Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2017 from OUS - Department of Haematology

54 publications found

Andresen MS, Ali HO, Myklebust CF, Sandset PM, Stavik B, Iversen N, Skretting G (2017)
Estrogen induced expression of tissue factor pathway inhibitor-2 in MCF7 cells involves lysine-specific demethylase 1
Mol Cell Endocrinol, 443, 80-88
DOI 10.1016/j.mce.2017.01.016, PubMed 28088469

Berentsen S, Randen U, Oksman M, Birgens H, Tvedt THA, Dalgaard J, Galteland E, Haukås E, Brudevold R, Sørbø JH, Næss IA, Malecka A, Tjønnfjord GE (2017)
Bendamustine plus rituximab for chronic cold agglutinin disease: results of a Nordic prospective multicenter trial
Blood, 130 (4), 537-541
DOI 10.1182/blood-2017-04-778175, PubMed 28533306

Berntorp E, Dargaud Y, Hart D, Lobet S, Mancuso ME, d'Oiron R, Perry D, Pollard D, van den Berg M, Blatný J, Chambost H, Doria AS, Holme PA, Kaczmarek R, Mantovani L, McLaughlin P, Nanayakkara L, Petrini P, Sannié T, Laane E, Maia R, Dettoraki A, Farrell A, Halimeh S, Raza S et al. (2017)
The second Team Haemophilia Education Meeting, 2016, Frankfurt, Germany
Eur J Haematol, 98 Suppl 85, 1-15
DOI 10.1111/ejh.12828, PubMed 28101938

Byskov K, Boettger T, Ruehle PF, Nielsen NV, Etscheid M, Kanse SM (2017)
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells
Atherosclerosis, 265, 133-139
DOI 10.1016/j.atherosclerosis.2017.08.029, PubMed 28881271

Canaani J, Beohou E, Labopin M, Socié G, Huynh A, Volin L, Cornelissen J, Milpied N, Gedde-Dahl T, Deconinck E, Fegueux N, Blaise D, Mohty M, Nagler A (2017)
Impact of FAB classification on predicting outcome in acute myeloid leukemia, not otherwise specified, patients undergoing allogeneic stem cell transplantation in CR1: An analysis of 1690 patients from the acute leukemia working party of EBMT
Am J Hematol, 92 (4), 344-350
DOI 10.1002/ajh.24640, PubMed 28052366

Canaani J, Labopin M, Socié G, Nihtinen A, Huynh A, Cornelissen J, Deconinck E, Gedde-Dahl T, Forcade E, Chevallier P, Bourhis JH, Blaise D, Mohty M, Nagler A (2017)
Long term impact of hyperleukocytosis in newly diagnosed acute myeloid leukemia patients undergoing allogeneic stem cell transplantation: An analysis from the acute leukemia working party of the EBMT
Am J Hematol, 92 (7), 653-659
DOI 10.1002/ajh.24737, PubMed 28370339

Chollet ME, Andersen E, Skarpen E, Myklebust CF, Koehler C, Morth JP, Chuansumrit A, Pinotti M, Bernardi F, Thiede B, Sandset PM, Skretting G (2017)
Factor VII deficiency: Unveiling the cellular and molecular mechanisms underlying three model alterations of the enzyme catalytic domain
Biochim Biophys Acta Mol Basis Dis, 1864 (3), 660-667
DOI 10.1016/j.bbadis.2017.12.016, PubMed 29246447

Cui XY, Skretting G, Tinholt M, Stavik B, Dahm AEA, Sahlberg KK, Kanse S, Iversen N, Sandset PM (2017)
A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7
Thromb Res, 157, 111-116
DOI 10.1016/j.thromres.2017.07.013, PubMed 28734156

El-Galaly TC, Villa D, Michaelsen TY, Hutchings M, Mikhaeel NG, Savage KJ, Sehn LH, Barrington S, Hansen JW, Smith D, Rady K, Mylam KJ, Larsen TS, Holmberg S, Juul MB, Cordua S, Clausen MR, Jensen KB, Johnsen HE, Seymour JF, Connors JM, de Nully Brown P, Bøgsted M, Cheah CY (2017)
The number of extranodal sites assessed by PET/CT scan is a powerful predictor of CNS relapse for patients with diffuse large B-cell lymphoma: An international multicenter study of 1532 patients treated with chemoimmunotherapy
Eur J Cancer, 75, 195-203
DOI 10.1016/j.ejca.2016.12.029, PubMed 28237865

