Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2014 from OUS - Institute for Cancer Genetics and Informatics

41 publications found

Amant F, Floquet A, Friedlander M, Kristensen G, Mahner S, Nam EJ, Powell MA, Ray-Coquard I, Siddiqui N, Sykes P, Westermann AM, Seddon B (2014)
Gynecologic Cancer InterGroup (GCIG) consensus review for endometrial stromal sarcoma
Int J Gynecol Cancer, 24 (9 Suppl 3), S67-72
DOI 10.1097/IGC.0000000000000205, PubMed 25033257

Chilamakuri CS, Lorenz S, Madoui MA, Vodák D, Sun J, Hovig E, Myklebost O, Meza-Zepeda LA (2014)
Performance comparison of four exome capture systems for deep sequencing
BMC Genomics, 15, 449
DOI 10.1186/1471-2164-15-449, PubMed 24912484

Clancy T, Hovig E (2014)
Differential protein network analysis of the immune cell lineage
Biomed Res Int, 2014, 363408
DOI 10.1155/2014/363408, PubMed 25309909

Clancy T, Hovig E (2014)
From proteomes to complexomes in the era of systems biology
Proteomics, 14 (1), 24-41
DOI 10.1002/pmic.201300230, PubMed 24243660

Friedlander ML, Covens A, Glasspool RM, Hilpert F, Kristensen G, Kwon S, Selle F, Small W, Witteveen E, Russell P (2014)
Gynecologic Cancer InterGroup (GCIG) consensus review for mullerian adenosarcoma of the female genital tract
Int J Gynecol Cancer, 24 (9 Suppl 3), S78-82
DOI 10.1097/IGC.0000000000000239, PubMed 25341585

Haugvik SP, Gorunova L, Haugom L, Eibak AM, Gladhaug IP, Heim S, Micci F (2014)
Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms
Oncol Rep, 32 (3), 906-12
DOI 10.3892/or.2014.3328, PubMed 25018013

Heim S (2014)
Boveri at 100: Boveri, chromosomes and cancer
J Pathol, 234 (2), 138-41
DOI 10.1002/path.4406, PubMed 25043504

Hillestad V, Espe EK, Cero F, Larsen KO, Sjaastad I, Nygård S, Skjønsberg OH, Christensen G (2014)
IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice
Acta Physiol (Oxf), 213 (2), 492-504
DOI 10.1111/apha.12376, PubMed 25182570

Hompland T, Lund KV, Ellingsen C, Kristensen GB, Rofstad EK (2014)
Peritumoral interstitial fluid flow velocity predicts survival in cervical carcinoma
Radiother Oncol, 113 (1), 132-8
DOI 10.1016/j.radonc.2014.09.011, PubMed 25443501

Hveem TS, Merok MA, Pretorius ME, Novelli M, Bævre MS, Sjo OH, Clinch N, Liestøl K, Svindland A, Lothe RA, Nesbakken A, Danielsen HE (2014)
Prognostic impact of genomic instability in colorectal cancer
Br J Cancer, 110 (8), 2159-64
DOI 10.1038/bjc.2014.133, PubMed 24642618

Håkelien AM, Bryne JC, Harstad KG, Lorenz S, Paulsen J, Sun J, Mikkelsen TS, Myklebost O, Meza-Zepeda LA (2014)
The regulatory landscape of osteogenic differentiation
Stem Cells, 32 (10), 2780-93
DOI 10.1002/stem.1759, PubMed 24898411

Kumar RP, Albregtsen F, Reimers M, Edwin B, Langø T, Elle OJ (2014)
Three-Dimensional Blood Vessel Segmentation and Centerline Extraction based on Two-Dimensional Cross-Section Analysis
Ann Biomed Eng, 43 (5), 1223-34
DOI 10.1007/s10439-014-1184-4, PubMed 25398332

Lindemann K, Malander S, Christensen RD, Mirza MR, Kristensen GB, Aavall-Lundqvist E, Vergote I, Rosenberg P, Boman K, Nordstrøm B (2014)
Examestane in advanced or recurrent endometrial carcinoma: a prospective phase II study by the Nordic Society of Gynecologic Oncology (NSGO)
BMC Cancer, 14, 68
DOI 10.1186/1471-2407-14-68, PubMed 24498853

Lundin C, Forestier E, Klarskov Andersen M, Autio K, Barbany G, Cavelier L, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kjeldsen E, Nordgren A, Palmqvist L, Johansson B, Nordic Society of Pediatric Hematology Oncology (NOPHO), Swedish Cytogenetic Leukemia Study Group (SCLSG), NOPHO Leukemia Cytogenetic Study Group (NLCSG) (2014)
Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries
J Hematol Oncol, 7, 32
DOI 10.1186/1756-8722-7-32, PubMed 24726034

