Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2015 from OUS - Institute for Surgical Research ISR

36 publications found

Baysa A, Sagave J, Carpi A, Zaglia T, Campesan M, Dahl CP, Bilbija D, Troitskaya M, Gullestad L, Giorgio M, Mongillo M, Di Lisa F, Vaage JI, Valen G (2015)
The p66ShcA adaptor protein regulates healing after myocardial infarction
Basic Res Cardiol, 110 (2), 13
DOI 10.1007/s00395-015-0470-0, PubMed 25680868

Bersvendsen J, Orderud F, Massey RJ, Fosså K, Gerard O, Urheim S, Samset E (2015)
Automated Segmentation of the Right Ventricle in 3D Echocardiography: A Kalman Filter State Estimation Approach
IEEE Trans Med Imaging, 35 (1), 42-51
DOI 10.1109/TMI.2015.2453551, PubMed 26168434

Boe E, Russell K, Eek C, Eriksen M, Remme EW, Smiseth OA, Skulstad H (2015)
Non-invasive myocardial work index identifies acute coronary occlusion in patients with non-ST-segment elevation-acute coronary syndrome
Eur Heart J Cardiovasc Imaging, 16 (11), 1247-55
DOI 10.1093/ehjci/jev078, PubMed 25851329

Broch K, Urheim S, Lønnebakken MT, Stueflotten W, Massey R, Fosså K, Hopp E, Aakhus S, Gullestad L (2015)
Controlled release metoprolol for aortic regurgitation: a randomised clinical trial
Heart, 102 (3), 191-7
DOI 10.1136/heartjnl-2015-308416, PubMed 26661319

Dhondup Y, Sjaastad I, Scott H, Sandanger Ø, Zhang L, Haugstad SB, Aronsen JM, Ranheim T, Holmen SD, Alfsnes K, Ahmed MS, Attramadal H, Gullestad L, Aukrust P, Christensen G, Yndestad A, Vinge LE (2015)
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715, PubMed 26461521

Dumont KA, Karlsen JS, Helle-Valle T, Fiane AE, Lundblad R, Urheim S (2015)
Mitral valve analysis adding a virtual semi-transparent annulus plane for detection of prolapsing segments
Cardiovasc Ultrasound, 13, 25
DOI 10.1186/s12947-015-0019-2, PubMed 25986226

Espe EK, Aronsen JM, Eriksen GS, Zhang L, Smiseth OA, Edvardsen T, Sjaastad I, Eriksen M (2015)
Assessment of regional myocardial work in rats
Circ Cardiovasc Imaging, 8 (2), e002695
DOI 10.1161/CIRCIMAGING.114.002695, PubMed 25673647

Estensen ME, Grindheim G, Remme EW, Godang K, Henriksen T, Aukrust P, Aakhus S, Gullestad L, Ueland T (2015)
Elevated inflammatory markers in preeclamptic pregnancies, but no relation to systemic arterial stiffness
Pregnancy Hypertens, 5 (4), 325-9
DOI 10.1016/j.preghy.2015.09.003, PubMed 26597749

Flachskampf FA, Biering-Sørensen T, Solomon SD, Duvernoy O, Bjerner T, Smiseth OA (2015)
Cardiac Imaging to Evaluate Left Ventricular Diastolic Function
JACC Cardiovasc Imaging, 8 (9), 1071-1093
DOI 10.1016/j.jcmg.2015.07.004, PubMed 26381769

Hals IK, Bruerberg SG, Ma Z, Scholz H, Björklund A, Grill V (2015)
Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia
PLoS One, 10 (9), e0138558
DOI 10.1371/journal.pone.0138558, PubMed 26401848

Hasselberg NE, Haugaa KH, Bernard A, Ribe MP, Kongsgaard E, Donal E, Edvardsen T (2015)
Left ventricular markers of mortality and ventricular arrhythmias in heart failure patients with cardiac resynchronization therapy
Eur Heart J Cardiovasc Imaging, 17 (3), 343-50
DOI 10.1093/ehjci/jev173, PubMed 26164406