Espada S, Stavik B, Holm S, Sagen EL, Bjerkeli V, Skjelland M, Dahl TB, Espevik T, Kanse S, Sandset PM, Skretting G, Halvorsen B (2017)
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages
Biochem Biophys Res Commun, 491 (2), 442-448
DOI 10.1016/j.bbrc.2017.07.070, PubMed 28712870

Garabet L, Ghanima W, Monceyron Jonassen C, Skov V, Holst R, Mowinckel MC, Hasselbalch HC, Kruse TA, Thomassen M, Liebman H, Bussel JB, Sandset PM (2017)
Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia
Platelets, 1-7 (in press)
DOI 10.1080/09537104.2017.1394451, PubMed 29215956

Ghanima W, Wik HS, Tavoly M, Enden T, Jelsness-Jørgensen LP (2017)
Late consequences of venous thromboembolism: Measuring quality of life after deep vein thrombosis and pulmonary embolism
Thromb Res, 164, 170-176
DOI 10.1016/j.thromres.2017.07.025, PubMed 28760416

Gjevestad GO, Ottestad I, Biong AS, Iversen PO, Retterstøl K, Raastad T, Skålhegg BS, Ulven SM, Holven KB (2017)
Consumption of protein-enriched milk has minor effects on inflammation in older adults-A 12-week double-blind randomized controlled trial
Mech Ageing Dev, 162, 1-8
DOI 10.1016/j.mad.2017.01.011, PubMed 28163108

Grasso S, Neumann A, Lang IM, Etscheid M, von Köckritz-Blickwede M, Kanse SM (2017)
Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs)
Thromb Res, 161, 36-42
DOI 10.1016/j.thromres.2017.11.012, PubMed 29178989

Gravensteen IK, Jacobsen EM, Sandset PM, Helgadottir LB, Rådestad I, Sandvik L, Ekeberg Ø (2017)
Healthcare utilisation, induced labour and caesarean section in the pregnancy after stillbirth: a prospective study
BJOG, 125 (2), 202-210
DOI 10.1111/1471-0528.14750, PubMed 28516500

Gullaksen SE, Skavland J, Gavasso S, Tosevski V, Warzocha K, Dumrese C, Ferrant A, Gedde-Dahl T, Hellmann A, Janssen J, Labar B, Lang A, Majeed W, Mihaylov G, Stentoft J, Stenke L, Thaler J, Thielen N, Verhoef G, Voglova J, Ossenkoppele G, Hochhaus A, Hjorth-Hansen H, Mustjoki S, Sopper S et al. (2017)
Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib
Haematologica, 102 (8), 1361-1367
DOI 10.3324/haematol.2017.167080, PubMed 28522574

Gustavsen A, Skattum L, Bergseth G, Lorentzen B, Floisand Y, Bosnes V, Mollnes TE, Barratt-Due A (2017)
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report
Medicine (Baltimore), 96 (11), e6338
DOI 10.1097/MD.0000000000006338, PubMed 28296762

Herold J, Nowak S, Kostin S, Daniel JM, Francke A, Subramaniam S, Braun-Dullaeus RC, Kanse SM (2017)
Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model
Am J Transl Res, 9 (6), 3084-3095
PubMed 28670395

Holme PA, Tjønnfjord GE, Batorova A (2017)
Continuous infusion of coagulation factor concentrates during intensive treatment
Haemophilia, 24 (1), 24-32
DOI 10.1111/hae.13331, PubMed 28873263

Johannsdottir IM, Loge JH, Kiserud CE, Karlstad Ø, Skurtveit S (2017)
Increased prescription rates of anxiolytics and hypnotics to survivors of cancer in childhood, adolescence, and young adulthood-A population-based study
Pediatr Blood Cancer, 65 (2)
DOI 10.1002/pbc.26860, PubMed 29077266

Klohe K, Prazeres da Costa C, Lien N, Holmboe-Ottesen G, Rychlik M, Haavardsson I, Stordalen G, Singh S, Engebretsen I, Iversen PO, Winkler AS (2017)
Nutrition – A global challenge for health
Tidsskr Nor Laegeforen, 137 (23-24)
DOI 10.4045/tidsskr.17.0679, PubMed 29231665

