Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Institute for Experimental Medical Research IEMR

34 publications found

Barth Z, Schwartz T, Flatø B, Aaløkken TM, Koller A, Lund MB, Sjaastad I, Sanner H (2019)
Association Between Nailfold Capillary Density and Pulmonary and Cardiac Involvement in Medium to Longstanding Juvenile Dermatomyositis
Arthritis Care Res (Hoboken), 71 (4), 492-497
DOI 10.1002/acr.23687, PubMed 29953739

Berntsen KS, Edvardsen E, Hansen BH, Flatø B, Sjaastad I, Sanner H (2019)
Cardiorespiratory fitness in long-term juvenile dermatomyositis: a controlled, cross-sectional study of active/inactive disease
Rheumatology (Oxford), 58 (3), 492-501
DOI 10.1093/rheumatology/key342, PubMed 30508195

Brynildsen J, Myhre PL, Lyngbakken MN, Klaeboe LG, Stridsberg M, Christensen G, Edvardsen T, Omland T, Røsjø H (2019)
Circulating secretoneurin concentrations in patients with moderate to severe aortic stenosis
Clin Biochem, 71, 17-23
DOI 10.1016/j.clinbiochem.2019.06.008, PubMed 31228433

Brynildsen J, Petäjä L, Myhre PL, Lyngbakken MN, Nygård S, Stridsberg M, Christensen G, Ottesen AH, Pettilä V, Omland T, Røsjø H (2019)
Circulating Secretoneurin Concentrations After Cardiac Surgery: Data From the FINNish Acute Kidney Injury Heart Study
Crit Care Med, 47 (5), e412-e419
DOI 10.1097/CCM.0000000000003670, PubMed 30730440

Colli DF, Blood SR, Sankarankutty AC, Sachse FB, Frisk M, Louch WE, Kekenes-Huskey PM (2019)
A Matched-Filter-Based Algorithm for Subcellular Classification of T-System in Cardiac Tissues
Biophys J, 116 (8), 1386-1393
DOI 10.1016/j.bpj.2019.03.010, PubMed 30979553

de Boer RA, De Keulenaer G, Bauersachs J, Brutsaert D, Cleland JG, Diez J, Du XJ, Ford P, Heinzel FR, Lipson KE, McDonagh T, Lopez-Andres N, Lunde IG, Lyon AR, Pollesello P, Prasad SK, Tocchetti CG, Mayr M, Sluijter JPG, Thum T, Tschöpe C, Zannad F, Zimmermann WH, Ruschitzka F, Filippatos G et al. (2019)
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology
Eur J Heart Fail, 21 (3), 272-285
DOI 10.1002/ejhf.1406, PubMed 30714667

Fosheim IK, Alnaes-Katjavivi P, Redman C, Roald B, Staff AC, Størvold GL (2019)
Acute atherosis of decidua basalis; characterization of spiral arteries, endothelial status and activation
Placenta, 82, 10-16
DOI 10.1016/j.placenta.2019.04.006, PubMed 31174621

Garcia-Pavia P, Kim Y, Restrepo-Cordoba MA, Lunde IG, Wakimoto H, Smith AM, Toepfer CN, Getz K, Gorham J, Patel P, Ito K, Willcox JA, Arany Z, Li J, Owens AT, Govind R, Nuñez B, Mazaika E, Bayes-Genis A, Walsh R, Finkelman B, Lupon J, Whiffin N, Serrano I, Midwinter W et al. (2019)
Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy
Circulation, 140 (1), 31-41
DOI 10.1161/CIRCULATIONAHA.118.037934, PubMed 30987448

Gomes CPC, Ágg B, Andova A, Arslan S, Baker A, Barteková M, Beis D, Betsou F, Wettinger SB, Bugarski B, Condorelli G, Silva GJJD, Danilin S, de Gonzalo-Calvo D, Buil A, Carmo-Fonseca M, Enguita FJ, Felekkis K, Ferdinandy P, Gyöngyösi M, Hackl M, Karaduzovic-Hadziabdic K, Hellemans J, Heymans S, Hlavackova M et al. (2019)
Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129
Noncoding RNA, 5 (2)
DOI 10.3390/ncrna5020031, PubMed 30934986

Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ (2019)
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279

Hazen J, Vistnes M, Barca ML, Eldholm RS, Persson K, Brækhus A, Saltvedt I, Selbæk G, Engedal K, Knapskog AB (2019)
The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia
Alzheimer Dis Assoc Disord (in press)
DOI 10.1097/WAD.0000000000000342, PubMed 31414991

Johnsen GM, Størvold GL, Alnaes-Katjavivi PH, Roald B, Golic M, Dechend R, Redman CWG, Staff AC (2019)
Lymphocyte characterization of decidua basalis spiral arteries with acute atherosis in preeclamptic and normotensive pregnancies
J Reprod Immunol, 132, 42-48
DOI 10.1016/j.jri.2019.03.003, PubMed 30928772

Kononova N, Sikkeland LIB, Mahmood F, Vistnes M, Kongerud J, Einvik G, Søyseth V (2019)
Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample
BMC Pulm Med, 19 (1), 90
DOI 10.1186/s12890-018-0765-7, PubMed 31072364

Lipsett DB, Frisk M, Aronsen JM, Nordén ES, Buonarati OR, Cataliotti A, Hell JW, Sjaastad I, Christensen G, Louch WE (2019)
Cardiomyocyte substructure reverts to an immature phenotype during heart failure
J Physiol, 597 (7), 1833-1853
DOI 10.1113/JP277273, PubMed 30707448

Mathiesen SB, Lunde M, Aronsen JM, Romaine A, Kaupang A, Martinsen M, de Souza GA, Nyman TA, Sjaastad I, Christensen G, Carlson CR (2019)
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J Biol Chem, 294 (22), 8717-8731
DOI 10.1074/jbc.RA118.006423, PubMed 30967474

McGinley G, Bendiksen BA, Zhang L, Aronsen JM, Nordén ES, Sjaastad I, Espe EKS (2019)
Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding
PLoS One, 14 (7), e0218874
DOI 10.1371/journal.pone.0218874, PubMed 31276508

Mohammadzadeh N, Lunde IG, Andenæs K, Strand ME, Aronsen JM, Skrbic B, Marstein HS, Bandlien C, Nygård S, Gorham J, Sjaastad I, Chakravarti S, Christensen G, Engebretsen KVT, Tønnessen T (2019)
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
Sci Rep, 9 (1), 9206
DOI 10.1038/s41598-019-45651-9, PubMed 31235849

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE (2019)
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765

Røe ÅT, Ruud M, Espe EK, Manfra O, Longobardi S, Aronsen JM, Nordén ES, Husebye T, Kolstad TRS, Cataliotti A, Christensen G, Sejersted OM, Niederer SA, Andersen GØ, Sjaastad I, Louch WE (2019)
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
DOI 10.1093/cvr/cvy257, PubMed 30351410

Sheard TMD, Hurley ME, Colyer J, White E, Norman R, Pervolaraki E, Narayanasamy KK, Hou Y, Kirton HM, Yang Z, Hunter L, Shim JU, Clowsley AH, Smith AJ, Baddeley D, Soeller C, Colman MA, Jayasinghe I (2019)
Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy
ACS Nano, 13 (2), 2143-2157
DOI 10.1021/acsnano.8b08742, PubMed 30715853

Skogestad J, Aronsen JM, Tovsrud N, Wanichawan P, Hougen K, Stokke MK, Carlson CR, Sjaastad I, Sejersted OM, Swift F (2019)
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc Res (in press)
DOI 10.1093/cvr/cvz087, PubMed 30949686

Skogestad J, Lines GT, Louch WE, Sejersted OM, Sjaastad I, Aronsen JM (2019)
Evidence for heterogeneous subsarcolemmal Na+ levels in rat ventricular myocytes
Am J Physiol Heart Circ Physiol, 316 (5), H941-H957
DOI 10.1152/ajpheart.00637.2018, PubMed 30657726

