Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Institute for Cancer Genetics and Informatics

31 publications found

Bindesbøll C, Aas A, Ogmundsdottir MH, Pankiv S, Reine T, Zoncu R, Simonsen A (2020)
NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease
Sci Rep, 10 (1), 4528
DOI 10.1038/s41598-020-61352-0, PubMed 32161285

Blindheim A, Fosså S, Babigumira R, Myklebust TÅ, Haug E, Arum CJ, Andreassen BK (2020)
T1 bladder cancer in Norway: treatment and survival
Scand J Urol
DOI 10.1080/21681805.2020.1803401, PubMed 32783590

Brandal P, Bergfeldt K, Aggerholm-Pedersen N, Bäckström G, Kerna I, Gubanski M, Björnlinger K, Evensen ME, Kuddu M, Pettersson E, Brydøy M, Hellebust TP, Dale E, Valdman A, Weber L, Høyer M (2020)
A Nordic-Baltic perspective on indications for proton therapy with strategies for identification of proper patients
Acta Oncol
DOI 10.1080/0284186X.2020.1817977, PubMed 32902341

Brunetti M, Panagopoulos I, Kostolomov I, Davidson B, Heim S, Micci F (2020)
Mutation analysis and genomic imbalances of cells found in effusion fluids from patients with ovarian cancer
Oncol Lett, 20 (3), 2273-2279
DOI 10.3892/ol.2020.11782, PubMed 32782545

Davidson B, McFadden E, Holth A, Brunetti M, Flørenes VA (2020)
Death domain-associated protein (DAXX) expression is associated with poor survival in metastatic high-grade serous carcinoma
Virchows Arch
DOI 10.1007/s00428-020-02842-4, PubMed 32533344

Ersvaer E, Hveem TS, Vlatkovic L, Brennhovd B, Kleppe A, Tobin KAR, Pradhan M, Cyll K, Waehre H, Kerr DJ, Danielsen HE (2020)
Prognostic value of DNA ploidy and automated assessment of stroma fraction in prostate cancer
Int J Cancer, 147 (4), 1228-1234
DOI 10.1002/ijc.32832, PubMed 31846064

Ferrante L, Opdal SH, Nygård S, Vege Å, Rognum TO (2020)
Gene expression profile in cases of infectious death in infancy
Pediatr Res
DOI 10.1038/s41390-020-0896-4, PubMed 32299088

Fjeldbo CS, Hompland T, Hillestad T, Aarnes EK, Günther CC, Kristensen GB, Malinen E, Lyng H (2020)
Combining imaging- and gene-based hypoxia biomarkers in cervical cancer improves prediction of chemoradiotherapy failure independent of intratumour heterogeneity
EBioMedicine, 57, 102841
DOI 10.1016/j.ebiom.2020.102841, PubMed 32580139

Gorunova L, Bjerkehagen B, Micci F, Heim S, Panagopoulos I (2020)
Cytogenetic and Molecular Study of an Adult Sclerosing Rhabdomyosarcoma of the Extremity: MYOD1-mutation and Clonal Evolution
Cancer Genomics Proteomics, 17 (5), 563-569
DOI 10.21873/cgp.20212, PubMed 32859634

Hillestad T, Hompland T, Fjeldbo CS, Skingen VE, Salberg UB, Aarnes EK, Nilsen A, Lund KV, Evensen TS, Kristensen GB, Stokke T, Lyng H (2020)
MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer
Cancer Res, 80 (18), 3993-4003
DOI 10.1158/0008-5472.CAN-20-0950, PubMed 32606004

Jeanmougin M, Håvik AB, Cekaite L, Brandal P, Sveen A, Meling TR, Ågesen TH, Scheie D, Heim S, Lothe RA, Lind GE (2020)
Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
Mol Oncol, 14 (5), 1016-1027
DOI 10.1002/1878-0261.12668, PubMed 32171051

Jin Y, Saatcioglu F (2020)
Targeting the Unfolded Protein Response in Hormone-Regulated Cancers
Trends Cancer, 6 (2), 160-171
DOI 10.1016/j.trecan.2019.12.001, PubMed 32061305

Kierulf-Vieira KS, Sandberg CJ, Waaler J, Lund K, Skaga E, Saberniak BM, Panagopoulos I, Brandal P, Krauss S, Langmoen IA, Vik-Mo EO (2020)
A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061630, PubMed 32575464

Liu MS, Zhao H, Xu CX, Xie PB, Wang W, Yang YY, Lee WH, Jin Y, Zhou HQ (2020)
Clinical significance of EPHX2 deregulation in prostate cancer
Asian J Androl (in press)
DOI 10.4103/aja.aja_34_20, PubMed 32687069

Lund KV, Simonsen TG, Kristensen GB, Rofstad EK (2020)
DCE-MRI of locally-advanced carcinoma of the uterine cervix: Tofts analysis versus non-model-based analyses
Radiat Oncol, 15 (1), 79
DOI 10.1186/s13014-020-01526-2, PubMed 32293487

Monk BJ, Grisham RN, Banerjee S, Kalbacher E, Mirza MR, Romero I, Vuylsteke P, Coleman RL, Hilpert F, Oza AM, Westermann A, Oehler MK, Pignata S, Aghajanian C, Colombo N, Drill E, Cibula D, Moore KN, Christy-Bittel J, Del Campo JM, Berger R, Marth C, Sehouli J, O'Malley DM, Churruca C et al. (2020)
MILO/ENGOT-ov11: Binimetinib Versus Physician's Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum
J Clin Oncol, JCO2001164 (in press)
DOI 10.1200/JCO.20.01164, PubMed 32822286

