Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2020 from OUS - Department of Ophthalmology
51 publications found
Region of interest and directional analysis of subbasal nerves in wide-area corneal nerve plexus mosaics in type 2 diabetes mellitus
Sci Rep, 10 (1), 10802
DOI 10.1038/s41598-020-67737-5, PubMed 32612112
Dry eye disease treatment: the role of tear substitutes, their future, and an updated classification
Eur Rev Med Pharmacol Sci, 24 (17), 8642-8652
DOI 10.26355/eurrev_202009_22801, PubMed 32964952
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
Sci Transl Med, 12 (565)
DOI 10.1126/scitranslmed.abb0580, PubMed 33055243
Long-term myofibroblast persistence in the capsular bag contributes to the late spontaneous in-the-bag intraocular lens dislocation
Sci Rep, 10 (1), 20532
DOI 10.1038/s41598-020-77207-7, PubMed 33239706
Does Pharmaceutical Compounding of Vascular Endothelial Growth Factor Inhibitors for Intravitreal Use Alter the Risk of Post-injection Endophthalmitis?
Ocul Immunol Inflamm
DOI 10.1080/09273948.2020.1820530, PubMed 33026900
Venular oxygen saturation is increased in young patients with type 1 diabetes and mild nonproliferative diabetic retinopathy
Acta Ophthalmol, 98 (8), 800-807
DOI 10.1111/aos.14462, PubMed 32410388
Longitudinal corneal endothelial cell loss after corrective surgery for late in-the-bag IOL dislocation: a randomized clinical trial
J Cataract Refract Surg, 46 (7), 1030-1036
DOI 10.1097/j.jcrs.0000000000000213, PubMed 32304486
European real-world data about the use of a new delivery system containing a preservative-free multi-dose glaucoma treatment
Eur J Ophthalmol, 1120672120919342
DOI 10.1177/1120672120919342, PubMed 32375561
Unilateral acute anterior uveitis is associated with ipsilateral changes in the tear fluid proteome that involves the LXR/RXR pathway
J Ophthalmic Inflamm Infect, 10 (1), 13
DOI 10.1186/s12348-020-00204-4, PubMed 32458144
TFOS European Ambassador meeting: Unmet needs and future scientific and clinical solutions for ocular surface diseases
Ocul Surf, 18 (4), 936-962
DOI 10.1016/j.jtos.2020.05.006, PubMed 32504856
Multiple Vitelliform Lesions as a Retinal Manifestation of Alport Syndrome
Case Rep Ophthalmol, 11 (1), 79-84
DOI 10.1159/000505948, PubMed 32231557
Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries
Br J Ophthalmol (in press)
DOI 10.1136/bjophthalmol-2020-316613, PubMed 32933936
Global Retinoblastoma Presentation and Analysis by National Income Level
JAMA Oncol, 6 (5), 685-695
DOI 10.1001/jamaoncol.2019.6716, PubMed 32105305
Cost-effectiveness of the triple procedure - phacovitrectomy with posterior capsulotomy compared to phacovitrectomy and sequential procedures
Acta Ophthalmol, 98 (6), 592-602
DOI 10.1111/aos.14367, PubMed 32078246
Clinical features and molecular genetics of patients with ABCA4-retinal dystrophies
Acta Ophthalmol
DOI 10.1111/aos.14679, PubMed 33258285
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538
The Effects of Prolonged Storage on ARPE-19 Cells Stored at Three Different Storage Temperatures
Molecules, 25 (24)
DOI 10.3390/molecules25245809, PubMed 33317020
In Vivo Evidence for Impaired Glymphatic Function in the Visual Pathway of Patients With Normal Pressure Hydrocephalus
Invest Ophthalmol Vis Sci, 61 (13), 24
DOI 10.1167/iovs.61.13.24, PubMed 33201186
A traffic perimetry test that adheres to the European visual field requirements
Acta Ophthalmol
DOI 10.1111/aos.14633, PubMed 32996716
The Value of Macular Optical Coherence Tomography in Watchful Waiting of Suprasellar Masses: A 2-Year Observational Study
J Neuroophthalmol (in press)
DOI 10.1097/WNO.0000000000000993, PubMed 33252889
Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells
Int J Mol Sci, 21 (3)
DOI 10.3390/ijms21030813, PubMed 32012692
Sericin-Induced Melanogenesis in Cultured Retinal Pigment Epithelial Cells Is Associated with Elevated Levels of Hydrogen Peroxide and Inflammatory Proteins
Molecules, 25 (19)
DOI 10.3390/molecules25194395, PubMed 32987810
The Silk Protein Sericin Promotes Viability of ARPE-19 and Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells in vitro
Curr Eye Res