Haugaa KH, Bundgaard H, Edvardsen T, Eschen O, Gilljam T, Hansen J, Jensen HK, Platonov PG, Svensson A, Svendsen JH (2015)
Management of patients with Arrhythmogenic Right Ventricular Cardiomyopathy in the Nordic countries
Scand Cardiovasc J, 49 (6), 299-307
DOI 10.3109/14017431.2015.1086017, PubMed 26395672

Haugaa KH, Haland TF, Leren IS, Saberniak J, Edvardsen T (2015)
Arrhythmogenic right ventricular cardiomyopathy, clinical manifestations, and diagnosis
Europace, 18 (7), 965-72
DOI 10.1093/europace/euv340, PubMed 26498164

Hyde ER, Behar JM, Claridge S, Jackson T, Lee AW, Remme EW, Sohal M, Plank G, Razavi R, Rinaldi CA, Niederer SA (2015)
Beneficial Effect on Cardiac Resynchronization From Left Ventricular Endocardial Pacing Is Mediated by Early Access to High Conduction Velocity Tissue: Electrophysiological Simulation Study
Circ Arrhythm Electrophysiol, 8 (5), 1164-72
DOI 10.1161/CIRCEP.115.002677, PubMed 26136400

Joel M, Mughal AA, Grieg Z, Murrell W, Palmero S, Mikkelsen B, Fjerdingstad HB, Sandberg CJ, Behnan J, Glover JC, Langmoen IA, Stangeland B (2015)
Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo
Mol Cancer, 14, 121
DOI 10.1186/s12943-015-0398-x, PubMed 26081429

Kierulf-Vieira KS, Sandberg CJ, Grieg Z, Günther CC, Langmoen IA, Vik-Mo EO (2015)
Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation
Exp Cell Res, 340 (1), 53-61
DOI 10.1016/j.yexcr.2015.12.010, PubMed 26712519

Lauritzen KH, Kleppa L, Aronsen JM, Eide L, Carlsen H, Haugen ØP, Sjaastad I, Klungland A, Rasmussen LJ, Attramadal H, Storm-Mathisen J, Bergersen LH (2015)
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Am J Physiol Heart Circ Physiol, 309 (3), H434-49
DOI 10.1152/ajpheart.00253.2014, PubMed 26055793

Leren IS, Hasselberg NE, Saberniak J, Håland TF, Kongsgård E, Smiseth OA, Edvardsen T, Haugaa KH (2015)
Cardiac Mechanical Alterations and Genotype Specific Differences in Subjects With Long QT Syndrome
JACC Cardiovasc Imaging, 8 (5), 501-510
DOI 10.1016/j.jcmg.2014.12.023, PubMed 25890583

Leren IS, Saberniak J, Majid E, Haland TF, Edvardsen T, Haugaa KH (2015)
Nadolol decreases the incidence and severity of ventricular arrhythmias during exercise stress testing compared with β1-selective β-blockers in patients with catecholaminergic polymorphic ventricular tachycardia
Heart Rhythm, 13 (2), 433-40
DOI 10.1016/j.hrthm.2015.09.029, PubMed 26432584

Lund J, Hafstad AD, Boardman NT, Rossvoll L, Rolim NP, Ahmed MS, Florholmen G, Attramadal H, Wisløff U, Larsen TS, Aasum E (2015)
Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice
Am J Physiol Heart Circ Physiol, 308 (8), H823-9
DOI 10.1152/ajpheart.00734.2014, PubMed 25637547

McLeod K, Noack M, Saberniak J, Haugaa K (2015)
Structural Abnormality Detection of ARVC Patients via Localised Distance-to-Average Mapping
LECT NOTES COMPUT SC, 8896, 177-186

Morland C, Lauritzen KH, Puchades M, Holm-Hansen S, Andersson K, Gjedde A, Attramadal H, Storm-Mathisen J, Bergersen LH (2015)
The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain
J Neurosci Res, 93 (7), 1045-55
DOI 10.1002/jnr.23593, PubMed 25881750

Mughal AA, Grieg Z, Skjellegrind H, Fayzullin A, Lamkhannat M, Joel M, Ahmed MS, Murrell W, Vik-Mo EO, Langmoen IA, Stangeland B (2015)
Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells
Mol Cancer, 14, 160
DOI 10.1186/s12943-015-0432-z, PubMed 26292663

