Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2017 from OUS - Institute for Cancer Genetics and Informatics

45 publications found

Agostini A, Brunetti M, Davidson B, Tropé CG, Heim S, Panagopoulos I, Micci F (2017)
Genomic imbalances are involved in miR-30c and let-7a deregulation in ovarian tumors: implications for HMGA2 expression
Oncotarget, 8 (13), 21554-21560
DOI 10.18632/oncotarget.15795, PubMed 28423547

Andreassen BK, Myklebust TÅ, Haug ES (2017)
Crude mortality and loss of life expectancy of patients diagnosed with urothelial carcinoma of the urinary bladder in Norway
Scand J Urol, 51 (1), 38-43
DOI 10.1080/21681805.2016.1271354, PubMed 28084860

Brunetti M, Agostini A, Davidson B, Tropé CG, Heim S, Panagopoulos I, Micci F (2017)
Recurrent fusion transcripts in squamous cell carcinomas of the vulva
Oncotarget, 8 (10), 16843-16850
DOI 10.18632/oncotarget.15167, PubMed 28186972

Brunetti M, Panagopoulos I, Gorunova L, Davidson B, Heim S, Micci F (2017)
RNA-sequencing identifies novel GREB1-NCOA2 fusion gene in a uterine sarcoma with the chromosomal translocation t(2;8)(p25;q13)
Genes Chromosomes Cancer, 57 (4), 176-181
DOI 10.1002/gcc.22518, PubMed 29218853

Braadland PR, Giskeødegård G, Sandsmark E, Bertilsson H, Euceda LR, Hansen AF, Guldvik IJ, Selnæs KM, Grytli HH, Katz B, Svindland A, Bathen TF, Eri LM, Nygård S, Berge V, Taskén KA, Tessem MB (2017)
Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy
Br J Cancer, 117 (11), 1656-1664
DOI 10.1038/bjc.2017.346, PubMed 28972967

Cyll K, Ersvær E, Vlatkovic L, Pradhan M, Kildal W, Avranden Kjær M, Kleppe A, Hveem TS, Carlsen B, Gill S, Löffeler S, Haug ES, Wæhre H, Sooriakumaran P, Danielsen HE (2017)
Tumour heterogeneity poses a significant challenge to cancer biomarker research
Br J Cancer, 117 (3), 367-375
DOI 10.1038/bjc.2017.171, PubMed 28618431

Davidson B, Hellesylt E, Holth A, Danielsen HE, Skeie-Jensen T, Katz B (2017)
Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma
Virchows Arch, 471 (3), 355-362
DOI 10.1007/s00428-017-2172-5, PubMed 28643014

Davidson B, Micci F (2017)
Molecular characteristics of uterine sarcomas
Expert Rev Mol Diagn, 17 (5), 515-522
DOI 10.1080/14737159.2017.1311790, PubMed 28335657

de Vries EMG, Färkkilä M, Milkiewicz P, Hov JR, Eksteen B, Thorburn D, Chazouillères O, Pares A, Nygård S, Gilja OH, Wunsch E, Invernizzi P, Carbone M, Bernuzzi F, Boberg KM, Røsjø H, Rosenberg W, Beuers UH, Ponsioen CY, Karlsen TH, Vesterhus M (2017)
Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
Liver Int, 37 (10), 1554-1561
DOI 10.1111/liv.13402, PubMed 28267887

Domanska D, Vodák D, Lund-Andersen C, Salvatore S, Hovig E, Sandve GK (2017)
The rainfall plot: its motivation, characteristics and pitfalls
BMC Bioinformatics, 18 (1), 264
DOI 10.1186/s12859-017-1679-8, PubMed 28521741

Helland Å, Brustugun OT, Nakken S, Halvorsen AR, Dønnem T, Bremnes R, Busund LT, Sun J, Lorenz S, Solberg SK, Jørgensen LH, Vodak D, Myklebost O, Hovig E, Meza-Zepeda LA (2017)
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival
Int J Cancer, 141 (1), 184-190
DOI 10.1002/ijc.30726, PubMed 28387924

Jin Y, Nenseth HZ, Saatcioglu F (2017)
Role of PLZF as a tumor suppressor in prostate cancer
Oncotarget, 8 (41), 71317-71324
DOI 10.18632/oncotarget.19813, PubMed 29050363

Kildal W, Pradhan M, Cyll K, Jacobsen JE, Kristensen GB, Danielsen HE (2017)
Characteristics of tumor cell DNA affect prognosis
Tidsskr. Nor. Laegeforen., 137 (19), 1519-1523