Komperød MJ, Sommer C, Mellin-Olsen T, Iversen PO, Røseth AG, Valeur J (2017)
Persistent symptoms in patients with Crohn's disease in remission: An exploratory study on the role of diet
Scand J Gastroenterol, 53 (5), 573-578
DOI 10.1080/00365521.2017.1397736, PubMed 29168412

Krishnan K, Jusufovic M, Sandset PM, Sandset EC (2017)
Antiplatelet Therapy in Noncardioembolic Stroke: A Review of Current Evidence
Semin Neurol, 37 (3), 366-375
DOI 10.1055/s-0037-1603469, PubMed 28759917

Lazarevic VL, Labopin M, Depei W, Yakoub-Agha I, Huynh A, Ljungman P, Schaap N, Cornelissen JJ, Maillard N, Pioltelli P, Gedde-Dahl T, Lenhoff S, Houhou M, Esteve J, Mohty M, Nagler A (2017)
Relatively favorable outcome after allogeneic stem cell transplantation for BCR-ABL1-positive AML: A survey from the acute leukemia working party of the European Society for blood and marrow transplantation (EBMT)
Am J Hematol, 93 (1), 31-39
DOI 10.1002/ajh.24928, PubMed 28971504

Muhoozi GKM, Atukunda P, Diep LM, Mwadime R, Kaaya AN, Skaare AB, Willumsen T, Westerberg AC, Iversen PO (2017)
Nutrition, hygiene, and stimulation education to improve growth, cognitive, language, and motor development among infants in Uganda: A cluster-randomized trial
Matern Child Nutr, 14 (2), e12527
DOI 10.1111/mcn.12527, PubMed 28925580

Ngari MM, Thitiri J, Mwalekwa L, Timbwa M, Iversen PO, Fegan GW, Berkley JA (2017)
The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study
Matern Child Nutr, 14 (2), e12569
DOI 10.1111/mcn.12569, PubMed 29178404

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262

Osooli M, Steen Carlsson K, Baghaei F, Holmström M, Rauchensteiner S, Holme PA, Hvitfeldt L, Astermark J, Berntorp E (2017)
The association between health utility and joint status among people with severe haemophilia A: findings from the KAPPA register
Haemophilia, 23 (3), e180-e187
DOI 10.1111/hae.13231, PubMed 28393468

Ottestad I, Løvstad AT, Gjevestad GO, Hamarsland H, Šaltytė Benth J, Andersen LF, Bye A, Biong AS, Retterstøl K, Iversen PO, Raastad T, Ulven SM, Holven KB (2017)
Intake of a Protein-Enriched Milk and Effects on Muscle Mass and Strength. A 12-Week Randomized Placebo Controlled Trial among Community-Dwelling Older Adults
J Nutr Health Aging, 21 (10), 1160-1169
DOI 10.1007/s12603-016-0856-1, PubMed 29188875

Pahnke S, Larfors G, Axdorph-Nygell U, Fischer-Nielsen A, Haastrup E, Heldal D, Itälä-Remes M, Johansson JE, Kauppila M, Lenhoff S, Ljungman P, Niittyvuopio R, Sandstedt A, Hägglund H (2017)
Short-term side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors
J Clin Apher, 33 (3), 226-235
DOI 10.1002/jca.21576, PubMed 28833474

Panagopoulos I, Gorunova L, Torkildsen S, Tierens A, Heim S, Micci F (2017)
FAM53B truncation caused by t(10;19)(q26;q13) chromosome translocation in acute lymphoblastic leukemia
Oncol Lett, 13 (4), 2216-2220
DOI 10.3892/ol.2017.5705, PubMed 28454383

Panagopoulos I, Gorunova L, Torkildsen S, Tjønnfjord GE, Micci F, Heim S (2017)
DEK-NUP214-Fusion Identified by RNA-Sequencing of an Acute Myeloid Leukemia with t(9;12)(q34;q15)
Cancer Genomics Proteomics, 14 (6), 437-443
DOI 10.21873/cgp.20053, PubMed 29109093

