Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2017 from OUS - Institute for Experimental Medical Research IEMR

47 publications found

Abraityte A, Lunde IG, Askevold ET, Michelsen AE, Christensen G, Aukrust P, Yndestad A, Fiane A, Andreassen A, Aakhus S, Dahl CP, Gullestad L, Broch K, Ueland T (2017)
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Sci Rep, 7 (1), 3490
DOI 10.1038/s41598-017-03625-9, PubMed 28615692

Abraityte A, Vinge LE, Askevold ET, Lekva T, Michelsen AE, Ranheim T, Alfsnes K, Fiane A, Aakhus S, Lunde IG, Dahl CP, Aukrust P, Christensen G, Gullestad L, Yndestad A, Ueland T (2017)
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J Mol Med (Berl), 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1, PubMed 28357477

Altara R, Giordano M, Nordén ES, Cataliotti A, Kurdi M, Bajestani SN, Booz GW (2017)
Targeting Obesity and Diabetes to Treat Heart Failure with Preserved Ejection Fraction
Front Endocrinol (Lausanne), 8, 160
DOI 10.3389/fendo.2017.00160, PubMed 28769873

Alvadia CM, Sommer T, Bjerregaard-Andersen K, Damkier HH, Montrasio M, Aalkjaer C, Morth JP (2017)
The crystal structure of the regulatory domain of the human sodium-driven chloride/bicarbonate exchanger
Sci Rep, 7 (1), 12131
DOI 10.1038/s41598-017-12409-0, PubMed 28935959

Aronsen JM, Espe EKS, Skårdal K, Hasic A, Zhang L, Sjaastad I (2017)
Noninvasive stratification of postinfarction rats based on the degree of cardiac dysfunction using magnetic resonance imaging and echocardiography
Am J Physiol Heart Circ Physiol, 312 (5), H932-H942
DOI 10.1152/ajpheart.00668.2016, PubMed 28188213

Berntsen KS, Tollisen A, Schwartz T, Kirkhus E, Aaløkken TM, Lund MB, Flatø B, Sjaastad I, Sanner H (2017)
Submaximal Exercise Capacity in Juvenile Dermatomyositis after Longterm Disease: The Contribution of Muscle, Lung, and Heart Involvement
J Rheumatol, 44 (6), 827-834
DOI 10.3899/jrheum.160997, PubMed 28365577

Chollet ME, Andersen E, Skarpen E, Myklebust CF, Koehler C, Morth JP, Chuansumrit A, Pinotti M, Bernardi F, Thiede B, Sandset PM, Skretting G (2017)
Factor VII deficiency: Unveiling the cellular and molecular mechanisms underlying three model alterations of the enzyme catalytic domain
Biochim Biophys Acta Mol Basis Dis, 1864 (3), 660-667
DOI 10.1016/j.bbadis.2017.12.016, PubMed 29246447

de Vries EMG, Färkkilä M, Milkiewicz P, Hov JR, Eksteen B, Thorburn D, Chazouillères O, Pares A, Nygård S, Gilja OH, Wunsch E, Invernizzi P, Carbone M, Bernuzzi F, Boberg KM, Røsjø H, Rosenberg W, Beuers UH, Ponsioen CY, Karlsen TH, Vesterhus M (2017)
Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
Liver Int, 37 (10), 1554-1561
DOI 10.1111/liv.13402, PubMed 28267887

Dhondup Y, Sjaastad I, Sandanger Ø, Aronsen JM, Ahmed MS, Attramadal H, Finsen AV, Zhang L, Ranheim T, Alfsnes K, Aukrust P, Christensen G, Yndestad A, Vinge LE (2017)
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediators Inflamm, 2017, 9450439
DOI 10.1155/2017/9450439, PubMed 28490840

Edwards AG, Louch WE (2017)
Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus
Clin Med Insights Cardiol, 11, 1179546816686061
DOI 10.1177/1179546816686061, PubMed 28469490