Micci F, Gorunova L, Gatius S, Matias-Guiu X, Davidson B, Heim S, Panagopoulos I (2014)
MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma
Cancer Lett, 347 (1), 75-8
DOI 10.1016/j.canlet.2014.01.030, PubMed 24530230

Micci F, Haugom L, Abeler VM, Davidson B, Tropé CG, Heim S (2014)
Genomic profile of ovarian carcinomas
BMC Cancer, 14, 315
DOI 10.1186/1471-2407-14-315, PubMed 24886194

Micci F, Panagopoulos I, Thorsen J, Davidson B, Tropé CG, Heim S (2014)
Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas
PLoS Biol, 12 (2), e1001784
DOI 10.1371/journal.pbio.1001784, PubMed 24504521

Nenseth HZ, Dezitter X, Tesikova M, Mueller F, Klokk TI, Hager GL, Saatcioglu F (2014)
Distinctly different dynamics and kinetics of two steroid receptors at the same response elements in living cells
PLoS One, 9 (8), e105204
DOI 10.1371/journal.pone.0105204, PubMed 25133404

Nielsen B, Hveem TS, Kildal W, Abeler VM, Kristensen GB, Albregtsen F, Danielsen HE (2014)
Entropy-based adaptive nuclear texture features are independent prognostic markers in a total population of uterine sarcomas
Cytometry A, 87 (4), 315-25
DOI 10.1002/cyto.a.22601, PubMed 25483227

Nygård S, Reitan T, Clancy T, Nygaard V, Bjørnstad J, Skrbic B, Tønnessen T, Christensen G, Hovig E (2014)
Identifying pathogenic processes by integrating microarray data with prior knowledge
BMC Bioinformatics, 15, 115
DOI 10.1186/1471-2105-15-115, PubMed 24758699

Olsen TK, Gorunova L, Meling TR, Micci F, Scheie D, Due-Tønnessen B, Heim S, Brandal P (2014)
Genomic characterization of ependymomas reveals 6q loss as the most common aberration
Oncol Rep, 32 (2), 483-90
DOI 10.3892/or.2014.3271, PubMed 24939246

Oppelt A, Haugsten EM, Zech T, Danielsen HE, Sveen A, Lobert VH, Skotheim RI, Wesche J (2014)
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1
Biochem J, 461 (3), 383-90
DOI 10.1042/BJ20140132, PubMed 24840251

Panagopoulos I, Bjerkehagen B, Gorunova L, Berner JM, Boye K, Heim S (2014)
Several fusion genes identified by whole transcriptome sequencing in a spindle cell sarcoma with rearrangements of chromosome arm 12q and MDM2 amplification
Int J Oncol, 45 (5), 1829-36
DOI 10.3892/ijo.2014.2605, PubMed 25176350

Panagopoulos I, Brandal P, Gorunova L, Bjerkehagen B, Heim S (2014)
Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors
Int J Oncol, 44 (5), 1425-32
DOI 10.3892/ijo.2014.2326, PubMed 24604026

Panagopoulos I, Gorunova L, Bjerkehagen B, Boye K, Heim S (2014)
Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma
Oncol Rep, 32 (1), 40-4
DOI 10.3892/or.2014.3180, PubMed 24839999

Panagopoulos I, Gorunova L, Bjerkehagen B, Heim S (2014)
The "grep" command but not FusionMap, FusionFinder or ChimeraScan captures the CIC-DUX4 fusion gene from whole transcriptome sequencing data on a small round cell tumor with t(4;19)(q35;q13)
PLoS One, 9 (6), e99439
DOI 10.1371/journal.pone.0099439, PubMed 24950227

Panagopoulos I, Gorunova L, Davidson B, Heim S (2014)
Novel TNS3-MAP3K3 and ZFPM2-ELF5 fusion genes identified by RNA sequencing in multicystic mesothelioma with t(7;17)(p12;q23) and t(8;11)(q23;p13)
Cancer Lett, 357 (2), 502-9
DOI 10.1016/j.canlet.2014.12.002, PubMed 25484136

Panagopoulos I, Thorsen J, Gorunova L, Micci F, Heim S (2014)
Sequential combination of karyotyping and RNA-sequencing in the search for cancer-specific fusion genes
Int J Biochem Cell Biol, 53, 462-5
DOI 10.1016/j.biocel.2014.05.018, PubMed 24863361

Panagopoulos I, Torkildsen S, Gorunova L, Tierens A, Tjønnfjord GE, Heim S (2014)
Comparison between karyotyping-FISH-reverse transcription PCR and RNA-sequencing-fusion gene identification programs in the detection of KAT6A-CREBBP in acute myeloid leukemia
PLoS One, 9 (5), e96570
DOI 10.1371/journal.pone.0096570, PubMed 24798186