Kildal W, Pradhan M, Cyll K, Jacobsen JE, Kristensen GB, Danielsen HE (2017)
[Properties of cancer cell DNA affects the prognosis]
Tidsskr Nor Laegeforen, 137 (19)
DOI 10.4045/tidsskr.16.0966, PubMed 29043733

Lewis N, Soslow RA, Delair DF, Park KJ, Murali R, Hollmann TJ, Davidson B, Micci F, Panagopoulos I, Hoang LN, Arias-Stella JA, Oliva E, Young RH, Hensley ML, Leitao MM, Hameed M, Benayed R, Ladanyi M, Frosina D, Jungbluth AA, Antonescu CR, Chiang S (2017)
ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity
Mod Pathol, 31 (4), 674-684
DOI 10.1038/modpathol.2017.162, PubMed 29192652

Lindemann K, Gibbs E, Åvall-Lundqvist E, dePont Christensen R, Woie K, Kalling M, Auranen A, Grenman S, Hoegberg T, Rosenberg P, Skeie-Jensen T, Hjerpe E, Dørum A, Gebski V, Kristensen G (2017)
Chemotherapy vs tamoxifen in platinum-resistant ovarian cancer: a phase III, randomised, multicentre trial (Ovaresist)
Br J Cancer, 116 (4), 455-463
DOI 10.1038/bjc.2016.435, PubMed 28118323

López-García C, Sansregret L, Domingo E, McGranahan N, Hobor S, Birkbak NJ, Horswell S, Grönroos E, Favero F, Rowan AJ, Matthews N, Begum S, Phillimore B, Burrell R, Oukrif D, Spencer-Dene B, Kovac M, Stamp G, Stewart A, Danielsen H, Novelli M, Tomlinson I, Swanton C (2017)
BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer
Cancer Cell, 31 (1), 79-93
DOI 10.1016/j.ccell.2016.11.001, PubMed 28073006

Lund KV, Simonsen TG, Kristensen GB, Rofstad EK (2017)
Pretreatment late-phase DCE-MRI predicts outcome in locally advanced cervix cancer
Acta Oncol, 56 (5), 675-681
DOI 10.1080/0284186X.2017.1294762, PubMed 28447564

Meisal R, Rounge TB, Christiansen IK, Eieland AK, Worren MM, Molden TF, Kommedal Ø, Hovig E, Leegaard TM, Ambur OH (2017)
HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization
PLoS One, 12 (1), e0169074
DOI 10.1371/journal.pone.0169074, PubMed 28045981

Micci F, Brunetti M, Dal Cin P, Nucci MR, Gorunova L, Heim S, Panagopoulos I (2017)
Fusion of the genes BRD8 and PHF1 in endometrial stromal sarcoma
Genes Chromosomes Cancer, 56 (12), 841-845
DOI 10.1002/gcc.22485, PubMed 28758277

Møller P, Seppälä TT, Bernstein I, Holinski-Feder E, Sala P, Gareth Evans D, Lindblom A, Macrae F, Blanco I, Sijmons RH, Jeffries J, Vasen HFA, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen JT, Jenkins MA, Green K, Lalloo F, Sunde L, Mints M et al. (2017)
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
Gut, 67 (7), 1306-1316
DOI 10.1136/gutjnl-2017-314057, PubMed 28754778

Namløs HM, Zaikova O, Bjerkehagen B, Vodák D, Hovig E, Myklebost O, Boye K, Meza-Zepeda LA (2017)
Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report
BMC Cancer, 17 (1), 29
DOI 10.1186/s12885-016-2992-8, PubMed 28061772

Ooi J, Wilson P, Walker G, Blaker P, DeMartino S, O'Donohue J, Reffitt D, Lanaspre E, Chang F, Meenan J, Dunn JM (2017)
Dedicated Barrett's surveillance sessions managed by trained endoscopists improve dysplasia detection rate
Endoscopy, 49 (6), 524-528
DOI 10.1055/s-0043-103410, PubMed 28399610

Panagopoulos I, Gorunova L, Bjerkehagen B, Andersen K, Lund-Iversen M, Heim S (2017)
Loss of chromosome 13 material in cellular angiofibromas indicates pathogenetic similarity with spindle cell lipomas
Diagn Pathol, 12 (1), 17
DOI 10.1186/s13000-017-0607-6, PubMed 28193293