Prebensen C, Trøseid M, Ueland T, Dahm A, Sandset PM, Aaberge I, Waalen K, Dyrhol-Riise AM, Taskén K, Kvale D (2017)
Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial
PLoS One, 12 (5), e0176527
DOI 10.1371/journal.pone.0176527, PubMed 28464042

Retterstøl K, Narverud I, Selmer R, Berge KE, Osnes IV, Ulven SM, Halvorsen B, Aukrust P, Holven KB, Iversen PO (2017)
Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics
Lipids Health Dis, 16 (1), 115
DOI 10.1186/s12944-017-0511-9, PubMed 28606150

Ringdén O, Labopin M, Sadeghi B, Mailhol A, Beelen D, Fløisand Y, Ghavamzadeh A, Finke J, Ehninger G, Volin L, Socié G, Kröger N, Stuhler G, Ganser A, Schmid C, Giebel S, Mohty M, Nagler A (2017)
What is the outcome in patients with acute leukaemia who survive severe acute graft-versus-host disease?
J Intern Med, 283 (2), 166-177
DOI 10.1111/joim.12695, PubMed 29027756

Rørholt M, Ghanima W, Farkas DK, Nørgaard M (2017)
Risk of cardiovascular events and pulmonary hypertension following splenectomy - a Danish population-based cohort study from 1996-2012
Haematologica, 102 (8), 1333-1341
DOI 10.3324/haematol.2016.157008, PubMed 28572164

Sacco S, Merki-Feld GS, Ægidius KL, Bitzer J, Canonico M, Kurth T, Lampl C, Lidegaard Ø, Anne MacGregor E, MaassenVanDenBrink A, Mitsikostas DD, Nappi RE, Ntaios G, Sandset PM, Martelletti P, European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC) (2017)
Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)
J Headache Pain, 18 (1), 108
DOI 10.1186/s10194-017-0815-1, PubMed 29086160

Sagedal S, Sandvik L, Klingenberg O, Sandset PM (2017)
β-Thromboglobulin may not reflect platelet activation during haemodialysis with the HeprAN membrane
Scand J Clin Lab Invest, 77 (8), 679-684
DOI 10.1080/00365513.2017.1397288, PubMed 29117741

Schultz NH, Tran HTT, Bjørnsen S, Henriksson CE, Sandset PM, Holme PA (2017)
The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor
Thromb J, 15, 6
DOI 10.1186/s12959-017-0129-1, PubMed 28239301

Schultz NH, Tran HTT, Bjørnsen S, Henriksson CE, Sandset PM, Holme PA (2017)
The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII in apixaban-treated patients in vitro
Res Pract Thromb Haemost, 1 (1), 49-56
DOI 10.1002/rth2.12015, PubMed 30046673

Server A, Bargalló N, Fløisand Y, Sponheim J, Graus F, Hald JK (2017)
Imaging spectrum of central nervous system complications of hematopoietic stem cell and solid organ transplantation
Neuroradiology, 59 (2), 105-126
DOI 10.1007/s00234-017-1804-4, PubMed 28255902

Slack J, Albert MH, Balashov D, Belohradsky BH, Bertaina A, Bleesing J, Booth C, Buechner J, Buckley RH, Ouachée-Chardin M, Deripapa E, Drabko K, Eapen M, Feuchtinger T, Finocchi A, Gaspar HB, Ghosh S, Gillio A, Gonzalez-Granado LI, Grunebaum E, Güngör T, Heilmann C, Helminen M, Higuchi K, Imai K et al. (2017)
Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders
J Allergy Clin Immunol, 141 (1), 322-328.e10
DOI 10.1016/j.jaci.2017.02.036, PubMed 28392333

Sperling C, Maitz MF, Grasso S, Werner C, Kanse SM (2017)
A Positively Charged Surface Triggers Coagulation Activation Through Factor VII Activating Protease (FSAP)
ACS Appl Mater Interfaces, 9 (46), 40107-40116
DOI 10.1021/acsami.7b14281, PubMed 29091393

Stavik B, Holm S, Espada S, Iversen N, Sporsheim B, Bjerkeli V, Dahl TB, Sandset PM, Skjelland M, Espevik T, Skretting G, Halvorsen B (2017)
Increased expression of TFPI in human carotid stenosis
Thromb Res, 155, 31-37
DOI 10.1016/j.thromres.2017.04.024, PubMed 28482260