Espe EKS, Aronsen JM, Eriksen M, Sejersted OM, Zhang L, Sjaastad I (2017)
Regional Dysfunction After Myocardial Infarction in Rats
Circ Cardiovasc Imaging, 10 (9)
DOI 10.1161/CIRCIMAGING.116.005997, PubMed 28838960

Fuglerud BM, Lemma RB, Wanichawan P, Sundaram AYM, Eskeland R, Gabrielsen OS (2017)
A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function
Nucleic Acids Res, 45 (13), 7681-7696
DOI 10.1093/nar/gkx364, PubMed 28472346

Gattoni S, Røe ÅT, Aronsen JM, Sjaastad I, Louch WE, Smith NP, Niederer SA (2017)
Compensatory and decompensatory alterations in cardiomyocyte Ca2+ dynamics in hearts with diastolic dysfunction following aortic banding
J Physiol, 595 (12), 3867-3889
DOI 10.1113/JP273879, PubMed 28542952

Herum KM, Choppe J, Kumar A, Engler AJ, McCulloch AD (2017)
Mechanical regulation of cardiac fibroblast profibrotic phenotypes
Mol Biol Cell, 28 (14), 1871-1882
DOI 10.1091/mbc.E17-01-0014, PubMed 28468977

Herum KM, Lunde IG, McCulloch AD, Christensen G (2017)
The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart
J Clin Med, 6 (5)
DOI 10.3390/jcm6050053, PubMed 28534817

Hodne K, Lipsett DB, Louch WE (2017)
Gene Transfer in Isolated Adult Cardiomyocytes
Methods Mol Biol, 1521, 169-182
DOI 10.1007/978-1-4939-6588-5_11, PubMed 27910048

Holditch SJ, Schreiber CA, Harris PC, LaRusso NF, Ramirez-Alvarado M, Cataliotti A, Torres VE, Ikeda Y (2017)
B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease
Kidney Int, 92 (3), 657-668
DOI 10.1016/j.kint.2017.02.017, PubMed 28416225

Johansen IB, Sandblom E, Skov PV, Gräns A, Ekström A, Lunde IG, Vindas MA, Zhang L, Höglund E, Frisk M, Sjaastad I, Nilsson GE, Øverli Ø (2017)
Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids
J Exp Biol, 220 (Pt 14), 2545-2553
DOI 10.1242/jeb.135046, PubMed 28476893

Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A (2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
Cell Discov, 3, 17013
DOI 10.1038/celldisc.2017.13, PubMed 28529766

Lie ØH, Saberniak J, Dejgaard LA, Stokke MK, Hegbom F, Anfinsen OG, Edvardsen T, Haugaa KH (2017)
Lower than expected burden of premature ventricular contractions impairs myocardial function
ESC Heart Fail, 4 (4), 585-594
DOI 10.1002/ehf2.12180, PubMed 29154430

Lubelwana Hafver T, Wanichawan P, Manfra O, de Souza GA, Lunde M, Martinsen M, Louch WE, Sejersted OM, Carlson CR (2017)
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1)
Proteomics, 17 (17-18)
DOI 10.1002/pmic.201600417, PubMed 28755400

Lubner JM, Dodge-Kafka KL, Carlson CR, Church GM, Chou MF, Schwartz D (2017)
Cushing's syndrome mutant PKAL205R exhibits altered substrate specificity
FEBS Lett, 591 (3), 459-467
DOI 10.1002/1873-3468.12562, PubMed 28100013

Lyngbakken MN, Pervez MO, Brynildsen J, Pedersen MH, Sølvernes J, Christensen G, Høiseth AD, Omland T, Røsjø H (2017)
Fibroblast growth factor 23 in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study
Clin Biochem, 52, 41-47
DOI 10.1016/j.clinbiochem.2017.10.015, PubMed 29074091

