Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2018 from OUS - Department of Ophthalmology

34 publications found

Akhtar S, Petrovski G, Albert R, Alkanaan A, Kirat O, Khan AD, Almubrad T (2018)
Ultrastructure and 3D transmission electron tomography of collagen fibrils and proteoglycans of swollen human corneal stroma
Histol Histopathol, 18029 (in press)
DOI 10.14670/HH-18-029, PubMed 30019745

Anisimova NS, Arbisser LB, Petrovski G, Petrichuk SV, Sobolev NP, Petrovski B, Borsenok SA, Komah YA, Malyugin BE (2018)
Effect of NSAIDs on Pupil Diameter and Expression of Aqueous Humor Cytokines in FLACS Versus Conventional Phacoemulsification
J Refract Surg, 34 (10), 646-652
DOI 10.3928/1081597X-20180814-02, PubMed 30296325

Azqueta A, Rundén-Pran E, Elje E, Nicolaissen B, Berg KH, Smeringaiova I, Jirsova K, Collins AR (2018)
The comet assay applied to cells of the eye
Mutagenesis, 33 (1), 21-24
DOI 10.1093/mutage/gex025, PubMed 29077953

Colijn JM, den Hollander AI, Demirkan A, Cougnard-Grégoire A, Verzijden T, Kersten E, Meester-Smoor MA, Merle BMJ, Papageorgiou G, Ahmad S, Mulder MT, Costa MA, Benlian P, Bertelsen G, Bron AM, Claes B, Creuzot-Garcher C, Erke MG, Fauser S, Foster PJ, Hammond CJ, Hense HW, Hoyng CB, Khawaja AP, Korobelnik JF et al. (2018)
Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia
Ophthalmology (in press)
DOI 10.1016/j.ophtha.2018.09.045, PubMed 30315903

Djirackor L, Shakir D, Kalirai H, Petrovski G, Coupland SE (2018)
Nestin expression in primary and metastatic uveal melanoma - possible biomarker for high-risk uveal melanoma
Acta Ophthalmol, 96 (5), 503-509
DOI 10.1111/aos.13645, PubMed 29338117

Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G et al. (2018)
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Redox Biol, 20, 1-12 (in press)
DOI 10.1016/j.redox.2018.09.011, PubMed 30253279

Hagem AM, Thorsrud A, Sandvik GF, Drolsum L (2018)
Randomized Study of Collagen Cross-Linking With Conventional Versus Accelerated UVA Irradiation Using Riboflavin With Hydroxypropyl Methylcellulose: Two-Year Results
Cornea (in press)
DOI 10.1097/ICO.0000000000001791, PubMed 30365412

Jelin E, Wisløff T, Moe MC, Heiberg T (2018)
Development and testing of a patient-derived questionnaire for treatment of neovascular age-related macular degeneration: dimensions of importance in treatment of neovascular age-related macular degeneration
Acta Ophthalmol, 96 (8), 804-811
DOI 10.1111/aos.13847, PubMed 30198182

Jørstad ØK, Wigers AR, Marthinsen PB, Moe MC, Evang JA (2018)
Loss of horizontal macular ganglion cell complex asymmetry: an optical coherence tomography indicator of chiasmal compression
BMJ Open Ophthalmol, 3 (1), e000195
DOI 10.1136/bmjophth-2018-000195, PubMed 30519642

Katta K, Sembajwe LF, Kusche-Gullberg M (2018)
Potential role for Ext1-dependent heparan sulfate in regulating P311 gene expression in A549 carcinoma cells
Biochim Biophys Acta Gen Subj, 1862 (6), 1472-1481
DOI 10.1016/j.bbagen.2018.03.024, PubMed 29580921

Khan AZ, Utheim TP, Reppe S, Sandvik L, Lyberg T, Roald BB, Ibrahim IB, Eidet JR (2018)
Cultured Human Retinal Pigment Epithelial (hRPE) Sheets: A Search for Suitable Storage Conditions
Microsc Microanal, 24 (2), 147-155
DOI 10.1017/S1431927618000144, PubMed 29637873

Landsend ECS, Pedersen HR, Utheim ØA, Xiao J, Adil MY, Tashbayev B, Lagali N, Dartt DA, Baraas RC, Utheim TP (2018)
Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia
Br J Ophthalmol (in press)
DOI 10.1136/bjophthalmol-2017-310927, PubMed 29519880

Landsend ECS, Utheim ØA, Pedersen HR, Aass HCD, Lagali N, Dartt DA, Baraas RC, Utheim TP (2018)
The Level of Inflammatory Tear Cytokines is Elevated in Congenital Aniridia and Associated with Meibomian Gland Dysfunction
Invest Ophthalmol Vis Sci, 59 (5), 2197-2204
DOI 10.1167/iovs.18-24027, PubMed 29801153

Lorenzo Y, Haug Berg K, Ringvold A, Petrovski G, Moe MC, Collins A, Nicolaissen B (2018)
Levels of oxidative DNA damage are low in ex vivo engineered human limbal epithelial tissue
Acta Ophthalmol, 96 (8), 834-840
DOI 10.1111/aos.13811, PubMed 30239138

Lång E, Połeć A, Lång A, Valk M, Blicher P, Rowe AD, Tønseth KA, Jackson CJ, Utheim TP, Janssen LMC, Eriksson J, Bøe SO (2018)
Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding
Nat Commun, 9 (1), 3665
DOI 10.1038/s41467-018-05578-7, PubMed 30202009

Momtazi L, Dartt DA, Nilsen O, Eidet JR (2018)
Molecular layer deposition builds biocompatible substrates for epithelial cells
J Biomed Mater Res A, 106 (12), 3090-3098
DOI 10.1002/jbm.a.36499, PubMed 30194710

