Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2018 from OUS - Department of Pediatric Research

37 publications found

Almaas R, Haflidadottir S, Kaldestad RH, Matthews IL (2018)
Asthma, Eczema, and Food Allergy in Children Following Liver Transplantation
J Pediatr, 204, 263-269
DOI 10.1016/j.jpeds.2018.08.050, PubMed 30270158

Aresvik DM, Øverland T, Lima K, Pettersen RD, Abrahamsen TG (2018)
Lymphocyte Apoptosis and FAS Expression in Patients with 22q11.2 Deletion Syndrome
J Clin Immunol, 39 (1), 65-74
DOI 10.1007/s10875-018-0579-7, PubMed 30569262

Benterud T, Manueldas S, Rivera S, Henckel E, Løberg EM, Norgren S, Baumbusch LO, Solberg R, Saugstad OD (2018)
Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide
Dis Markers, 2018, 5046372
DOI 10.1155/2018/5046372, PubMed 29651324

Bik-Multanowski M, Revhaug C, Grabowska A, Dobosz A, Madetko-Talowska A, Zasada M, Saugstad OD (2018)
Hyperoxia induces epigenetic changes in newborn mice lungs
Free Radic Biol Med, 121, 51-56
DOI 10.1016/j.freeradbiomed.2018.04.566, PubMed 29698744

Bjørnland K, Hinna M, Aksnes G, Stensrud KJ, Ertresvåg K, Bjørnstad-Østensen A, Sanengen T, Line PD, Aagenæs I, Aabakken L, Emblem R, Almaas R (2018)
Outcome for biliary atresia patients treated at a low-volume centre
Scand J Gastroenterol, 53 (4), 471-474
DOI 10.1080/00365521.2018.1439097, PubMed 29546790

Bogdanova M, Kostina A, Zihlavnikova Enayati K, Zabirnyk A, Malashicheva A, Stensløkken KO, Sullivan GJ, Kaljusto ML, Kvitting JP, Kostareva A, Vaage J, Rutkovskiy A (2018)
Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells
Front Physiol, 9, 1635
DOI 10.3389/fphys.2018.01635, PubMed 30524301

Crowley S, Holgersen MG, Nielsen KG (2018)
Variation in treatment strategies for the eradication of Pseudomonas aeruginosa in primary ciliary dyskinesia across European centers
Chron Respir Dis, 16, 1479972318787919
DOI 10.1177/1479972318787919, PubMed 30021461

de Lange C, Solberg R, Holtedahl JE, Tulipan A, Barlinn J, Trigg W, Wickstrøm T, Saugstad OD, Malinen E, Revheim ME (2018)
Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs
Nucl Med Biol, 66, 49-57
DOI 10.1016/j.nucmedbio.2018.08.004, PubMed 30257223

Heier M, Espeland CN, Brunborg C, Seljeflot I, Margeirsdottir HD, Hanssen KF, Fugelseth D, Dahl-Jørgensen K (2018)
Preserved endothelial function in young adults with type 1 diabetes
PLoS One, 13 (10), e0206523
DOI 10.1371/journal.pone.0206523, PubMed 30359432

Heier M, Stensæth KH, Brunborg C, Seljeflot I, Margeirsdottir HD, Hanssen KF, Dahl-Jørgensen K (2018)
Increased arterial stiffness in childhood onset diabetes: a cardiovascular magnetic resonance study
Eur Heart J Cardiovasc Imaging, 19 (6), 694-700
DOI 10.1093/ehjci/jex178, PubMed 28950341

Horwitz E, Krogvold L, Zhitomirsky S, Swisa A, Fischman M, Lax T, Dahan T, Hurvitz N, Weinberg-Corem N, Klochendler A, Powers AC, Brissova M, Jörns A, Lenzen S, Glaser B, Dahl-Jørgensen K, Dor Y (2018)
β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes
Diabetes, 67 (11), 2305-2318
DOI 10.2337/db17-1006, PubMed 30150306

Huun MU, Garberg H, Løberg EM, Escobar J, Martinez-Orgado J, Saugstad OD, Solberg R (2018)
DHA and therapeutic hypothermia in a short-term follow-up piglet model of hypoxia-ischemia: Effects on H+MRS biomarkers
PLoS One, 13 (8), e0201895
DOI 10.1371/journal.pone.0201895, PubMed 30086156

Huun MU, Garberg HT, Buonocore G, Longini M, Belvisi E, Bazzini F, Proietti F, Saugstad OD, Solberg R (2018)
Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets
J Perinat Med, 47 (1), 82-89
DOI 10.1515/jpm-2017-0355, PubMed 30110254