Norell CH, Butler J, Farrell R, Altman A, Bentley J, Cabasag CJ, Cohen PA, Fegan S, Fung-Kee-Fung M, Gourley C, Hacker NF, Hanna L, Høgdall CK, Kristensen G, Kwon J, McNally O, Nelson G, Nordin A, O'Donnell D, Schnack T, Sykes PH, Zotow E, Harrison S (2020)
Exploring international differences in ovarian cancer treatment: a comparison of clinical practice guidelines and patterns of care
Int J Gynecol Cancer (in press)
DOI 10.1136/ijgc-2020-001403, PubMed 32784203

Panagopoulos I, Gorunova L, Andersen K, Lobmaier I, Lund-Iversen M, Micci F, Heim S (2020)
Fusion of the Lumican (LUM) Gene With the Ubiquitin Specific Peptidase 6 (USP6) Gene in an Aneurysmal Bone Cyst Carrying a t(12;17)(q21;p13) Chromosome Translocation
Cancer Genomics Proteomics, 17 (5), 555-561
DOI 10.21873/cgp.20211, PubMed 32859633

Panagopoulos I, Gorunova L, Andersen K, Lund-Iversen M, Lobmaier I, Micci F, Heim S (2020)
NDRG1-PLAG1 and TRPS1-PLAG1 Fusion Genes in Chondroid Syringoma
Cancer Genomics Proteomics, 17 (3), 237-248
DOI 10.21873/cgp.20184, PubMed 32345665

Panagopoulos I, Gorunova L, Andersen K, Tafjord S, Lund-Iversen M, Lobmaier I, Micci F, Heim S (2020)
Recurrent Fusion of the GRB2 Associated Binding Protein 1 (GAB1) Gene With ABL Proto-oncogene 1 (ABL1) in Benign Pediatric Soft Tissue Tumors
Cancer Genomics Proteomics, 17 (5), 499-508
DOI 10.21873/cgp.20206, PubMed 32859628

Panagopoulos I, Gorunova L, Johannsdottir IMR, Andersen K, Holth A, Beiske K, Heim S (2020)
Chromosome Translocation t(14;21)(q11;q22) Activates Both OLIG1 and OLIG2 in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis
Cancer Genomics Proteomics, 17 (1), 41-48
DOI 10.21873/cgp.20166, PubMed 31882550

Panagopoulos I, Gorunova L, Kostolomov I, Lobmaier I, Bjerkehagen B, Heim S (2020)
Chronic Expanding Hematoma with a t(11;19)(q13;q13) Chromosomal Translocation
Anticancer Res, 40 (1), 97-100
DOI 10.21873/anticanres.13930, PubMed 31892557

Panagopoulos I, Gorunova L, Lobmaier I, Andersen K, Kostolomov I, Lund-Iversen M, Bjerkehagen B, Heim S (2020)
FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma
Cancer Genomics Proteomics, 17 (2), 161-168
DOI 10.21873/cgp.20176, PubMed 32108038

Panagopoulos I, Gorunova L, Lobmaier I, Andersen K, Lund-Iversen M, Micci F, Heim S (2020)
Fusion of the COL4A5 Gene With NR2F2-AS1 in a Hemangioma Carrying a t(X;15)(q22;q26) Chromosomal Translocation
Cancer Genomics Proteomics, 17 (4), 383-390
DOI 10.21873/cgp.20197, PubMed 32576583

Panagopoulos I, Gorunova L, Rise TV, Andersen K, Micci F, Heim S (2020)
An Unbalanced Chromosome Translocation Between 7p22 and 12q13 Leads to ACTB-GLI1 Fusion in Pericytoma
Anticancer Res, 40 (3), 1239-1245
DOI 10.21873/anticanres.14065, PubMed 32132020

Skeie M, Nikolaysen F, Chitano Y, Stang E (2020)
Hsp90 inhibition and co-incubation with pertuzumab induce internalization and degradation of trastuzumab: Implications for use of T-DM1
J Cell Mol Med
DOI 10.1111/jcmm.15643, PubMed 32672902

Skrede OJ, De Raedt S, Kleppe A, Hveem TS, Liestøl K, Maddison J, Askautrud HA, Pradhan M, Nesheim JA, Albregtsen F, Farstad IN, Domingo E, Church DN, Nesbakken A, Shepherd NA, Tomlinson I, Kerr R, Novelli M, Kerr DJ, Danielsen HE (2020)
Deep learning for prediction of colorectal cancer outcome: a discovery and validation study
Lancet, 395 (10221), 350-360
DOI 10.1016/S0140-6736(19)32998-8, PubMed 32007170

Stadskleiv K, Stensvold E, Stokka K, Bechensteen AG, Brandal P (2020)
Neuropsychological functioning in survivors of childhood medulloblastoma/CNS-PNET: The role of secondary medical complications
Clin Neuropsychol
DOI 10.1080/13854046.2020.1794045, PubMed 32729777

Stensvold E, Stadskleiv K, Myklebust TÅ, Wesenberg F, Helseth E, Bechensteen AG, Brandal P (2020)
Unmet rehabilitation needs in 86% of Norwegian paediatric embryonal brain tumour survivors
Acta Paediatr, 109 (9), 1875-1886
DOI 10.1111/apa.15188, PubMed 31977119

Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C (2020)
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol, 22 (7), 856-867
DOI 10.1038/s41556-020-0537-5, PubMed 32601372

Zhang T, Li N, Sun C, Jin Y, Sheng X (2020)
MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?
EMBO Mol Med, 12 (5), e11845
DOI 10.15252/emmm.201911845, PubMed 32310340

 
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