E, Itälä-Remes M, Schaap M, Socié G, Bay JO, Beguin Y, Bruno B, Cornelissen JJ, Gedde-Dahl T, Ljungman P, Rubio MT, Yakoub-Agha I, Klyuchnikov E, Olavarria E et al. (2018)
Outcome of patients with Myelofibrosis relapsing after allogeneic stem cell transplant: a retrospective study by the Chronic Malignancies Working Party of EBMT
Br J Haematol, 182 (3), 418-422
DOI 10.1111/bjh.15407, PubMed 29808926

Muhoozi GKM, Atukunda P, Skaare AB, Willumsen T, Diep LM, Westerberg AC, Iversen PO (2018)
Effects of nutrition and hygiene education on oral health and growth among toddlers in rural Uganda: follow-up of a cluster-randomised controlled trial
Trop Med Int Health, 23 (4), 391-404
DOI 10.1111/tmi.13036, PubMed 29381827

Myhrvold IK, Cremaschi A, Hermansen JU, Tjønnfjord GE, Munthe LA, Taskén K, Skånland SS (2018)
Single cell profiling of phospho-protein levels in chronic lymphocytic leukemia
Oncotarget, 9 (10), 9273-9284
DOI 10.18632/oncotarget.23949, PubMed 29507689

Nahalomo A, Iversen PO, Rukundo PM, Kaaya A, Kikafunda J, Eide WB, Marais M, Wamala E, Kabahenda M (2018)
Realization of the right to adequate food and the nutritional status of land evictees: a case for mothers/caregivers and their children in rural Central Uganda
BMC Int Health Hum Rights, 18 (1), 21
DOI 10.1186/s12914-018-0162-6, PubMed 29793472

Navarro-Fernández J, Eugenia de la Morena-Barrio M, Martínez-Alonso E, Dybedal I, Toderici M, Bohdan N, Miñano A, Heimdal K, Abildgaard U, Martínez-Menárguez JÁ, Corral J, Vicente V (2018)
Biochemical and cellular consequences of the antithrombin p.Met1? mutation identified in a severe thrombophilic family
Oncotarget, 9 (69), 33202-33214
DOI 10.18632/oncotarget.26059, PubMed 30237862

Nesvold MB, Jensen JL, Hove LH, Singh PB, Young A, Palm Ø, Andersen LF, Carlsen MH, Iversen PO (2018)
Dietary Intake, Body Composition, and Oral Health Parameters among Female Patients with Primary Sjögren's Syndrome
Nutrients, 10 (7)
DOI 10.3390/nu10070866, PubMed 29973575

Ngari MM, Iversen PO, Thitiri J, Mwalekwa L, Timbwa M, Fegan GW, Berkley JA (2018)
Linear growth following complicated severe malnutrition: 1-year follow-up cohort of Kenyan children
Arch Dis Child (in press)
DOI 10.1136/archdischild-2018-315641, PubMed 30266874

Ngari MM, Mwalekwa L, Timbwa M, Hamid F, Ali R, Iversen PO, Fegan GW, Berkley JA (2018)
Changes in susceptibility to life-threatening infections after treatment for complicated severe malnutrition in Kenya
Am J Clin Nutr, 107 (4), 626-634
DOI 10.1093/ajcn/nqy007, PubMed 29635501

Olsson M, Stanne TM, Pedersen A, Lorentzen E, Kara E, Martinez-Palacian A, Rønnow Sand NP, Jacobsen AF, Sandset PM, Sidelmann JJ, Engström G, Melander O, Kanse SM, Jern C (2018)
Genome-wide analysis of genetic determinants of circulating factor VII-activating protease (FSAP) activity
J Thromb Haemost, 16 (10), 2024-2034
DOI 10.1111/jth.14258, PubMed 30070759

Panagopoulos I, Gorunova L, Jacobsen EM, Andersen K, Micci F, Heim S (2018)
RUNX1-PDCD6 fusion resulting from a novel t(5;21)(p15;q22) chromosome translocation in myelodysplastic syndrome secondary to chronic lymphocytic leukemia
PLoS One, 13 (4), e0196181
DOI 10.1371/journal.pone.0196181, PubMed 29672642

Pathak M, Diep PP, Lai X, Brinch L, Ruud E, Drolsum L (2018)
Ocular findings and ocular graft-versus-host disease after allogeneic stem cell transplantation without total body irradiation
Bone Marrow Transplant, 53 (7), 863-872
DOI 10.1038/s41409-018-0090-z, PubMed 29382955

Qvigstad C, Tait RC, Rauchensteiner S, Berntorp E, de Moerloose P, Schutgens RE, Holme PA, ADVANCE Working Group (2018)
The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment
Medicine (Baltimore), 97 (39), e12551
DOI 10.1097/MD.0000000000012551, PubMed 30278553

Reikvam H, Skavland J, Gullaksen SE, Hovland R, Gedde-Dahl T, Bruserud Ø, Gjertsen BT (2018)
Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation
Case Rep Hematol, 2018, 2045985
DOI 10.1155/2018/2045985, PubMed 30345125

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H (2018)
The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function
EMBO J, 37 (6)
DOI 10.15252/embj.201899170, PubMed 29545456

Rogne M, Svaerd O, Madsen-Østerbye J, Hashim A, Tjønnfjord GE, Staerk J (2018)
Cytokinesis arrest and multiple centrosomes in B cell chronic lymphocytic leukaemia
J Cell Mol Med, 22 (5), 2846-2855
DOI 10.1111/jcmm.13579, PubMed 29516674