Huun MU, Garberg HT, Escobar J, Chafer C, Vento M, Holme IM, Saugstad OD, Solberg R (2018)
DHA reduces oxidative stress following hypoxia-ischemia in newborn piglets: a study of lipid peroxidation products in urine and plasma
J Perinat Med, 46 (2), 209-217
DOI 10.1515/jpm-2016-0334, PubMed 28632497

Kolenda T, Przybyła W, Kapałczyńska M, Teresiak A, Zajączkowska M, Bliźniak R, Lamperska KM (2018)
Tumor microenvironment - Unknown niche with powerful therapeutic potential
Rep Pract Oncol Radiother, 23 (3), 143-153
DOI 10.1016/j.rpor.2018.01.004, PubMed 29760589

Kotlarz D, Marquardt B, Barøy T, Lee WS, Konnikova L, Hollizeck S, Magg T, Lehle AS, Walz C, Borggraefe I, Hauck F, Bufler P, Conca R, Wall SM, Schumacher EM, Misceo D, Frengen E, Bentsen BS, Uhlig HH, Hopfner KP, Muise AM, Snapper SB, Strømme P, Klein C (2018)
Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy
Nat Genet, 50 (3), 344-348
DOI 10.1038/s41588-018-0063-6, PubMed 29483653

Magnus MC, Olsen SF, Granstrom C, Lund-Blix NA, Svensson J, Johannesen J, Fraser A, Skrivarhaug T, Joner G, Njølstad PR, Størdal K, Stene LC (2018)
Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes
Int J Epidemiol, 47 (2), 417-426
DOI 10.1093/ije/dyx266, PubMed 29415279

Manueldas S, Benterud T, Rueegg CS, Garberg HT, Huun MU, Pankratov L, Åsegg-Atneosen M, Solberg R, Escobar J, Saugstad OD, Baumbusch LO (2018)
Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia
PLoS One, 13 (11), e0206601
DOI 10.1371/journal.pone.0206601, PubMed 30475817

Oei JL, Saugstad OD, Vento M (2018)
Oxygen and preterm infant resuscitation: what else do we need to know?
Curr Opin Pediatr, 30 (2), 192-198
DOI 10.1097/MOP.0000000000000610, PubMed 29406439

Olberg HK, Odland HH, Kask A, Engelsen BA (2018)
A woman in her 30s with seizure relapse after a previous diagnosis of epilepsy
Tidsskr. Nor. Laegeforen., 138 (8), 744-747

Ormstad H, Bryn V, Saugstad OD, Skjeldal O, Maes M (2018)
Role of the Immune System in Autism Spectrum Disorders (ASD)
CNS Neurol Disord Drug Targets, 17 (7), 489-495
DOI 10.2174/1871527317666180706123229, PubMed 29984670

Ormstad H, Bryn V, Verkerk R, Skjeldal OH, Halvorsen B, Saugstad OD, Isaksen J, Maes M (2018)
Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders
CNS Neurol Disord Drug Targets, 17 (8), 626-639
DOI 10.2174/1871527317666180720163221, PubMed 30033880

Parr CL, Magnus MC, Karlstad Ø, Holvik K, Lund-Blix NA, Haugen M, Page CM, Nafstad P, Ueland PM, London SJ, Håberg SE, Nystad W (2018)
Vitamin A and D intake in pregnancy, infant supplementation, and asthma development: the Norwegian Mother and Child Cohort
Am J Clin Nutr, 107 (5), 789-798
DOI 10.1093/ajcn/nqy016, PubMed 29722838

Pisal RV, Suchanek J, Siller R, Soukup T, Hrebikova H, Bezrouk A, Kunke D, Micuda S, Filip S, Sullivan G, Mokry J (2018)
Directed reprogramming of comprehensively characterized dental pulp stem cells extracted from natal tooth
Sci Rep, 8 (1), 6168
DOI 10.1038/s41598-018-24421-z, PubMed 29670257

Rognlien AGW, Wollen EJ, Atneosen-Åsegg M, Suganthan R, Bjørås M, Saugstad OD (2018)
Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation
J Perinat Med, 47 (1), 114-124
DOI 10.1515/jpm-2018-0172, PubMed 30020889

Saugstad OD (2018)
Oxygenation of the Immature Infant: A Commentary and Recommendations for Oxygen Saturation Targets and Alarm Limits
Neonatology, 114 (1), 69-75
DOI 10.1159/000486751, PubMed 29669357