Paulsen J, Rødland EA, Holden L, Holden M, Hovig E (2014)
A statistical model of ChIA-PET data for accurate detection of chromatin 3D interactions
Nucleic Acids Res, 42 (18), e143
DOI 10.1093/nar/gku738, PubMed 25114054

Pujade-Lauraine E, Hilpert F, Weber B, Reuss A, Poveda A, Kristensen G, Sorio R, Vergote I, Witteveen P, Bamias A, Pereira D, Wimberger P, Oaknin A, Mirza MR, Follana P, Bollag D, Ray-Coquard I (2014)
Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial
J Clin Oncol, 32 (13), 1302-8
DOI 10.1200/JCO.2013.51.4489, PubMed 24637997

Sagae S, Susumu N, Viswanathan AN, Aoki D, Backes FJ, Provencher DM, Vaughan M, Creutzberg CL, Kurzeder C, Kristensen G, Lee C, Kurtz JE, Glasspool RM, Small W (2014)
Gynecologic Cancer InterGroup (GCIG) consensus review for uterine serous carcinoma
Int J Gynecol Cancer, 24 (9 Suppl 3), S83-9
DOI 10.1097/IGC.0000000000000264, PubMed 25341586

Sikkeland J, Jin Y, Saatcioglu F (2014)
Methods to assess lipid accumulation in cancer cells
Methods Enzymol, 542, 407-23
DOI 10.1016/B978-0-12-416618-9.00021-2, PubMed 24862278

Skårn M, Noordhuis P, Wang MY, Veuger M, Kresse SH, Egeland EV, Micci F, Namløs HM, Håkelien AM, Olafsrud SM, Lorenz S, Haraldsen G, Kvalheim G, Meza-Zepeda LA, Myklebost O (2014)
Generation and characterization of an immortalized human mesenchymal stromal cell line
Stem Cells Dev, 23 (19), 2377-89
DOI 10.1089/scd.2013.0599, PubMed 24857590

Smebye ML, Sveen A, Haugom L, Davidson B, Tropé CG, Lothe RA, Heim S, Skotheim RI, Micci F (2014)
Chromosome 19 rearrangements in ovarian carcinomas: zinc finger genes are particularly targeted
Genes Chromosomes Cancer, 53 (7), 558-67
DOI 10.1002/gcc.22166, PubMed 24634323

Sternemalm J, Russnes HG, Zhao X, Risberg B, Nord S, Caldas C, Børresen-Dale AL, Stokke T, Patzke S (2014)
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer
Br J Cancer, 111 (2), 326-38
DOI 10.1038/bjc.2014.297, PubMed 24901235

Torsvik A, Stieber D, Enger PØ, Golebiewska A, Molven A, Svendsen A, Westermark B, Niclou SP, Olsen TK, Chekenya Enger M, Bjerkvig R (2014)
U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells
Cancer Med, 3 (4), 812-24
DOI 10.1002/cam4.219, PubMed 24810477

Wang L, Wenners A, Hilpert F, Fredrik R, Micci F, Onkes W, Caliebe A, Maass N, Weimer J, Arnold N (2014)
Frequent translocations of 11q13.2 and 19p13.2 in ovarian cancer
Genes Chromosomes Cancer, 53 (6), 447-53
DOI 10.1002/gcc.22152, PubMed 24615723

Wang Y, Herrstedt J, Havsteen H, DePoint Christensen R, Mirza MR, Lund B, Maenpaa J, Kristensen G (2014)
A multicenter, non-randomized, phase II study of docetaxel and carboplatin administered every 3 weeks as second line chemotherapy in patients with first relapse of platinum sensitive epithelial ovarian, peritoneal or fallopian tube cancer
BMC Cancer, 14, 937
DOI 10.1186/1471-2407-14-937, PubMed 25494701

Wollen EJ, Kwinta P, Bik-Multanowski M, Madetko-Talowska A, Sejersted Y, Wright MS, Günther CC, Nygård S, Saugstad OD, Pietrzyk JJ (2014)
Hypoxia-reoxygenation affects whole-genome expression in the newborn eye
Invest Ophthalmol Vis Sci, 55 (3), 1393-401
DOI 10.1167/iovs.13-13159, PubMed 24458145

Wu X, Sagave J, Rutkovskiy A, Haugen F, Baysa A, Nygård S, Czibik G, Dahl CP, Gullestad L, Vaage J, Valen G (2014)
Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart
Life Sci, 97 (2), 145-54
DOI 10.1016/j.lfs.2013.12.030, PubMed 24398041

 
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