Sacco S, Merki-Feld GS, Ægidius KL, Bitzer J, Canonico M, Gantenbein AR, Kurth T, Lampl C, Lidegaard Ø, Anne MacGregor E, MaassenVanDenBrink A, Mitsikostas DD, Nappi RE, Ntaios G, Paemeleire K, Sandset PM, Terwindt GM, Vetvik KG, Martelletti P, European Headache Federation (EHF), the European Society of Contraception and Reproductive Health (ESCRH) (2018)
Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)
J Headache Pain, 19 (1), 76
DOI 10.1186/s10194-018-0896-5, PubMed 30171365

Savikj M, Ruby MA, Kostovski E, Iversen PO, Zierath JR, Krook A, Widegren U (2018)
Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals
Physiol Rep, 6 (12), e13739
DOI 10.14814/phy2.13739, PubMed 29906337

Schultz NH, Lundblad R, Holme PA (2018)
Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: a case series
J Med Case Rep, 12 (1), 138
DOI 10.1186/s13256-018-1660-9, PubMed 29764497

Schwab C, Gabrysch A, Olbrich P, Patiño V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom DM, Lucena JM, Seidl M, Schmitt-Graeff A, Reiser V, Emmerich F, Frede N, Bulashevska A, Salzer U, Schubert D, Hayakawa S, Okada S, Kanariou M et al. (2018)
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects
J Allergy Clin Immunol, 142 (6), 1932-1946
DOI 10.1016/j.jaci.2018.02.055, PubMed 29729943

Shapiro AD, Nakar C, Parker JM, Albert GR, Moran JE, Thibaudeau K, Thukral N, Hardesty BM, Laurin P, Sandset PM (2018)
Plasminogen replacement therapy for the treatment of children and adults with congenital plasminogen deficiency
Blood, 131 (12), 1301-1310
DOI 10.1182/blood-2017-09-806729, PubMed 29321155

Sioud M, Westby P, Vasovic V, Fløisand Y, Peng Q (2018)
Development of a new high-affinity human antibody with antitumor activity against solid and blood malignancies
FASEB J, 32 (9), 5063-5077
DOI 10.1096/fj.201701544R, PubMed 29913558

Skaarud KJ, Hjermstad MJ, Bye A, Veierød MB, Gudmundstuen AM, Lundin KEA, Distante S, Brinch L, Tjønnfjord GE, Iversen PO (2018)
Effects of individualized nutrition after allogeneic hematopoietic stem cell transplantation following myeloablative conditioning; a randomized controlled trial
Clin Nutr ESPEN, 28, 59-66
DOI 10.1016/j.clnesp.2018.08.002, PubMed 30390894

Subramaniam S, Kanse SM, Kothari H, Reinhardt C, Fletcher C (2018)
Post-transcriptional, post-translational and pharmacological regulation of tissue factor pathway inhibitor
Blood Coagul Fibrinolysis, 29 (8), 668-682
DOI 10.1097/MBC.0000000000000775, PubMed 30439766

Tangen JM, Tjønnfjord GE, Gulbrandsen N, Gedde-Dahl T, Stormorken E, Anderson K, Vo CD, Schjesvold FH, For Oslo Myeloma Center (2018)
Improved outcome in patients following autologous stem cell transplantation for multiple myeloma in south eastern Norway 2001-2010: a retrospective, population based analysis
BMC Cancer, 18 (1), 801
DOI 10.1186/s12885-018-4722-x, PubMed 30089450

Tavoly M, Wik HS, Sirnes PA, Jelsness-Jørgensen LP, Ghanima JP, Klok FA, Sandset PM, Ghanima W (2018)
The impact of post-pulmonary embolism syndrome and its possible determinants
Thromb Res, 171, 84-91
DOI 10.1016/j.thromres.2018.09.048, PubMed 30267974

Tinholt M, Garred Ø, Borgen E, Beraki E, Schlichting E, Kristensen V, Sahlberg KK, Iversen N (2018)
Subtype-specific clinical and prognostic relevance of tumor-expressed F5 and regulatory F5 variants in breast cancer: the CoCaV study
J Thromb Haemost, 16 (7), 1347-1356
DOI 10.1111/jth.14151, PubMed 29766637

Tulstrup M, Grosjean M, Nielsen SN, Grell K, Wolthers BO, Wegener PS, Jonsson OG, Lund B, Harila-Saari A, Abrahamsson J, Vaitkeviciene G, Pruunsild K, Toft N, Holm M, Hulegårdh E, Liestøl S, Griskevicius L, Punab M, Wang J, Carroll WL, Zhang Z, Dalgaard MD, Gupta R, Nersting J, Schmiegelow K (2018)
NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia
Leukemia, 32 (12), 2527-2535
DOI 10.1038/s41375-018-0245-3, PubMed 30201983

Utne KK, Dahm A, Wik HS, Jelsness-Jørgensen LP, Sandset PM, Ghanima W (2018)
Rivaroxaban versus warfarin for the prevention of post-thrombotic syndrome
Thromb Res, 163, 6-11
DOI 10.1016/j.thromres.2018.01.013, PubMed 29324334

Zhang B, Durán PA, Piechaczyk L, Fløisand Y, Safont MMS, Karlsen IT, Fandalyuk Z, Tadele D, Mierlo PV, Rowe AD, Robertson JM, Gjertsen BT, McCormack E, Enserink JM, Bjørn Tore Gjertsen Group, Emmet McCormack Group (2018)
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica (in press)
DOI 10.3324/haematol.2018.189399, PubMed 29748445

 
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