Remme EW, Niederer S, Gjesdal O, Russell K, Hyde ER, Smith N, Smiseth OA (2015)
Factors determining the magnitude of the pre-ejection leftward septal motion in left bundle branch block
Europace, 18 (12), 1905-1913
DOI 10.1093/europace/euv381, PubMed 26612883

Risøe PK, Rutkovskiy A, Ågren J, Kolseth IB, Kjeldsen SF, Valen G, Vaage J, Dahle MK (2015)
Higher TNFα responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression
Hum Immunol, 76 (6), 427-30
DOI 10.1016/j.humimm.2015.03.018, PubMed 25959651

Sahraoui A, Winzell MS, Gorman T, Smith DM, Skrtic S, Hoeyem M, Abadpour S, Johansson L, Korsgren O, Foss A, Scholz H (2015)
The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model
PLoS One, 10 (3), e0121204
DOI 10.1371/journal.pone.0121204, PubMed 25793295

Sandanger Ø, Gao E, Ranheim T, Bliksøen M, Kaasbøll OJ, Alfsnes K, Nymo SH, Rashidi A, Ohm IK, Attramadal H, Aukrust P, Vinge LE, Yndestad A (2015)
NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective
Biochem Biophys Res Commun, 469 (4), 1012-20
DOI 10.1016/j.bbrc.2015.12.051, PubMed 26706279

Sarvari SI, Haugaa KH, Stokke TM, Ansari HZ, Leren IS, Hegbom F, Smiseth OA, Edvardsen T (2015)
Strain echocardiographic assessment of left atrial function predicts recurrence of atrial fibrillation
Eur Heart J Cardiovasc Imaging, 17 (6), 660-7
DOI 10.1093/ehjci/jev185, PubMed 26219297

Schive SW, Scholz H, Sahraoui A, Kloster-Jensen K, Hafsahl G, Korsgren O, Foss A, Jenssen TG (2015)
Graft function 1 year after pregnancy in an islet-transplanted patient
Transpl Int, 28 (10), 1235-9
DOI 10.1111/tri.12596, PubMed 25903157

Seethala S, Singh P, Shusterman V, Ribe M, Haugaa KH, Němec J (2015)
QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome
J Am Heart Assoc, 4 (12)
DOI 10.1161/JAHA.115.002395, PubMed 26675252

Shegarfi H, Krohn CD, Gundersen Y, Kjeldsen SF, Hviid CV, Ruud TE, Aasen AO (2015)
Regulation of CCN1 (Cyr61) in a porcine model of intestinal ischemia/reperfusion
Innate Immun, 21 (5), 453-62
DOI 10.1177/1753425915569089, PubMed 25783840

Smedsrud MK, Gravning J, Omland T, Eek C, Mørkrid L, Skulstad H, Aaberge L, Bendz B, Kjekshus J, Edvardsen T (2015)
Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain
Int J Cardiovasc Imaging, 31 (5), 967-73
DOI 10.1007/s10554-015-0646-6, PubMed 25788439

Smiseth OA, Torp H, Opdahl A, Haugaa KH, Urheim S (2015)
Myocardial strain imaging: how useful is it in clinical decision making?
Eur Heart J, 37 (15), 1196-207
DOI 10.1093/eurheartj/ehv529, PubMed 26508168

Stangeland B, Mughal AA, Grieg Z, Sandberg CJ, Joel M, Nygård S, Meling T, Murrell W, Vik Mo EO, Langmoen IA (2015)
Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells
Oncotarget, 6 (28), 26192-215
DOI 10.18632/oncotarget.4613, PubMed 26295306

Ståhle M, Foss A, Gustafsson B, Lempinen M, Lundgren T, Rafael E, Tufveson G, Korsgren O, Friberg A (2015)
Clostripain, the Missing Link in the Enzyme Blend for Efficient Human Islet Isolation
Transplant Direct, 1 (5), e19
DOI 10.1097/TXD.0000000000000528, PubMed 27500221

Tønseth KA, Filip C, Hermann R, Vindenes H, Høgevold HE (2015)
Extraordinary Large Giant Congenital Melanocytic Nevus Treated with Integra Dermal Regeneration Template
Plast Reconstr Surg Glob Open, 3 (7), e469
DOI 10.1097/GOX.0000000000000454, PubMed 26301158

 
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