Maleckar MM, Edwards AG, Louch WE, Lines GT (2017)
Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling
Clin Med Insights Cardiol, 11, 1179546817698602
DOI 10.1177/1179546817698602, PubMed 28469494

Manfra O, Frisk M, Louch WE (2017)
Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy
Curr Heart Fail Rep, 14 (3), 167-178
DOI 10.1007/s11897-017-0329-9, PubMed 28447290

Manner IW, Waldum-Grevbo B, Witczak BN, Bækken M, Øktedalen O, Os I, Schwartz T, Sjaastad I (2017)
Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients
Blood Press, 26 (6), 332-340
DOI 10.1080/08037051.2017.1346459, PubMed 28675304

Meier S, Andressen KW, Aronsen JM, Sjaastad I, Hougen K, Skomedal T, Osnes JB, Qvigstad E, Levy FO, Moltzau LR (2017)
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur J Pharmacol, 812, 174-183
DOI 10.1016/j.ejphar.2017.07.014, PubMed 28697992

Myhre PL, Stridsberg M, Linko R, Okkonen M, Nygård S, Christensen G, Pettilä V, Omland T, Røsjø H, FINNALI Study Group (2017)
Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study
Biomarkers, 22 (8), 775-781
DOI 10.1080/1354750X.2016.1269200, PubMed 28049363

Nolan JP, Soar J, Cariou A, Cronberg T, Moulaert VRM, Deakin C, Bottiger BW, Friberg H, Sunde K, Sandroni C (2017)
Post Resuscitation Care Section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015
Notfall Rettungsmed., 20 1, 90-117

Norum HM, Broch K, Michelsen AE, Lunde IG, Lekva T, Abraityte A, Dahl CP, Fiane AE, Andreassen AK, Christensen G, Aakhus S, Aukrust P, Gullestad L, Ueland T (2017)
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy
J Cardiovasc Transl Res, 10 (4), 401-410
DOI 10.1007/s12265-017-9748-y, PubMed 28474304

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262

Ottesen AH, Carlson CR, Louch WE, Dahl MB, Sandbu RA, Johansen RF, Jarstadmarken H, Bjørås M, Høiseth AD, Brynildsen J, Sjaastad I, Stridsberg M, Omland T, Christensen G, Røsjø H (2017)
Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis
Circ Heart Fail, 10 (2)
DOI 10.1161/CIRCHEARTFAILURE.116.003675, PubMed 28209766

Ottesen AH, Christensen G, Omland T, Røsjø H (2017)
Glycosylated Chromogranin A: Potential Role in the Pathogenesis of Heart Failure
Curr Heart Fail Rep, 14 (6), 478-488
DOI 10.1007/s11897-017-0360-x, PubMed 28975588

Parikh SS, Blackwell DJ, Gomez-Hurtado N, Frisk M, Wang L, Kim K, Dahl CP, Fiane A, Tønnessen T, Kryshtal DO, Louch WE, Knollmann BC (2017)
Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Circ Res, 121 (12), 1323-1330
DOI 10.1161/CIRCRESAHA.117.311920, PubMed 28974554

Pervez MO, Lyngbakken MN, Myhre PL, Brynildsen J, Langsjøen EC, Høiseth AD, Christensen G, Omland T, Røsjø H (2017)
Mid-regional pro-adrenomedullin in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study
Clin Biochem, 50 (7-8), 394-400
DOI 10.1016/j.clinbiochem.2016.12.010, PubMed 28065681

Roe AT, Sjaastad I, Louch WE (2017)
Heart failure with preserved ejection fraction
Tidsskr. Nor. Laegeforen., 137 (18), 1426-1431

Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Bendiksen B, Robinson EL, Aronsen JM, Herum KM, Danielsen HE, Sjaastad I, Christensen G, Gullberg D (2017)
Overexpression of integrin α11 induces cardiac fibrosis in mice
Acta Physiol (Oxf), 222 (2)
DOI 10.1111/apha.12932, PubMed 28771943