Sokolova M, Sjaastad I, Louwe MC, Alfsnes K, Aronsen JM, Zhang L, Haugstad SB, Bendiksen BA, Øgaard J, Bliksøen M, Lien E, Berge RK, Aukrust P, Ranheim T, Yndestad A (2019)
NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity
Front Immunol, 10, 1621
DOI 10.3389/fimmu.2019.01621, PubMed 31379826

Tazmini K, Nymo SH, Louch WE, Ranhoff AH, Øie E (2019)
Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study
PLoS One, 14 (4), e0215673
DOI 10.1371/journal.pone.0215673, PubMed 31022222

Thorlacius EM, Suominen PK, Wåhlander H, Keski-Nisula J, Vistnes M, Ricksten SE, Synnergren M, Romlin BS, Castellheim A (2019)
The Effect of Levosimendan Versus Milrinone on the Occurrence Rate of Acute Kidney Injury Following Congenital Heart Surgery in Infants: A Randomized Clinical Trial
Pediatr Crit Care Med (in press)
DOI 10.1097/PCC.0000000000002017, PubMed 31274775

Toepfer CN, Wakimoto H, Garfinkel AC, McDonough B, Liao D, Jiang J, Tai AC, Gorham JM, Lunde IG, Lun M, Lynch TL, McNamara JW, Sadayappan S, Redwood CS, Watkins HC, Seidman JG, Seidman CE (2019)
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin
Sci Transl Med, 11 (476)
DOI 10.1126/scitranslmed.aat1199, PubMed 30674652

Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO, Chopra VK, de Boer RA, de Windt L, Hamdani N, Hasenfuss G, Heymans S, Hulot JS, Konstam M, Lee RT, Linke WA, Lunde IG, Lyon AR, Maack C, Mann DL, Mebazaa A et al. (2019)
The continuous heart failure spectrum: moving beyond an ejection fraction classification
Eur Heart J, 40 (26), 2155-2163
DOI 10.1093/eurheartj/ehz158, PubMed 30957868

Udjus C, Cero FT, Halvorsen B, Behmen D, Carlson CR, Bendiksen BA, Espe EKS, Sjaastad I, Løberg EM, Yndestad A, Aukrust P, Christensen G, Skjønsberg OH, Larsen KO (2019)
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, 316 (6), L999-L1012
DOI 10.1152/ajplung.00322.2018, PubMed 30908936

Witczak BN, Hetlevik SO, Sanner H, Barth Z, Schwartz T, Flatø B, Lilleby V, Sjaastad I (2019)
Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study
J Rheumatol, 46 (7), 739-747
DOI 10.3899/jrheum.180526, PubMed 30877222

Wæhre A, Schorkopf M (2019)
Gender variance, medical treatment and our responsibility
Tidsskr Nor Laegeforen, 139 (7)
DOI 10.4045/tidsskr.19.0178, PubMed 30969045

Zeltz C, Primac I, Erusappan P, Alam J, Noel A, Gullberg D (2019)
Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
Semin Cancer Biol (in press)
DOI 10.1016/j.semcancer.2019.08.004, PubMed 31415910

Zhou KQ, Draghi V, Lear CA, Dean JM, Ashton JL, Hou Y, Bennet L, Gunn AJ, Davidson JO (2019)
Protection of axonal integrity with 48 or 72 h of cerebral hypothermia in near-term fetal sheep
Pediatr Res (in press)
DOI 10.1038/s41390-019-0475-8, PubMed 31234193

Zouein FA, Booz GW, Altara R (2019)
STAT3 and Endothelial Cell-Cardiomyocyte Dialog in Cardiac Remodeling
Front Cardiovasc Med, 6, 50
DOI 10.3389/fcvm.2019.00050, PubMed 31069236

Züchner M, Lervik A, Kondratskaya E, Bettembourg V, Zhang L, Haga HA, Boulland JL (2019)
Development of a Multimodal Apparatus to Generate Biomechanically Reproducible Spinal Cord Injuries in Large Animals
Front Neurol, 10, 223
DOI 10.3389/fneur.2019.00223, PubMed 30941086

 
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