Panagopoulos I, Gorunova L, Brunetti M, Agostini A, Andersen HK, Lobmaier I, Bjerkehagen B, Heim S (2017)
Genetic heterogeneity in leiomyomas of deep soft tissue
Oncotarget, 8 (30), 48769-48781
DOI 10.18632/oncotarget.17953, PubMed 28591699

Panagopoulos I, Gorunova L, Lobmaier I, Andersen HK, Bjerkehagen B, Heim S (2017)
Cytogenetic Analysis of a Pseudoangiomatous Pleomorphic/Spindle Cell Lipoma
Anticancer Res, 37 (5), 2219-2223
DOI 10.21873/anticanres.11557, PubMed 28476785

Panagopoulos I, Gorunova L, Lobmaier I, Bjerkehagen B, Heim S (2017)
Identification of SETD2-NF1 fusion gene in a pediatric spindle cell tumor with the chromosomal translocation t(3;17)(p21;q12)
Oncol Rep, 37 (6), 3181-3188
DOI 10.3892/or.2017.5628, PubMed 28498454

Panagopoulos I, Gorunova L, Lobmaier I, Bjerkehagen B, Heim S (2017)
Karyotyping and analysis of GNAS locus in intramuscular myxomas
Oncotarget, 8 (13), 22086-22094
DOI 10.18632/oncotarget.14986, PubMed 28160572

Panagopoulos I, Gorunova L, Spetalen S, Bassarova A, Beiske K, Micci F, Heim S (2017)
Fusion of the genes ataxin 2 like, ATXN2L, and Janus kinase 2, JAK2, in cutaneous CD4 positive T-cell lymphoma
Oncotarget, 8 (61), 103775-103784
DOI 10.18632/oncotarget.21790, PubMed 29262599

Panagopoulos I, Gorunova L, Torkildsen S, Tierens A, Heim S, Micci F (2017)
FAM53B truncation caused by t(10;19)(q26;q13) chromosome translocation in acute lymphoblastic leukemia
Oncol Lett, 13 (4), 2216-2220
DOI 10.3892/ol.2017.5705, PubMed 28454383

Panagopoulos I, Gorunova L, Torkildsen S, Tjønnfjord GE, Micci F, Heim S (2017)
DEK-NUP214-Fusion Identified by RNA-Sequencing of an Acute Myeloid Leukemia with t(9;12)(q34;q15)
Cancer Genomics Proteomics, 14 (6), 437-443
DOI 10.21873/cgp.20053, PubMed 29109093

Proctor L, Pradhan M, Leung S, Cheng A, Lee CH, Soslow RA, Gilks CB, Talhouk A, McAlpine JM, Danielsen HE, Hoang LN (2017)
Assessment of DNA Ploidy in the ProMisE molecular subgroups of endometrial cancer
Gynecol Oncol, 146 (3), 596-602
DOI 10.1016/j.ygyno.2017.06.020, PubMed 28647100

Ray-Coquard I, Trama A, Seckl MJ, Fotopoulou C, Pautier P, Pignata S, Kristensen G, Mangili G, Falconer H, Massuger L, Sehouli J, Pujade-Lauraine E, Lorusso D, Amant F, Rokkones E, Vergote I, Ledermann JA, RARECARENet Working Group (2017)
Rare ovarian tumours: Epidemiology, treatment challenges in and outside a network setting
Eur J Surg Oncol (in press)
DOI 10.1016/j.ejso.2017.09.025, PubMed 29108961

Ree AH, Russnes HG, Heinrich D, Dueland S, Boye K, Nygaard V, Silwal-Pandit L, Østrup O, Hovig E, Nygaard V, Rødland EA, Nakken S, Øien JT, Johansen C, Bergheim IR, Skarpeteig V, Sathermugathevan M, Sauer T, Lund-Iversen M, Beiske K, Nasser S, Julsrud L, Reisse CH, Ruud EA, Flørenes VA et al. (2017)
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate
ESMO Open, 2 (2), e000158
DOI 10.1136/esmoopen-2017-000158, PubMed 28761742

Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Bendiksen B, Robinson EL, Aronsen JM, Herum KM, Danielsen HE, Sjaastad I, Christensen G, Gullberg D (2017)
Overexpression of integrin α11 induces cardiac fibrosis in mice
Acta Physiol (Oxf), 222 (2)
DOI 10.1111/apha.12932, PubMed 28771943