Rutkovskiy A, Sagave J, Czibik G, Baysa A, Zihlavnikova Enayati K, Hillestad V, Dahl CP, Fiane A, Gullestad L, Gravning J, Ahmed S, Attramadal H, Valen G, Vaage J (2017)
Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans
Scand J Clin Lab Invest, 77 (5), 321-331
DOI 10.1080/00365513.2017.1318447, PubMed 28460577

Røe ÅT, Aronsen JM, Skårdal K, Hamdani N, Linke WA, Danielsen HE, Sejersted OM, Sjaastad I, Louch WE (2017)
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Cardiovasc Res, 113 (10), 1161-1172
DOI 10.1093/cvr/cvx087, PubMed 28472418

Røe ÅT, Sjaastad I, Louch WE (2017)
Heart failure with preserved ejection fraction
Tidsskr Nor Laegeforen, 137 (18)
DOI 10.4045/tidsskr.16.1068, PubMed 28972354

Soeller C, Hou Y, Jayasinghe ID, Baddeley D, Crossman D (2017)
Correlative Single-Molecule Localization Microscopy and Confocal Microscopy
Methods Mol Biol, 1663, 205-217
DOI 10.1007/978-1-4939-7265-4_17, PubMed 28924670

Thorsen K, Dam VS, Kjaer-Sorensen K, Pedersen LN, Skeberdis VA, Jurevičius J, Treinys R, Petersen IMBS, Nielsen MS, Oxvig C, Morth JP, Matchkov VV, Aalkjær C, Bundgaard H, Jensen HK (2017)
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Nat Commun, 8 (1), 1696
DOI 10.1038/s41467-017-01630-0, PubMed 29167417

van Bilsen M, Patel HC, Bauersachs J, Böhm M, Borggrefe M, Brutsaert D, Coats AJS, de Boer RA, de Keulenaer GW, Filippatos GS, Floras J, Grassi G, Jankowska EA, Kornet L, Lunde IG, Maack C, Mahfoud F, Pollesello P, Ponikowski P, Ruschitzka F, Sabbah HN, Schultz HD, Seferovic P, Slart RHJA, Taggart P et al. (2017)
The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology
Eur J Heart Fail, 19 (11), 1361-1378
DOI 10.1002/ejhf.921, PubMed 28949064

Vesterhus M, Holm A, Hov JR, Nygård S, Schrumpf E, Melum E, Thorbjørnsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJLB, Vatn M, Schaap FG, Jansen PLM, Ueland T, Røsjø H, Moum B, Ponsioen CY, Boberg KM, Färkkilä M, Karlsen TH, Lund-Johansen F (2017)
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J Hepatol, 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472

Vistnes M, Tapia G, Mårild K, Midttun Ø, Ueland PM, Viken MK, Magnus P, Berg JP, Gillespie KM, Skrivarhaug T, Njølstad PR, Joner G, Størdal K, Stene LC (2017)
Plasma immunological markers in pregnancy and cord blood: A possible link between macrophage chemo-attractants and risk of childhood type 1 diabetes
Am J Reprod Immunol, 79 (3)
DOI 10.1111/aji.12802, PubMed 29266506

Weber JJ, Golla M, Guaitoli G, Wanichawan P, Hayer SN, Hauser S, Krahl AC, Nagel M, Samer S, Aronica E, Carlson CR, Schöls L, Riess O, Gloeckner CJ, Nguyen HP, Hübener-Schmid J (2017)
A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3
Brain, 140 (5), 1280-1299
DOI 10.1093/brain/awx039, PubMed 28334907

Winther JA, Brynildsen J, Høiseth AD, Strand H, Følling I, Christensen G, Nygård S, Røsjø H, Omland T (2017)
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study
Respir Res, 18 (1), 184
DOI 10.1186/s12931-017-0665-z, PubMed 29100503

 
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