DOI 10.1080/02713683.2020.1809001, PubMed 32777180
UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells
Invest. Ophthalmol. Vis. Sci., 61 (4), 7
Dislocation of artificial lens
Tidsskr. Nor. Laegeforen., 140 (7), 693-694
Prevalence and incidence of keratoconus in Norway: a nationwide register study
Acta Ophthalmol
DOI 10.1111/aos.14668, PubMed 33196151
Quantification of ocular surface microcirculation by computer assisted video microscopy and diffuse reflectance spectroscopy
Exp Eye Res, 201, 108312
DOI 10.1016/j.exer.2020.108312, PubMed 33157128
Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma
BMC Ophthalmol, 20 (1), 103
DOI 10.1186/s12886-020-01367-3, PubMed 32178641
Outcomes of Vitrectomy for Long-Duration Macular Hole
J Clin Med, 9 (2)
DOI 10.3390/jcm9020444, PubMed 32041208
Intraductal Meibomian Gland Probing and its Efficacy in the Treatment of Meibomian Gland Dysfunction
Surv Ophthalmol (in press)
DOI 10.1016/j.survophthal.2020.11.005, PubMed 33352147
Isolation and Culture of Corneal Stromal Stem Cells
Methods Mol Biol, 2145, 1-15
DOI 10.1038/srep10839, PubMed 32542596
Ultra-widefield autofluorescence imaging findings in retinoschisis, rhegmatogenous retinal detachment and combined retinoschisis retinal detachment
Acta Ophthalmol
DOI 10.1111/aos.14521, PubMed 32602221
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis
Exp Eye Res, 108426 (in press)
DOI 10.1016/j.exer.2020.108426, PubMed 33387485
Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma
Head Neck, 42 (8), 2088-2098
DOI 10.1002/hed.26140, PubMed 32202693
PAX6 Genotypic and Retinal Phenotypic Characterization in Congenital Aniridia
Invest Ophthalmol Vis Sci, 61 (5), 14
DOI 10.1167/iovs.61.5.14, PubMed 32396632
Protein Composition of the Subretinal Fluid Suggests Selective Diffusion of Vitreous Proteins in Retinal Detachment
Transl Vis Sci Technol, 9 (11), 16
DOI 10.1167/tvst.9.11.16, PubMed 33117608
Stem cell function is conserved during short-term storage of cultured epidermal cell sheets at 12°C
PLoS One, 15 (5), e0232270
DOI 10.1371/journal.pone.0232270, PubMed 32433698
Digital Image Analysis of the Angle and Optic Nerve: A Simple, Fast, and Low-Cost Method for Glaucoma Assessment
J Ophthalmol, 2020, 3595610
DOI 10.1155/2020/3595610, PubMed 33194227
The prevalence and incidence of glaucoma in Norway 2004-2018: A nationwide population-based study
PLoS One, 15 (12), e0242786
DOI 10.1371/journal.pone.0242786, PubMed 33301476
Brightness perception changes related to pupil size
Vision Res, 178, 41-47
DOI 10.1016/j.visres.2020.09.004, PubMed 33113435
Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture
BMJ Open Ophthalmol, 5 (1), e000545
DOI 10.1136/bmjophth-2020-000545, PubMed 32995498
Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study
Sci Rep, 10 (1), 2063
DOI 10.1038/s41598-020-59078-0, PubMed 32034249
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease
Sci Rep, 10 (1), 5542
DOI 10.1038/s41598-020-62583-x, PubMed 32218518
Intense pulsed light treatment in meibomian gland dysfunction: A concise review
Ocul Surf, 18 (4), 583-594
DOI 10.1016/j.jtos.2020.06.002, PubMed 32629039
Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients
Ocul Surf, 19, 68-73 (in press)
DOI 10.1016/j.jtos.2020.11.009, PubMed 33246035
Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjogren's syndrome
Clin. Exp. Rheumatol., 38 (4 126), S301-S309
Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjögren's syndrome
Clin Exp Rheumatol, 38 Suppl 126 (4), 301-309
PubMed 33025899
Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus
J Diabetes Res, 2020, 8849116
DOI 10.1155/2020/8849116, PubMed 33313325
A porous collagen-based hydrogel and implantation method for corneal stromal regeneration and sustained local drug delivery
Sci Rep, 10 (1), 16936
DOI 10.1038/s41598-020-73730-9, PubMed 33037282
Response of human oral mucosal epithelial cells to different storage temperatures: A structural and transcriptional study
PLoS One, 15 (12), e0243914
DOI 10.1371/journal.pone.0243914, PubMed 33326470
Prognostic Factor Analysis of Visual Outcome after Vitrectomy for Rhegmatogenous Retinal Detachment
J Clin Med, 9 (10)
DOI 10.3390/jcm9103251, PubMed 33053642