Rossi BM, Palmero EI, López-Kostner F, Sarroca C, Vaccaro CA, Spirandelli F, Ashton-Prolla P, Rodriguez Y, de Campos Reis Galvão H, Reis RM, Escremim de Paula A, Capochin Romagnolo LG, Alvarez K, Della Valle A, Neffa F, Kalfayan PG, Spirandelli E, Chialina S, Gutiérrez Angulo M, Castro-Mujica MDC, Sanchez de Monte J, Quispe R, da Silva SD, Rossi NT, Barletta-Carrillo C et al. (2017)
A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America
BMC Cancer, 17 (1), 623
DOI 10.1186/s12885-017-3599-4, PubMed 28874130

Røe ÅT, Aronsen JM, Skårdal K, Hamdani N, Linke WA, Danielsen HE, Sejersted OM, Sjaastad I, Louch WE (2017)
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Cardiovasc Res, 113 (10), 1161-1172
DOI 10.1093/cvr/cvx087, PubMed 28472418

Seppälä T, Pylvänäinen K, Evans DG, Järvinen H, Renkonen-Sinisalo L, Bernstein I, Holinski-Feder E, Sala P, Lindblom A, Macrae F, Blanco I, Sijmons R, Jeffries J, Vasen H, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen J, Jenkins M, Genuardi M, Green K et al. (2017)
Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report
Hered Cancer Clin Pract, 15, 18
DOI 10.1186/s13053-017-0078-5, PubMed 29046738

Simovski B, Vodák D, Gundersen S, Domanska D, Azab A, Holden L, Holden M, Grytten I, Rand K, Drabløs F, Johansen M, Mora A, Lund-Andersen C, Fromm B, Eskeland R, Gabrielsen OS, Ferkingstad E, Nakken S, Bengtsen M, Nederbragt AJ, Thorarensen HS, Akse JA, Glad I, Hovig E, Sandve GK (2017)
GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome
Gigascience, 6 (7), 1-12
DOI 10.1093/gigascience/gix032, PubMed 28459977

Smebye ML, Agostini A, Johannessen B, Thorsen J, Davidson B, Tropé CG, Heim S, Skotheim RI, Micci F (2017)
Involvement of DPP9 in gene fusions in serous ovarian carcinoma
BMC Cancer, 17 (1), 642
DOI 10.1186/s12885-017-3625-6, PubMed 28893231

Torkildsen S, Brunetti M, Gorunova L, Spetalen S, Beiske K, Heim S, Panagopoulos I (2017)
Rearrangement of the Chromatin Organizer Special AT-rich Binding Protein 1 Gene, SATB1, Resulting from a t(3;5)(p24;q14) Chromosomal Translocation in Acute Myeloid Leukemia
Anticancer Res, 37 (2), 693-698
DOI 10.21873/anticanres.11365, PubMed 28179318

Urbanucci A, Barfeld SJ, Kytölä V, Itkonen HM, Coleman IM, Vodák D, Sjöblom L, Sheng X, Tolonen T, Minner S, Burdelski C, Kivinummi KK, Kohvakka A, Kregel S, Takhar M, Alshalalfa M, Davicioni E, Erho N, Lloyd P, Karnes RJ, Ross AE, Schaeffer EM, Vander Griend DJ, Knapp S, Corey E et al. (2017)
Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
Cell Rep, 19 (10), 2045-2059
DOI 10.1016/j.celrep.2017.05.049, PubMed 28591577

Vesterhus M, Holm A, Hov JR, Nygård S, Schrumpf E, Melum E, Thorbjørnsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJLB, Vatn M, Schaap FG, Jansen PLM, Ueland T, Røsjø H, Moum B, Ponsioen CY, Boberg KM, Färkkilä M, Karlsen TH, Lund-Johansen F (2017)
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J Hepatol, 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472

Vistad I, Bjørge L, Solheim O, Fiane B, Sachse K, Tjugum J, Skrøppa S, Bentzen AG, Stokstad T, Iversen GA, Salvesen HB, Kristensen GB, Dørum A (2017)
A national, prospective observational study of first recurrence after primary treatment for gynecological cancer in Norway
Acta Obstet Gynecol Scand, 96 (10), 1162-1169
DOI 10.1111/aogs.13199, PubMed 28795770

Winther JA, Brynildsen J, Høiseth AD, Strand H, Følling I, Christensen G, Nygård S, Røsjø H, Omland T (2017)
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study
Respir Res, 18 (1), 184
DOI 10.1186/s12931-017-0665-z, PubMed 29100503

 
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