Skah S, Richartz N, Duthil E, Gilljam KM, Bindesbøll C, Naderi EH, Eriksen AB, Ruud E, Dirdal MM, Simonsen A, Blomhoff HK (2018)
cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53
Oncotarget, 9 (54), 30434-30449
DOI 10.18632/oncotarget.25758, PubMed 30100998

Stenson B, Saugstad OD (2018)
Oxygen Treatment for Immature Infants beyond the Delivery Room: Lessons from Randomized Studies
J Pediatr, 200, 12-18
DOI 10.1016/j.jpeds.2018.05.001, PubMed 29961642

Størdal K, McArdle HJ, Hayes H, Tapia G, Viken MK, Lund-Blix NA, Haugen M, Joner G, Skrivarhaug T, Mårild K, Njølstad PR, Eggesbø M, Mandal S, Page CM, London SJ, Lie BA, Stene LC (2018)
Prenatal iron exposure and childhood type 1 diabetes
Sci Rep, 8 (1), 9067
DOI 10.1038/s41598-018-27391-4, PubMed 29899542

Suski M, Bokiniec R, Szwarc-Duma M, Madej J, Bujak-Giżycka B, Borszewska-Kornacka MK, Książek T, Grabowska A, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ, Kwinta P (2018)
Plasma proteome changes in cord blood samples from preterm infants
J Perinatol, 38 (9), 1182-1189
DOI 10.1038/s41372-018-0150-7, PubMed 29910464

Suski M, Bokiniec R, Szwarc-Duma M, Madej J, Bujak-Giżycka B, Kwinta P, Borszewska-Kornacka MK, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ (2018)
Prospective plasma proteome changes in preterm infants with different gestational ages
Pediatr Res, 84 (1), 104-111
DOI 10.1038/s41390-018-0003-2, PubMed 29795197

Syltern J, Markestad T, Saugstad OD, Støen R (2018)
NICU Dialects: Understanding Norwegian Practice Variation
Pediatrics, 142 (Suppl 1), S545-S551
DOI 10.1542/peds.2018-0478E, PubMed 30171140

Thomas AM, Schjalm C, Nilsson PH, Lindenskov PHH, Rørtveit R, Solberg R, Saugstad OD, Berglund MM, Strömberg P, Lau C, Espevik T, Jansen JH, Castellheim A, Mollnes TE, Barratt-Due A (2018)
Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome
Neonatology, 113 (4), 322-330
DOI 10.1159/000486542, PubMed 29486477

Thorsteinsdottir H, Diseth TH, Lie A, Tangeraas T, Matthews I, Åsberg A, Bjerre A (2018)
Small effort, high impact: Focus on physical activity improves oxygen uptake (VO2peak ), quality of life, and mental health after pediatric renal transplantation
Pediatr Transplant, 22 (6), e13242
DOI 10.1111/petr.13242, PubMed 29921004

Umphrey L, Breindahl M, Brown A, Saugstad OD, Thio M, Trevisanuto D, Roehr CC, Blennow M (2018)
When Helping Babies Breathe Is Not Enough: Designing a Novel, Mid-Level Neonatal Resuscitation Algorithm for Médecins Sans Frontières Field Teams Working in Low-Resource Hospital Settings
Neonatology, 114 (2), 112-123
DOI 10.1159/000486705, PubMed 29804116

Vecchio F, Lo Buono N, Stabilini A, Nigi L, Dufort MJ, Geyer S, Rancoita PM, Cugnata F, Mandelli A, Valle A, Leete P, Mancarella F, Linsley PS, Krogvold L, Herold KC, Elding Larsson H, Richardson SJ, Morgan NG, Dahl-Jørgensen K, Sebastiani G, Dotta F, Bosi E, DRI_Biorepository Group, Type 1 Diabetes TrialNet Study Group, Battaglia M (2018)
Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes
JCI Insight, 3 (18)
DOI 10.1172/jci.insight.122146, PubMed 30232284

Zasada M, Suski M, Bokiniec R, Szwarc-Duma M, Borszewska-Kornacka MK, Madej J, Bujak-Gizycka B, Madetko-Talowska A, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ, Kwinta P (2018)
An iTRAQ-Based Quantitative Proteomic Analysis of Plasma Proteins in Preterm Newborns With Retinopathy of Prematurity
Invest Ophthalmol Vis Sci, 59 (13), 5312-5319
DOI 10.1167/iovs.18-24914, PubMed 30398622

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