Navaratnam J, Dedi L, Tjølsen AM, Bragadóttir R (2018)
Identification of Dietzia Species in a Patient with Endophthalmitis following Penetrating Injury with Retained Intraocular Metallic Foreign Body
Case Rep Infect Dis, 2018, 3027846
DOI 10.1155/2018/3027846, PubMed 30356339

Odegaard EM, Jorstad OK, Kerty E (2018)
A teenager with acute bilateral vision loss
Tidsskr. Nor. Laegeforen., 138 (12), 1144-1147

Pasovic L, Utheim TP, Reppe S, Khan AZ, Jackson CJ, Thiede B, Berg JP, Messelt EB, Eidet JR (2018)
Improvement of Storage Medium for Cultured Human Retinal Pigment Epithelial Cells Using Factorial Design
Sci Rep, 8 (1), 5688
DOI 10.1038/s41598-018-24121-8, PubMed 29632395

Pathak M, Diep PP, Lai X, Brinch L, Ruud E, Drolsum L (2018)
Ocular findings and ocular graft-versus-host disease after allogeneic stem cell transplantation without total body irradiation
Bone Marrow Transplant, 53 (7), 863-872
DOI 10.1038/s41409-018-0090-z, PubMed 29382955

Pedersen HR, Hagen LA, Landsend ECS, Gilson SJ, Utheim ØA, Utheim TP, Neitz M, Baraas RC (2018)
Color Vision in Aniridia
Invest Ophthalmol Vis Sci, 59 (5), 2142-2152
DOI 10.1167/iovs.17-23047, PubMed 29801149

Piippo N, Korhonen E, Hytti M, Skottman H, Kinnunen K, Josifovska N, Petrovski G, Kaarniranta K, Kauppinen A (2018)
Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
Sci Rep, 8 (1), 6720
DOI 10.1038/s41598-018-25123-2, PubMed 29712950

Riise N, Lindberg BR, Kulseth MA, Fredwall SO, Lundby R, Estensen ME, Drolsum L, Merckoll E, Krohg-Sørensen K, Paus B (2018)
Clinical diagnosis of Larsen syndrome, Stickler syndrome and Loeys-Dietz syndrome in a 19-year old male: a case report
BMC Med Genet, 19 (1), 155
DOI 10.1186/s12881-018-0671-0, PubMed 30170566

Salvanos P, Moe MC, Utheim TP, Bragadóttir R, Kerty E (2018)
ULTRA-WIDE-FIELD FUNDUS IMAGING IN THE DIAGNOSIS AND FOLLOW-UP OF SUSAC SYNDROME
Retin Cases Brief Rep, 12 (3), 234-239
DOI 10.1097/ICB.0000000000000470, PubMed 27828899

Sandvik GF, Vanem TT, Rand-Hendriksen S, Cholidis S, Saethre M, Drolsum L (2018)
Ten-year reinvestigation of ocular manifestations in Marfan syndrome
Clin Exp Ophthalmol (in press)
DOI 10.1111/ceo.13408, PubMed 30260057

Schippert AC, Jelin E, Moe MC, Heiberg T, Grov EK (2018)
The Impact of Age-Related Macular Degeneration on Quality of Life and Its Association With Demographic Data: Results From the NEI VFQ-25 Questionnaire in a Norwegian Population
Gerontol Geriatr Med, 4, 2333721418801601
DOI 10.1177/2333721418801601, PubMed 30263908

Sembajwe LF, Katta K, Grønning M, Kusche-Gullberg M (2018)
The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulphate structure in human breast carcinoma cell lines
Biosci Rep, 38 (4)
DOI 10.1042/BSR20180770, PubMed 30054430

Sivertsen MS, Jørstad ØK, Grevys A, Foss S, Moe MC, Andersen JT (2018)
Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties
Sci Rep, 8 (1), 2101
DOI 10.1038/s41598-018-20525-8, PubMed 29391560

Slettedal JK, Sandvik L, Ringvold A (2018)
Lifespan reduction due to neoplasia is nullified by pseudoexfoliation syndrome
Heliyon, 4 (10), e00832
DOI 10.1016/j.heliyon.2018.e00832, PubMed 30302411

Talsma DT, Katta K, Ettema MAB, Kel B, Kusche-Gullberg M, Daha MR, Stegeman CA, van den Born J, Wang L (2018)
Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy
Lab Invest, 98 (4), 427-438
DOI 10.1038/s41374-017-0015-2, PubMed 29330473

Thorsrud A, Hagem AM, Sandvik GF, Drolsum L (2018)
Superior outcome of corneal collagen cross-linking using riboflavin with methylcellulose than riboflavin with dextran as the main supplement
Acta Ophthalmol (in press)
DOI 10.1111/aos.13928, PubMed 30284383

Utheim OA, Lyberg T, Eidet JR, Raeder S, Sehic A, Roald B, Messelt E, de la Paz MF, Dartt DA, Utheim TP (2018)
Effect of Transportation on Cultured Limbal Epithelial Sheets for Worldwide Treatment of Limbal Stem Cell Deficiency
Sci Rep, 8 (1), 10502
DOI 10.1038/s41598-018-28553-0, PubMed 30002380

Utheim TP, Aass Utheim Ø, Salvanos P, Jackson CJ, Schrader S, Geerling G, Sehic A (2018)
Concise Review: Altered Versus Unaltered Amniotic Membrane as a Substrate for Limbal Epithelial Cells
Stem Cells Transl Med, 7 (5), 415-427
DOI 10.1002/sctm.17-0257, PubMed 29573222

Wankel VD, Bondø G, Jørstad ØK (2018)
Visual requirements for driving licences
Tidsskr Nor Laegeforen, 138 (16)
DOI 10.4045/tidsskr.18.0559, PubMed 30344329

 
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