Steffensen IL, Frølich W, Dahl KH, Iversen PO, Lyche JL, Lillegaard ITL, Alexander J (2017)
Benefit and risk assessment of increasing potassium intake by replacement of sodium chloride with potassium chloride in industrial food products in Norway
Food Chem Toxicol, 111, 329-340
DOI 10.1016/j.fct.2017.11.044, PubMed 29175183

Strømmen K, Haag A, Moltu SJ, Veierød MB, Blakstad EW, Nakstad B, Almaas AN, Brække K, Rønnestad AE, Daniel H, Drevon CA, Iversen PO (2017)
Enhanced nutrient supply to very low birth weight infants is associated with higher blood amino acid concentrations and improved growth
Clin Nutr ESPEN, 18, 16-22
DOI 10.1016/j.clnesp.2017.01.003, PubMed 29132733

Tikkinen KAO, Craigie S, Agarwal A, Siemieniuk RAC, Cartwright R, Violette PD, Novara G, Naspro R, Agbassi C, Ali B, Imam M, Ismaila N, Kam D, Gould MK, Sandset PM, Guyatt GH (2017)
Procedure-specific Risks of Thrombosis and Bleeding in Urological Non-cancer Surgery: Systematic Review and Meta-analysis
Eur Urol, 73 (2), 236-241
DOI 10.1016/j.eururo.2017.02.025, PubMed 28284738

Tikkinen KAO, Craigie S, Agarwal A, Violette PD, Novara G, Cartwright R, Naspro R, Siemieniuk RAC, Ali B, Eryuzlu L, Geraci J, Winkup J, Yoo D, Gould MK, Sandset PM, Guyatt GH (2017)
Procedure-specific Risks of Thrombosis and Bleeding in Urological Cancer Surgery: Systematic Review and Meta-analysis
Eur Urol, 73 (2), 242-251
DOI 10.1016/j.eururo.2017.03.008, PubMed 28342641

Tjønnfjord E, Vengen ØA, Berentsen S, Tjønnfjord GE (2017)
Prophylactic use of eculizumab during surgery in chronic cold agglutinin disease
BMJ Case Rep, 2017
DOI 10.1136/bcr-2016-219066, PubMed 28487302

Torkildsen S, Brunetti M, Gorunova L, Spetalen S, Beiske K, Heim S, Panagopoulos I (2017)
Rearrangement of the Chromatin Organizer Special AT-rich Binding Protein 1 Gene, SATB1, Resulting from a t(3;5)(p24;q14) Chromosomal Translocation in Acute Myeloid Leukemia
Anticancer Res, 37 (2), 693-698
DOI 10.21873/anticanres.11365, PubMed 28179318

Vojdeman FJ, Herman SEM, Kirkby N, Wiestner A, van T' Veer MB, Tjønnfjord GE, Itälä-Remes MA, Kimby E, Farooqui MZ, Polliack A, Wu KL, Doorduijn JK, Alemayehu WG, Wittebol S, Kozak T, Walewski J, Abrahamse-Testroote MCJ, van Oers MHJ, Geisler CH, Niemann CU (2017)
Soluble CD52 is an indicator of disease activity in chronic lymphocytic leukemia
Leuk Lymphoma, 58 (10), 2356-2362
DOI 10.1080/10428194.2017.1285027, PubMed 28278728

Wang D, Fløisand Y, Myklebust CV, Bürgler S, Parente-Ribes A, Hofgaard PO, Bogen B, Taskén K, Tjønnfjord GE, Schjesvold F, Dalgaard J, Tveita A, Munthe LA (2017)
Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice
Leukemia, 31 (10), 2114-2121
DOI 10.1038/leu.2017.69, PubMed 28232741

Wik HS, Enden TR, Ghanima W, Engeseth M, Kahn SR, Sandset PM (2017)
Diagnostic scales for the post-thrombotic syndrome
Thromb Res, 164, 110-115
DOI 10.1016/j.thromres.2017.10.022, PubMed 29126608

Wik HS, Ghanima W, Sandset PM, Kahn SR (2017)
Scoring Systems for Postthrombotic Syndrome
Semin Thromb Hemost, 43 (5), 500-504
DOI 10.1055/s-0037-1599142, PubMed 28470653

 
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